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The map label for this gene is hutC [H]

Identifier: 146338669

GI number: 146338669

Start: 1712408

End: 1713139

Strand: Reverse

Name: hutC [H]

Synonym: BRADO1601

Alternate gene names: 146338669

Gene position: 1713139-1712408 (Counterclockwise)

Preceding gene: 146338670

Following gene: 146338668

Centisome position: 22.97

GC content: 66.67

Gene sequence:

>732_bases
ATGAGCCTCGCGGAGGATCGCGCCAAGCCGAGCACGCTCTACAAGACGATCCGGCAGGACATCGAGCGCCGCATCCTCAC
GGGCGAATGGCCGCCCGGCCATCGCATCCCGTTCGAGCACGAGATCATGGAGCACTATGGCTGCTCGCGCATGACCGTGA
ACAAGGCGCTGTCCGAGCTTGCGCAGGCCGATCTGATCGAGCGGCGGCGCCGCGCCGGCACCTTCGTGCGGCGGCCGCAA
TTCCTGTCGGCGGTGCTGAAGATTCCGGACATCCGCGCCGAGATCGGCGCGCTCGGCCGCGCCTATGGCTATGAGTTGAT
CGCATCAGCGCGGCGCACCGCCAACGCGGCCGATCGCGAGCGCCTTGGTGTCAAGACGCCGTGCAAGGTGATCGCGATCC
GTTGCCGCCACAGCGCCGACGGCCTGCCGTTCGCGATCGAAGACCGTTTGATTGATCTCGATGCCGTGCCGGATGCGGCG
AAAGCGAATTTCAAGATCGATCCGCCGGGCTCATGGCTGCTGCATCACGTGCCCTGGACCGAGGCCGAGCATGCGATCAG
CGCCATCGTCGCCGATGAGGCGATCGCAACCAGCCTCGACATCGAGACGGGCGCGCCGTGCCTCGTCATCGAGCGCCATA
CCTGGCGGCAAGGCCGACCGCTGACGGCTGTCAGGCTGGTCTATCCCGGTGAGCAGCATCGCCTCGTCGCGCGGTTCAGG
GGCAGCGAATGA

Upstream 100 bases:

>100_bases
GCGTCTGGGCCGGGGGCGCGAAACTCGTCCAGGGGGGCCAGCACCGATCGCGCGAAGCGGCGCGGCGCGGCTTCAACACG
GCGGTGCGGAGGCTGCTCGC

Downstream 100 bases:

>100_bases
CATGCGCGTGGACGCGGCCGAGCACGAGATTTGCAAGCAGGTGGGCAGCGCTTGCAGAGACATGTGGCCGTCGCAGTCCT
CGCGGGCTGCGACCCGCACG

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSLAEDRAKPSTLYKTIRQDIERRILTGEWPPGHRIPFEHEIMEHYGCSRMTVNKALSELAQADLIERRRRAGTFVRRPQ
FLSAVLKIPDIRAEIGALGRAYGYELIASARRTANAADRERLGVKTPCKVIAIRCRHSADGLPFAIEDRLIDLDAVPDAA
KANFKIDPPGSWLLHHVPWTEAEHAISAIVADEAIATSLDIETGAPCLVIERHTWRQGRPLTAVRLVYPGEQHRLVARFR
GSE

Sequences:

>Translated_243_residues
MSLAEDRAKPSTLYKTIRQDIERRILTGEWPPGHRIPFEHEIMEHYGCSRMTVNKALSELAQADLIERRRRAGTFVRRPQ
FLSAVLKIPDIRAEIGALGRAYGYELIASARRTANAADRERLGVKTPCKVIAIRCRHSADGLPFAIEDRLIDLDAVPDAA
KANFKIDPPGSWLLHHVPWTEAEHAISAIVADEAIATSLDIETGAPCLVIERHTWRQGRPLTAVRLVYPGEQHRLVARFR
GSE
>Mature_242_residues
SLAEDRAKPSTLYKTIRQDIERRILTGEWPPGHRIPFEHEIMEHYGCSRMTVNKALSELAQADLIERRRRAGTFVRRPQF
LSAVLKIPDIRAEIGALGRAYGYELIASARRTANAADRERLGVKTPCKVIAIRCRHSADGLPFAIEDRLIDLDAVPDAAK
ANFKIDPPGSWLLHHVPWTEAEHAISAIVADEAIATSLDIETGAPCLVIERHTWRQGRPLTAVRLVYPGEQHRLVARFRG
SE

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=156, Percent_Identity=30.7692307692308, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27293; Mature: 27161

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLAEDRAKPSTLYKTIRQDIERRILTGEWPPGHRIPFEHEIMEHYGCSRMTVNKALSEL
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
AQADLIERRRRAGTFVRRPQFLSAVLKIPDIRAEIGALGRAYGYELIASARRTANAADRE
HHHHHHHHHHHHCHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RLGVKTPCKVIAIRCRHSADGLPFAIEDRLIDLDAVPDAAKANFKIDPPGSWLLHHVPWT
HCCCCCCHHEEEEEECCCCCCCCEEECCCEEECCCCCCCCCCCEEECCCCCEEEEECCCC
EAEHAISAIVADEAIATSLDIETGAPCLVIERHTWRQGRPLTAVRLVYPGEQHRLVARFR
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEEEECCCHHEEEEEEC
GSE
CCC
>Mature Secondary Structure 
SLAEDRAKPSTLYKTIRQDIERRILTGEWPPGHRIPFEHEIMEHYGCSRMTVNKALSEL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
AQADLIERRRRAGTFVRRPQFLSAVLKIPDIRAEIGALGRAYGYELIASARRTANAADRE
HHHHHHHHHHHHCHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RLGVKTPCKVIAIRCRHSADGLPFAIEDRLIDLDAVPDAAKANFKIDPPGSWLLHHVPWT
HCCCCCCHHEEEEEECCCCCCCCEEECCCEEECCCCCCCCCCCEEECCCCCEEEEECCCC
EAEHAISAIVADEAIATSLDIETGAPCLVIERHTWRQGRPLTAVRLVYPGEQHRLVARFR
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEEEECCCHHEEEEEEC
GSE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]