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The map label for this gene is cusR [H]

Identifier: 146301656

GI number: 146301656

Start: 4664153

End: 4664845

Strand: Direct

Name: cusR [H]

Synonym: Fjoh_3918

Alternate gene names: 146301656

Gene position: 4664153-4664845 (Clockwise)

Preceding gene: 146301653

Following gene: 146301657

Centisome position: 76.5

GC content: 34.2

Gene sequence:

>693_bases
ATGAACAAAGTATTATTAGTAGAAGATGATCCGCGTGTTGCATCTTTTATTTTAAGAGGTCTTGAAGAAAACCTATATCA
GGTAAAAACCGTTTCAAAAGGATATGAAGCTGTAAACGAAGTCATGGAAAATGATTTTGATATTATCATTCTCGATATTA
TGCTTCCTGATATTACTGGTTTTGAAGTTTGTGAGATTTTAAGAAACAGAAAAATAATCGTTCCCATTCTTATCTTAAGC
GCGCTTGATACACCTCACGAAAAGGTAAAAGGTTTACAATCCGGCGCAGATGATTATTTGGCTAAACCTTTTTTGTTTGA
AGAACTTTTGGCGAGAATAAATGCGCAGCTTCGCCGTGCCGAATTCAGCTCCGGAATTTTAGATTTTCAGTCTTATGCGG
GAATCGAAATCAATATGAAAGAACAAAGTGCTTCAAGAGACGGAAAAGAACTTAATCTTTCGTCCAGAGAACTTAAGCTT
TTAATTTTCTTTATGAAAAACCGCGAAAAAGCACTTTCGAGAATTGCAATTGCAGAAGCTGTCTGGAATCTTGAACTTGA
CATGAACTCAAATACGGTTGATGTTTATATAAATTACTTAAGAAACAAAGTCGATAAAAACTTTTCTGAACCTTTGATCC
ATACAGTAAAAGGAACCGGATATATGCTTAAGAAAAAAACACATGAATCTTAA

Upstream 100 bases:

>100_bases
TACAACAAAACAACTCATTAAAACTCTTATTCTTTCCTGTTTTTTTTCGGGGAATACTACATCTTTTAATTACTTTTATC
ACATTAATTTCTCATTTGCA

Downstream 100 bases:

>100_bases
AAACAAACTTTCTGTAAATTCTACGCTGTTATTTGCTTTTACTGTTGGACTCGTTCTGGCTGGTTCTTTTTTGCTTTTTA
AAAAACACAGACAGGATCTT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MNKVLLVEDDPRVASFILRGLEENLYQVKTVSKGYEAVNEVMENDFDIIILDIMLPDITGFEVCEILRNRKIIVPILILS
ALDTPHEKVKGLQSGADDYLAKPFLFEELLARINAQLRRAEFSSGILDFQSYAGIEINMKEQSASRDGKELNLSSRELKL
LIFFMKNREKALSRIAIAEAVWNLELDMNSNTVDVYINYLRNKVDKNFSEPLIHTVKGTGYMLKKKTHES

Sequences:

>Translated_230_residues
MNKVLLVEDDPRVASFILRGLEENLYQVKTVSKGYEAVNEVMENDFDIIILDIMLPDITGFEVCEILRNRKIIVPILILS
ALDTPHEKVKGLQSGADDYLAKPFLFEELLARINAQLRRAEFSSGILDFQSYAGIEINMKEQSASRDGKELNLSSRELKL
LIFFMKNREKALSRIAIAEAVWNLELDMNSNTVDVYINYLRNKVDKNFSEPLIHTVKGTGYMLKKKTHES
>Mature_230_residues
MNKVLLVEDDPRVASFILRGLEENLYQVKTVSKGYEAVNEVMENDFDIIILDIMLPDITGFEVCEILRNRKIIVPILILS
ALDTPHEKVKGLQSGADDYLAKPFLFEELLARINAQLRRAEFSSGILDFQSYAGIEINMKEQSASRDGKELNLSSRELKL
LIFFMKNREKALSRIAIAEAVWNLELDMNSNTVDVYINYLRNKVDKNFSEPLIHTVKGTGYMLKKKTHES

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=40.3587443946188, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=39.2694063926941, Blast_Score=170, Evalue=9e-44,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=32.5892857142857, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=30.8370044052863, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=34.0807174887892, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=32.1428571428571, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=30.3964757709251, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=30.2222222222222, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=27.8026905829596, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI2367329, Length=233, Percent_Identity=30.9012875536481, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=28.6363636363636, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=30.9012875536481, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI145693140, Length=240, Percent_Identity=27.9166666666667, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=29.646017699115, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789149, Length=125, Percent_Identity=32, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26302; Mature: 26302

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVLLVEDDPRVASFILRGLEENLYQVKTVSKGYEAVNEVMENDFDIIILDIMLPDITG
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCH
FEVCEILRNRKIIVPILILSALDTPHEKVKGLQSGADDYLAKPFLFEELLARINAQLRRA
HHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHH
EFSSGILDFQSYAGIEINMKEQSASRDGKELNLSSRELKLLIFFMKNREKALSRIAIAEA
HHHCCCHHHHHHCCCEEEECHHCCCCCCCCCCCCHHHHEEEEEEHHCHHHHHHHHHHHHH
VWNLELDMNSNTVDVYINYLRNKVDKNFSEPLIHTVKGTGYMLKKKTHES
HHEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEECCCCCC
>Mature Secondary Structure
MNKVLLVEDDPRVASFILRGLEENLYQVKTVSKGYEAVNEVMENDFDIIILDIMLPDITG
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCH
FEVCEILRNRKIIVPILILSALDTPHEKVKGLQSGADDYLAKPFLFEELLARINAQLRRA
HHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHH
EFSSGILDFQSYAGIEINMKEQSASRDGKELNLSSRELKLLIFFMKNREKALSRIAIAEA
HHHCCCHHHHHHCCCEEEECHHCCCCCCCCCCCCHHHHEEEEEEHHCHHHHHHHHHHHHH
VWNLELDMNSNTVDVYINYLRNKVDKNFSEPLIHTVKGTGYMLKKKTHES
HHEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]