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The map label for this gene is bioA [H]

Identifier: 145299797

GI number: 145299797

Start: 3102879

End: 3104153

Strand: Direct

Name: bioA [H]

Synonym: ASA_2878

Alternate gene names: 145299797

Gene position: 3102879-3104153 (Clockwise)

Preceding gene: 145299791

Following gene: 145299798

Centisome position: 65.98

GC content: 61.57

Gene sequence:

>1275_bases
ATGACCAACCAAGAATTCGACCTGAATCACATCTGGCACCCCTATACCTCTCTCACCCATCCCCTGCCCTGCTATGAAGT
GGACAGCGCCAAAGGAGTCACCATCACTCTCGCCGATGGTCGCGAACTGGTGGATGGCATGAGCTCCTGGTGGGCCTGTA
TTCACGGCTATCAGGTGCCTGAACTCGACGCGGCCGCCACCGCCCAGCTCAGCAAGATGTCCCATGTCATGTTTGGCGGC
CTGACCCATGCCCCGGCGGTCGAGCTGTGCCGGAAGCTGGTGGAGATCACCCCGGCCGGTTTGGACCGGGTGTTTCTGGC
CGACTCGGGATCGGTGGCGGTGGAAGTGGCGCTCAAGATGGCCCAGCAGTACTGGCACGCCAAAGGCACCCCCAGAGCCA
AGTTCGTCACACTGCGCGGCGGCTATCACGGCGACACCTTCGGTGCCATGAGCGTTTGTGACCCGGATGGCGGCATGCAC
GAGCTCTACCAGGGCTTCCTGCCCGAGCACTACTTTGCCCCGGCCCCCAGCTGCCGTTTCCACGCCCAGTGGGACGAAGA
GTGTGTGGTGGATCTCGCCACGCTCGTCGCTGACCATCATGAAGAGATCGCAGCCATCATCCTCGAACCCATAGTGCAGG
GAGCGGGCGGCATGCGCTTCTACCACCCCCGCTATCTGCAATGGGTACGCGCTTTGTGCGACGAGTTCGGCCTGCTGCTG
ATTGCCGACGAGATTGCCACCGGGTTTGGTCGCACAGGCCAGCTGTTTGCCTGTGACTGGGCTGGCATCAGCCCCGACAT
CATGTGCCTTGGCAAGGCGCTCACCGGCGGTTACATGACCCTCTCAGCCACCCTCACCACTGAGCATGTCGCCCGCACGA
TTTGCGACGGGAAAGCGGGGGTCTTTATGCACGGACCCACCTTTATGGGCAATCCGCTGGCCTGCGCCGTGGCCTGTGCC
TCCATCGATCTGCTGCTGGCCTCGCCGTGGCAGGAGTGGGTGCAGGCCATCGAGCATCAGCTCAAAACCGAGCTGGTGCG
GCTAACCCTGAACCCTTTGGTTGCCGATGTGAGAGTACTTGGCGCCATCGGCGTGGTGGAGATGAAGGAGCGGGTAGATG
TGGCCCGTATCCAGCGCAAGTTTGTGGAGTTAGGTGCCTGGATCCGGCCATTTGGCAAACTCATCTACCTGATGCCCCCC
TTCGTCATCACACCGGCACAATTGAGTGTGCTGACCCAGGCCATCCATGAAGCCATCGCCAGCAGCGAGTTCTAA

Upstream 100 bases:

>100_bases
CGAGTGAGGAGCCAAGTGGCTGAAATTGTTGGCTAGTGTAGAGAGCGCGCGTAGACTGTCAACACCGACCAGATCAGACC
AATTGACAATAGAACACAAA

Downstream 100 bases:

>100_bases
GCCGGCATGAAAAGGCCCTGCATGAGAATGCAGGGCCTTTTGACTCTTTTTTATCAGAATGTGAGCAAGACACCAGACCC
GGGCGACCATGACGAGTAGA

Product: adenosylmethionine-8-amino-7- oxononanoatetransaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTNQEFDLNHIWHPYTSLTHPLPCYEVDSAKGVTITLADGRELVDGMSSWWACIHGYQVPELDAAATAQLSKMSHVMFGG
LTHAPAVELCRKLVEITPAGLDRVFLADSGSVAVEVALKMAQQYWHAKGTPRAKFVTLRGGYHGDTFGAMSVCDPDGGMH
ELYQGFLPEHYFAPAPSCRFHAQWDEECVVDLATLVADHHEEIAAIILEPIVQGAGGMRFYHPRYLQWVRALCDEFGLLL
IADEIATGFGRTGQLFACDWAGISPDIMCLGKALTGGYMTLSATLTTEHVARTICDGKAGVFMHGPTFMGNPLACAVACA
SIDLLLASPWQEWVQAIEHQLKTELVRLTLNPLVADVRVLGAIGVVEMKERVDVARIQRKFVELGAWIRPFGKLIYLMPP
FVITPAQLSVLTQAIHEAIASSEF

Sequences:

>Translated_424_residues
MTNQEFDLNHIWHPYTSLTHPLPCYEVDSAKGVTITLADGRELVDGMSSWWACIHGYQVPELDAAATAQLSKMSHVMFGG
LTHAPAVELCRKLVEITPAGLDRVFLADSGSVAVEVALKMAQQYWHAKGTPRAKFVTLRGGYHGDTFGAMSVCDPDGGMH
ELYQGFLPEHYFAPAPSCRFHAQWDEECVVDLATLVADHHEEIAAIILEPIVQGAGGMRFYHPRYLQWVRALCDEFGLLL
IADEIATGFGRTGQLFACDWAGISPDIMCLGKALTGGYMTLSATLTTEHVARTICDGKAGVFMHGPTFMGNPLACAVACA
SIDLLLASPWQEWVQAIEHQLKTELVRLTLNPLVADVRVLGAIGVVEMKERVDVARIQRKFVELGAWIRPFGKLIYLMPP
FVITPAQLSVLTQAIHEAIASSEF
>Mature_423_residues
TNQEFDLNHIWHPYTSLTHPLPCYEVDSAKGVTITLADGRELVDGMSSWWACIHGYQVPELDAAATAQLSKMSHVMFGGL
THAPAVELCRKLVEITPAGLDRVFLADSGSVAVEVALKMAQQYWHAKGTPRAKFVTLRGGYHGDTFGAMSVCDPDGGMHE
LYQGFLPEHYFAPAPSCRFHAQWDEECVVDLATLVADHHEEIAAIILEPIVQGAGGMRFYHPRYLQWVRALCDEFGLLLI
ADEIATGFGRTGQLFACDWAGISPDIMCLGKALTGGYMTLSATLTTEHVARTICDGKAGVFMHGPTFMGNPLACAVACAS
IDLLLASPWQEWVQAIEHQLKTELVRLTLNPLVADVRVLGAIGVVEMKERVDVARIQRKFVELGAWIRPFGKLIYLMPPF
VITPAQLSVLTQAIHEAIASSEF

