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The map label for this gene is rnc [H]

Identifier: 145296037

GI number: 145296037

Start: 2154844

End: 2155587

Strand: Reverse

Name: rnc [H]

Synonym: cgR_1959

Alternate gene names: 145296037

Gene position: 2155587-2154844 (Counterclockwise)

Preceding gene: 145296038

Following gene: 145296036

Centisome position: 65.04

GC content: 56.45

Gene sequence:

>744_bases
GTGAGCAGGAAAAAGAATCGCCTCACCGGGGTAGATGCACTCAATGAAGCATTCGATGCAGTAGATCATCAGCCGCTGCT
TGACCACCTTGGTGTGGACATCCAGCGCGATCTGTTGGTGCTTGCGTTGACTCACCGCTCTTTCGCCAACGAAAACGGCA
TGCTGCCCAATAATGAGCGCTTGGAGTTCCTCGGCGACGCCGTCTTGGGTCTCTCCGTGGCCAACAAGCTCTATGAGCAG
TACCCCAGCAGTCCTGAATCTGATGTCTCCAAGATGCGCGCTTCAATTGTCAGCCGTTACGGCCTGGCAGATATCGCTCG
CGAAATTGATCTTGGCAACCACATTTTGCTGGGCAAAGGCGAATTGCTCACCGAAGGTCGCAGTAAGGATTCCATTCTTG
CGGACACCACAGAGGCGTTGTTGGGCGCGATTTTCCGCCAGCACGGTTTTGAAACCGCCCGCGACGTAATTTTGCGCCTG
TTTGCCTACAAGATCGATAACGCATCGGCCAGGGGCATTCACCAGGACTGGAAGACCACGCTGCAGGAGGAACTTGCCCA
GCGCAAGCGCCCCATGGCTGAATATTCCGCCACCTCAGTCGGTCCGGATCACGATCTAGTGTTCACCGCCATCGTGACGT
TGGAAGGTGAAGAAATGGGTCGGGGAGAAGGCCCGAACAAGAAGCTGGCCGAGCAGGAAGCAGCGCGCCAGGCATTCCGA
AAGCTTCGGGAGTCCCGTGCCTGA

Upstream 100 bases:

>100_bases
CATGCCAGGATGATGAAACGCCAGCTCCTGATGGTGTCTCTGAAGAAGTAGAAGACGAGGAAAAGGTCGATCCTCGCTGG
GCTGGTTTGGAGAAGTTCCT

Downstream 100 bases:

>100_bases
ACTGCCTGAAGTTGAGGTGGTGCGCCGCGGTTTAGAAGATCATATGGTCGGCCACACCATCGTGTCCGCCACAGTGCTCC
ACCCGCGCGCAGCCCGCAAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MSRKKNRLTGVDALNEAFDAVDHQPLLDHLGVDIQRDLLVLALTHRSFANENGMLPNNERLEFLGDAVLGLSVANKLYEQ
YPSSPESDVSKMRASIVSRYGLADIAREIDLGNHILLGKGELLTEGRSKDSILADTTEALLGAIFRQHGFETARDVILRL
FAYKIDNASARGIHQDWKTTLQEELAQRKRPMAEYSATSVGPDHDLVFTAIVTLEGEEMGRGEGPNKKLAEQEAARQAFR
KLRESRA

Sequences:

>Translated_247_residues
MSRKKNRLTGVDALNEAFDAVDHQPLLDHLGVDIQRDLLVLALTHRSFANENGMLPNNERLEFLGDAVLGLSVANKLYEQ
YPSSPESDVSKMRASIVSRYGLADIAREIDLGNHILLGKGELLTEGRSKDSILADTTEALLGAIFRQHGFETARDVILRL
FAYKIDNASARGIHQDWKTTLQEELAQRKRPMAEYSATSVGPDHDLVFTAIVTLEGEEMGRGEGPNKKLAEQEAARQAFR
KLRESRA
>Mature_246_residues
SRKKNRLTGVDALNEAFDAVDHQPLLDHLGVDIQRDLLVLALTHRSFANENGMLPNNERLEFLGDAVLGLSVANKLYEQY
PSSPESDVSKMRASIVSRYGLADIAREIDLGNHILLGKGELLTEGRSKDSILADTTEALLGAIFRQHGFETARDVILRLF
AYKIDNASARGIHQDWKTTLQEELAQRKRPMAEYSATSVGPDHDLVFTAIVTLEGEEMGRGEGPNKKLAEQEAARQAFRK
LRESRA

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=214, Percent_Identity=28.0373831775701, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI155030236, Length=214, Percent_Identity=28.0373831775701, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI1788920, Length=183, Percent_Identity=41.5300546448087, Blast_Score=131, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17506883, Length=213, Percent_Identity=30.5164319248826, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193202651, Length=213, Percent_Identity=30.5164319248826, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137682, Length=237, Percent_Identity=27.0042194092827, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27466; Mature: 27335

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKKNRLTGVDALNEAFDAVDHQPLLDHLGVDIQRDLLVLALTHRSFANENGMLPNNER
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCH
LEFLGDAVLGLSVANKLYEQYPSSPESDVSKMRASIVSRYGLADIAREIDLGNHILLGKG
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
ELLTEGRSKDSILADTTEALLGAIFRQHGFETARDVILRLFAYKIDNASARGIHQDWKTT
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LQEELAQRKRPMAEYSATSVGPDHDLVFTAIVTLEGEEMGRGEGPNKKLAEQEAARQAFR
HHHHHHHHHCCHHHHHCCCCCCCCCEEEHHHEEECCHHHCCCCCCCHHHHHHHHHHHHHH
KLRESRA
HHHHCCC
>Mature Secondary Structure 
SRKKNRLTGVDALNEAFDAVDHQPLLDHLGVDIQRDLLVLALTHRSFANENGMLPNNER
CCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCH
LEFLGDAVLGLSVANKLYEQYPSSPESDVSKMRASIVSRYGLADIAREIDLGNHILLGKG
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
ELLTEGRSKDSILADTTEALLGAIFRQHGFETARDVILRLFAYKIDNASARGIHQDWKTT
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LQEELAQRKRPMAEYSATSVGPDHDLVFTAIVTLEGEEMGRGEGPNKKLAEQEAARQAFR
HHHHHHHHHCCHHHHHCCCCCCCCCEEEHHHEEECCHHHCCCCCCCHHHHHHHHHHHHHH
KLRESRA
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]