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The map label for this gene is phbA [H]

Identifier: 146337694

GI number: 146337694

Start: 577130

End: 578314

Strand: Direct

Name: phbA [H]

Synonym: BRADO0562

Alternate gene names: 146337694

Gene position: 577130-578314 (Clockwise)

Preceding gene: 146337692

Following gene: 146337695

Centisome position: 7.74

GC content: 67.43

Gene sequence:

>1185_bases
ATGCCCATGTCAGACGATGTCGTCATCGTCAGCGCCGCCCGCACCCCGGTTGGAAGCTTCAACGGTGCGTTTGCCAATGT
CCCGGCCCATGAGTTGGGCGCCGTTGCCATCAAGGCCGCGCTGGAGCGGGCCGGCGTCGAGCCGGGCCGGGTCTCCGAGG
TCATCATGGGCCAGATCCTGACCGCGGCGCAGGGCCAGAACCCGGCGCGTCAGGCCTCGATCGCCGCCGGCATTCCGGTC
GACAGCCCGGCCTGGGGGATCAACCAGCTGTGCGGCTCGGGCCTGCGCTCGGTTGCGCTGGGCTACCAGGCGCTGAAGAA
CGGCGACTCCGACATCGTCGTCGCCGGCGGCCAGGAGTCGATGAGCATGGCGCCGCACGCGCAATATCTGCGCGGCGGCG
TCAAGATGGGCTCGCTCGAGTTCGTCGACACCATGATCAAGGACGGCCTGTGGGACGCCTTCAACGGCTATCACATGGGC
AACACCGCCGAGAACGTTGCGAAGCAGTATCAGATCACGCGCGCGCAGCAGGACGAGTTCGCGGTTGCGTCGCAGAACAA
GGCCGAAGCCGCGCAGAGGGCCGGCAAGTTCAAGGACGAGATCGTCGCGGTCACGATCAAGGGCCGCAAGGGCGACACCG
TGGTCGACACCGACGAATATCCGCGTCATGGCGCCACGCTCGACGCGATGGCCAAGCTGCGCGCCGCGTTCGAGAAGGAC
GGCACCGTGACGGCCGGCAACGCGTCGGGCATCAATGACGGCGCCGCCGCTGTGGTGCTGATGACCGCCAAGCAGGCCGC
CAAGGAAGGCAAGACGCCGCTGGCGCGGATCGTGTCCTGGGGCCAGGCCGGCGTCGATCCGAAGATCATGGGCACCGGGC
CGATCCCGGCCTCGCGCTCCGCACTCAAGAAGGCCGGCTGGAATATTGCCGACCTCGACCTGATCGAAGCGAACGAGGCG
TTCGCGGCGCAGGCCTGCGCGGTCAACAAGGATCTCGGCTGGGATCCGGCCAAGGTCAATGTGAACGGCGGCGCGATCGC
GATCGGTCATCCGATCGGCGCGTCCGGCGCCCGCGTGCTCGTCACACTGCTGCACGAGATGCAGAAGCGCGACGCCAAGA
AAGGTCTTGCCACGCTGTGCATCGGCGGTGGCATGGGCATCGCGCTGTGCGTTGCACGCGACTAA

Upstream 100 bases:

>100_bases
ACGGCCGGCACGACCGTGAACTGAAAAATTCGTTTTCATTTCAAATACCCCAAAGCTCTCAAGCCTCGCTCTCACGCCTC
AAGATCAAGAACCTCAGGAG

Downstream 100 bases:

>100_bases
AAACGCGGCACTGATTGCGACTCGTTCGGCCTTCGCAGTCGCGTCCCGCTCAACTAAAGATCAACGCCCGGCGATCTCGC
CGGGCGTTTTGTTCTTGATG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MPMSDDVVIVSAARTPVGSFNGAFANVPAHELGAVAIKAALERAGVEPGRVSEVIMGQILTAAQGQNPARQASIAAGIPV
DSPAWGINQLCGSGLRSVALGYQALKNGDSDIVVAGGQESMSMAPHAQYLRGGVKMGSLEFVDTMIKDGLWDAFNGYHMG
NTAENVAKQYQITRAQQDEFAVASQNKAEAAQRAGKFKDEIVAVTIKGRKGDTVVDTDEYPRHGATLDAMAKLRAAFEKD
GTVTAGNASGINDGAAAVVLMTAKQAAKEGKTPLARIVSWGQAGVDPKIMGTGPIPASRSALKKAGWNIADLDLIEANEA
FAAQACAVNKDLGWDPAKVNVNGGAIAIGHPIGASGARVLVTLLHEMQKRDAKKGLATLCIGGGMGIALCVARD

Sequences:

