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The map label for this gene is cusC [C]

Identifier: 145299913

GI number: 145299913

Start: 3240413

End: 3241786

Strand: Direct

Name: cusC [C]

Synonym: ASA_3005

Alternate gene names: 145299913

Gene position: 3240413-3241786 (Clockwise)

Preceding gene: 145299912

Following gene: 145299914

Centisome position: 68.91

GC content: 63.03

Gene sequence:

>1374_bases
ATGACGATGCACAACTTATCCAAACTGGCGCTCTGCCTGGCCCTTGCTGCTGGCGTGAGCGCCTGCAGCCAGCAGAGCAC
CTATCACAGACAAGATCTGGTACTGGCTCCGAGCTGGCAACAGCCGGATGACGGCCTCACCCATCAGCAGGCCGGCCTCT
GGTGGCAAGGGTTCCATGATCCGGCGCTGGATCAGCTGGTGGAAGCCGTGCTGGCCGCCAACCCGGACATGCAGGTCGCC
GGGTTGAGGCTCAGGAGCGCACTGCTGGGCGCAGATTTTGCCGATACCAACCAGGCCCCCTCGGTCAGTGCCAGCCTGGG
GGCCAACGGCACCAAAAATCTGAAAGATGGCAGTGCCAGCAGCAGCATGGGCCCCTCTCTCACCCTCAGTTATGAGGTGG
ATCTCTGGGGTCGGCTCGCCTCGGCGCGGGATCAGGCGAGCTGGGAAGCCCAGGCTTCCGCCCAGGATCTGGCGGCCACC
CGCCTGATGCTGATCGGCAAGGCGCTGGAGCAGTACTGGCAGCTGGCCTATCTCGGCTCGGCCATCACACTGGGCGAGCG
GCAACTGGCAAACTACACCCGCGCCGAACAACTGACCCAGGCCAAGTACCAGGCCGGCGCCATCACCCGGCTCGATCTGG
TGCAGGCCAGCAAGCAGAAGGCCAACAAACAAGCTGAGCTCACTTCGCTCTTGATGCAGCAGGAACAGGCCCGCAACGGG
CTGCGCCTCTTGCTTGGGCGCAGCAGCGGACCGCTGGAATTTGCCCCGACCGCACTGACGACGAGCCCGGTGCCATCACT
GGCGGTCGGCATTCCAGCGGATGTGCTGGCACGGCGCCCCGACGTGCGCGCCGCCGAGTTGCGCCTGCGCAAGACACTGG
CAAAAGGGGATGAGATCCGCACCGGTTTCTATCCCAGCTTGAGTCTCACCGGAGGTGCCAGCAGCACCTCGGACACCCTG
ACCCAGGTATTGCAAAATCCGGTGGGCACTCTGAGTGCTAGCCTGGCGCTGCCTTTCCTCGAATACAACAAGACCCGGAT
CTCCATTGCGAGCTCAGAGCTTGATTACCAGATTGCCGAAACCGAATTTCGCAAGCAGCTTTATACCGCCCTGGTCGAGG
TGGAAGACGGCCTGGCCGCCCGCCATCACGGCGAGCAGCGCCTGAACTATCTGGCCGAGCAGCTGACGTTTGCCAAAGAG
GCGGAACCGCTTGCCCAGGCTCGCTTCCAGGCCGGTGCCACCGGGGTACAACCCTGGCTGGATGAGCAGAACCGCCTGTG
GGATGCCGAGCTTTCCTTGCTCAACCAGCAAAAGGAGCTGCTCAATACCATGGCCAGGATCTACAAGGCGCTGGGGGGCA
GTGATAACAGCTAA

Upstream 100 bases:

>100_bases
TGATGGCGTTTGGTTGCTCCTCGCTCATCGGGATCCTGTTTGGTTACCTGCCCGCCCGCAATGCCGCCCGGCTCGATCCG
GTCGAGGCGCTGGCGAGGGA

Downstream 100 bases:

>100_bases
CCCAACGCCTCGTTACGCCGCCACTCATGTCATGAGAGGCGGCGTTTTTCTTCCCTGTTCATGCCCCTTTCCTGACGGGC
TGCCACACAAAGCAATTGAT

Product: outer membrane efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTMHNLSKLALCLALAAGVSACSQQSTYHRQDLVLAPSWQQPDDGLTHQQAGLWWQGFHDPALDQLVEAVLAANPDMQVA
GLRLRSALLGADFADTNQAPSVSASLGANGTKNLKDGSASSSMGPSLTLSYEVDLWGRLASARDQASWEAQASAQDLAAT
RLMLIGKALEQYWQLAYLGSAITLGERQLANYTRAEQLTQAKYQAGAITRLDLVQASKQKANKQAELTSLLMQQEQARNG
LRLLLGRSSGPLEFAPTALTTSPVPSLAVGIPADVLARRPDVRAAELRLRKTLAKGDEIRTGFYPSLSLTGGASSTSDTL
TQVLQNPVGTLSASLALPFLEYNKTRISIASSELDYQIAETEFRKQLYTALVEVEDGLAARHHGEQRLNYLAEQLTFAKE
AEPLAQARFQAGATGVQPWLDEQNRLWDAELSLLNQQKELLNTMARIYKALGGSDNS

