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The map label for this gene is ald [H]

Identifier: 146300658

GI number: 146300658

Start: 3451816

End: 3453015

Strand: Direct

Name: ald [H]

Synonym: Fjoh_2909

Alternate gene names: 146300658

Gene position: 3451816-3453015 (Clockwise)

Preceding gene: 146300657

Following gene: 146300659

Centisome position: 56.62

GC content: 35.17

Gene sequence:

>1200_bases
ATGTCAATTACCTTAACTCCATTTACAAAACAACAATTGATTCCGCAAGAAGAAAAACTTGAGGTTGGTCGTTTTAAAAG
AGAACTTTTTATAGGAATCCCTAAGGAAACAAGTTATCAGGAACGTCGTATTTGTTTGACACCGGATGCCGTAAATTCCC
TTACTTATGAAGGGCATCGTGTTATGATTGAATCTGGTGCCGGAGAAAGTTCGAGTTACACAGATAAGGAATATTCAGAT
GCTGGTGCAGAAATTACAAAAGACACTAAAAGAGTTTTTGGATGTCCGTTTTTATTAAAAGTAGAACCGCCTACATTAGC
TGAAATTGAAATGATTAATCCTGAAACGGTAATTATTTCAGCAATTCAGTTAAAAACAAAAAAAAGAGAATACTTTGAAG
CTTTGGCACAAAAAAAGATTACTGCCCTTGCCTTCGAATATATAAAAGATGAAGATGGTTCTTATCCAGCTGTAAAATCT
TTAAGCGAAATTGCAGGAACGGCTTCTATTCTTATCGCTGCCGAATTAATGATTACAAATGAATTTGGAAAAGGACTTTT
ATTCGGGAACATTACCGGAGTACCGCCTACCGAAGTTGTAATTCTTGGAGCTGGAACAGTTGGAGAATTCGCTGCAAAAA
CTGCAATTGGATTGGGTGCAAACGTAAAAGTTTTTGATAATTCGATTACAAAATTACGCCGTTTACAAAACAATTTAAGC
CAAAGAATTTTTACTTCTACCATTCAGCAAAAAGCATTATTAAAAGCTTTAAGACGTTGTGATGTAGCAATTGGCGCTAT
GCGGGGAAAAGAACGCTGTCCAATTGTTGTTAGTGAAACTATGGTAGAACACATGAAAAAAGGTGCTGTAATAGTTGACG
TAAGCATCGATACAGGTGGCTGCTTTGAAAGTTCTGAAGTAACAACGCATGAAAAACCAACTTTTATTAAAAACAATGTT
TTGCACTATTGTGTACCAAATATACCTTCTCGTTATTCTAAAACTGCCTCATTATCAATTAGTAACATCTTAACACCTTA
TCTTCATCAGATAGCCGAAGATGGTGGTATCGAAAGTGCTATAAGATGCAATAAAGGCTTAAAAAACGGAATTTATTTAT
ATCATGGAATTCTAACAAATAAAGCTATTGGCGACTGGTTCGACCTGCCAGACAACGATATTAATTTACTTGTATTTTAA

Upstream 100 bases:

>100_bases
GCAAAAAATAACTTAACATTCGACATTAGTATTAGCACAATTTTTACACTAATTTTAAAACTTTTTACGTAATTTGTACC
CTTAATTTTTTGCATTATCC

Downstream 100 bases:

>100_bases
AGGAACTTTAATGTACCTTTGCAAAAATTTTATTTCATGAAGTTCGTACACCGTTTTGCCTATTATTTGATTGGATTAGT
TATGGGATGCTTTTTTGTAG

Product: NAD(P) transhydrogenase subunit alpha

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSITLTPFTKQQLIPQEEKLEVGRFKRELFIGIPKETSYQERRICLTPDAVNSLTYEGHRVMIESGAGESSSYTDKEYSD
AGAEITKDTKRVFGCPFLLKVEPPTLAEIEMINPETVIISAIQLKTKKREYFEALAQKKITALAFEYIKDEDGSYPAVKS
LSEIAGTASILIAAELMITNEFGKGLLFGNITGVPPTEVVILGAGTVGEFAAKTAIGLGANVKVFDNSITKLRRLQNNLS
QRIFTSTIQQKALLKALRRCDVAIGAMRGKERCPIVVSETMVEHMKKGAVIVDVSIDTGGCFESSEVTTHEKPTFIKNNV
LHYCVPNIPSRYSKTASLSISNILTPYLHQIAEDGGIESAIRCNKGLKNGIYLYHGILTNKAIGDWFDLPDNDINLLVF

Sequences:

>Translated_399_residues
MSITLTPFTKQQLIPQEEKLEVGRFKRELFIGIPKETSYQERRICLTPDAVNSLTYEGHRVMIESGAGESSSYTDKEYSD
AGAEITKDTKRVFGCPFLLKVEPPTLAEIEMINPETVIISAIQLKTKKREYFEALAQKKITALAFEYIKDEDGSYPAVKS
LSEIAGTASILIAAELMITNEFGKGLLFGNITGVPPTEVVILGAGTVGEFAAKTAIGLGANVKVFDNSITKLRRLQNNLS
QRIFTSTIQQKALLKALRRCDVAIGAMRGKERCPIVVSETMVEHMKKGAVIVDVSIDTGGCFESSEVTTHEKPTFIKNNV
LHYCVPNIPSRYSKTASLSISNILTPYLHQIAEDGGIESAIRCNKGLKNGIYLYHGILTNKAIGDWFDLPDNDINLLVF
>Mature_398_residues
SITLTPFTKQQLIPQEEKLEVGRFKRELFIGIPKETSYQERRICLTPDAVNSLTYEGHRVMIESGAGESSSYTDKEYSDA
GAEITKDTKRVFGCPFLLKVEPPTLAEIEMINPETVIISAIQLKTKKREYFEALAQKKITALAFEYIKDEDGSYPAVKSL
SEIAGTASILIAAELMITNEFGKGLLFGNITGVPPTEVVILGAGTVGEFAAKTAIGLGANVKVFDNSITKLRRLQNNLSQ
RIFTSTIQQKALLKALRRCDVAIGAMRGKERCPIVVSETMVEHMKKGAVIVDVSIDTGGCFESSEVTTHEKPTFIKNNVL
HYCVPNIPSRYSKTASLSISNILTPYLHQIAEDGGIESAIRCNKGLKNGIYLYHGILTNKAIGDWFDLPDNDINLLVF

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=387, Percent_Identity=28.9405684754522, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI122939153, Length=387, Percent_Identity=28.9405684754522, Blast_Score=146, Evalue=3e-35,
Organism=Escherichia coli, GI1787887, Length=345, Percent_Identity=29.8550724637681, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17550456, Length=365, Percent_Identity=26.8493150684932, Blast_Score=127, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 43949; Mature: 43818

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITLTPFTKQQLIPQEEKLEVGRFKRELFIGIPKETSYQERRICLTPDAVNSLTYEGHR
CEEEECCCHHHHHCCCHHHHHHHHHEEEHEEECCCCCCCCCCEEEECCHHHHCCEECCCE
VMIESGAGESSSYTDKEYSDAGAEITKDTKRVFGCPFLLKVEPPTLAEIEMINPETVIIS
EEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCEEEEE
AIQLKTKKREYFEALAQKKITALAFEYIKDEDGSYPAVKSLSEIAGTASILIAAELMITN
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHEEHEEEC
EFGKGLLFGNITGVPPTEVVILGAGTVGEFAAKTAIGLGANVKVFDNSITKLRRLQNNLS
CCCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHH
QRIFTSTIQQKALLKALRRCDVAIGAMRGKERCPIVVSETMVEHMKKGAVIVDVSIDTGG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCEEEEEEECCCC
CFESSEVTTHEKPTFIKNNVLHYCVPNIPSRYSKTASLSISNILTPYLHQIAEDGGIESA
CCCCCCCCCCCCCCHHHCCEEEEECCCCCHHHCCHHEEEHHHHHHHHHHHHHHCCCCHHH
IRCNKGLKNGIYLYHGILTNKAIGDWFDLPDNDINLLVF
HHHCCCCCCCEEEEEEEHHCCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SITLTPFTKQQLIPQEEKLEVGRFKRELFIGIPKETSYQERRICLTPDAVNSLTYEGHR
EEEECCCHHHHHCCCHHHHHHHHHEEEHEEECCCCCCCCCCEEEECCHHHHCCEECCCE
VMIESGAGESSSYTDKEYSDAGAEITKDTKRVFGCPFLLKVEPPTLAEIEMINPETVIIS
EEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCEEEEE
AIQLKTKKREYFEALAQKKITALAFEYIKDEDGSYPAVKSLSEIAGTASILIAAELMITN
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHEEHEEEC
EFGKGLLFGNITGVPPTEVVILGAGTVGEFAAKTAIGLGANVKVFDNSITKLRRLQNNLS
CCCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHH
QRIFTSTIQQKALLKALRRCDVAIGAMRGKERCPIVVSETMVEHMKKGAVIVDVSIDTGG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCEEEEEEECCCC
CFESSEVTTHEKPTFIKNNVLHYCVPNIPSRYSKTASLSISNILTPYLHQIAEDGGIESA
CCCCCCCCCCCCCCHHHCCEEEEECCCCCHHHCCHHEEEHHHHHHHHHHHHHHCCCCHHH
IRCNKGLKNGIYLYHGILTNKAIGDWFDLPDNDINLLVF
HHHCCCCCCCEEEEEEEHHCCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]