>Translated_394_residues
MPMSDDVVIVSAARTPVGSFNGAFANVPAHELGAVAIKAALERAGVEPGRVSEVIMGQILTAAQGQNPARQASIAAGIPV
DSPAWGINQLCGSGLRSVALGYQALKNGDSDIVVAGGQESMSMAPHAQYLRGGVKMGSLEFVDTMIKDGLWDAFNGYHMG
NTAENVAKQYQITRAQQDEFAVASQNKAEAAQRAGKFKDEIVAVTIKGRKGDTVVDTDEYPRHGATLDAMAKLRAAFEKD
GTVTAGNASGINDGAAAVVLMTAKQAAKEGKTPLARIVSWGQAGVDPKIMGTGPIPASRSALKKAGWNIADLDLIEANEA
FAAQACAVNKDLGWDPAKVNVNGGAIAIGHPIGASGARVLVTLLHEMQKRDAKKGLATLCIGGGMGIALCVARD
>Mature_393_residues
PMSDDVVIVSAARTPVGSFNGAFANVPAHELGAVAIKAALERAGVEPGRVSEVIMGQILTAAQGQNPARQASIAAGIPVD
SPAWGINQLCGSGLRSVALGYQALKNGDSDIVVAGGQESMSMAPHAQYLRGGVKMGSLEFVDTMIKDGLWDAFNGYHMGN
TAENVAKQYQITRAQQDEFAVASQNKAEAAQRAGKFKDEIVAVTIKGRKGDTVVDTDEYPRHGATLDAMAKLRAAFEKDG
TVTAGNASGINDGAAAVVLMTAKQAAKEGKTPLARIVSWGQAGVDPKIMGTGPIPASRSALKKAGWNIADLDLIEANEAF
AAQACAVNKDLGWDPAKVNVNGGAIAIGHPIGASGARVLVTLLHEMQKRDAKKGLATLCIGGGMGIALCVARD

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=59.5419847328244, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=43.8287153652393, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI4557237, Length=395, Percent_Identity=43.7974683544304, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=39.7435897435897, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=30.2816901408451, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI194353979, Length=386, Percent_Identity=29.7927461139896, Blast_Score=139, Evalue=5e-33,
Organism=Escherichia coli, GI87082165, Length=390, Percent_Identity=55.8974358974359, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=56.7430025445293, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI1787663, Length=398, Percent_Identity=42.2110552763819, Blast_Score=297, Evalue=7e-82,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=40.3508771929825, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1788683, Length=410, Percent_Identity=33.9024390243902, Blast_Score=197, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=46.0154241645244, Blast_Score=337, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI25147385, Length=377, Percent_Identity=42.7055702917772, Blast_Score=304, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=39.8989898989899, Blast_Score=273, Evalue=9e-74,
Organism=Caenorhabditis elegans, GI17535917, Length=382, Percent_Identity=32.7225130890052, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=423, Percent_Identity=29.7872340425532, Blast_Score=171, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6325229, Length=391, Percent_Identity=46.2915601023018, Blast_Score=306, Evalue=5e-84,
Organism=Saccharomyces cerevisiae, GI6322031, Length=391, Percent_Identity=38.3631713554987, Blast_Score=219, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24655093, Length=388, Percent_Identity=60.5670103092783, Blast_Score=485, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24640423, Length=383, Percent_Identity=48.5639686684073, Blast_Score=327, Evalue=6e-90,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=42.5641025641026, Blast_Score=295, Evalue=3e-80,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=30.2816901408451, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40695; Mature: 40564

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMSDDVVIVSAARTPVGSFNGAFANVPAHELGAVAIKAALERAGVEPGRVSEVIMGQIL
CCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
TAAQGQNPARQASIAAGIPVDSPAWGINQLCGSGLRSVALGYQALKNGDSDIVVAGGQES
HHHCCCCHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
MSMAPHAQYLRGGVKMGSLEFVDTMIKDGLWDAFNGYHMGNTAENVAKQYQITRAQQDEF
CCCCCHHHHHHCCCCCCHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCH
AVASQNKAEAAQRAGKFKDEIVAVTIKGRKGDTVVDTDEYPRHGATLDAMAKLRAAFEKD
HHHCCCHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCC
GTVTAGNASGINDGAAAVVLMTAKQAAKEGKTPLARIVSWGQAGVDPKIMGTGPIPASRS
CCEEECCCCCCCCCCEEEEEEEHHHHHHCCCCHHHHHHHHCCCCCCCEEEECCCCCCCHH
ALKKAGWNIADLDLIEANEAFAAQACAVNKDLGWDPAKVNVNGGAIAIGHPIGASGARVL
HHHHCCCCEEEEEEEECCHHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCCCCCHHHHH
VTLLHEMQKRDAKKGLATLCIGGGMGIALCVARD
HHHHHHHHHHHHHCCCEEEEECCCCEEEEEEECC
>Mature Secondary Structure 
PMSDDVVIVSAARTPVGSFNGAFANVPAHELGAVAIKAALERAGVEPGRVSEVIMGQIL
CCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
TAAQGQNPARQASIAAGIPVDSPAWGINQLCGSGLRSVALGYQALKNGDSDIVVAGGQES
HHHCCCCHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
MSMAPHAQYLRGGVKMGSLEFVDTMIKDGLWDAFNGYHMGNTAENVAKQYQITRAQQDEF
CCCCCHHHHHHCCCCCCHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCH
AVASQNKAEAAQRAGKFKDEIVAVTIKGRKGDTVVDTDEYPRHGATLDAMAKLRAAFEKD
HHHCCCHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCC
GTVTAGNASGINDGAAAVVLMTAKQAAKEGKTPLARIVSWGQAGVDPKIMGTGPIPASRS
CCEEECCCCCCCCCCEEEEEEEHHHHHHCCCCHHHHHHHHCCCCCCCEEEECCCCCCCHH
ALKKAGWNIADLDLIEANEAFAAQACAVNKDLGWDPAKVNVNGGAIAIGHPIGASGARVL
HHHHCCCCEEEEEEEECCHHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCCCCCHHHHH
VTLLHEMQKRDAKKGLATLCIGGGMGIALCVARD
HHHHHHHHHHHHHCCCEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566717 [H]