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=412, Percent_Identity=31.5533980582524, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI284507298, Length=322, Percent_Identity=33.5403726708075, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI13994255, Length=426, Percent_Identity=26.9953051643192, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI226442709, Length=379, Percent_Identity=24.802110817942, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI226442705, Length=379, Percent_Identity=24.802110817942, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI37574042, Length=379, Percent_Identity=24.802110817942, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI24119277, Length=375, Percent_Identity=24.5333333333333, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1786991, Length=419, Percent_Identity=65.1551312649165, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI145693181, Length=396, Percent_Identity=32.5757575757576, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789016, Length=414, Percent_Identity=29.951690821256, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789759, Length=343, Percent_Identity=33.2361516034985, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1788044, Length=327, Percent_Identity=35.1681957186544, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787560, Length=409, Percent_Identity=28.8508557457213, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786349, Length=335, Percent_Identity=28.3582089552239, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=396, Percent_Identity=28.030303030303, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI25144274, Length=209, Percent_Identity=33.9712918660287, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17541228, Length=294, Percent_Identity=26.530612244898, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324386, Length=456, Percent_Identity=48.4649122807018, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6323470, Length=420, Percent_Identity=30, Blast_Score=132, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=398, Percent_Identity=26.8844221105528, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321456, Length=320, Percent_Identity=24.6875, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357415, Length=409, Percent_Identity=31.5403422982885, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI21356575, Length=392, Percent_Identity=26.530612244898, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574759, Length=432, Percent_Identity=26.1574074074074, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI161085790, Length=361, Percent_Identity=26.8698060941828, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI281366494, Length=291, Percent_Identity=24.3986254295533, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24667139, Length=291, Percent_Identity=24.3986254295533, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24667143, Length=291, Percent_Identity=24.3986254295533, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 46505; Mature: 46374

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQEFDLNHIWHPYTSLTHPLPCYEVDSAKGVTITLADGRELVDGMSSWWACIHGYQVP
CCCCCCCCCCCCCCHHHCCCCCCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCC
ELDAAATAQLSKMSHVMFGGLTHAPAVELCRKLVEITPAGLDRVFLADSGSVAVEVALKM
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHH
AQQYWHAKGTPRAKFVTLRGGYHGDTFGAMSVCDPDGGMHELYQGFLPEHYFAPAPSCRF
HHHHHCCCCCCCEEEEEEECCCCCCCCCCCEEECCCCCHHHHHHHCCCCCCCCCCCCCEE
HAQWDEECVVDLATLVADHHEEIAAIILEPIVQGAGGMRFYHPRYLQWVRALCDEFGLLL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHCCEEE
IADEIATGFGRTGQLFACDWAGISPDIMCLGKALTGGYMTLSATLTTEHVARTICDGKAG
EEHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEEEEHHHHHHHHHHHCCCCC
VFMHGPTFMGNPLACAVACASIDLLLASPWQEWVQAIEHQLKTELVRLTLNPLVADVRVL
EEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAIGVVEMKERVDVARIQRKFVELGAWIRPFGKLIYLMPPFVITPAQLSVLTQAIHEAIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEECHHHHHHHHHHHHHHHH
SSEF
CCCC
>Mature Secondary Structure 
TNQEFDLNHIWHPYTSLTHPLPCYEVDSAKGVTITLADGRELVDGMSSWWACIHGYQVP
CCCCCCCCCCCCCHHHCCCCCCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCC
ELDAAATAQLSKMSHVMFGGLTHAPAVELCRKLVEITPAGLDRVFLADSGSVAVEVALKM
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHH
AQQYWHAKGTPRAKFVTLRGGYHGDTFGAMSVCDPDGGMHELYQGFLPEHYFAPAPSCRF
HHHHHCCCCCCCEEEEEEECCCCCCCCCCCEEECCCCCHHHHHHHCCCCCCCCCCCCCEE
HAQWDEECVVDLATLVADHHEEIAAIILEPIVQGAGGMRFYHPRYLQWVRALCDEFGLLL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHCCEEE
IADEIATGFGRTGQLFACDWAGISPDIMCLGKALTGGYMTLSATLTTEHVARTICDGKAG
EEHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEEEEHHHHHHHHHHHCCCCC
VFMHGPTFMGNPLACAVACASIDLLLASPWQEWVQAIEHQLKTELVRLTLNPLVADVRVL
EEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAIGVVEMKERVDVARIQRKFVELGAWIRPFGKLIYLMPPFVITPAQLSVLTQAIHEAIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEECHHHHHHHHHHHHHHHH
SSEF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 2971595 [H]