Click here to switch to the map view.

The map label for this gene is clpP [H]

Identifier: 146337660

GI number: 146337660

Start: 534544

End: 535161

Strand: Direct

Name: clpP [H]

Synonym: BRADO0526

Alternate gene names: 146337660

Gene position: 534544-535161 (Clockwise)

Preceding gene: 146337659

Following gene: 146337665

Centisome position: 7.17

GC content: 63.75

Gene sequence:

>618_bases
ATGCGCGACACGATGCAACTCGTCCCCATGGTCATCGAGCAGTCCAGCCGCGGCGAGCGGTCCTTCGACATCTATTCGCG
GCTGCTGCGCGAGCGCATCGTGTTCCTCAACGGCGAGGTCAACGACACCGTGTCCGCTTTGGTCTGCGCGCAACTGCTGT
TCCTCGAGGCGGAAAACCCGAAGCGGCCGATACACCTCTACATCAACTCGCCCGGCGGTGTGGTCACCAGCGGGCTCGCG
ATGTACGACACGATGCAGTTCGTCAAGGCGCCAGTGCACACACTGTGCATGGGAACGGCGCGGTCGATGGGATCGTTCCT
GCTGATGGCGGGCGAACCCGGCGAGCGGACGGCGCTGCCCAATGCCAGCCTTCATGTCCATCAGCCGCTCGGCGGCTTCC
AGGGGCAGGCGTCCGACATCATGATCCATGCGAGGGAAATGGAGCAGACCAAGCGCCGCATGATCCGGCTGTATGCCGAG
CATTGCGGGCGCAGCTACGAAGATGTCGAGCGCACGCTCGACCGTGATCACTTCATGACGGCGGACGAGGCGCAGGACTG
GGGGCTGATCGACCGGGTCGTGAAGCAGCGCGATCTGAAGAGTCTCAGCAGCGACTGA

Upstream 100 bases:

>100_bases
TCCGGCGGGCGCCGCAGGCGGCCAACAGCAATGCGCGCCGTCTGATGCGCGTGGCCTGACGACTCACCACATCGCCAACT
CACTGAACGGGAGCTCGCGC

Downstream 100 bases:

>100_bases
TACGCCCGTGCGAGGCGATGGCGATTGCCAAGGCAACAGGTGTCGTCACCCGCGAAGGCGAGTGACCCAGTACTCCGCGG
CGATTGTGATCACCCGAGAG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MRDTMQLVPMVIEQSSRGERSFDIYSRLLRERIVFLNGEVNDTVSALVCAQLLFLEAENPKRPIHLYINSPGGVVTSGLA
MYDTMQFVKAPVHTLCMGTARSMGSFLLMAGEPGERTALPNASLHVHQPLGGFQGQASDIMIHAREMEQTKRRMIRLYAE
HCGRSYEDVERTLDRDHFMTADEAQDWGLIDRVVKQRDLKSLSSD

Sequences:

>Translated_205_residues
MRDTMQLVPMVIEQSSRGERSFDIYSRLLRERIVFLNGEVNDTVSALVCAQLLFLEAENPKRPIHLYINSPGGVVTSGLA
MYDTMQFVKAPVHTLCMGTARSMGSFLLMAGEPGERTALPNASLHVHQPLGGFQGQASDIMIHAREMEQTKRRMIRLYAE
HCGRSYEDVERTLDRDHFMTADEAQDWGLIDRVVKQRDLKSLSSD
>Mature_205_residues
MRDTMQLVPMVIEQSSRGERSFDIYSRLLRERIVFLNGEVNDTVSALVCAQLLFLEAENPKRPIHLYINSPGGVVTSGLA
MYDTMQFVKAPVHTLCMGTARSMGSFLLMAGEPGERTALPNASLHVHQPLGGFQGQASDIMIHAREMEQTKRRMIRLYAE
HCGRSYEDVERTLDRDHFMTADEAQDWGLIDRVVKQRDLKSLSSD

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=53.4031413612565, Blast_Score=232, Evalue=2e-61,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=60.3092783505155, Blast_Score=258, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=55.9139784946236, Blast_Score=226, Evalue=5e-60,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=56.7708333333333, Blast_Score=246, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23173; Mature: 23173

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDTMQLVPMVIEQSSRGERSFDIYSRLLRERIVFLNGEVNDTVSALVCAQLLFLEAENP
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
KRPIHLYINSPGGVVTSGLAMYDTMQFVKAPVHTLCMGTARSMGSFLLMAGEPGERTALP
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCC
NASLHVHQPLGGFQGQASDIMIHAREMEQTKRRMIRLYAEHCGRSYEDVERTLDRDHFMT
CCCEEEECCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
ADEAQDWGLIDRVVKQRDLKSLSSD
CCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRDTMQLVPMVIEQSSRGERSFDIYSRLLRERIVFLNGEVNDTVSALVCAQLLFLEAENP
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
KRPIHLYINSPGGVVTSGLAMYDTMQFVKAPVHTLCMGTARSMGSFLLMAGEPGERTALP
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCC
NASLHVHQPLGGFQGQASDIMIHAREMEQTKRRMIRLYAEHCGRSYEDVERTLDRDHFMT
CCCEEEECCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
ADEAQDWGLIDRVVKQRDLKSLSSD
CCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]