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The map label for this gene is hisB [H]

Identifier: 146337379

GI number: 146337379

Start: 225121

End: 225714

Strand: Direct

Name: hisB [H]

Synonym: BRADO0212

Alternate gene names: 146337379

Gene position: 225121-225714 (Clockwise)

Preceding gene: 146337373

Following gene: 146337380

Centisome position: 3.02

GC content: 63.97

Gene sequence:

>594_bases
ATGCGTAGCGCGGCCATCAAGCGCAAGACCAAAGAGACCGACATCGAGGTGTCCGTGAACCTCGACGGCACCGGCGTCGT
CGAGATCGCGACCGGTATCGGCTTCTTCGATCACATGCTGGACCTGCTCGCCCGCCATTCCCGCATCGACATGACCGTCA
AGGCGGTCGGCGACCTGCATATCGACTTCCACCACACCACCGAGGATGTCGGCATCGCGCTCGGCCAGGCTGTCAAGCAG
GCGCTCGGCGACATGGCCGGCATCACCCGCTATGCCTCCATCCACATGCCGATGGACGAGACCTTGACCCGCGTCGTCAT
CGACGTCTCGGGCCGGCCGATGCTGGTGTTCCGCACGGCCTTTTCGCGCGACAAGATCGGCGAGTTCGACACCGAGCTGG
TGCGCGAATGGTTCAATGCGTTTGCGATGAACGCCGGCATCACCCTCCACGTCGAGACCTTGTACGGCGAGAACGCCCAT
CACATCGCCGAATCCTGCTTCAAGGGTCTGGCGCGGGCGTTGCGCGCAGCGCTCGCGATCGATCCGCGCAACAAGGGTGA
AGTGCCCTCCACCAAGGGTCAGCTCGGCGGCTGA

Upstream 100 bases:

>100_bases
TCACCATGGCCCGAGATCAGGCACGATGCGCGTCATCCCGCAGTAGCTAAGGTGTCATCCGCCTGATAAAAGGGCCGCGT
TTTCAAGGGAAAGCTGACCC

Downstream 100 bases:

>100_bases
CCTCCCTCCTCCAAGCTCGTTCGTCAGAGGGATTTTCAAGATGCCCGTCTATACGGTCCACGCGCCCCTCGCTGCTGGAG
CCGATCTGCGTTCGACGGAT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MRSAAIKRKTKETDIEVSVNLDGTGVVEIATGIGFFDHMLDLLARHSRIDMTVKAVGDLHIDFHHTTEDVGIALGQAVKQ
ALGDMAGITRYASIHMPMDETLTRVVIDVSGRPMLVFRTAFSRDKIGEFDTELVREWFNAFAMNAGITLHVETLYGENAH
HIAESCFKGLARALRAALAIDPRNKGEVPSTKGQLGG

Sequences:

>Translated_197_residues
MRSAAIKRKTKETDIEVSVNLDGTGVVEIATGIGFFDHMLDLLARHSRIDMTVKAVGDLHIDFHHTTEDVGIALGQAVKQ
ALGDMAGITRYASIHMPMDETLTRVVIDVSGRPMLVFRTAFSRDKIGEFDTELVREWFNAFAMNAGITLHVETLYGENAH
HIAESCFKGLARALRAALAIDPRNKGEVPSTKGQLGG
>Mature_197_residues
MRSAAIKRKTKETDIEVSVNLDGTGVVEIATGIGFFDHMLDLLARHSRIDMTVKAVGDLHIDFHHTTEDVGIALGQAVKQ
ALGDMAGITRYASIHMPMDETLTRVVIDVSGRPMLVFRTAFSRDKIGEFDTELVREWFNAFAMNAGITLHVETLYGENAH
HIAESCFKGLARALRAALAIDPRNKGEVPSTKGQLGG

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=45.8762886597938, Blast_Score=175, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=42.6605504587156, Blast_Score=178, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21545; Mature: 21545

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSAAIKRKTKETDIEVSVNLDGTGVVEIATGIGFFDHMLDLLARHSRIDMTVKAVGDLH
CCCCHHHCCCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECEEE
IDFHHTTEDVGIALGQAVKQALGDMAGITRYASIHMPMDETLTRVVIDVSGRPMLVFRTA
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHEEEEECCCCEEEEEEEC
FSRDKIGEFDTELVREWFNAFAMNAGITLHVETLYGENAHHIAESCFKGLARALRAALAI
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
DPRNKGEVPSTKGQLGG
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRSAAIKRKTKETDIEVSVNLDGTGVVEIATGIGFFDHMLDLLARHSRIDMTVKAVGDLH
CCCCHHHCCCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECEEE
IDFHHTTEDVGIALGQAVKQALGDMAGITRYASIHMPMDETLTRVVIDVSGRPMLVFRTA
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHEEEEECCCCEEEEEEEC
FSRDKIGEFDTELVREWFNAFAMNAGITLHVETLYGENAHHIAESCFKGLARALRAALAI
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
DPRNKGEVPSTKGQLGG
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA