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The map label for this gene is hemA [H]

Identifier: 146340550

GI number: 146340550

Start: 3785771

End: 3787003

Strand: Direct

Name: hemA [H]

Synonym: BRADO3594

Alternate gene names: 146340550

Gene position: 3785771-3787003 (Clockwise)

Preceding gene: 146340546

Following gene: 146340551

Centisome position: 50.77

GC content: 65.94

Gene sequence:

>1233_bases
GTGAAGAACTACGACCGCTATTTCGACCATGCCCTCGATCAGCTCCACCAGGAGCGCCGCTACCGCGTGTTCGCCGACCT
CGAGCGCCGTGCCGGCCGGTTTCCGCACGCGATCTGGCATTCGCCCGAAGGTCCGCGGGATGTGGTGATCTGGTGCTCCA
ACGATTATCTCGGGATGGGACAGCATCCGAAGGTGATCGGCGCGATGGTCGATGTGGCCGCGCGCATGGGCACCGGCGCG
GGCGGCACCCGAAACATCGCCGGCACCAACCACCCGCTGGTCGAGCTCGAACGCGAGCTCGCCGATCTCCACGGCAAGGA
GGCGGCGCTGGTGTTCACCTCGGGCTACGTCTCCAACGAGACCGGTATCTCGACGATCGCCAAGCTGTTGTCGAATTGCC
TGCTGCTGTCCGACGCGCTGAACCACAATTCGATGATCGAAGGCGTGCGCAAGGCCGGCACGGAGAAGCAGGTGTGGCGG
CACAATGATCTGGCGCACCTCGAGGAGCTGCTGCAGGCGGCCGATCCCGACCGGCCCAAGCTGATCGTCTGCGAGAGTCT
GTATTCGATGGACGGTGATGTCGCGCCCCTGCATCGGATCTGCGATCTCGCCGATCGCTACGGCGCGTTGACCTATGTCG
ACGAGGTCCATGCTGTCGGCATGTATGGCCCGCGTGGCGGCGGCATTGCCGAGCGCGACGGCGCGATGGCCCGCATCGAT
ATCCTTGAAGGCACCCTGGCGAAAGCGTTCGGCTGCCTGGGCGGCTACATCGCCGCCAATGCCAATTTGATCGATGCCGT
CAGGTCCTACGCCCCGGGCTTCATTTTCACTACGGCCCTGCCGCCGCCGGTCTGCGCCGCGGCAACCGCCGCGATCCGGC
ATCTGAAGACCTCGCAATGGGAGCGCGACCGGCATCAGGACCGTGCCGCCCGGCTCAAGGCGGTGCTGAACGCGTCAGGC
TTGCCGGTGATGCCTTCGGATACTCACATCGTCCCGGTCCATGTCGGCGATCCCGAGAAGTGCAAGAGCGCCTCCGACCT
GCTCCTGGCAGAGCACGGCATCTACATCCAGCCGATCAACTACCCGACGGTACCGCGCGGTCTGGAGCGGCTGCGGATCA
CCCCGTCGCCGTACCATGATGATGGCCTGATCGATGCGCTGGCGGAAGCGCTGGTCGACGTCTGGGACCGGCTCGGCCTG
CCGCGCGCCGCGCAGGCGATGGCCGCGGAGTAG

Upstream 100 bases:

>100_bases
GAACGCCTTGCATAACTGGGCTTTTGTCCCATCCGGAACAAACCTTTAGGGGCGCGCCGCAACGCTGGCGCTGGCCGCCG
GGCAGGGGAAGGACGACCAG

Downstream 100 bases:

>100_bases
GTCTGTCCGACTGTTTTGTCAGGCGACCCTGTCAAGTTTGATCTGCCGCAATGCCGCCCGCGCCCGCGCGGGCGTAATCT
TTTCTGAAGAGGGGAACATG

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MKNYDRYFDHALDQLHQERRYRVFADLERRAGRFPHAIWHSPEGPRDVVIWCSNDYLGMGQHPKVIGAMVDVAARMGTGA
GGTRNIAGTNHPLVELERELADLHGKEAALVFTSGYVSNETGISTIAKLLSNCLLLSDALNHNSMIEGVRKAGTEKQVWR
HNDLAHLEELLQAADPDRPKLIVCESLYSMDGDVAPLHRICDLADRYGALTYVDEVHAVGMYGPRGGGIAERDGAMARID
ILEGTLAKAFGCLGGYIAANANLIDAVRSYAPGFIFTTALPPPVCAAATAAIRHLKTSQWERDRHQDRAARLKAVLNASG
LPVMPSDTHIVPVHVGDPEKCKSASDLLLAEHGIYIQPINYPTVPRGLERLRITPSPYHDDGLIDALAEALVDVWDRLGL
PRAAQAMAAE

Sequences:

