Click here to switch to the map view.

The map label for this gene is aqpZ [H]

Identifier: 146300119

GI number: 146300119

Start: 2834864

End: 2835580

Strand: Reverse

Name: aqpZ [H]

Synonym: Fjoh_2364

Alternate gene names: 146300119

Gene position: 2835580-2834864 (Counterclockwise)

Preceding gene: 146300120

Following gene: 146300118

Centisome position: 46.51

GC content: 40.17

Gene sequence:

>717_bases
ATGAAAAAATTATTTGCTGAGTTCTTCGGAACTTATTGGCTGGTTTTTGGAGGATGCGGAAGCGCTGTCTTTGCTGCCGG
ATATCCTACTCTGGGAATTGGGTTTGCTGGTGTTGCCTTGGCATTTGGTTTAACGGTTTTAACAATGGCTTATGCCGTTG
GGCACATCTCAGGCGGACATTTTAATCCTGCTGTTTCATTTGGTTTATGGGCTGGCGGACGATTTTCTGCCAAAGATCTT
CTTCCTTACATTGCTGCCCAGTGTGTTGGTGCAATAACAGCAGCAGGAACCTTATATACAATTGCATCTGGAAAAGCTGG
GTTTGTAATTGATAATACTAAAGCCGGAGCTTTTGCCTCAAATGGTTTTGGTGCTTTTTCTCCTGATGGATATTCATTTC
AGGCTGCTTTTATTGCCGAATTTGTATTGACTTTATTTTTCTTACTGGTAATTTTAGGTGCTACAGATAAGTTTGCAAAC
GGAAGATTTGCCGGCATAGCAATAGGTCTTGCCTTAACCTTAATTCATTTAATTAGTATTCCAATTACCAATACATCTGT
AAATCCTGCCAGATCATTATCTCAGGCTATATTTGTAGGCGGAACGCCTCTTACTCAGGTTTGGGTGTTTTGGGCAGCAC
CGATTTTAGGCGCAATTACAGCCGGATTTATTTACAAATCATTATTACAAAATCATACACAAGATCATACAAACTAA

Upstream 100 bases:

>100_bases
GATTTTATTTGTACGTTTGCCCTTACAATTAGTTTTGATTATTTGGGCATTCCAATATACCCTTTAACAATCAAATCTAT
TAATCTAAAATTATTTTATT

Downstream 100 bases:

>100_bases
AACAAAATTTATTATATCATGAGTTTTTTATATTTTTTACTTATTGGAGCAATTTCGGGATGGCTGGCTGGCCAAATTTG
GAAAGGTGCAGGTTTCGGAC

Product: MIP family channel protein

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKKLFAEFFGTYWLVFGGCGSAVFAAGYPTLGIGFAGVALAFGLTVLTMAYAVGHISGGHFNPAVSFGLWAGGRFSAKDL
LPYIAAQCVGAITAAGTLYTIASGKAGFVIDNTKAGAFASNGFGAFSPDGYSFQAAFIAEFVLTLFFLLVILGATDKFAN
GRFAGIAIGLALTLIHLISIPITNTSVNPARSLSQAIFVGGTPLTQVWVFWAAPILGAITAGFIYKSLLQNHTQDHTN

Sequences:

>Translated_238_residues
MKKLFAEFFGTYWLVFGGCGSAVFAAGYPTLGIGFAGVALAFGLTVLTMAYAVGHISGGHFNPAVSFGLWAGGRFSAKDL
LPYIAAQCVGAITAAGTLYTIASGKAGFVIDNTKAGAFASNGFGAFSPDGYSFQAAFIAEFVLTLFFLLVILGATDKFAN
GRFAGIAIGLALTLIHLISIPITNTSVNPARSLSQAIFVGGTPLTQVWVFWAAPILGAITAGFIYKSLLQNHTQDHTN
>Mature_238_residues
MKKLFAEFFGTYWLVFGGCGSAVFAAGYPTLGIGFAGVALAFGLTVLTMAYAVGHISGGHFNPAVSFGLWAGGRFSAKDL
LPYIAAQCVGAITAAGTLYTIASGKAGFVIDNTKAGAFASNGFGAFSPDGYSFQAAFIAEFVLTLFFLLVILGATDKFAN
GRFAGIAIGLALTLIHLISIPITNTSVNPARSLSQAIFVGGTPLTQVWVFWAAPILGAITAGFIYKSLLQNHTQDHTN

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502183, Length=232, Percent_Identity=36.6379310344828, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI37694062, Length=248, Percent_Identity=35.8870967741936, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI6912506, Length=230, Percent_Identity=35.6521739130435, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4502179, Length=230, Percent_Identity=34.7826086956522, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI4502181, Length=230, Percent_Identity=32.1739130434783, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4755125, Length=230, Percent_Identity=31.7391304347826, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI86792455, Length=233, Percent_Identity=33.4763948497854, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI157266307, Length=258, Percent_Identity=30.2325581395349, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4502187, Length=245, Percent_Identity=28.9795918367347, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI45446752, Length=212, Percent_Identity=29.7169811320755, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4826645, Length=253, Percent_Identity=28.8537549407115, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1787101, Length=231, Percent_Identity=68.3982683982684, Blast_Score=282, Evalue=1e-77,
Organism=Escherichia coli, GI1790362, Length=252, Percent_Identity=28.1746031746032, Blast_Score=84, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71993722, Length=234, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17558372, Length=239, Percent_Identity=30.5439330543933, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531429, Length=248, Percent_Identity=29.8387096774194, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17531431, Length=248, Percent_Identity=29.8387096774194, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24652747, Length=242, Percent_Identity=33.8842975206612, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45551084, Length=242, Percent_Identity=33.8842975206612, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24652751, Length=233, Percent_Identity=33.9055793991416, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922038, Length=232, Percent_Identity=33.6206896551724, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136672, Length=238, Percent_Identity=28.1512605042017, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45550503, Length=234, Percent_Identity=26.0683760683761, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24762344, Length=237, Percent_Identity=26.5822784810127, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24762342, Length=194, Percent_Identity=26.2886597938144, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24762346, Length=237, Percent_Identity=26.5822784810127, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24762348, Length=237, Percent_Identity=26.5822784810127, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI20130305, Length=237, Percent_Identity=26.5822784810127, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 24741; Mature: 24741

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLFAEFFGTYWLVFGGCGSAVFAAGYPTLGIGFAGVALAFGLTVLTMAYAVGHISGGH
CHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FNPAVSFGLWAGGRFSAKDLLPYIAAQCVGAITAAGTLYTIASGKAGFVIDNTKAGAFAS
CCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCCCC
NGFGAFSPDGYSFQAAFIAEFVLTLFFLLVILGATDKFANGRFAGIAIGLALTLIHLISI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHC
PITNTSVNPARSLSQAIFVGGTPLTQVWVFWAAPILGAITAGFIYKSLLQNHTQDHTN
CCCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKKLFAEFFGTYWLVFGGCGSAVFAAGYPTLGIGFAGVALAFGLTVLTMAYAVGHISGGH
CHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FNPAVSFGLWAGGRFSAKDLLPYIAAQCVGAITAAGTLYTIASGKAGFVIDNTKAGAFAS
CCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCCCC
NGFGAFSPDGYSFQAAFIAEFVLTLFFLLVILGATDKFANGRFAGIAIGLALTLIHLISI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHC
PITNTSVNPARSLSQAIFVGGTPLTQVWVFWAAPILGAITAGFIYKSLLQNHTQDHTN
CCCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]