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The map label for this gene is moeA [H]

Identifier: 145299993

GI number: 145299993

Start: 3332991

End: 3334736

Strand: Direct

Name: moeA [H]

Synonym: ASA_3090

Alternate gene names: 145299993

Gene position: 3332991-3334736 (Clockwise)

Preceding gene: 145299992

Following gene: 145299994

Centisome position: 70.88

GC content: 67.18

Gene sequence:

>1746_bases
ATGACACCGGCCCCCACTCTTCCCCTGCTCGGCTTTGCGGCCTGGAGCGGTACCGGCAAGACCACGCTGCTGGAACAACT
CATCCCCATTCTGGTAAGCCGCGGTCTGCGCCTGGGTGTGCTCAAGCACGCCCATCACGACTTTGACACCGACCAGCCGG
GCAAGGACAGCTACCGCCTGCGCAAGGCGGGAGCGGATCAGGTGATGGCGGCTTCGCGCCGTCGTCACGCCCGCATCGTC
GAGACGCCCGACGCCGAGCCCCCGTTTCACGCCTTGCTGGCCAGCTTCGACCAGACCCGGCTCGACCTGCTGCTGGTGGA
AGGGTTCAAGCACGAGCACTTCCCCAAGATAGAGCTACACCGCGCGGCGCTTGGCAAGCCGCTGCTGTTTCCGATTGATA
GCGACATCATCGCCTTGGCAAGCGATCAGCCGGCAGATACTGCCCTGCCCCGGCTCGATATCAATGATCTGGCGGCCATC
GCCGACTTCGTCTGCGCGTACCTCGAGCGCAGCCGGCAGCAAGAGCTGGCGCCGGGGGCCGGTTTTCTGTCGGTGGAAGG
GGCCCGCAGCGCCATTCTGGACGCACTCACCCCCACCACTCGCAGCACGGACTCGCCACTGGCCCTGTGCCACAGCGCCG
TGCTCGCACAGGACTTGGTGAGCCCCATCAATGTGCCCCCCCACGCCAATTCGGCGATGGACGGGATTGGCCTTCGCGGC
GACGACCTCGCCGCCGGTCGCTGGCAACTGGTGGGTGAAGTGCTGGCGGGCCAGCAGCACCATGAGCCTGTGCTGGCTGG
TCAGGCGGTGCAGATCATGACGGGGGCGCCGCTGCCCCCCGGCGTCGATACGGTCGTGATGCGCGAAGAGACCCAAGTTG
AGGGCGAGTGGGTCACCATCAGCGCCCCCATCAAAGCGGGGCAGAACGTGCGTCTGGCCGGGGAAGATCTCGCCAAGGGC
GCGGTCGCCATCCCGGCCGGTACTCGCCTTGGCGCCCCCCAGCTGGGACTGGCGGCCTCCTTGGGTCAGGCCAGCCTGTC
GGTACGCACCCCGCTCAAGGTGGCACTGTTCAGCACCGGCGATGAGGTGCAGGCACCGGGCGAAACGCTGGCCCCGGGCC
ATATCTTCGACAGCAACCGCTTCACCCTGATGGCGCTCATCGCCGCCGCAGGCTGCGAGGTGATGGACTTGGGCATCATC
CCCGATGATCCCGCCATACTACGCCAGCAGCTGGAACAGGCCGCGGCCAACGCCGATCTGGTGCTGAGCTCGGGCGGCGT
CTCGGTGGGCAATGCCGACTTCATCAAGCAGGTGCTGGCGGAGCTTGGCCAGATAGCCTTCTGGCGCATTCAGATGCGGC
CAGGTCGCCCGCTGGCGTTTGGCAAGCTGGGGACTACCCCCTTCTTCGGCCTGCCGGGCAATCCGGTGGCAGCCATGGTC
TGCTTCTTGCAATTTGTCGAACCCGCCATCGCTCGCCTGCAAGGCCGGGTCTGGCAGCCGCTGCGCCTCTCGGCGCAGGC
CGAGCAGGAGATGCAGAGCCGCCCTGGCCGCACCGAGTTTCTGCGCGGCGTCTTCCATCAGGATGCCAGCGGCGTGCTGC
GGGTGCGCACTACCGGGCCGCAGGGCTCCGGCATTCTCAGCTCCATGGCCGAGGCCAACTGCCTGATTGAAATTGTCCCC
GCCCAGCCGGCCATCGCGGTCGGCGAGCGGGTCTGGATCCACCCACTCCAGGGACGAGTGGCCTGA

Upstream 100 bases:

