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The map label for this gene is thrB [H]

Identifier: 146300329

GI number: 146300329

Start: 3060792

End: 3061712

Strand: Reverse

Name: thrB [H]

Synonym: Fjoh_2574

Alternate gene names: 146300329

Gene position: 3061712-3060792 (Counterclockwise)

Preceding gene: 146300330

Following gene: 146300328

Centisome position: 50.22

GC content: 41.8

Gene sequence:

>921_bases
ATGGAAATAAAATTATTCTGTCCCGCTACAATCGCAAACCTCTCATGCGGATTTGACGTATTGGGACTTTGCTTAGACAA
TGCGGGCGATGAAATGATTGTTCGAAAAGTCGATCAAAAAGGAGTTCGAATCACTAAAATTGTAGGTGCCGATTTACCTT
TGGAAACCGAGAAAAACGTTTCCGGAGTTGCTGCTTTGGCAATGTTAGAAACTTTGGACGAACTAGATTTTGGATTCGAA
ATCGAAATTTATAAACACATAAAAGCGGGAAGCGGAATTGGAAGCAGTGCTGCAAGTTCTGCGGGAGCGGTTTTCGGAAT
TAATGAATTATTAGGAAGACCGTATTCGCGTAAAGATTTGGTTCAGTTTGCGATGCAGGGCGAGAAATTAGCCAGCGGAA
ACGCACATGCCGACAACGTTGCTCCTGCCCTTTTAGGCGGCTTTACTTTGGTAAGAAGTTATGCCCCGCTTGACATTATC
AGAATTGACAGTCCAGAGGAATTGTACGCAACAGTGGTTCACCCGCAAATTGAGTTAAAAACTTCTGACGCGCGTTCGGT
TTTAAAACAAAATGTTTCCCTAAAAAGTGCCATTATGCAATGGGGAAATGTGGGCGGATTAGTAGCAGGTCTTTACACTA
AAGATTACGAATTAATTGGACGTTCGCTTCATGATGAAATCGTTGAGCCATTAAGAAGTGTTTTAATTCCTGGTTTTGAC
CAAATCAAACAAACGGCTTACGAAAACGGCGCTTTAGGTTCTGGAATTTCAGGTTCTGGTCCGTCTATTTTCGCTTTAAG
CAGAGGAAAAGAAACCGCCGACCAAATCGCAAAAGCCATGAGCGACGTTTACGAAAAAATGAATTTGCCGTATGAAATTC
ACGTTTCGAAGATTAACCCAGACGGCGTAAGAATTATTTAA

Upstream 100 bases:

>100_bases
CAACTCAGAGTCTCAAAACCTTAAAAAAAAATGGTGATAGTTTGCAAAGCAAAAACCTTAGAACCTTAGCAACTCAGAAC
CTTAGAACCTTTAAAAAGAA

Downstream 100 bases:

>100_bases
AATGAGTGCTTAGTTCCTAGTCCTTAGTAATTAGTCGCAAAAGACTAAGACTAGCAGCTAAGGACTAAGGACTAATTACT
AAGAACTAATAAAAATGAAA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MEIKLFCPATIANLSCGFDVLGLCLDNAGDEMIVRKVDQKGVRITKIVGADLPLETEKNVSGVAALAMLETLDELDFGFE
IEIYKHIKAGSGIGSSAASSAGAVFGINELLGRPYSRKDLVQFAMQGEKLASGNAHADNVAPALLGGFTLVRSYAPLDII
RIDSPEELYATVVHPQIELKTSDARSVLKQNVSLKSAIMQWGNVGGLVAGLYTKDYELIGRSLHDEIVEPLRSVLIPGFD
QIKQTAYENGALGSGISGSGPSIFALSRGKETADQIAKAMSDVYEKMNLPYEIHVSKINPDGVRII

Sequences:

>Translated_306_residues
MEIKLFCPATIANLSCGFDVLGLCLDNAGDEMIVRKVDQKGVRITKIVGADLPLETEKNVSGVAALAMLETLDELDFGFE
IEIYKHIKAGSGIGSSAASSAGAVFGINELLGRPYSRKDLVQFAMQGEKLASGNAHADNVAPALLGGFTLVRSYAPLDII
RIDSPEELYATVVHPQIELKTSDARSVLKQNVSLKSAIMQWGNVGGLVAGLYTKDYELIGRSLHDEIVEPLRSVLIPGFD
QIKQTAYENGALGSGISGSGPSIFALSRGKETADQIAKAMSDVYEKMNLPYEIHVSKINPDGVRII
>Mature_306_residues
MEIKLFCPATIANLSCGFDVLGLCLDNAGDEMIVRKVDQKGVRITKIVGADLPLETEKNVSGVAALAMLETLDELDFGFE
IEIYKHIKAGSGIGSSAASSAGAVFGINELLGRPYSRKDLVQFAMQGEKLASGNAHADNVAPALLGGFTLVRSYAPLDII
RIDSPEELYATVVHPQIELKTSDARSVLKQNVSLKSAIMQWGNVGGLVAGLYTKDYELIGRSLHDEIVEPLRSVLIPGFD
QIKQTAYENGALGSGISGSGPSIFALSRGKETADQIAKAMSDVYEKMNLPYEIHVSKINPDGVRII

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=311, Percent_Identity=32.1543408360129, Blast_Score=153, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321814, Length=340, Percent_Identity=24.4117647058824, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 32782; Mature: 32782

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKLFCPATIANLSCGFDVLGLCLDNAGDEMIVRKVDQKGVRITKIVGADLPLETEKNV
CEEEEECCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
SGVAALAMLETLDELDFGFEIEIYKHIKAGSGIGSSAASSAGAVFGINELLGRPYSRKDL
HHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHCCCCCEEEHHHHHCCCCCHHHH
VQFAMQGEKLASGNAHADNVAPALLGGFTLVRSYAPLDIIRIDSPEELYATVVHPQIELK
HHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHEEECCEEEEE
TSDARSVLKQNVSLKSAIMQWGNVGGLVAGLYTKDYELIGRSLHDEIVEPLRSVLIPGFD
CHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QIKQTAYENGALGSGISGSGPSIFALSRGKETADQIAKAMSDVYEKMNLPYEIHVSKINP
HHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECC
DGVRII
CCCEEC
>Mature Secondary Structure
MEIKLFCPATIANLSCGFDVLGLCLDNAGDEMIVRKVDQKGVRITKIVGADLPLETEKNV
CEEEEECCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
SGVAALAMLETLDELDFGFEIEIYKHIKAGSGIGSSAASSAGAVFGINELLGRPYSRKDL
HHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHCCCCCEEEHHHHHCCCCCHHHH
VQFAMQGEKLASGNAHADNVAPALLGGFTLVRSYAPLDIIRIDSPEELYATVVHPQIELK
HHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHEEECCEEEEE
TSDARSVLKQNVSLKSAIMQWGNVGGLVAGLYTKDYELIGRSLHDEIVEPLRSVLIPGFD
CHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QIKQTAYENGALGSGISGSGPSIFALSRGKETADQIAKAMSDVYEKMNLPYEIHVSKINP
HHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECC
DGVRII
CCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA