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The map label for this gene is fur [H]

Identifier: 145299747

GI number: 145299747

Start: 3024671

End: 3025099

Strand: Direct

Name: fur [H]

Synonym: ASA_2824

Alternate gene names: 145299747

Gene position: 3024671-3025099 (Clockwise)

Preceding gene: 145299745

Following gene: 145299751

Centisome position: 64.32

GC content: 54.08

Gene sequence:

>429_bases
ATGGCAGACAACAACCAAGCGTTAAAAAAGGCCGGGCTCAAGATCACCTTGCCCCGCGTCAAAATTCTGGAAATCCTGCA
ACAGCCGGATTGCCAGCACACCAGTGCGGAAGATCTGTACAAACGACTGATCGACCAGGGTGAAGAGATTGGTCTCGCTA
CCGTATATCGCGTTCTCAACCAGTTTGATGATGCCGGTATTGTTACCCGTCACCACTTCGAAGGTGGCAAGTCGGTATTC
GAGCTGGCCACCCAGGAACACCACGACCACCTGGTCTGCCTCGATTGTGGCAAGGTGATCGAGTTTTCCGACGAAGTGAT
CGAGCAGCGCCAGCGCGATATCGCCAAGCATCACAATATTCGCCTGACCAATCACAGCCTCTATCTGTATGGCCACTGCG
CCAACGGCGACTGCAAGCACGACGACTGA

Upstream 100 bases:

>100_bases
GGCTACGACCTATAATGACAGGCCAAGCGAGTTCGTGGTTGCCATTCCAGCGGCAGTCAATCAGAATAACCACACCTTCG
AGAATGCGAATAAGTAGAAT

Downstream 100 bases:

>100_bases
TGGCGTCTTGCACCGGTCAATAAAAAAGCCAGCATAGCGCTGGCTTTTTTTGTGTCCGTAATCCGGGCAAGAAGTGGCAG
GGTCTCCCCTGCCCTCTGCC

Product: ferric uptake regulator

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MADNNQALKKAGLKITLPRVKILEILQQPDCQHTSAEDLYKRLIDQGEEIGLATVYRVLNQFDDAGIVTRHHFEGGKSVF
ELATQEHHDHLVCLDCGKVIEFSDEVIEQRQRDIAKHHNIRLTNHSLYLYGHCANGDCKHDD

Sequences:

>Translated_142_residues
MADNNQALKKAGLKITLPRVKILEILQQPDCQHTSAEDLYKRLIDQGEEIGLATVYRVLNQFDDAGIVTRHHFEGGKSVF
ELATQEHHDHLVCLDCGKVIEFSDEVIEQRQRDIAKHHNIRLTNHSLYLYGHCANGDCKHDD
>Mature_141_residues
ADNNQALKKAGLKITLPRVKILEILQQPDCQHTSAEDLYKRLIDQGEEIGLATVYRVLNQFDDAGIVTRHHFEGGKSVFE
LATQEHHDHLVCLDCGKVIEFSDEVIEQRQRDIAKHHNIRLTNHSLYLYGHCANGDCKHDD

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=142, Percent_Identity=81.6901408450704, Blast_Score=244, Evalue=1e-66,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 16211; Mature: 16080

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNNQALKKAGLKITLPRVKILEILQQPDCQHTSAEDLYKRLIDQGEEIGLATVYRVLN
CCCCHHHHHHCCCEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
QFDDAGIVTRHHFEGGKSVFELATQEHHDHLVCLDCGKVIEFSDEVIEQRQRDIAKHHNI
HCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCE
RLTNHSLYLYGHCANGDCKHDD
EEECCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
ADNNQALKKAGLKITLPRVKILEILQQPDCQHTSAEDLYKRLIDQGEEIGLATVYRVLN
CCCHHHHHHCCCEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
QFDDAGIVTRHHFEGGKSVFELATQEHHDHLVCLDCGKVIEFSDEVIEQRQRDIAKHHNI
HCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCE
RLTNHSLYLYGHCANGDCKHDD
EEECCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9055816 [H]