>Translated_410_residues
MKNYDRYFDHALDQLHQERRYRVFADLERRAGRFPHAIWHSPEGPRDVVIWCSNDYLGMGQHPKVIGAMVDVAARMGTGA
GGTRNIAGTNHPLVELERELADLHGKEAALVFTSGYVSNETGISTIAKLLSNCLLLSDALNHNSMIEGVRKAGTEKQVWR
HNDLAHLEELLQAADPDRPKLIVCESLYSMDGDVAPLHRICDLADRYGALTYVDEVHAVGMYGPRGGGIAERDGAMARID
ILEGTLAKAFGCLGGYIAANANLIDAVRSYAPGFIFTTALPPPVCAAATAAIRHLKTSQWERDRHQDRAARLKAVLNASG
LPVMPSDTHIVPVHVGDPEKCKSASDLLLAEHGIYIQPINYPTVPRGLERLRITPSPYHDDGLIDALAEALVDVWDRLGL
PRAAQAMAAE
>Mature_410_residues
MKNYDRYFDHALDQLHQERRYRVFADLERRAGRFPHAIWHSPEGPRDVVIWCSNDYLGMGQHPKVIGAMVDVAARMGTGA
GGTRNIAGTNHPLVELERELADLHGKEAALVFTSGYVSNETGISTIAKLLSNCLLLSDALNHNSMIEGVRKAGTEKQVWR
HNDLAHLEELLQAADPDRPKLIVCESLYSMDGDVAPLHRICDLADRYGALTYVDEVHAVGMYGPRGGGIAERDGAMARID
ILEGTLAKAFGCLGGYIAANANLIDAVRSYAPGFIFTTALPPPVCAAATAAIRHLKTSQWERDRHQDRAARLKAVLNASG
LPVMPSDTHIVPVHVGDPEKCKSASDLLLAEHGIYIQPINYPTVPRGLERLRITPSPYHDDGLIDALAEALVDVWDRLGL
PRAAQAMAAE

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=411, Percent_Identity=49.1484184914842, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI83977440, Length=411, Percent_Identity=49.1484184914842, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI83977444, Length=411, Percent_Identity=49.1484184914842, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI4502025, Length=402, Percent_Identity=50.2487562189055, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI40316939, Length=402, Percent_Identity=50.2487562189055, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI7657118, Length=348, Percent_Identity=35.9195402298851, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=35.9195402298851, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI119220554, Length=408, Percent_Identity=29.4117647058824, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4758668, Length=395, Percent_Identity=27.8481012658228, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI5454084, Length=248, Percent_Identity=25.4032258064516, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1790046, Length=356, Percent_Identity=34.8314606741573, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=29.8850574712644, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71994529, Length=358, Percent_Identity=34.3575418994413, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI32566772, Length=374, Percent_Identity=28.6096256684492, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17560914, Length=387, Percent_Identity=27.906976744186, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17560912, Length=387, Percent_Identity=27.906976744186, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI71982617, Length=229, Percent_Identity=27.9475982532751, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71982625, Length=229, Percent_Identity=27.9475982532751, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320438, Length=422, Percent_Identity=47.6303317535545, Blast_Score=396, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=30.7065217391304, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323954, Length=263, Percent_Identity=23.574144486692, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17137420, Length=401, Percent_Identity=46.3840399002494, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24662918, Length=354, Percent_Identity=34.7457627118644, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI17136286, Length=373, Percent_Identity=28.1501340482574, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24653280, Length=257, Percent_Identity=24.5136186770428, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24653276, Length=257, Percent_Identity=24.5136186770428, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24653278, Length=257, Percent_Identity=24.5136186770428, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44821; Mature: 44821

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNYDRYFDHALDQLHQERRYRVFADLERRAGRFPHAIWHSPEGPRDVVIWCSNDYLGMG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEEECCCCCCCC
QHPKVIGAMVDVAARMGTGAGGTRNIAGTNHPLVELERELADLHGKEAALVFTSGYVSNE
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCC
TGISTIAKLLSNCLLLSDALNHNSMIEGVRKAGTEKQVWRHNDLAHLEELLQAADPDRPK
CCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCCCCCCC
LIVCESLYSMDGDVAPLHRICDLADRYGALTYVDEVHAVGMYGPRGGGIAERDGAMARID
EEEEHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEH
ILEGTLAKAFGCLGGYIAANANLIDAVRSYAPGFIFTTALPPPVCAAATAAIRHLKTSQW
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
ERDRHQDRAARLKAVLNASGLPVMPSDTHIVPVHVGDPEKCKSASDLLLAEHGIYIQPIN
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHCCHHHHHEECCCCEEEECC
YPTVPRGLERLRITPSPYHDDGLIDALAEALVDVWDRLGLPRAAQAMAAE
CCCCCCCHHHEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
>Mature Secondary Structure
MKNYDRYFDHALDQLHQERRYRVFADLERRAGRFPHAIWHSPEGPRDVVIWCSNDYLGMG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEEECCCCCCCC
QHPKVIGAMVDVAARMGTGAGGTRNIAGTNHPLVELERELADLHGKEAALVFTSGYVSNE
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCC
TGISTIAKLLSNCLLLSDALNHNSMIEGVRKAGTEKQVWRHNDLAHLEELLQAADPDRPK
CCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCCCCCCC
LIVCESLYSMDGDVAPLHRICDLADRYGALTYVDEVHAVGMYGPRGGGIAERDGAMARID
EEEEHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEH
ILEGTLAKAFGCLGGYIAANANLIDAVRSYAPGFIFTTALPPPVCAAATAAIRHLKTSQW
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
ERDRHQDRAARLKAVLNASGLPVMPSDTHIVPVHVGDPEKCKSASDLLLAEHGIYIQPIN
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHCCHHHHHEECCCCEEEECC
YPTVPRGLERLRITPSPYHDDGLIDALAEALVDVWDRLGLPRAAQAMAAE
CCCCCCCHHHEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]