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The map label for this gene is iclR [H]

Identifier: 145297061

GI number: 145297061

Start: 3281189

End: 3281956

Strand: Reverse

Name: iclR [H]

Synonym: cgR_2957

Alternate gene names: 145297061

Gene position: 3281956-3281189 (Counterclockwise)

Preceding gene: 145297062

Following gene: 145297060

Centisome position: 99.03

GC content: 51.95

Gene sequence:

>768_bases
ATGACTTCCCCAGACTCAGATGTGGCTGCGCCTGTAGAGTCAGTAGACCGCGCGCTACGCCTGCTGCTCTATTTACGTGA
CCATGATTCCATATCGGTAAAAGAAGCAGCCGAGTATCTAGATATTGCAGCGTCAACAGCTCACCGATTGCTTACTACCC
TGGCCAGGCGAGGTTTTGCCGTACAGGACTTCTCACGCCGATACCGCTTGGGTGGCATCATCATGGGACCACAGCAACCA
AAGATCAGCCATGATGTGTTAAGAGCTGCCGCAATGGATCCCATGACGCAGCTCAATGCTTCAGTTCGAGAAACTGTGCA
GGTCATGGCTTTGAGCGGTGGAAATATTCGATTCCTCGATGGAGTGGAATCAGATGCCATCTTAAGGGTTTCGCGCCGGG
TTGGTGATGAAATGCCCGCCTTCGTTTCCTCTGGCGGCAAGGTGATTCTTGGCAGGTTATCCAACCAAGAAGTAGAAGAG
ATCTACAGGCGAGGTCTTATTGAATGGCCGACGCGCAAAGTGACATCGTTGAAAATGTTAAAACGCATGCTGACGCAAGT
TCGCCGCGATGGCTACGCGGTGAGCATGGAGGAAACCGAGCAGGGTGTGGTCGGCGTTGGTGTGGTGATTCTAGGCAGTG
ATGCGCGGCCAGTGGGGGCTATGACTCTTGCGATTCCAGTTTCACGCTATGACAAGAATCGGTTACCGGAGTATGTCGAG
GGTTTGAGAAAAGCAACAGCGCAAGTGGAAGAAATTCTCTTCACTTAA

Upstream 100 bases:

>100_bases
AGTGGCTTGCAGATTTTGACGAGCTGCCCATTAAAGATGAGGTACGTCCAAAAATTTTCAAAGACAACGCTTTGCGTGCA
CTAGGTGTTAAGCAGTAGCG

Downstream 100 bases:

>100_bases
GACCAATGGGGCAGATTCCTAATTAAGGAATCTGCCCCCAAATTATTTTGTTTGCGCAGGTGGTAGGCCTGGATATTGGG
GTGGGGGCGGGTAAATGGGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MTSPDSDVAAPVESVDRALRLLLYLRDHDSISVKEAAEYLDIAASTAHRLLTTLARRGFAVQDFSRRYRLGGIIMGPQQP
KISHDVLRAAAMDPMTQLNASVRETVQVMALSGGNIRFLDGVESDAILRVSRRVGDEMPAFVSSGGKVILGRLSNQEVEE
IYRRGLIEWPTRKVTSLKMLKRMLTQVRRDGYAVSMEETEQGVVGVGVVILGSDARPVGAMTLAIPVSRYDKNRLPEYVE
GLRKATAQVEEILFT

Sequences:

>Translated_255_residues
MTSPDSDVAAPVESVDRALRLLLYLRDHDSISVKEAAEYLDIAASTAHRLLTTLARRGFAVQDFSRRYRLGGIIMGPQQP
KISHDVLRAAAMDPMTQLNASVRETVQVMALSGGNIRFLDGVESDAILRVSRRVGDEMPAFVSSGGKVILGRLSNQEVEE
IYRRGLIEWPTRKVTSLKMLKRMLTQVRRDGYAVSMEETEQGVVGVGVVILGSDARPVGAMTLAIPVSRYDKNRLPEYVE
GLRKATAQVEEILFT
>Mature_254_residues
TSPDSDVAAPVESVDRALRLLLYLRDHDSISVKEAAEYLDIAASTAHRLLTTLARRGFAVQDFSRRYRLGGIIMGPQQPK
ISHDVLRAAAMDPMTQLNASVRETVQVMALSGGNIRFLDGVESDAILRVSRRVGDEMPAFVSSGGKVILGRLSNQEVEEI
YRRGLIEWPTRKVTSLKMLKRMLTQVRRDGYAVSMEETEQGVVGVGVVILGSDARPVGAMTLAIPVSRYDKNRLPEYVEG
LRKATAQVEEILFT

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=247, Percent_Identity=28.3400809716599, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788131, Length=257, Percent_Identity=28.0155642023346, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1786468, Length=239, Percent_Identity=27.1966527196653, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786715, Length=226, Percent_Identity=25.6637168141593, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28172; Mature: 28041

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPDSDVAAPVESVDRALRLLLYLRDHDSISVKEAAEYLDIAASTAHRLLTTLARRGFA
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VQDFSRRYRLGGIIMGPQQPKISHDVLRAAAMDPMTQLNASVRETVQVMALSGGNIRFLD
HHHHHHHHHHCCEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHEECCCCEEEEC
GVESDAILRVSRRVGDEMPAFVSSGGKVILGRLSNQEVEEIYRRGLIEWPTRKVTSLKML
CCCCHHHHHHHHHHCCCCCHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHH
KRMLTQVRRDGYAVSMEETEQGVVGVGVVILGSDARPVGAMTLAIPVSRYDKNRLPEYVE
HHHHHHHHHCCEEEEHHHHCCCEEEEEEEEECCCCCCCCEEEEEEEHHHHCCCCCHHHHH
GLRKATAQVEEILFT
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSPDSDVAAPVESVDRALRLLLYLRDHDSISVKEAAEYLDIAASTAHRLLTTLARRGFA
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VQDFSRRYRLGGIIMGPQQPKISHDVLRAAAMDPMTQLNASVRETVQVMALSGGNIRFLD
HHHHHHHHHHCCEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHEECCCCEEEEC
GVESDAILRVSRRVGDEMPAFVSSGGKVILGRLSNQEVEEIYRRGLIEWPTRKVTSLKML
CCCCHHHHHHHHHHCCCCCHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHH
KRMLTQVRRDGYAVSMEETEQGVVGVGVVILGSDARPVGAMTLAIPVSRYDKNRLPEYVE
HHHHHHHHHCCEEEEHHHHCCCEEEEEEEEECCCCCCCCEEEEEEEHHHHCCCCCHHHHH
GLRKATAQVEEILFT
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]