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The map label for this gene is czcS [H]

Identifier: 146301657

GI number: 146301657

Start: 4664835

End: 4666202

Strand: Direct

Name: czcS [H]

Synonym: Fjoh_3919

Alternate gene names: 146301657

Gene position: 4664835-4666202 (Clockwise)

Preceding gene: 146301656

Following gene: 146301658

Centisome position: 76.51

GC content: 31.58

Gene sequence:

>1368_bases
ATGAATCTTAAAAACAAACTTTCTGTAAATTCTACGCTGTTATTTGCTTTTACTGTTGGACTCGTTCTGGCTGGTTCTTT
TTTGCTTTTTAAAAAACACAGACAGGATCTTTATTTTGAAAGACTCGAAGACAGTGCCTTAATAACTGCTTTTTTTTATT
TTGAAAAAGATGAAATTACAAAAGTTGACAGTTCCCGTTACCAAAGAATAGAAATTCAATATAAAAAAATCACCAATCAG
ACGATCAGGATATACAATGCAAAAACCAAAGAATTGTATTTGAAAGACGATATTGATATTACACTGACTGACAAAGAATT
AAAAGCAATTTCTAAAAACAGAATATTGCATTTCATAAAAGAAGACAGACAATTTACAGGTTTATATTATAAGGATAACC
AGGGTGATTTTATTATTGTAGTATCTGGAATTGATACTGTTGGTGACCGTCAATTTGATGTATTGGGTTTAATGTTTATT
GGGTTTTATCTGCTGGCCATTCCGTTGAATTTTCTTTTAGGCAGATTTTTGGCAAGACAAACTTTCAGGCCTTTTGAAGA
TGTTATTGCAAAAGTAAACACCATTACAACAGAAAACCTGCATTCGAGACTCGAAATGCCCACAGTAAGCGGAAAAGATG
AAATAAAAGAACTTATAACCACTTTTAATTATTTATTAGAACGTCTTGAAAACGGGGTAACAATACAAAAGAATTTTCTA
AAAAATGCATCGCACGAACTAAAAACACCGCTTACCATTATTATTGGTGATATTGATGTATCGTTGCAGCAGCCCAGAAC
TAACGAGCAATATGAAGAAGTTCTAAAATCGCTCAGAAAAGATACTTTTCATCTTAAATCTATATTAGACGGACTTTTGA
TTTTATCCGGATTACAGATTTCTGAACCAGAACAAATGGAATTGGTAAGAATAGATGAAATTTTATGGAATGTATTAGAA
AAAAAGGCAATTGAATATCCTGAATCAAAAGTGTCTGTAAATCTCGACGCTATTGCAGATCAGGAAAATCTGCTTTCTGT
TTATGCCAATAAACATATGCTTTTTACAGCTCTTTATAACATTATAGATAATGCGATTAAATTCTCATTTCCTGAAAAAG
TTGAAGTTTTGGTTTATTCAGAAGAAGGTAAGCTTTTAATAAAAATTATAGATCAGGGAGCCGGAATTTCTAAAAGTGAT
CAGGAATCAATTTTTGAACTGTTTTTTAGGAGCGATCGCACCCGCCATATTAAAGGTCAGGGATTAGGACTTTTTATTAC
CATGCAGATTCTTAAACTTCATAATATTGAATTAGAAGTAGATTCTGAACTCGAAAAAGGAACTACTTTTTCTTTATTAT
TTCCTTGA

Upstream 100 bases:

>100_bases
GTTTATATAAATTACTTAAGAAACAAAGTCGATAAAAACTTTTCTGAACCTTTGATCCATACAGTAAAAGGAACCGGATA
TATGCTTAAGAAAAAAACAC

Downstream 100 bases:

>100_bases
AAGAATTAATTATTAGATATTCATACAAAGTAACATAAAGAGCCATGGGCTCAATCCATATTGTAGGGCCGGATTTCAAT
CCGGTCAATCAAGGAAGATC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MNLKNKLSVNSTLLFAFTVGLVLAGSFLLFKKHRQDLYFERLEDSALITAFFYFEKDEITKVDSSRYQRIEIQYKKITNQ
TIRIYNAKTKELYLKDDIDITLTDKELKAISKNRILHFIKEDRQFTGLYYKDNQGDFIIVVSGIDTVGDRQFDVLGLMFI
GFYLLAIPLNFLLGRFLARQTFRPFEDVIAKVNTITTENLHSRLEMPTVSGKDEIKELITTFNYLLERLENGVTIQKNFL
KNASHELKTPLTIIIGDIDVSLQQPRTNEQYEEVLKSLRKDTFHLKSILDGLLILSGLQISEPEQMELVRIDEILWNVLE
KKAIEYPESKVSVNLDAIADQENLLSVYANKHMLFTALYNIIDNAIKFSFPEKVEVLVYSEEGKLLIKIIDQGAGISKSD
QESIFELFFRSDRTRHIKGQGLGLFITMQILKLHNIELEVDSELEKGTTFSLLFP

Sequences:

>Translated_455_residues
MNLKNKLSVNSTLLFAFTVGLVLAGSFLLFKKHRQDLYFERLEDSALITAFFYFEKDEITKVDSSRYQRIEIQYKKITNQ
TIRIYNAKTKELYLKDDIDITLTDKELKAISKNRILHFIKEDRQFTGLYYKDNQGDFIIVVSGIDTVGDRQFDVLGLMFI
GFYLLAIPLNFLLGRFLARQTFRPFEDVIAKVNTITTENLHSRLEMPTVSGKDEIKELITTFNYLLERLENGVTIQKNFL
KNASHELKTPLTIIIGDIDVSLQQPRTNEQYEEVLKSLRKDTFHLKSILDGLLILSGLQISEPEQMELVRIDEILWNVLE
KKAIEYPESKVSVNLDAIADQENLLSVYANKHMLFTALYNIIDNAIKFSFPEKVEVLVYSEEGKLLIKIIDQGAGISKSD
QESIFELFFRSDRTRHIKGQGLGLFITMQILKLHNIELEVDSELEKGTTFSLLFP
>Mature_455_residues
MNLKNKLSVNSTLLFAFTVGLVLAGSFLLFKKHRQDLYFERLEDSALITAFFYFEKDEITKVDSSRYQRIEIQYKKITNQ
TIRIYNAKTKELYLKDDIDITLTDKELKAISKNRILHFIKEDRQFTGLYYKDNQGDFIIVVSGIDTVGDRQFDVLGLMFI
GFYLLAIPLNFLLGRFLARQTFRPFEDVIAKVNTITTENLHSRLEMPTVSGKDEIKELITTFNYLLERLENGVTIQKNFL
KNASHELKTPLTIIIGDIDVSLQQPRTNEQYEEVLKSLRKDTFHLKSILDGLLILSGLQISEPEQMELVRIDEILWNVLE
KKAIEYPESKVSVNLDAIADQENLLSVYANKHMLFTALYNIIDNAIKFSFPEKVEVLVYSEEGKLLIKIIDQGAGISKSD
QESIFELFFRSDRTRHIKGQGLGLFITMQILKLHNIELEVDSELEKGTTFSLLFP

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=280, Percent_Identity=27.8571428571429, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790346, Length=277, Percent_Identity=27.4368231046931, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=28.8888888888889, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1788393, Length=260, Percent_Identity=22.6923076923077, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788549, Length=220, Percent_Identity=27.7272727272727, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788279, Length=285, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790861, Length=244, Percent_Identity=24.5901639344262, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789808, Length=245, Percent_Identity=22.8571428571429, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082128, Length=252, Percent_Identity=25.7936507936508, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789149, Length=240, Percent_Identity=25.8333333333333, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI48994928, Length=251, Percent_Identity=26.6932270916335, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=23.2456140350877, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=26.2931034482759, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=252, Percent_Identity=24.2063492063492, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52571; Mature: 52571

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKNKLSVNSTLLFAFTVGLVLAGSFLLFKKHRQDLYFERLEDSALITAFFYFEKDEIT
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCHHH
KVDSSRYQRIEIQYKKITNQTIRIYNAKTKELYLKDDIDITLTDKELKAISKNRILHFIK
HCCCCCCEEEEEEEEECCCCEEEEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHH
EDRQFTGLYYKDNQGDFIIVVSGIDTVGDRQFDVLGLMFIGFYLLAIPLNFLLGRFLARQ
CCCEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFRPFEDVIAKVNTITTENLHSRLEMPTVSGKDEIKELITTFNYLLERLENGVTIQKNFL
CCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHH
KNASHELKTPLTIIIGDIDVSLQQPRTNEQYEEVLKSLRKDTFHLKSILDGLLILSGLQI
HCCCHHHCCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SEPEQMELVRIDEILWNVLEKKAIEYPESKVSVNLDAIADQENLLSVYANKHMLFTALYN
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCHHHHHHHHHCCHHHHHHHHH
IIDNAIKFSFPEKVEVLVYSEEGKLLIKIIDQGAGISKSDQESIFELFFRSDRTRHIKGQ
HHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCC
GLGLFITMQILKLHNIELEVDSELEKGTTFSLLFP
CCEEEEHEEHHHHHCCEEEECCCCCCCCEEEEECC
>Mature Secondary Structure
MNLKNKLSVNSTLLFAFTVGLVLAGSFLLFKKHRQDLYFERLEDSALITAFFYFEKDEIT
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCHHH
KVDSSRYQRIEIQYKKITNQTIRIYNAKTKELYLKDDIDITLTDKELKAISKNRILHFIK
HCCCCCCEEEEEEEEECCCCEEEEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHH
EDRQFTGLYYKDNQGDFIIVVSGIDTVGDRQFDVLGLMFIGFYLLAIPLNFLLGRFLARQ
CCCEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFRPFEDVIAKVNTITTENLHSRLEMPTVSGKDEIKELITTFNYLLERLENGVTIQKNFL
CCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHH
KNASHELKTPLTIIIGDIDVSLQQPRTNEQYEEVLKSLRKDTFHLKSILDGLLILSGLQI
HCCCHHHCCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SEPEQMELVRIDEILWNVLEKKAIEYPESKVSVNLDAIADQENLLSVYANKHMLFTALYN
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCHHHHHHHHHCCHHHHHHHHH
IIDNAIKFSFPEKVEVLVYSEEGKLLIKIIDQGAGISKSDQESIFELFFRSDRTRHIKGQ
HHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCC
GLGLFITMQILKLHNIELEVDSELEKGTTFSLLFP
CCEEEEHEEHHHHHCCEEEECCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]