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The map label for this gene is tdcB [H]

Identifier: 146340517

GI number: 146340517

Start: 3751981

End: 3753219

Strand: Direct

Name: tdcB [H]

Synonym: BRADO3559

Alternate gene names: 146340517

Gene position: 3751981-3753219 (Clockwise)

Preceding gene: 146340516

Following gene: 146340518

Centisome position: 50.32

GC content: 66.02

Gene sequence:

>1239_bases
ATGGGTAGACACATGACCACCTATGACCTCAACGATCTGCCCGTTACCATCAACGATGTGCGCGCCGCTGCTGACACGAT
CAGCGGCGCGGTGCTCACCACGGCCTGCAACCAGAGCCGGACGCTCGGCGAGATCTGCGGCTGCAACATCTGGCTGAAGT
TCGAGAACCTGCAGTTCACGTCCTCCTTCAAGGAGCGCGGCGCGCTCAACCGGTTGAATGCGCTGTCGTCAGAGCAGAGA
GAGCGCGGCGTGATCGCGATGTCCGCCGGCAATCACGCGCAGGGCGTCGCCTACAACGCGCGTCGCCTCGGCATTCCCGC
AACCATCGTGATGCCCGTGGGCACGCCGATGGTGAAGGTGGAGAACACCCGCCGGCACGGCGCCGAGGTCGTGATCTCCG
GCGCCACGCTGGAGGAAGCAGGCACGTTCGCGCGGGAGCACGGCGCGGCCCGCGGCATGACCATGATCCATCCGTATGAC
GATCCGCTGATCATTGCCGGGCAGGGGACGGTCGCGCTGGAGATGCTGGCCGTCGTTCCCGAGCTCGACACGCTGGTGGT
GCCGATCGGCGGCGGCGGGCTGATCTCGGGCATCGCGGTCGCGGCGCGCGCGCTCAAGCCATCGATGCGGATCGTCGGCG
TGCAGGCCGAGCTCTATCCCTCGATGTACAATGCCATCAGCGGGCGGTCACTGCCGATGCGCGGCGATACGCTGGCGGAG
GGCATCGCGGTGAAATCGCCGGGCCGGATCACGACCGAGATCATCCGGCATCTCGTCGACGAGATCCTGCTCGTCACCGA
GCCGCAGATCGAGCGTGCGCTGGCCACCTTGATCTCGATCGAGAAGACCGTGGTCGAAGGCGCCGGCGCCGTCGGCCTTG
CCGCGGTTCTCGCGCATCAGGATCAATTTGCGGGCCGCAATGTCGGTCTCGTGCTGTGTGGAGGCAATATCGACACCCGG
CTGATCGCCTCGGTGCTGACGCGCGAACTCGCCCGCGAAGGCCGGCTGACCCAGCTGTCGATCGATATCGTCGATCGTCC
GGGACAGCTCGCCGCGGTGTCCGCGCTGCTGGCCGATGCCGGCGCCAACATTATCGAGGTCTCGCATCAGCGCACGTTTT
CCGACTTGCCCGCCAAGGCGACCTTGCTGGAACTGGTGATCGAGACCCGCGACCAGGCGCATCTCAACGAGGTGATGGAC
AGGCTGGTCGCAGCCGATTTCAAGGCGCGCTGCACCTGA

Upstream 100 bases:

>100_bases
ATGCGGCTGATGCTGGGTCTGCCCGATCTCGCCTGAGATCGGACGGAATCATCCGGCCGGACTTCTGCCGGCCGCCGCAG
GGATGCACGGCCAGACATCG

Downstream 100 bases:

>100_bases
GCGAGCCTCCCACTGCTACCGATTTTGGAACGTCATCGATGTTCAAGACCATTCGACACATCTCCGACGTCGAGCCTGCG
GTCGCGGGCAAGAAGGAGAT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MGRHMTTYDLNDLPVTINDVRAAADTISGAVLTTACNQSRTLGEICGCNIWLKFENLQFTSSFKERGALNRLNALSSEQR
ERGVIAMSAGNHAQGVAYNARRLGIPATIVMPVGTPMVKVENTRRHGAEVVISGATLEEAGTFAREHGAARGMTMIHPYD
DPLIIAGQGTVALEMLAVVPELDTLVVPIGGGGLISGIAVAARALKPSMRIVGVQAELYPSMYNAISGRSLPMRGDTLAE
GIAVKSPGRITTEIIRHLVDEILLVTEPQIERALATLISIEKTVVEGAGAVGLAAVLAHQDQFAGRNVGLVLCGGNIDTR
LIASVLTRELAREGRLTQLSIDIVDRPGQLAAVSALLADAGANIIEVSHQRTFSDLPAKATLLELVIETRDQAHLNEVMD
RLVAADFKARCT

Sequences:

>Translated_412_residues
MGRHMTTYDLNDLPVTINDVRAAADTISGAVLTTACNQSRTLGEICGCNIWLKFENLQFTSSFKERGALNRLNALSSEQR
ERGVIAMSAGNHAQGVAYNARRLGIPATIVMPVGTPMVKVENTRRHGAEVVISGATLEEAGTFAREHGAARGMTMIHPYD
DPLIIAGQGTVALEMLAVVPELDTLVVPIGGGGLISGIAVAARALKPSMRIVGVQAELYPSMYNAISGRSLPMRGDTLAE
GIAVKSPGRITTEIIRHLVDEILLVTEPQIERALATLISIEKTVVEGAGAVGLAAVLAHQDQFAGRNVGLVLCGGNIDTR
LIASVLTRELAREGRLTQLSIDIVDRPGQLAAVSALLADAGANIIEVSHQRTFSDLPAKATLLELVIETRDQAHLNEVMD
RLVAADFKARCT
>Mature_411_residues
GRHMTTYDLNDLPVTINDVRAAADTISGAVLTTACNQSRTLGEICGCNIWLKFENLQFTSSFKERGALNRLNALSSEQRE
RGVIAMSAGNHAQGVAYNARRLGIPATIVMPVGTPMVKVENTRRHGAEVVISGATLEEAGTFAREHGAARGMTMIHPYDD
PLIIAGQGTVALEMLAVVPELDTLVVPIGGGGLISGIAVAARALKPSMRIVGVQAELYPSMYNAISGRSLPMRGDTLAEG
IAVKSPGRITTEIIRHLVDEILLVTEPQIERALATLISIEKTVVEGAGAVGLAAVLAHQDQFAGRNVGLVLCGGNIDTRL
IASVLTRELAREGRLTQLSIDIVDRPGQLAAVSALLADAGANIIEVSHQRTFSDLPAKATLLELVIETRDQAHLNEVMDR
LVAADFKARCT

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=313, Percent_Identity=36.741214057508, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI19923959, Length=142, Percent_Identity=35.9154929577465, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI33469958, Length=322, Percent_Identity=25.776397515528, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1789505, Length=318, Percent_Identity=43.0817610062893, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1790207, Length=331, Percent_Identity=36.2537764350453, Blast_Score=162, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71991565, Length=391, Percent_Identity=39.386189258312, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17537387, Length=404, Percent_Identity=33.6633663366337, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17508781, Length=318, Percent_Identity=31.4465408805031, Blast_Score=148, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6322631, Length=314, Percent_Identity=39.4904458598726, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6320930, Length=378, Percent_Identity=33.8624338624339, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319788, Length=186, Percent_Identity=31.7204301075269, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355833, Length=393, Percent_Identity=38.9312977099237, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24645328, Length=289, Percent_Identity=38.0622837370242, Blast_Score=149, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43786; Mature: 43655

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRHMTTYDLNDLPVTINDVRAAADTISGAVLTTACNQSRTLGEICGCNIWLKFENLQFT
CCCCCEEEECCCCCEEHHHHHHHHHHHCCEEEEEECCCCCCHHHHHCCEEEEEEECCEEH
SSFKERGALNRLNALSSEQRERGVIAMSAGNHAQGVAYNARRLGIPATIVMPVGTPMVKV
HHHHHCCHHHHHHHHHHHHHHCCEEEEECCCCCCCEEECCEECCCCEEEEEECCCCEEEE
ENTRRHGAEVVISGATLEEAGTFAREHGAARGMTMIHPYDDPLIIAGQGTVALEMLAVVP
ECCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHCC
ELDTLVVPIGGGGLISGIAVAARALKPSMRIVGVQAELYPSMYNAISGRSLPMRGDTLAE
CCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCHHHC
GIAVKSPGRITTEIIRHLVDEILLVTEPQIERALATLISIEKTVVEGAGAVGLAAVLAHQ
CEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
DQFAGRNVGLVLCGGNIDTRLIASVLTRELAREGRLTQLSIDIVDRPGQLAAVSALLADA
HHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHC
GANIIEVSHQRTFSDLPAKATLLELVIETRDQAHLNEVMDRLVAADFKARCT
CCCEEEECCHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GRHMTTYDLNDLPVTINDVRAAADTISGAVLTTACNQSRTLGEICGCNIWLKFENLQFT
CCCCEEEECCCCCEEHHHHHHHHHHHCCEEEEEECCCCCCHHHHHCCEEEEEEECCEEH
SSFKERGALNRLNALSSEQRERGVIAMSAGNHAQGVAYNARRLGIPATIVMPVGTPMVKV
HHHHHCCHHHHHHHHHHHHHHCCEEEEECCCCCCCEEECCEECCCCEEEEEECCCCEEEE
ENTRRHGAEVVISGATLEEAGTFAREHGAARGMTMIHPYDDPLIIAGQGTVALEMLAVVP
ECCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHCC
ELDTLVVPIGGGGLISGIAVAARALKPSMRIVGVQAELYPSMYNAISGRSLPMRGDTLAE
CCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCHHHC
GIAVKSPGRITTEIIRHLVDEILLVTEPQIERALATLISIEKTVVEGAGAVGLAAVLAHQ
CEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
DQFAGRNVGLVLCGGNIDTRLIASVLTRELAREGRLTQLSIDIVDRPGQLAAVSALLADA
HHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHC
GANIIEVSHQRTFSDLPAKATLLELVIETRDQAHLNEVMDRLVAADFKARCT
CCCEEEECCHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA