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The map label for this gene is map [H]

Identifier: 146337838

GI number: 146337838

Start: 756932

End: 757756

Strand: Reverse

Name: map [H]

Synonym: BRADO0719

Alternate gene names: 146337838

Gene position: 757756-756932 (Counterclockwise)

Preceding gene: 146337839

Following gene: 146337837

Centisome position: 10.16

GC content: 64.24

Gene sequence:

>825_bases
ATGAGCTATATCGAAGCCACCGACACCGCTGCGCGCAAGAACGGCCAGATCAAGCTGCACGGTCCGAGCGGGTTCGCCGG
CATGCGCAAGGCCGGCGCGCTGGTGTCGAAGTGCCTCGATGCGCTCACCGACATCGTCAAGCCGGGCGTGCCGACCTCGC
GGATTGACGACGTCGTGCGCGACTTCGCCTTCAGCCATGGCGCCTATCCGGCAACCTTGATGTATCGCGGCTACCGCTAC
TCGACCTGCACCTCGATCAATCACGTGGTCTGTCACGGCATGCCGAACGACCGGCCGCTGAAGGAAGGCGACATCATCAA
TGTCGACGTCACCTTCATCGTCGACGGCTGGTATGGCGATTCGAGCCGGATGTATGCGATCGGGCCGATCTCGCGCAAGG
CCGAGCGGCTGATCGAGGTGACCTATGAATCGATGATGCGCGGCATCGCCGCGGTGAAGCCCGGCGCAACCACGGGCGAT
ATCGGCCACGCCATCCAGAGCTTCGTCGAGCCGCAGGGCATGAGCGTGGTGCGCGACTTCTGCGGCCATGGCCTCGGCCG
GCTGTTCCACGACGAGCCGAACATCATCCATGTCGGCCGTCCCGGCGAGGGCGTGCTGCTGAAGCCCGGCATGTTCTTTA
CCATCGAGCCGATGATCAATCTCGGCAAGCCGCACGTGAAGATCCTGTCCGATGGCTGGACCGCGGTCACCCGCGACCGC
TCGCTGTCGGCGCAGTTCGAGCATTCGGTCGGCGTCACCAATGACGGGGTCGAGATCTTCACCCTGTCCGAGCGCCATGG
CGAGAAGCCGCTGACGCAGGTGTGA

Upstream 100 bases:

>100_bases
GCCACGGCCCGACCCGCCGTGCAGACCCGGCTTGCACCGGGGGGCAGGATCATTAAATTAGGCGATCACCTCACGACATG
TCCGAGAACGAACCAGGTCC

Downstream 100 bases:

>100_bases
GCGCGTGCAGCGCCGCGCGGCCGCACGGCGTCCGATTGTTGCCATTCGCGGCTGCTCGACTGCCTCCATCGCGCATGATC
GCTGGAGGCTTCCGTGACGA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MSYIEATDTAARKNGQIKLHGPSGFAGMRKAGALVSKCLDALTDIVKPGVPTSRIDDVVRDFAFSHGAYPATLMYRGYRY
STCTSINHVVCHGMPNDRPLKEGDIINVDVTFIVDGWYGDSSRMYAIGPISRKAERLIEVTYESMMRGIAAVKPGATTGD
IGHAIQSFVEPQGMSVVRDFCGHGLGRLFHDEPNIIHVGRPGEGVLLKPGMFFTIEPMINLGKPHVKILSDGWTAVTRDR
SLSAQFEHSVGVTNDGVEIFTLSERHGEKPLTQV

Sequences:

>Translated_274_residues
MSYIEATDTAARKNGQIKLHGPSGFAGMRKAGALVSKCLDALTDIVKPGVPTSRIDDVVRDFAFSHGAYPATLMYRGYRY
STCTSINHVVCHGMPNDRPLKEGDIINVDVTFIVDGWYGDSSRMYAIGPISRKAERLIEVTYESMMRGIAAVKPGATTGD
IGHAIQSFVEPQGMSVVRDFCGHGLGRLFHDEPNIIHVGRPGEGVLLKPGMFFTIEPMINLGKPHVKILSDGWTAVTRDR
SLSAQFEHSVGVTNDGVEIFTLSERHGEKPLTQV
>Mature_273_residues
SYIEATDTAARKNGQIKLHGPSGFAGMRKAGALVSKCLDALTDIVKPGVPTSRIDDVVRDFAFSHGAYPATLMYRGYRYS
TCTSINHVVCHGMPNDRPLKEGDIINVDVTFIVDGWYGDSSRMYAIGPISRKAERLIEVTYESMMRGIAAVKPGATTGDI
GHAIQSFVEPQGMSVVRDFCGHGLGRLFHDEPNIIHVGRPGEGVLLKPGMFFTIEPMINLGKPHVKILSDGWTAVTRDRS
LSAQFEHSVGVTNDGVEIFTLSERHGEKPLTQV

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=258, Percent_Identity=42.2480620155039, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI40385867, Length=245, Percent_Identity=38.7755102040816, Blast_Score=184, Evalue=6e-47,
Organism=Escherichia coli, GI1786364, Length=248, Percent_Identity=48.7903225806452, Blast_Score=251, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI71996291, Length=245, Percent_Identity=42.4489795918367, Blast_Score=203, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6323273, Length=252, Percent_Identity=40.0793650793651, Blast_Score=199, Evalue=4e-52,
Organism=Drosophila melanogaster, GI21355531, Length=260, Percent_Identity=40.3846153846154, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24583427, Length=237, Percent_Identity=37.9746835443038, Blast_Score=186, Evalue=1e-47,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29904; Mature: 29772

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYIEATDTAARKNGQIKLHGPSGFAGMRKAGALVSKCLDALTDIVKPGVPTSRIDDVVR
CCCCCCCCHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DFAFSHGAYPATLMYRGYRYSTCTSINHVVCHGMPNDRPLKEGDIINVDVTFIVDGWYGD
HHHHCCCCCCCEEEECCCCEEHHCCCCEEEEECCCCCCCCCCCCEEEEEEEEEEEEEECC
SSRMYAIGPISRKAERLIEVTYESMMRGIAAVKPGATTGDIGHAIQSFVEPQGMSVVRDF
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
CGHGLGRLFHDEPNIIHVGRPGEGVLLKPGMFFTIEPMINLGKPHVKILSDGWTAVTRDR
HCCCHHHHCCCCCCEEEECCCCCCEEECCCCEEEEECHHCCCCCCEEEEECCCEEEECCC
SLSAQFEHSVGVTNDGVEIFTLSERHGEKPLTQV
CCCCHHHCCCCCCCCCEEEEEECHHCCCCCCCCC
>Mature Secondary Structure 
SYIEATDTAARKNGQIKLHGPSGFAGMRKAGALVSKCLDALTDIVKPGVPTSRIDDVVR
CCCCCCCHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DFAFSHGAYPATLMYRGYRYSTCTSINHVVCHGMPNDRPLKEGDIINVDVTFIVDGWYGD
HHHHCCCCCCCEEEECCCCEEHHCCCCEEEEECCCCCCCCCCCCEEEEEEEEEEEEEECC
SSRMYAIGPISRKAERLIEVTYESMMRGIAAVKPGATTGDIGHAIQSFVEPQGMSVVRDF
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
CGHGLGRLFHDEPNIIHVGRPGEGVLLKPGMFFTIEPMINLGKPHVKILSDGWTAVTRDR
HCCCHHHHCCCCCCEEEECCCCCCEEECCCCEEEEECHHCCCCCCEEEEECCCEEEECCC
SLSAQFEHSVGVTNDGVEIFTLSERHGEKPLTQV
CCCCHHHCCCCCCCCCEEEEEECHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]