>100_bases
CGGATGCCTTCATCAACCTCAACACCCCGGCCGAGCTGGCCGCCTACGAGGCGCGCCTGCTGAACTCGTCTACCGACCCC
CGACAAGGAGCCACAGCATC

Downstream 100 bases:

>100_bases
TAAATCGCGATCACCCCGCCGGGCGTGGCGGGGTGCTTGCGCCCATGACCCGAGGCTTGTCCCTTGCGCCTGAATACCCC
CCTCTCCCGGCTCGATCTGC

Product: bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MTPAPTLPLLGFAAWSGTGKTTLLEQLIPILVSRGLRLGVLKHAHHDFDTDQPGKDSYRLRKAGADQVMAASRRRHARIV
ETPDAEPPFHALLASFDQTRLDLLLVEGFKHEHFPKIELHRAALGKPLLFPIDSDIIALASDQPADTALPRLDINDLAAI
ADFVCAYLERSRQQELAPGAGFLSVEGARSAILDALTPTTRSTDSPLALCHSAVLAQDLVSPINVPPHANSAMDGIGLRG
DDLAAGRWQLVGEVLAGQQHHEPVLAGQAVQIMTGAPLPPGVDTVVMREETQVEGEWVTISAPIKAGQNVRLAGEDLAKG
AVAIPAGTRLGAPQLGLAASLGQASLSVRTPLKVALFSTGDEVQAPGETLAPGHIFDSNRFTLMALIAAAGCEVMDLGII
PDDPAILRQQLEQAAANADLVLSSGGVSVGNADFIKQVLAELGQIAFWRIQMRPGRPLAFGKLGTTPFFGLPGNPVAAMV
CFLQFVEPAIARLQGRVWQPLRLSAQAEQEMQSRPGRTEFLRGVFHQDASGVLRVRTTGPQGSGILSSMAEANCLIEIVP
AQPAIAVGERVWIHPLQGRVA

Sequences:

>Translated_581_residues
MTPAPTLPLLGFAAWSGTGKTTLLEQLIPILVSRGLRLGVLKHAHHDFDTDQPGKDSYRLRKAGADQVMAASRRRHARIV
ETPDAEPPFHALLASFDQTRLDLLLVEGFKHEHFPKIELHRAALGKPLLFPIDSDIIALASDQPADTALPRLDINDLAAI
ADFVCAYLERSRQQELAPGAGFLSVEGARSAILDALTPTTRSTDSPLALCHSAVLAQDLVSPINVPPHANSAMDGIGLRG
DDLAAGRWQLVGEVLAGQQHHEPVLAGQAVQIMTGAPLPPGVDTVVMREETQVEGEWVTISAPIKAGQNVRLAGEDLAKG
AVAIPAGTRLGAPQLGLAASLGQASLSVRTPLKVALFSTGDEVQAPGETLAPGHIFDSNRFTLMALIAAAGCEVMDLGII
PDDPAILRQQLEQAAANADLVLSSGGVSVGNADFIKQVLAELGQIAFWRIQMRPGRPLAFGKLGTTPFFGLPGNPVAAMV
CFLQFVEPAIARLQGRVWQPLRLSAQAEQEMQSRPGRTEFLRGVFHQDASGVLRVRTTGPQGSGILSSMAEANCLIEIVP
AQPAIAVGERVWIHPLQGRVA
>Mature_580_residues
TPAPTLPLLGFAAWSGTGKTTLLEQLIPILVSRGLRLGVLKHAHHDFDTDQPGKDSYRLRKAGADQVMAASRRRHARIVE
TPDAEPPFHALLASFDQTRLDLLLVEGFKHEHFPKIELHRAALGKPLLFPIDSDIIALASDQPADTALPRLDINDLAAIA
DFVCAYLERSRQQELAPGAGFLSVEGARSAILDALTPTTRSTDSPLALCHSAVLAQDLVSPINVPPHANSAMDGIGLRGD
DLAAGRWQLVGEVLAGQQHHEPVLAGQAVQIMTGAPLPPGVDTVVMREETQVEGEWVTISAPIKAGQNVRLAGEDLAKGA
VAIPAGTRLGAPQLGLAASLGQASLSVRTPLKVALFSTGDEVQAPGETLAPGHIFDSNRFTLMALIAAAGCEVMDLGIIP
DDPAILRQQLEQAAANADLVLSSGGVSVGNADFIKQVLAELGQIAFWRIQMRPGRPLAFGKLGTTPFFGLPGNPVAAMVC
FLQFVEPAIARLQGRVWQPLRLSAQAEQEMQSRPGRTEFLRGVFHQDASGVLRVRTTGPQGSGILSSMAEANCLIEIVPA
QPAIAVGERVWIHPLQGRVA

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=365, Percent_Identity=36.986301369863, Blast_Score=202, Evalue=8e-52,
Organism=Homo sapiens, GI66932975, Length=365, Percent_Identity=36.986301369863, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI1787049, Length=379, Percent_Identity=46.4379947229551, Blast_Score=340, Evalue=2e-94,
Organism=Escherichia coli, GI145693204, Length=172, Percent_Identity=53.4883720930233, Blast_Score=177, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI25147659, Length=366, Percent_Identity=30.327868852459, Blast_Score=152, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=338, Percent_Identity=23.9644970414201, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136978, Length=357, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24638841, Length=357, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 61720; Mature: 61588

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPAPTLPLLGFAAWSGTGKTTLLEQLIPILVSRGLRLGVLKHAHHDFDTDQPGKDSYRL
CCCCCCCCHHEEEEECCCCHHHHHHHHHHHHHHCCCCEEHHHHHCCCCCCCCCCCCCHHH
RKAGADQVMAASRRRHARIVETPDAEPPFHALLASFDQTRLDLLLVEGFKHEHFPKIELH
HHCCHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCHHHEEEEEEECCCCCCCCCCEEH
RAALGKPLLFPIDSDIIALASDQPADTALPRLDINDLAAIADFVCAYLERSRQQELAPGA
HHHCCCCEEEECCCCEEEEECCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GFLSVEGARSAILDALTPTTRSTDSPLALCHSAVLAQDLVSPINVPPHANSAMDGIGLRG
CEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
DDLAAGRWQLVGEVLAGQQHHEPVLAGQAVQIMTGAPLPPGVDTVVMREETQVEGEWVTI
CCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEE
SAPIKAGQNVRLAGEDLAKGAVAIPAGTRLGAPQLGLAASLGQASLSVRTPLKVALFSTG
ECCCCCCCCEEECCHHHCCCCEECCCCCCCCCCCCCHHHHCCCCCEEECCCEEEEEEECC
DEVQAPGETLAPGHIFDSNRFTLMALIAAAGCEVMDLGIIPDDPAILRQQLEQAAANADL
CCCCCCCCCCCCCEEECCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCE
VLSSGGVSVGNADFIKQVLAELGQIAFWRIQMRPGRPLAFGKLGTTPFFGLPGNPVAAMV
EEECCCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHH
CFLQFVEPAIARLQGRVWQPLRLSAQAEQEMQSRPGRTEFLRGVFHQDASGVLRVRTTGP
HHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCC
QGSGILSSMAEANCLIEIVPAQPAIAVGERVWIHPLQGRVA
CCCHHHHHHHCCCEEEEEECCCCCEECCCEEEEEECCCCCC
>Mature Secondary Structure 
TPAPTLPLLGFAAWSGTGKTTLLEQLIPILVSRGLRLGVLKHAHHDFDTDQPGKDSYRL
CCCCCCCHHEEEEECCCCHHHHHHHHHHHHHHCCCCEEHHHHHCCCCCCCCCCCCCHHH
RKAGADQVMAASRRRHARIVETPDAEPPFHALLASFDQTRLDLLLVEGFKHEHFPKIELH
HHCCHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCHHHEEEEEEECCCCCCCCCCEEH
RAALGKPLLFPIDSDIIALASDQPADTALPRLDINDLAAIADFVCAYLERSRQQELAPGA
HHHCCCCEEEECCCCEEEEECCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GFLSVEGARSAILDALTPTTRSTDSPLALCHSAVLAQDLVSPINVPPHANSAMDGIGLRG
CEEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
DDLAAGRWQLVGEVLAGQQHHEPVLAGQAVQIMTGAPLPPGVDTVVMREETQVEGEWVTI
CCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEE
SAPIKAGQNVRLAGEDLAKGAVAIPAGTRLGAPQLGLAASLGQASLSVRTPLKVALFSTG
ECCCCCCCCEEECCHHHCCCCEECCCCCCCCCCCCCHHHHCCCCCEEECCCEEEEEEECC
DEVQAPGETLAPGHIFDSNRFTLMALIAAAGCEVMDLGIIPDDPAILRQQLEQAAANADL
CCCCCCCCCCCCCEEECCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCE
VLSSGGVSVGNADFIKQVLAELGQIAFWRIQMRPGRPLAFGKLGTTPFFGLPGNPVAAMV
EEECCCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHH
CFLQFVEPAIARLQGRVWQPLRLSAQAEQEMQSRPGRTEFLRGVFHQDASGVLRVRTTGP
HHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCC
QGSGILSSMAEANCLIEIVPAQPAIAVGERVWIHPLQGRVA
CCCHHHHHHHCCCEEEEEECCCCCEECCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]