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The map label for this gene is gyaR [H]

Identifier: 146340042

GI number: 146340042

Start: 3248646

End: 3249638

Strand: Direct

Name: gyaR [H]

Synonym: BRADO3050

Alternate gene names: 146340042

Gene position: 3248646-3249638 (Clockwise)

Preceding gene: 146340041

Following gene: 146340044

Centisome position: 43.57

GC content: 66.97

Gene sequence:

>993_bases
GTGGTACCATCCGGCATGCTCGACAAAGTCCTGATCTACTCCCGCCTACCAAAGTCGATGACCCAGCGGTTTTCCGATCG
CTTCGACCTTCTCGACACCGGCGGCAAGCCGGCGCGTGAGGTGTTTTCAGCGGAGGAGGTGGCACAGGTCCGGGCGCTGA
TCACGGCGGGTGCGACGCCGCTCGCGGCCGAGCAAATGGACCGGCTGCCGGCACTCGGGGCGATCGTCTGCTACGGCACC
GGCTATGACGGGGTCGACCTGAAGGCGGCGGCGGCGCGCAATATCGCGGTCGGTCACAGCCCCGGCGCTAATGCCGCGGC
GGTGGCCGACGTCGCGGTCATGCTGATGCTGGCGAGCACGCGGCGGCTGGTCGTCGCCGACGCCTATGTCCGCGACGGCG
GCTGGGCCGGGGCGAAGCCGTCGCCGCTGATGAGGCCGCCGCCGAGCCTCGCTGGCTGCAAGGTCGGCGTCTACGGCATG
GGCGCGATCGGCCGCAAGATCGCCGCTCGCGTCGCCGCGTTCGAGACCGAAGTCGGGTATTTCAATCGCACCCGCTATGA
CGACCTGCCGTACCAGTATGTCTCGAGCCTGGATGCGCTCGCCGAGTGGTGCACCGTGCTGATGGTCGCGGTGCGCGCCA
GCGCCGAGACGACCCACGTGGTCAATGCGCATCTGCTGAAGAAGCTCGGCCCGGACGGCCACGTCATCAACATCTCGCGC
GGCTCGGTCATCGACCAGCAGGCACTGGTCGCGGCGCTGAAGGACGGCACCATTGCAGGGGCCGGGCTCGACGTGTTCGA
GAAGGAACCTCATGCGCCGGATGAACTGACGGCGCTTCCGAATGTCGTGGTGACACCCCATATCGGCGGCAACACCCGTG
AGTCGCATGTGGCGATGCAGGCCTGCGTGGTAGCCAATCTCACGGCTTTCTTCGTCGGCGAGAAGCTGCCTTACGCGGTA
TCCGCATCCTCGGGGGCCTATGAGCGAGTTTAG

Upstream 100 bases:

>100_bases
GGCGTCAAGGTCGAGCCGGGCACCGTGCTCGCCTAAGCGGCCAAGCATGAGCTAGATTAGGAAGGGCGGGATCGTTCAAC
GATCCCGCCCTTCGCATTTC

Downstream 100 bases:

>100_bases
GAGCTCTTAGCAGGTGGGTCGTGCCGCTAATTGGTGCGATTTTTGCCCTAGGGGGTCTTGGCAATCCGTCATCGACCCGT
TAAAGAACCGGCTTCCGGGC

Product: putative glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MVPSGMLDKVLIYSRLPKSMTQRFSDRFDLLDTGGKPAREVFSAEEVAQVRALITAGATPLAAEQMDRLPALGAIVCYGT
GYDGVDLKAAAARNIAVGHSPGANAAAVADVAVMLMLASTRRLVVADAYVRDGGWAGAKPSPLMRPPPSLAGCKVGVYGM
GAIGRKIAARVAAFETEVGYFNRTRYDDLPYQYVSSLDALAEWCTVLMVAVRASAETTHVVNAHLLKKLGPDGHVINISR
GSVIDQQALVAALKDGTIAGAGLDVFEKEPHAPDELTALPNVVVTPHIGGNTRESHVAMQACVVANLTAFFVGEKLPYAV
SASSGAYERV

Sequences:

>Translated_330_residues
MVPSGMLDKVLIYSRLPKSMTQRFSDRFDLLDTGGKPAREVFSAEEVAQVRALITAGATPLAAEQMDRLPALGAIVCYGT
GYDGVDLKAAAARNIAVGHSPGANAAAVADVAVMLMLASTRRLVVADAYVRDGGWAGAKPSPLMRPPPSLAGCKVGVYGM
GAIGRKIAARVAAFETEVGYFNRTRYDDLPYQYVSSLDALAEWCTVLMVAVRASAETTHVVNAHLLKKLGPDGHVINISR
GSVIDQQALVAALKDGTIAGAGLDVFEKEPHAPDELTALPNVVVTPHIGGNTRESHVAMQACVVANLTAFFVGEKLPYAV
SASSGAYERV
>Mature_330_residues
MVPSGMLDKVLIYSRLPKSMTQRFSDRFDLLDTGGKPAREVFSAEEVAQVRALITAGATPLAAEQMDRLPALGAIVCYGT
GYDGVDLKAAAARNIAVGHSPGANAAAVADVAVMLMLASTRRLVVADAYVRDGGWAGAKPSPLMRPPPSLAGCKVGVYGM
GAIGRKIAARVAAFETEVGYFNRTRYDDLPYQYVSSLDALAEWCTVLMVAVRASAETTHVVNAHLLKKLGPDGHVINISR
GSVIDQQALVAALKDGTIAGAGLDVFEKEPHAPDELTALPNVVVTPHIGGNTRESHVAMQACVVANLTAFFVGEKLPYAV
SASSGAYERV

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=252, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI23308577, Length=327, Percent_Identity=27.217125382263, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI61743967, Length=248, Percent_Identity=28.2258064516129, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI4557497, Length=250, Percent_Identity=28.8, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI145580578, Length=250, Percent_Identity=30, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4557499, Length=250, Percent_Identity=30, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI145580575, Length=270, Percent_Identity=28.1481481481481, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI87082289, Length=313, Percent_Identity=31.629392971246, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1789279, Length=260, Percent_Identity=29.6153846153846, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87081824, Length=144, Percent_Identity=34.7222222222222, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787645, Length=265, Percent_Identity=26.7924528301887, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=278, Percent_Identity=28.4172661870504, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI25147481, Length=247, Percent_Identity=27.1255060728745, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=33.739837398374, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6322116, Length=284, Percent_Identity=29.2253521126761, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=292, Percent_Identity=28.7671232876712, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6325144, Length=168, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=271, Percent_Identity=23.9852398523985, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324964, Length=287, Percent_Identity=22.9965156794425, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28574284, Length=316, Percent_Identity=29.746835443038, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI45551003, Length=316, Percent_Identity=29.746835443038, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24585514, Length=316, Percent_Identity=29.746835443038, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI28574282, Length=316, Percent_Identity=29.746835443038, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI45552429, Length=314, Percent_Identity=29.9363057324841, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI28571528, Length=255, Percent_Identity=34.1176470588235, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28574286, Length=319, Percent_Identity=28.5266457680251, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24585516, Length=277, Percent_Identity=29.2418772563177, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646446, Length=237, Percent_Identity=31.2236286919831, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24646448, Length=237, Percent_Identity=31.2236286919831, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24646452, Length=237, Percent_Identity=31.2236286919831, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24646450, Length=237, Percent_Identity=31.2236286919831, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI62472511, Length=237, Percent_Identity=31.2236286919831, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19921140, Length=241, Percent_Identity=29.4605809128631, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34720; Mature: 34720

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPSGMLDKVLIYSRLPKSMTQRFSDRFDLLDTGGKPAREVFSAEEVAQVRALITAGATP
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
LAAEQMDRLPALGAIVCYGTGYDGVDLKAAAARNIAVGHSPGANAAAVADVAVMLMLAST
HHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHCC
RRLVVADAYVRDGGWAGAKPSPLMRPPPSLAGCKVGVYGMGAIGRKIAARVAAFETEVGY
CEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEECEECCCHHHHHHHHHHHHHHHHCCC
FNRTRYDDLPYQYVSSLDALAEWCTVLMVAVRASAETTHVVNAHLLKKLGPDGHVINISR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECC
GSVIDQQALVAALKDGTIAGAGLDVFEKEPHAPDELTALPNVVVTPHIGGNTRESHVAMQ
CCCHHHHHHHHHHCCCCEECCCCHHHCCCCCCCHHHHHCCCEEEECCCCCCCCHHHHHHH
ACVVANLTAFFVGEKLPYAVSASSGAYERV
HHHHHHHHHHHHCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MVPSGMLDKVLIYSRLPKSMTQRFSDRFDLLDTGGKPAREVFSAEEVAQVRALITAGATP
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
LAAEQMDRLPALGAIVCYGTGYDGVDLKAAAARNIAVGHSPGANAAAVADVAVMLMLAST
HHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHCC
RRLVVADAYVRDGGWAGAKPSPLMRPPPSLAGCKVGVYGMGAIGRKIAARVAAFETEVGY
CEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEECEECCCHHHHHHHHHHHHHHHHCCC
FNRTRYDDLPYQYVSSLDALAEWCTVLMVAVRASAETTHVVNAHLLKKLGPDGHVINISR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECC
GSVIDQQALVAALKDGTIAGAGLDVFEKEPHAPDELTALPNVVVTPHIGGNTRESHVAMQ
CCCHHHHHHHHHHCCCCEECCCCHHHCCCCCCCHHHHHCCCEEEECCCCCCCCHHHHHHH
ACVVANLTAFFVGEKLPYAVSASSGAYERV
HHHHHHHHHHHHCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA