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The map label for this gene is fabF [H]

Identifier: 146301549

GI number: 146301549

Start: 4518306

End: 4519580

Strand: Direct

Name: fabF [H]

Synonym: Fjoh_3810

Alternate gene names: 146301549

Gene position: 4518306-4519580 (Clockwise)

Preceding gene: 146301548

Following gene: 146301550

Centisome position: 74.11

GC content: 43.45

Gene sequence:

>1275_bases
ATGAGCAGAAGAGTTGTCATAACAGGTCTGGGTGTTGCAGCTCCAAACGGCGTTGGAATTGCTGCCTTCAGCCATGCTTT
AAAAAATGGAATATCAGGAATCAGGCATGACAAGCAGCTGGAGGAACTCCAGTTTTCCTGTCAGATAGCGGGTAGACCTG
AAATATCCGAAGAACTCAAGTCAAAATATTTTACAGAACTTGAACTTCGCGGTTTTAACAGTACGGGTATTTTATACGGT
GTTATTGCTGGAATGGAAGCTTGGGAAAATGCCGGATTACCAATAGAAAATAATGAAGAGCCGGATTGGGACAGCGGTAC
TATTTTTGGATCTGGCACCTCAGGCATCGATAAATTCCGCGAAAGCATTTATAAGATAGATGAATTACAAACCCGAAGGT
TAGGCAGTACTGTAGTGGCACAAACCATGAACAGCGGTATCAGTGCTTATCTTGGCGGGAAACTGGGACTCGGAAACCAG
GTTACCACCAATTCATCTGCCTGTGCAACGGGAACGGAAGCTATAATAATGGCGTACGAGCGTATACAATCCGGACAGGC
AAAACGCATATTGGCAGGAAGTACAAGCGACAGCGGACCTTACATTTGGGCAGGATTTGATGCTTTACGTGTCTGCAGTT
CAAAATTTAATGACAAACCTGAGCAGGGTTCACGCCCCATGAGTGTTACTGCCGCAGGATTTGTACCCGCAAGCGGCGCG
GGAGCATTGGTAATCGAAGATCTGGAAAGTGCTTTAGAACGCGGTGTGGAGATTTATGCTGAAATATTAGGCGGTAACGT
AAATTCCGGGGGACAGCGCGGCAATGGAAGCATGACCGCTCCTAACAGCAGTGCCGTACAGCAATGCATTAAAAAAGCCA
TCCAAAATTCAGGTATTTCTGCCGATGATATAGATGCCATAAACGGACATCTTACCGCCACTGCAAAGGACAGTCTTGAA
ATTGAAAACTGGACGAAAGCCTTAAACCGGAAGGGAACTGATTTTCCGTATATAAACTCCTTAAAAAGCATGACAGGACA
CTGTTTAAGCGCAGCGGGAAGCATAGAAAGCATCGCGGCGGTACTACAGCTTTATGAAGGTTTTGTTTTTGGAAATACGA
ATTGTGAAGATCTTCATCCTGAAATAAGTGCTCATATAAACTCTTCAAAAATACCCTTACAAACAATTGATTGTAAACCT
AATATAATTGCCAAGGCAAGTTTTGGCTTTGGTGATGTAAATGCCTGTGTAATATTTAAAAAATTTCAAAAATAA

Upstream 100 bases:

>100_bases
TTTTCAGGTTTGGAAAATTAAAATGTGATGTCATTATGAAAAACCAAGCTGGACAGGAAGTCTGCAAAGGCATTCTGTCG
GGCATGATTACCAATAAATT

Downstream 100 bases:

>100_bases
TTGTATGAACAAAGAAGAAGTTATAGCTCGACTCAAAGTAATTATAAAGCCATATGCAGCAAATATCCAAGCGTTTGAAA
GCCTTACTGAAAATACTGAT

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSRRVVITGLGVAAPNGVGIAAFSHALKNGISGIRHDKQLEELQFSCQIAGRPEISEELKSKYFTELELRGFNSTGILYG
VIAGMEAWENAGLPIENNEEPDWDSGTIFGSGTSGIDKFRESIYKIDELQTRRLGSTVVAQTMNSGISAYLGGKLGLGNQ
VTTNSSACATGTEAIIMAYERIQSGQAKRILAGSTSDSGPYIWAGFDALRVCSSKFNDKPEQGSRPMSVTAAGFVPASGA
GALVIEDLESALERGVEIYAEILGGNVNSGGQRGNGSMTAPNSSAVQQCIKKAIQNSGISADDIDAINGHLTATAKDSLE
IENWTKALNRKGTDFPYINSLKSMTGHCLSAAGSIESIAAVLQLYEGFVFGNTNCEDLHPEISAHINSSKIPLQTIDCKP
NIIAKASFGFGDVNACVIFKKFQK

Sequences:

>Translated_424_residues
MSRRVVITGLGVAAPNGVGIAAFSHALKNGISGIRHDKQLEELQFSCQIAGRPEISEELKSKYFTELELRGFNSTGILYG
VIAGMEAWENAGLPIENNEEPDWDSGTIFGSGTSGIDKFRESIYKIDELQTRRLGSTVVAQTMNSGISAYLGGKLGLGNQ
VTTNSSACATGTEAIIMAYERIQSGQAKRILAGSTSDSGPYIWAGFDALRVCSSKFNDKPEQGSRPMSVTAAGFVPASGA
GALVIEDLESALERGVEIYAEILGGNVNSGGQRGNGSMTAPNSSAVQQCIKKAIQNSGISADDIDAINGHLTATAKDSLE
IENWTKALNRKGTDFPYINSLKSMTGHCLSAAGSIESIAAVLQLYEGFVFGNTNCEDLHPEISAHINSSKIPLQTIDCKP
NIIAKASFGFGDVNACVIFKKFQK
>Mature_423_residues
SRRVVITGLGVAAPNGVGIAAFSHALKNGISGIRHDKQLEELQFSCQIAGRPEISEELKSKYFTELELRGFNSTGILYGV
IAGMEAWENAGLPIENNEEPDWDSGTIFGSGTSGIDKFRESIYKIDELQTRRLGSTVVAQTMNSGISAYLGGKLGLGNQV
TTNSSACATGTEAIIMAYERIQSGQAKRILAGSTSDSGPYIWAGFDALRVCSSKFNDKPEQGSRPMSVTAAGFVPASGAG
ALVIEDLESALERGVEIYAEILGGNVNSGGQRGNGSMTAPNSSAVQQCIKKAIQNSGISADDIDAINGHLTATAKDSLEI
ENWTKALNRKGTDFPYINSLKSMTGHCLSAAGSIESIAAVLQLYEGFVFGNTNCEDLHPEISAHINSSKIPLQTIDCKPN
IIAKASFGFGDVNACVIFKKFQK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=427, Percent_Identity=27.6346604215457, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI41872631, Length=261, Percent_Identity=26.8199233716475, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1788663, Length=426, Percent_Identity=32.6291079812207, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1787337, Length=432, Percent_Identity=31.0185185185185, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71983541, Length=425, Percent_Identity=29.1764705882353, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71983535, Length=267, Percent_Identity=31.8352059925094, Blast_Score=111, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320904, Length=457, Percent_Identity=28.4463894967177, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24644341, Length=431, Percent_Identity=29.4663573085847, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI19920632, Length=258, Percent_Identity=24.031007751938, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI221330659, Length=258, Percent_Identity=24.031007751938, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44952; Mature: 44821

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRVVITGLGVAAPNGVGIAAFSHALKNGISGIRHDKQLEELQFSCQIAGRPEISEELK
CCCEEEEEECCEECCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHEEECCCCCHHHHHH
SKYFTELELRGFNSTGILYGVIAGMEAWENAGLPIENNEEPDWDSGTIFGSGTSGIDKFR
HHHHHEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCHHHHHHH
ESIYKIDELQTRRLGSTVVAQTMNSGISAYLGGKLGLGNQVTTNSSACATGTEAIIMAYE
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
RIQSGQAKRILAGSTSDSGPYIWAGFDALRVCSSKFNDKPEQGSRPMSVTAAGFVPASGA
HHHCCCCCEEEECCCCCCCCEEEECHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCC
GALVIEDLESALERGVEIYAEILGGNVNSGGQRGNGSMTAPNSSAVQQCIKKAIQNSGIS
CEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
ADDIDAINGHLTATAKDSLEIENWTKALNRKGTDFPYINSLKSMTGHCLSAAGSIESIAA
CCCHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
VLQLYEGFVFGNTNCEDLHPEISAHINSSKIPLQTIDCKPNIIAKASFGFGDVNACVIFK
HHHHHCCEEECCCCHHHCCCHHHHCCCCCCCCEEEECCCCCEEEEECCCCCCCCCEEEEE
KFQK
ECCC
>Mature Secondary Structure 
SRRVVITGLGVAAPNGVGIAAFSHALKNGISGIRHDKQLEELQFSCQIAGRPEISEELK
CCEEEEEECCEECCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHEEECCCCCHHHHHH
SKYFTELELRGFNSTGILYGVIAGMEAWENAGLPIENNEEPDWDSGTIFGSGTSGIDKFR
HHHHHEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCHHHHHHH
ESIYKIDELQTRRLGSTVVAQTMNSGISAYLGGKLGLGNQVTTNSSACATGTEAIIMAYE
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
RIQSGQAKRILAGSTSDSGPYIWAGFDALRVCSSKFNDKPEQGSRPMSVTAAGFVPASGA
HHHCCCCCEEEECCCCCCCCEEEECHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCC
GALVIEDLESALERGVEIYAEILGGNVNSGGQRGNGSMTAPNSSAVQQCIKKAIQNSGIS
CEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
ADDIDAINGHLTATAKDSLEIENWTKALNRKGTDFPYINSLKSMTGHCLSAAGSIESIAA
CCCHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
VLQLYEGFVFGNTNCEDLHPEISAHINSSKIPLQTIDCKPNIIAKASFGFGDVNACVIFK
HHHHHCCEEECCCCHHHCCCHHHHCCCCCCCCEEEECCCCCEEEEECCCCCCCCCEEEEE
KFQK
ECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]