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The map label for this gene is paaX [H]

Identifier: 146339528

GI number: 146339528

Start: 2692072

End: 2692953

Strand: Direct

Name: paaX [H]

Synonym: BRADO2518

Alternate gene names: 146339528

Gene position: 2692072-2692953 (Clockwise)

Preceding gene: 146339527

Following gene: 146339529

Centisome position: 36.1

GC content: 71.77

Gene sequence:

>882_bases
ATGCCGCAGCCGCTGTCCCGCATCGTCGACCAGCTGAAGAGCGAGCCGTCGCGCACGGGCTCGCTGATCATCACCGTGTT
CGGCGACGCCATCGTGCCGCGCGGCGGCAGCGTCTGGCTCGGCACCCTGCTGGCCTTCTTCGAGGGGCTCGCCATCGATG
GCAGCGTGGTGCGCACCGCGATGTCGCGACTGACGGCGGAGGGCTGGTTCGAGCGTACCAAGAGCGGCCGCAACAGCTTC
TATCGCCTGACCCGGCGCGGCGAGCAGACCTTTGCCGGCGCCACCCGCCACATCTACGATTCGCCGCCGGGGGAATGGAA
CGGCAGCTTCGAGCTGGTCATGATCGGCAGCGCCGACGACCGCGAGCAGGCGCGGACCGCGTTGCGCGATGCCGGCTTCG
GCAGCCCGCTGCCGGGTGTGTTCGTGGCGCCCTCCGGCGTCGCCGTGCCGGACGTGGTGGAGGGCGCGATCCGGCTGCAG
GCGTCGGCCGGCTTCGACATCGCGCGCCGGCTGGTCGCCGAAAGCTGGGCGCTGGAACGGACGGCGGATGCCTACCGCAA
GTTCAGCGCGTCCTTCGCGCCGCTCAAGGCCAGCATCGCCCGCGGCGAGGCGCTCACCGATGGCCAGGCGTTCACCGCCC
GCATCCTGCTGATCCACCACTACCGTCGCATCGTGCTCCGCGATCCGCTGCTGCCGGCCGAACTGCTGCCGGAGAACTGG
CCGGGCCGGCAGGCAAGGGCGCTGTGCGCCGAGATCTACCGGCTGCTGCTGCCGGGCGCGGAGCGCTGGCTCGACGCGCA
CGCGACCAATGAGGAGGGCGCATTGCCGGCCGCCGGCGCGGCGCTGGAACGGCGGTTTGCGGACGCGCATGAGGAACGCT
GA

Upstream 100 bases:

>100_bases
CGCCTGATCGGGCTTCCCGGTTCAGTCGATCGCTCCTGCGAGGCCCGCTTTCGGCGGGCCTTTCCTTTTGTGATCGGGCG
AAACCGGCTAAGCCTGCGCC

Downstream 100 bases:

>100_bases
TATATTACGGAATTCGATTGCATCTCTCGAATTTTGTAATATGTTGGCGGCAACCAAGTCCTGGGAGGACGCCGCCGCAT
GTACACGCAGGCGCTTAATT

Product: phenylacetic acid degradation operon negative regulatory protein paaX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MPQPLSRIVDQLKSEPSRTGSLIITVFGDAIVPRGGSVWLGTLLAFFEGLAIDGSVVRTAMSRLTAEGWFERTKSGRNSF
YRLTRRGEQTFAGATRHIYDSPPGEWNGSFELVMIGSADDREQARTALRDAGFGSPLPGVFVAPSGVAVPDVVEGAIRLQ
ASAGFDIARRLVAESWALERTADAYRKFSASFAPLKASIARGEALTDGQAFTARILLIHHYRRIVLRDPLLPAELLPENW
PGRQARALCAEIYRLLLPGAERWLDAHATNEEGALPAAGAALERRFADAHEER

Sequences:

>Translated_293_residues
MPQPLSRIVDQLKSEPSRTGSLIITVFGDAIVPRGGSVWLGTLLAFFEGLAIDGSVVRTAMSRLTAEGWFERTKSGRNSF
YRLTRRGEQTFAGATRHIYDSPPGEWNGSFELVMIGSADDREQARTALRDAGFGSPLPGVFVAPSGVAVPDVVEGAIRLQ
ASAGFDIARRLVAESWALERTADAYRKFSASFAPLKASIARGEALTDGQAFTARILLIHHYRRIVLRDPLLPAELLPENW
PGRQARALCAEIYRLLLPGAERWLDAHATNEEGALPAAGAALERRFADAHEER
>Mature_292_residues
PQPLSRIVDQLKSEPSRTGSLIITVFGDAIVPRGGSVWLGTLLAFFEGLAIDGSVVRTAMSRLTAEGWFERTKSGRNSFY
RLTRRGEQTFAGATRHIYDSPPGEWNGSFELVMIGSADDREQARTALRDAGFGSPLPGVFVAPSGVAVPDVVEGAIRLQA
SAGFDIARRLVAESWALERTADAYRKFSASFAPLKASIARGEALTDGQAFTARILLIHHYRRIVLRDPLLPAELLPENWP
GRQARALCAEIYRLLLPGAERWLDAHATNEEGALPAAGAALERRFADAHEER

Specific function: Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'- WWTRTGATTCGYGWT-3'. Binding of paaX is specifically inhibited by phenylacetyl-coenzyme A [H]

COG id: COG3327

COG function: function code K; Phenylacetic acid-responsive transcriptional repressor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787666, Length=301, Percent_Identity=34.21926910299, Blast_Score=161, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012906
- InterPro:   IPR013225
- InterPro:   IPR011965 [H]

Pfam domain/function: PF07848 PaaX; PF08223 PaaX_C [H]

EC number: NA

Molecular weight: Translated: 31994; Mature: 31862

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQPLSRIVDQLKSEPSRTGSLIITVFGDAIVPRGGSVWLGTLLAFFEGLAIDGSVVRTA
CCCHHHHHHHHHHCCCCCCCCEEEEEECCEECCCCCCHHHHHHHHHHHCCCCCHHHHHHH
MSRLTAEGWFERTKSGRNSFYRLTRRGEQTFAGATRHIYDSPPGEWNGSFELVMIGSADD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCC
REQARTALRDAGFGSPLPGVFVAPSGVAVPDVVEGAIRLQASAGFDIARRLVAESWALER
HHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHEECCCCHHHHHHHHHHHHHHHH
TADAYRKFSASFAPLKASIARGEALTDGQAFTARILLIHHYRRIVLRDPLLPAELLPENW
HHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCC
PGRQARALCAEIYRLLLPGAERWLDAHATNEEGALPAAGAALERRFADAHEER
CCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PQPLSRIVDQLKSEPSRTGSLIITVFGDAIVPRGGSVWLGTLLAFFEGLAIDGSVVRTA
CCHHHHHHHHHHCCCCCCCCEEEEEECCEECCCCCCHHHHHHHHHHHCCCCCHHHHHHH
MSRLTAEGWFERTKSGRNSFYRLTRRGEQTFAGATRHIYDSPPGEWNGSFELVMIGSADD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCC
REQARTALRDAGFGSPLPGVFVAPSGVAVPDVVEGAIRLQASAGFDIARRLVAESWALER
HHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHEECCCCHHHHHHHHHHHHHHHH
TADAYRKFSASFAPLKASIARGEALTDGQAFTARILLIHHYRRIVLRDPLLPAELLPENW
HHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCC
PGRQARALCAEIYRLLLPGAERWLDAHATNEEGALPAAGAALERRFADAHEER
CCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9278503; 10766858 [H]