Sequences:

>Translated_457_residues
MTMHNLSKLALCLALAAGVSACSQQSTYHRQDLVLAPSWQQPDDGLTHQQAGLWWQGFHDPALDQLVEAVLAANPDMQVA
GLRLRSALLGADFADTNQAPSVSASLGANGTKNLKDGSASSSMGPSLTLSYEVDLWGRLASARDQASWEAQASAQDLAAT
RLMLIGKALEQYWQLAYLGSAITLGERQLANYTRAEQLTQAKYQAGAITRLDLVQASKQKANKQAELTSLLMQQEQARNG
LRLLLGRSSGPLEFAPTALTTSPVPSLAVGIPADVLARRPDVRAAELRLRKTLAKGDEIRTGFYPSLSLTGGASSTSDTL
TQVLQNPVGTLSASLALPFLEYNKTRISIASSELDYQIAETEFRKQLYTALVEVEDGLAARHHGEQRLNYLAEQLTFAKE
AEPLAQARFQAGATGVQPWLDEQNRLWDAELSLLNQQKELLNTMARIYKALGGSDNS
>Mature_456_residues
TMHNLSKLALCLALAAGVSACSQQSTYHRQDLVLAPSWQQPDDGLTHQQAGLWWQGFHDPALDQLVEAVLAANPDMQVAG
LRLRSALLGADFADTNQAPSVSASLGANGTKNLKDGSASSSMGPSLTLSYEVDLWGRLASARDQASWEAQASAQDLAATR
LMLIGKALEQYWQLAYLGSAITLGERQLANYTRAEQLTQAKYQAGAITRLDLVQASKQKANKQAELTSLLMQQEQARNGL
RLLLGRSSGPLEFAPTALTTSPVPSLAVGIPADVLARRPDVRAAELRLRKTLAKGDEIRTGFYPSLSLTGGASSTSDTLT
QVLQNPVGTLSASLALPFLEYNKTRISIASSELDYQIAETEFRKQLYTALVEVEDGLAARHHGEQRLNYLAEQLTFAKEA
EPLAQARFQAGATGVQPWLDEQNRLWDAELSLLNQQKELLNTMARIYKALGGSDNS

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Attached To The Outer Membrane By A Lipid Anchor [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=461, Percent_Identity=25.8134490238612, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI2367348, Length=339, Percent_Identity=26.8436578171091, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 49490; Mature: 49359

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMHNLSKLALCLALAAGVSACSQQSTYHRQDLVLAPSWQQPDDGLTHQQAGLWWQGFHD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHHCCCCCCCCCC
PALDQLVEAVLAANPDMQVAGLRLRSALLGADFADTNQAPSVSASLGANGTKNLKDGSAS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCC
SSMGPSLTLSYEVDLWGRLASARDQASWEAQASAQDLAATRLMLIGKALEQYWQLAYLGS
CCCCCCEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AITLGERQLANYTRAEQLTQAKYQAGAITRLDLVQASKQKANKQAELTSLLMQQEQARNG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LRLLLGRSSGPLEFAPTALTTSPVPSLAVGIPADVLARRPDVRAAELRLRKTLAKGDEIR
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCC
TGFYPSLSLTGGASSTSDTLTQVLQNPVGTLSASLALPFLEYNKTRISIASSELDYQIAE
CCCCCCEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHH
TEFRKQLYTALVEVEDGLAARHHGEQRLNYLAEQLTFAKEAEPLAQARFQAGATGVQPWL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCC
DEQNRLWDAELSLLNQQKELLNTMARIYKALGGSDNS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TMHNLSKLALCLALAAGVSACSQQSTYHRQDLVLAPSWQQPDDGLTHQQAGLWWQGFHD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHHCCCCCCCCCC
PALDQLVEAVLAANPDMQVAGLRLRSALLGADFADTNQAPSVSASLGANGTKNLKDGSAS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCC
SSMGPSLTLSYEVDLWGRLASARDQASWEAQASAQDLAATRLMLIGKALEQYWQLAYLGS
CCCCCCEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AITLGERQLANYTRAEQLTQAKYQAGAITRLDLVQASKQKANKQAELTSLLMQQEQARNG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LRLLLGRSSGPLEFAPTALTTSPVPSLAVGIPADVLARRPDVRAAELRLRKTLAKGDEIR
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCC
TGFYPSLSLTGGASSTSDTLTQVLQNPVGTLSASLALPFLEYNKTRISIASSELDYQIAE
CCCCCCEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHH
TEFRKQLYTALVEVEDGLAARHHGEQRLNYLAEQLTFAKEAEPLAQARFQAGATGVQPWL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCC
DEQNRLWDAELSLLNQQKELLNTMARIYKALGGSDNS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]