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The map label for this gene is pgsA [H]

Identifier: 146340320

GI number: 146340320

Start: 3540340

End: 3540894

Strand: Reverse

Name: pgsA [H]

Synonym: BRADO3343

Alternate gene names: 146340320

Gene position: 3540894-3540340 (Counterclockwise)

Preceding gene: 146340323

Following gene: 146340319

Centisome position: 47.49

GC content: 63.96

Gene sequence:

>555_bases
GTGACCATTCCCCACAGTATTCCCAACCTGATCACGCTGGGCCGAATCCTGCTGGTTCCGATCGTGGTGTGGGCCATCGC
GGCCGGCGAGATGGAGGTTGCCTTCATCGTGTTCGTCATCGCCGGGGTCAGCGACGCCGTGGACGGCTTCCTGGCCCGGC
GCTTCAACCTGCGCTCCGAGCTCGGCGCCCTGCTCGACCCGCTGGCCGACAAGGCGCTGCTGGTCTCGATCTTCGTCACG
CTCGGCATCTGGGGCGCCATCCCGCGCTGGATCGTCATCCTGGTGGTCTCGCGCGACATCATGATCGTCGCCGCCGTGAT
CGTCTCCTGGCTGTTCGACCGGCCGGTCGCAATGAAGCCGTTGATGGTGTCGAAGCTGAACACCGGGGCGCAGGTGGGAT
TTGCCGCGCTGGTGCTGGCATCGCTCAGCTTCGGCTTCGAGCCCAAGCCCTATGACAGTGTGCTGATGGTGCTGGTGACG
GCCTTTACCCTTGTATCCGTCGGGCTTTACCTGGTGGATTGGGTGCGCCACATGAATACCATCGAGGTGCGGTGA

Upstream 100 bases:

>100_bases
CGCAAGGGGCTCGTCCCCACCCTATCTAGGAACCGGACGGGTTCGCCGTGCTTCGCAATCGGGCCCTCCATTCATCGAGT
TTGTCGTCGGGACCAGCTGC

Downstream 100 bases:

>100_bases
GGCCGGCTTCGCGAGCCCCTCGCCCCTCCCCGCTGACACGACGACACGGAGCACCTCAACCTTGGCCGGCCATATTCCCC
CTCGTCAACTGGCCCTCGCT

Product: putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MTIPHSIPNLITLGRILLVPIVVWAIAAGEMEVAFIVFVIAGVSDAVDGFLARRFNLRSELGALLDPLADKALLVSIFVT
LGIWGAIPRWIVILVVSRDIMIVAAVIVSWLFDRPVAMKPLMVSKLNTGAQVGFAALVLASLSFGFEPKPYDSVLMVLVT
AFTLVSVGLYLVDWVRHMNTIEVR

Sequences:

>Translated_184_residues
MTIPHSIPNLITLGRILLVPIVVWAIAAGEMEVAFIVFVIAGVSDAVDGFLARRFNLRSELGALLDPLADKALLVSIFVT
LGIWGAIPRWIVILVVSRDIMIVAAVIVSWLFDRPVAMKPLMVSKLNTGAQVGFAALVLASLSFGFEPKPYDSVLMVLVT
AFTLVSVGLYLVDWVRHMNTIEVR
>Mature_183_residues
TIPHSIPNLITLGRILLVPIVVWAIAAGEMEVAFIVFVIAGVSDAVDGFLARRFNLRSELGALLDPLADKALLVSIFVTL
GIWGAIPRWIVILVVSRDIMIVAAVIVSWLFDRPVAMKPLMVSKLNTGAQVGFAALVLASLSFGFEPKPYDSVLMVLVTA
FTLVSVGLYLVDWVRHMNTIEVR

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=196, Percent_Identity=33.6734693877551, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI10092647, Length=196, Percent_Identity=33.6734693877551, Blast_Score=94, Evalue=5e-20,
Organism=Escherichia coli, GI1788220, Length=76, Percent_Identity=42.1052631578947, Blast_Score=60, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71984838, Length=181, Percent_Identity=33.1491712707182, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71984834, Length=181, Percent_Identity=33.1491712707182, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320059, Length=125, Percent_Identity=31.2, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650130, Length=152, Percent_Identity=31.5789473684211, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24650126, Length=152, Percent_Identity=31.5789473684211, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24650128, Length=152, Percent_Identity=31.5789473684211, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 20055; Mature: 19924

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPHSIPNLITLGRILLVPIVVWAIAAGEMEVAFIVFVIAGVSDAVDGFLARRFNLRSE
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGALLDPLADKALLVSIFVTLGIWGAIPRWIVILVVSRDIMIVAAVIVSWLFDRPVAMKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
LMVSKLNTGAQVGFAALVLASLSFGFEPKPYDSVLMVLVTAFTLVSVGLYLVDWVRHMNT
HHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEVR
HCCC
>Mature Secondary Structure 
TIPHSIPNLITLGRILLVPIVVWAIAAGEMEVAFIVFVIAGVSDAVDGFLARRFNLRSE
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGALLDPLADKALLVSIFVTLGIWGAIPRWIVILVVSRDIMIVAAVIVSWLFDRPVAMKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
LMVSKLNTGAQVGFAALVLASLSFGFEPKPYDSVLMVLVTAFTLVSVGLYLVDWVRHMNT
HHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEVR
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7750561; 9384377 [H]