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The map label for this gene is hutH [H]

Identifier: 146300331

GI number: 146300331

Start: 3064914

End: 3066485

Strand: Direct

Name: hutH [H]

Synonym: Fjoh_2576

Alternate gene names: 146300331

Gene position: 3064914-3066485 (Clockwise)

Preceding gene: 146300327

Following gene: 146300332

Centisome position: 50.27

GC content: 35.05

Gene sequence:

>1572_bases
ATGTTGCTTTTTAATGTTGATTTGTTGAATTTTGACGTTTTAAAATTTGAAATCATCATGAGAGAAATCCATTATATAAG
TACAGAAACGATAACTTTAGAAACACTTCACGAAATTTTATCAAATAACAAAACACTTGAACTGTCTGAAGAAGCTAAAG
TAAACGTTCAAAAATGCCGTGATTATTTAGATAAAAAAATGGCAACGCATACAGCGCCCATTTATGGTATTAATACTGGT
TTTGGATCTCTTTACAGCGTAAAAATCTCGAATGAAAATTTATCTAAACTTCAGGAAAACCTTGTAAAATCTCACGCCTG
CGGAACAGGGGAGGAAGTTCCTGCTGAAATTGTAAAAATGATGCTTTTGCTAAAGATTCAATCTTTAAGCTACGGGTATT
CTGGAATTCAGTTAATTACATTACAGCGTTTGGTTGATTTTTATAATAATGATGTTTTACCAATAATTTATACTCAGGGT
TCACTTGGAGCTTCTGGAGACTTGGCACCTTTAGCACATTTATCTTTGCCTTTAATTGGTGAAGGAAAAGTGTATTTTGA
AGGAAAAAAAACAGAATCAGCAGAAGTTTTAAAACATTTTAACTGGGAACCAATTGTTTTACAGTCAAAAGAAGGTTTGG
CTCTGTTAAACGGGACTCAGTTTATGAGTGCTTATGGTGCTCATATTTTAATTAAAGCATATAAATATTCGTATCTGGCA
GATTTAATTGGAACCATTTCTTTAGAAGGTTTTGATGGAAGAATCGAGCCATTTAACGAATTGATACATTATATTCGTCC
GCACAAAGGACAGATCGTAACCGCGCAGCGAATTACAGAGTTTTTAGACGGAAGCGAAATCATTGCTCAGGAAAAGAAAC
ATGTTCAGGACCCGTATTCTTTCCGTTGTATGCCTCAGGTTCACGGCGCTTCAAAAGACGCAATAGATTATGTTAGAAAG
GTTTTCAAAACAGAAATCAATTCAGTAACCGATAATCCTAATATATTTATTGAAGCCGATCAGATTATTTCAGGCGGTAA
TTTCCATGGTCAGCCTTTGGCTTTGGCTTTAGATTTTATGGCGATTGCTTTGGCAGAATTAGGAAGTATTTCTGAAAGAA
GAACGTATCAGTTAATTTCTGGATTGCGTAATCTTCCTGCGTTTTTAGTTGATAATCCGGGATTAAATTCTGGATTTATG
ATTCCGCAGTATACTGCTGCAAGTATTGCCAGCCAGAATAAACAATTGGCAACTCCTGCCAGTATTGACAGTATTGTTTC
GAGCAACGGACAAGAAGATCACGTAAGCATGGGAGCAAACGGCGCAACAAAAGCCTTACGAATTTTAGATAATTTAGAGC
GTATTTTAGCAATCGAATTATTAAATGCTTCGCAGGCAATTGCCTACAGAGAGCCTTTAAAATCAAGTGATTTTATTGAA
ATGTTTTTAAGCAGTTACAGAGAAGTAGTGCCTTTGGTAAAAGAAGACAGAATCTTACATAATGATATAGAAAACACAGT
GTTATTCCTGGAGAGTTTCCAAATAGAAAACGATTTGTTAACAATGGCTTAA

Upstream 100 bases:

