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The map label for this gene is bfmBAB [H]

Identifier: 146300590

GI number: 146300590

Start: 3371756

End: 3373732

Strand: Direct

Name: bfmBAB [H]

Synonym: Fjoh_2840

Alternate gene names: 146300590

Gene position: 3371756-3373732 (Clockwise)

Preceding gene: 146300580

Following gene: 146300595

Centisome position: 55.3

GC content: 37.38

Gene sequence:

>1977_bases
ATGATCTTTTACAGAGAAAACCTAACCGACGAAAAATTACTAGATTTATATAAAAAACTTCTAAAACCGCGCTTAATCGA
AGAAAAAATGCTGATTTTGATTCGACAGGGAAAAGTTTCTAAATGGTTTTCAGGAATAGGACAGGAAGCTATTGCGGTGG
GAGTTACATCTGTTTTAGATGATTCTGAATATGTATTGCCAATGCACCGAAATCTGGGCGTTTTTACAACCAGAAACATT
CCTCTGCACAGGCTTTTTTCGCAATGGCAGGGAAAAGCAAACGGTTTTACAAAAGGCCGTGACAGAAGTTTTCATTTTGG
AACTCAGAAATACAATATAATAGGAATGATTTCGCATTTGGGTCCGCAGCTTGGAATTGCTGACGGAATTGCCCTGGCGA
ATAAACTTCAGGATAATAAAAAAGTTACCGCTGTTTTTACCGGAGAAGGAGCAACGAGCGAAGGTGATTTTCACGAAGCA
TTAAACATTGCTGCAGTTTGGAAACTTCCGGTAATGTTTATTATCGAAAATAATGGCTACGGACTTTCTACACCAACAAA
TGAGCAGTATTTATGCGAAAATCTAGCCGATAAAGGAATTGGTTATGGTATTGAAAGCTGGATTATAGACGGAAATAACA
TTGTTGAAGTTTACAACAAGTTATCAAAACTTAAAGAAGAAATGATAGCAGATCCGCATCCGGTTTTTCTGGAATTTAAA
ACTTTTAGAATGCGCGGGCACGAAGAAGCGAGCGGCACTAAATATGTTCCGCAGGAATTAATGGATCAGTGGGAACTTAG
AGATCCTGTTACCAATTATAAAAAATACCTAACCGAAATTGGAGTTCTTACAGAAGAACTTGATGAGAAGTATAAAGCTG
AAATAAAACAGGAAATTGATGAAAATTGGGCAATGGCTAATGCCGAACCTGAAATCGAACCTACTTACAGCGGAGAATTA
GATGATGTTTATAAACCATTTCAATATGAGGAATATACACATAGTTCTGAATCAAAAAATATTCGCTTTATTGATGCTAT
TCGCAACAGTTTAGAACAATCTATGTGGCGCAATAAAAACCTGGTTATTATGGGGCAGGATATCGCTGAATATGGCGGAG
CTTTTAAAATTACTGAAGGTTTTGTTGATGCTTTTGGAAAAGAAAGAGTACGAAATACGCCAATTTGCGAAAGTGCAGTT
GTTTCGACCGGAATGGGATTATCTATAAACGGATATAAAGCAATTGTAGAAATGCAGTTTGCAGATTTTGTTTCAACTGG
ATTTAATCCGATTGTAAATTTATTGGCAAAATCTCATTACCGCTGGGGCGAAAAAGCCGATGTTGTGGTTCGTATGCCTT
GCGGAGGCGGAACGCAGGCTGGGCCTTTTCACTCACAGACAAATGAAGCCTGGTTTACCAAAACTCCAGGTCTAAAAGTG
GTATATCCGGCTTTTCCATACGACGCAAAAGGTTTATTGAATACTGCCATAAACGATCCTAATCCGGTTTTATTTTTTGA
ACACAAACAGTTGTACAGAAGTATTTACCAAGATGTTCCAACAGATTATTACACACTTCCGTTTGGAAAAGCTTCTTTAA
TAAAAGAAGGAAATACGGTAACCATTATTGCTTTTGGAGCTCCGGTTCACTGGGCTTTAGAAACTTTAGCCAAACATCCT
GAAATAGAAGCTGATTTAATTGACTTAAGAACGTTGCAGCCTCTTGATACCGAAACTATTTTTGCATCGGTTAAGAAAAC
AGGAAAAGCCCTTATTTATCAGGAAGATACTTTGTTTGGCGGAATTGCCAGCGATATTTCGGCTTTAATTATGGAAGAAT
GTTTTCAATATTTAGATGCTCCAGTAAAAAGAGTGGCAAGTTTAGATTCGCCAATTCCATTTACAAAAGCGCTTGAGGAC
CAATTTTTACCAAAAGATCGTTTTGAGGAAACTCTATTGGAACTATTAAAGTATTAA

Upstream 100 bases:

>100_bases
TTTTTATAAAATCAAAACATAAATAACACATTTCAAATATTTAACAAATAAAAGCTTAATTGTTATATTTTTATATATTT
GAATAAAAAATAACCTAATA

Downstream 100 bases:

>100_bases
TTATACAAATAGGTTTTTAACACATAGAAACATAGTTTTTGAAAACCGATAAAAGGCGTTTCACTTACTATAAATAAACA
TAGCTATGTGTGAGAAACTA

Product: dehydrogenase, E1 component

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MIFYRENLTDEKLLDLYKKLLKPRLIEEKMLILIRQGKVSKWFSGIGQEAIAVGVTSVLDDSEYVLPMHRNLGVFTTRNI
PLHRLFSQWQGKANGFTKGRDRSFHFGTQKYNIIGMISHLGPQLGIADGIALANKLQDNKKVTAVFTGEGATSEGDFHEA
LNIAAVWKLPVMFIIENNGYGLSTPTNEQYLCENLADKGIGYGIESWIIDGNNIVEVYNKLSKLKEEMIADPHPVFLEFK
TFRMRGHEEASGTKYVPQELMDQWELRDPVTNYKKYLTEIGVLTEELDEKYKAEIKQEIDENWAMANAEPEIEPTYSGEL
DDVYKPFQYEEYTHSSESKNIRFIDAIRNSLEQSMWRNKNLVIMGQDIAEYGGAFKITEGFVDAFGKERVRNTPICESAV
VSTGMGLSINGYKAIVEMQFADFVSTGFNPIVNLLAKSHYRWGEKADVVVRMPCGGGTQAGPFHSQTNEAWFTKTPGLKV
VYPAFPYDAKGLLNTAINDPNPVLFFEHKQLYRSIYQDVPTDYYTLPFGKASLIKEGNTVTIIAFGAPVHWALETLAKHP
EIEADLIDLRTLQPLDTETIFASVKKTGKALIYQEDTLFGGIASDISALIMEECFQYLDAPVKRVASLDSPIPFTKALED
QFLPKDRFEETLLELLKY

Sequences:

>Translated_658_residues
MIFYRENLTDEKLLDLYKKLLKPRLIEEKMLILIRQGKVSKWFSGIGQEAIAVGVTSVLDDSEYVLPMHRNLGVFTTRNI
PLHRLFSQWQGKANGFTKGRDRSFHFGTQKYNIIGMISHLGPQLGIADGIALANKLQDNKKVTAVFTGEGATSEGDFHEA
LNIAAVWKLPVMFIIENNGYGLSTPTNEQYLCENLADKGIGYGIESWIIDGNNIVEVYNKLSKLKEEMIADPHPVFLEFK
TFRMRGHEEASGTKYVPQELMDQWELRDPVTNYKKYLTEIGVLTEELDEKYKAEIKQEIDENWAMANAEPEIEPTYSGEL
DDVYKPFQYEEYTHSSESKNIRFIDAIRNSLEQSMWRNKNLVIMGQDIAEYGGAFKITEGFVDAFGKERVRNTPICESAV
VSTGMGLSINGYKAIVEMQFADFVSTGFNPIVNLLAKSHYRWGEKADVVVRMPCGGGTQAGPFHSQTNEAWFTKTPGLKV
VYPAFPYDAKGLLNTAINDPNPVLFFEHKQLYRSIYQDVPTDYYTLPFGKASLIKEGNTVTIIAFGAPVHWALETLAKHP
EIEADLIDLRTLQPLDTETIFASVKKTGKALIYQEDTLFGGIASDISALIMEECFQYLDAPVKRVASLDSPIPFTKALED
QFLPKDRFEETLLELLKY
>Mature_658_residues
MIFYRENLTDEKLLDLYKKLLKPRLIEEKMLILIRQGKVSKWFSGIGQEAIAVGVTSVLDDSEYVLPMHRNLGVFTTRNI
PLHRLFSQWQGKANGFTKGRDRSFHFGTQKYNIIGMISHLGPQLGIADGIALANKLQDNKKVTAVFTGEGATSEGDFHEA
LNIAAVWKLPVMFIIENNGYGLSTPTNEQYLCENLADKGIGYGIESWIIDGNNIVEVYNKLSKLKEEMIADPHPVFLEFK
TFRMRGHEEASGTKYVPQELMDQWELRDPVTNYKKYLTEIGVLTEELDEKYKAEIKQEIDENWAMANAEPEIEPTYSGEL
DDVYKPFQYEEYTHSSESKNIRFIDAIRNSLEQSMWRNKNLVIMGQDIAEYGGAFKITEGFVDAFGKERVRNTPICESAV
VSTGMGLSINGYKAIVEMQFADFVSTGFNPIVNLLAKSHYRWGEKADVVVRMPCGGGTQAGPFHSQTNEAWFTKTPGLKV
VYPAFPYDAKGLLNTAINDPNPVLFFEHKQLYRSIYQDVPTDYYTLPFGKASLIKEGNTVTIIAFGAPVHWALETLAKHP
EIEADLIDLRTLQPLDTETIFASVKKTGKALIYQEDTLFGGIASDISALIMEECFQYLDAPVKRVASLDSPIPFTKALED
QFLPKDRFEETLLELLKY

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=329, Percent_Identity=39.8176291793313, Blast_Score=253, Evalue=5e-67,
Organism=Homo sapiens, GI34101272, Length=329, Percent_Identity=39.8176291793313, Blast_Score=253, Evalue=5e-67,
Organism=Homo sapiens, GI156564403, Length=309, Percent_Identity=33.3333333333333, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI291084858, Length=307, Percent_Identity=32.5732899022801, Blast_Score=182, Evalue=9e-46,
Organism=Homo sapiens, GI11386135, Length=322, Percent_Identity=31.6770186335404, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI258645172, Length=322, Percent_Identity=31.6770186335404, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI4885543, Length=309, Percent_Identity=29.7734627831715, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI4505685, Length=308, Percent_Identity=27.9220779220779, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI291084742, Length=308, Percent_Identity=27.9220779220779, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI291084744, Length=315, Percent_Identity=26.984126984127, Blast_Score=107, Evalue=5e-23,
Organism=Homo sapiens, GI291084757, Length=309, Percent_Identity=23.9482200647249, Blast_Score=80, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17506935, Length=304, Percent_Identity=39.1447368421053, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17538422, Length=321, Percent_Identity=36.1370716510903, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI86563355, Length=322, Percent_Identity=33.8509316770186, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI86563357, Length=322, Percent_Identity=33.8509316770186, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17536047, Length=312, Percent_Identity=28.2051282051282, Blast_Score=129, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI32564172, Length=312, Percent_Identity=28.2051282051282, Blast_Score=129, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6319698, Length=319, Percent_Identity=37.6175548589342, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6321026, Length=316, Percent_Identity=26.8987341772152, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI160714828, Length=333, Percent_Identity=38.4384384384384, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI160714832, Length=333, Percent_Identity=38.4384384384384, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI21358145, Length=338, Percent_Identity=34.0236686390533, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24650940, Length=338, Percent_Identity=34.0236686390533, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI21355903, Length=295, Percent_Identity=30.1694915254237, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24639740, Length=314, Percent_Identity=27.3885350318471, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24639744, Length=314, Percent_Identity=27.3885350318471, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28571106, Length=314, Percent_Identity=27.3885350318471, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24639746, Length=273, Percent_Identity=28.2051282051282, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24639748, Length=310, Percent_Identity=25.8064516129032, Blast_Score=115, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 74413; Mature: 74413

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFYRENLTDEKLLDLYKKLLKPRLIEEKMLILIRQGKVSKWFSGIGQEAIAVGVTSVLD
CEEECCCCCHHHHHHHHHHHHCCHHHHHHHEEEEECCCHHHHHHHCCHHHHHHHHHHHHC
DSEYVLPMHRNLGVFTTRNIPLHRLFSQWQGKANGFTKGRDRSFHFGTQKYNIIGMISHL
CCCEEEEECCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCCCEECCCCCEEHEEEHHHC
GPQLGIADGIALANKLQDNKKVTAVFTGEGATSEGDFHEALNIAAVWKLPVMFIIENNGY
CCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHEEEECCEEEEEECCCC
GLSTPTNEQYLCENLADKGIGYGIESWIIDGNNIVEVYNKLSKLKEEMIADPHPVFLEFK
CCCCCCCHHHHHHHHHHCCCCCCCHHEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEE
TFRMRGHEEASGTKYVPQELMDQWELRDPVTNYKKYLTEIGVLTEELDEKYKAEIKQEID
EHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENWAMANAEPEIEPTYSGELDDVYKPFQYEEYTHSSESKNIRFIDAIRNSLEQSMWRNKN
HCCEECCCCCCCCCCCCCCHHHHCCCCCCHHHCCCCCCCCEEEHHHHHHHHHHHHHCCCC
LVIMGQDIAEYGGAFKITEGFVDAFGKERVRNTPICESAVVSTGMGLSINGYKAIVEMQF
EEEECCCHHHHCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEECCCEEEEHHHH
ADFVSTGFNPIVNLLAKSHYRWGEKADVVVRMPCGGGTQAGPFHSQTNEAWFTKTPGLKV
HHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEE
VYPAFPYDAKGLLNTAINDPNPVLFFEHKQLYRSIYQDVPTDYYTLPFGKASLIKEGNTV
EEECCCCCCHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCCEEECCCCCHHHEECCCEE
TIIAFGAPVHWALETLAKHPEIEADLIDLRTLQPLDTETIFASVKKTGKALIYQEDTLFG
EEEEECCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECCCHHC
GIASDISALIMEECFQYLDAPVKRVASLDSPIPFTKALEDQFLPKDRFEETLLELLKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIFYRENLTDEKLLDLYKKLLKPRLIEEKMLILIRQGKVSKWFSGIGQEAIAVGVTSVLD
CEEECCCCCHHHHHHHHHHHHCCHHHHHHHEEEEECCCHHHHHHHCCHHHHHHHHHHHHC
DSEYVLPMHRNLGVFTTRNIPLHRLFSQWQGKANGFTKGRDRSFHFGTQKYNIIGMISHL
CCCEEEEECCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCCCEECCCCCEEHEEEHHHC
GPQLGIADGIALANKLQDNKKVTAVFTGEGATSEGDFHEALNIAAVWKLPVMFIIENNGY
CCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHEEEECCEEEEEECCCC
GLSTPTNEQYLCENLADKGIGYGIESWIIDGNNIVEVYNKLSKLKEEMIADPHPVFLEFK
CCCCCCCHHHHHHHHHHCCCCCCCHHEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEE
TFRMRGHEEASGTKYVPQELMDQWELRDPVTNYKKYLTEIGVLTEELDEKYKAEIKQEID
EHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENWAMANAEPEIEPTYSGELDDVYKPFQYEEYTHSSESKNIRFIDAIRNSLEQSMWRNKN
HCCEECCCCCCCCCCCCCCHHHHCCCCCCHHHCCCCCCCCEEEHHHHHHHHHHHHHCCCC
LVIMGQDIAEYGGAFKITEGFVDAFGKERVRNTPICESAVVSTGMGLSINGYKAIVEMQF
EEEECCCHHHHCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEECCCEEEEHHHH
ADFVSTGFNPIVNLLAKSHYRWGEKADVVVRMPCGGGTQAGPFHSQTNEAWFTKTPGLKV
HHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEE
VYPAFPYDAKGLLNTAINDPNPVLFFEHKQLYRSIYQDVPTDYYTLPFGKASLIKEGNTV
EEECCCCCCHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCCEEECCCCCHHHEECCCEE
TIIAFGAPVHWALETLAKHPEIEADLIDLRTLQPLDTETIFASVKKTGKALIYQEDTLFG
EEEEECCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECCCHHC
GIASDISALIMEECFQYLDAPVKRVASLDSPIPFTKALEDQFLPKDRFEETLLELLKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]