>100_bases
AAAAACTGCCGGAAAAAGTACTAGCTGACACCATTTTACTATTGTTAAAAAAATAAAAGTATAGAAATGTGCAGGTTAAA
TTTTTAATTATTGTGATAAA

Downstream 100 bases:

>100_bases
CATTGCAAAGTATTAATGGAAGTAATTTTGCGCTATCAAAAATATAAAAATGTCAATAAACAGTATTTTCCAATTTTTAG
TGCCGAAAGACAAGAAATTC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MLLFNVDLLNFDVLKFEIIMREIHYISTETITLETLHEILSNNKTLELSEEAKVNVQKCRDYLDKKMATHTAPIYGINTG
FGSLYSVKISNENLSKLQENLVKSHACGTGEEVPAEIVKMMLLLKIQSLSYGYSGIQLITLQRLVDFYNNDVLPIIYTQG
SLGASGDLAPLAHLSLPLIGEGKVYFEGKKTESAEVLKHFNWEPIVLQSKEGLALLNGTQFMSAYGAHILIKAYKYSYLA
DLIGTISLEGFDGRIEPFNELIHYIRPHKGQIVTAQRITEFLDGSEIIAQEKKHVQDPYSFRCMPQVHGASKDAIDYVRK
VFKTEINSVTDNPNIFIEADQIISGGNFHGQPLALALDFMAIALAELGSISERRTYQLISGLRNLPAFLVDNPGLNSGFM
IPQYTAASIASQNKQLATPASIDSIVSSNGQEDHVSMGANGATKALRILDNLERILAIELLNASQAIAYREPLKSSDFIE
MFLSSYREVVPLVKEDRILHNDIENTVLFLESFQIENDLLTMA

Sequences:

>Translated_523_residues
MLLFNVDLLNFDVLKFEIIMREIHYISTETITLETLHEILSNNKTLELSEEAKVNVQKCRDYLDKKMATHTAPIYGINTG
FGSLYSVKISNENLSKLQENLVKSHACGTGEEVPAEIVKMMLLLKIQSLSYGYSGIQLITLQRLVDFYNNDVLPIIYTQG
SLGASGDLAPLAHLSLPLIGEGKVYFEGKKTESAEVLKHFNWEPIVLQSKEGLALLNGTQFMSAYGAHILIKAYKYSYLA
DLIGTISLEGFDGRIEPFNELIHYIRPHKGQIVTAQRITEFLDGSEIIAQEKKHVQDPYSFRCMPQVHGASKDAIDYVRK
VFKTEINSVTDNPNIFIEADQIISGGNFHGQPLALALDFMAIALAELGSISERRTYQLISGLRNLPAFLVDNPGLNSGFM
IPQYTAASIASQNKQLATPASIDSIVSSNGQEDHVSMGANGATKALRILDNLERILAIELLNASQAIAYREPLKSSDFIE
MFLSSYREVVPLVKEDRILHNDIENTVLFLESFQIENDLLTMA
>Mature_523_residues
MLLFNVDLLNFDVLKFEIIMREIHYISTETITLETLHEILSNNKTLELSEEAKVNVQKCRDYLDKKMATHTAPIYGINTG
FGSLYSVKISNENLSKLQENLVKSHACGTGEEVPAEIVKMMLLLKIQSLSYGYSGIQLITLQRLVDFYNNDVLPIIYTQG
SLGASGDLAPLAHLSLPLIGEGKVYFEGKKTESAEVLKHFNWEPIVLQSKEGLALLNGTQFMSAYGAHILIKAYKYSYLA
DLIGTISLEGFDGRIEPFNELIHYIRPHKGQIVTAQRITEFLDGSEIIAQEKKHVQDPYSFRCMPQVHGASKDAIDYVRK
VFKTEINSVTDNPNIFIEADQIISGGNFHGQPLALALDFMAIALAELGSISERRTYQLISGLRNLPAFLVDNPGLNSGFM
IPQYTAASIASQNKQLATPASIDSIVSSNGQEDHVSMGANGATKALRILDNLERILAIELLNASQAIAYREPLKSSDFIE
MFLSSYREVVPLVKEDRILHNDIENTVLFLESFQIENDLLTMA

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=485, Percent_Identity=43.0927835051546, Blast_Score=387, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17567831, Length=483, Percent_Identity=43.064182194617, Blast_Score=362, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 58273; Mature: 58273

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLFNVDLLNFDVLKFEIIMREIHYISTETITLETLHEILSNNKTLELSEEAKVNVQKCR
CEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCEEEECHHHCCCHHHHH
DYLDKKMATHTAPIYGINTGFGSLYSVKISNENLSKLQENLVKSHACGTGEEVPAEIVKM
HHHHHHHHHCCCCEEEEECCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
MLLLKIQSLSYGYSGIQLITLQRLVDFYNNDVLPIIYTQGSLGASGDLAPLAHLSLPLIG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHCCCCEEE
EGKVYFEGKKTESAEVLKHFNWEPIVLQSKEGLALLNGTQFMSAYGAHILIKAYKYSYLA
CCEEEEECCCCCHHHHHHHCCCCEEEEECCCCEEEECCHHHHHHHCCEEEEHHHHHHHHH
DLIGTISLEGFDGRIEPFNELIHYIRPHKGQIVTAQRITEFLDGSEIIAQEKKHVQDPYS
HHHHHEEECCCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHCCHHHHHHHHHHCCCCCC
FRCMPQVHGASKDAIDYVRKVFKTEINSVTDNPNIFIEADQIISGGNFHGQPLALALDFM
EEEEHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEECCCCCCCCHHHHHHHHH
AIALAELGSISERRTYQLISGLRNLPAFLVDNPGLNSGFMIPQYTAASIASQNKQLATPA
HHHHHHHCCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCH
SIDSIVSSNGQEDHVSMGANGATKALRILDNLERILAIELLNASQAIAYREPLKSSDFIE
HHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHH
MFLSSYREVVPLVKEDRILHNDIENTVLFLESFQIENDLLTMA
HHHHHHHHHHHHHHCCCHHHHCHHHHEEEEEHHEECCCCEECC
>Mature Secondary Structure
MLLFNVDLLNFDVLKFEIIMREIHYISTETITLETLHEILSNNKTLELSEEAKVNVQKCR
CEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCEEEECHHHCCCHHHHH
DYLDKKMATHTAPIYGINTGFGSLYSVKISNENLSKLQENLVKSHACGTGEEVPAEIVKM
HHHHHHHHHCCCCEEEEECCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
MLLLKIQSLSYGYSGIQLITLQRLVDFYNNDVLPIIYTQGSLGASGDLAPLAHLSLPLIG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHCCCCEEE
EGKVYFEGKKTESAEVLKHFNWEPIVLQSKEGLALLNGTQFMSAYGAHILIKAYKYSYLA
CCEEEEECCCCCHHHHHHHCCCCEEEEECCCCEEEECCHHHHHHHCCEEEEHHHHHHHHH
DLIGTISLEGFDGRIEPFNELIHYIRPHKGQIVTAQRITEFLDGSEIIAQEKKHVQDPYS
HHHHHEEECCCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHCCHHHHHHHHHHCCCCCC
FRCMPQVHGASKDAIDYVRKVFKTEINSVTDNPNIFIEADQIISGGNFHGQPLALALDFM
EEEEHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEECCCCCCCCHHHHHHHHH
AIALAELGSISERRTYQLISGLRNLPAFLVDNPGLNSGFMIPQYTAASIASQNKQLATPA
HHHHHHHCCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCH
SIDSIVSSNGQEDHVSMGANGATKALRILDNLERILAIELLNASQAIAYREPLKSSDFIE
HHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHH
MFLSSYREVVPLVKEDRILHNDIENTVLFLESFQIENDLLTMA
HHHHHHHHHHHHHHCCCHHHHCHHHHEEEEEHHEECCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA