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The map label for this gene is mrdA [H]

Identifier: 145295912

GI number: 145295912

Start: 2040304

End: 2042172

Strand: Reverse

Name: mrdA [H]

Synonym: cgR_1837

Alternate gene names: 145295912

Gene position: 2042172-2040304 (Counterclockwise)

Preceding gene: 145295913

Following gene: 145295911

Centisome position: 61.62

GC content: 54.52

Gene sequence:

>1869_bases
ATGAACAAGGTGCAGCGCAGGTCACTGATGGCGTTGTGCATGACGGTGGCATTTGCTGGAGGAAGCCTGACCGCGTGCAC
ACCTCGTCCTGATACCGCAGACCCCATCGCAGAGGAATTCCTTCAAGCTTGGGCATCGCAAGATTTCGACACTATTGCGG
ACATCACCGACCAAGCTGACCTTGCCACAGAAATGCTTAGCACCAGTTTCGATGGTCTGCAAGCAGACAGCGTTGAACTG
ACTTTGGATTCCGTGGATTCCCGGGACACCATCGCCACCGCCAATTTCTCCGTGGTGTGGAAGCTTCCCCGAGACAGAGA
AGTTTCCTATGACTCATCGATGACGCTGACCAAGATGCGCAACGAATGGACAGTGCGTTGGGAACCTTCCCTCGTGCACC
CCAAACTGGGCGCCAACCAGCACCTGGAATTGCGCGCCATTGAAGCGCAGCGAGCCAACGTAATTTCCTCCGATGGAGCT
CCGGTTCTCGCGCCGGGAAGTATCTACCGAGTTTTGGCTGACCCCAGCGCAGGGGATGCCGATGTGGTGGTCAAGAGGGT
GGCAGATTATTTGAATGAAGCCCATGCGACTGATGAGAATGTGAACACTCTTGATGTCGAAGACATTATGAGCAATCTTG
GCGATTCCACCTATTCACTCACCACAGTTGATGCCAATTTGGGTGCCCGCATGGAACAGGATCTAGCGGGGATTCCGGGG
CTGACGTTCAATGAGGAAGCATCCATGGTAGCCACCGACCCAGGTTTTGCTCCGGATATTGTGTCTCGCGTTGCGCGCAT
TGTGGAAGATGAATTAGAAGGATCCAATGGTTGGCGCGCCTCCATTGTCACTTCCAATGGTGCGGTGATTGATGATATCG
CCTACGACGCCCCAGAGCTTGCCCCCAGCGTGAGGATCAGCCTGGATCACAACGTCCAACGAGCAGCGGAAGAAGCCGTA
GACCTGCGTGCTGAGATGAAAGCCATGATGGTGGTCATGAGGCCATCCACTGGTGAAATCCTCGCAGTGGCCCAAACAGA
TGAAGCTGACAAAGACGGCGATGTTGCGCTGATGGGACAATACCCACCGGGATCGACATTCAAGATCATCACTGCAGCCG
CGGGGTTGGCGCATGAAGGATTAACTCCAGACAGCATTGTGCCATGCCCTGGCACCATGAATATCTACGGCCGAATTGTC
ACCAACTACAACAGCTTCTCTTTGGGCAACACCTCATTGGATGATGCCTTTGCCAATTCATGCAACACCACTTTTGCAGA
TATTTCCACCAATTTGGAGCCAGGCCAACTGAAAAATGTGGCCAAGCAATTTGGCCTCGGAATTGATTATCAAATCCCAG
GCCTTGACACCATGACGGGATCGGTGCCTGCAGGTGACATCGTGTTGGACCGTACCGAATCTGGTTACGGCCAGGGTCTT
GACCTAGCAAGTCCCTTTGGCATGGCGTTGGTCGCCTCCACTGCAGCCACCGGTTCAGTTCCCACGCCAACGCTGATTTC
TGGACATGAAACTGTTGCCAGTGAAGAAGTTCCGGCGCTTGATCCAGAAGTCCTTGCCAATGTGCAGCGGATGATGAAAT
CCGTGGTCAATGACGGTACCGCTCGTGGCATGCGCCAAACCGGTGGCCAGATCTACGCAAAGACAGGTGAGGCCGAAATC
AACGAAGGCTCCCATGCGTGGTTCACCGGCTACCGCGAAGATGACATCGCTTTTGCCACCCTCGTGGTGTTGGGCGGAGG
CTCCGAAGCGGCTGCTGCTGTGACAGATCAGTTCTTTGTGAAACTCGATGAGCTTCGCGCAGGGGGAGAAGTTGCAGTCA
GTGAAGCTGAAGAGCAGCCAGTCGGCTAA

Upstream 100 bases:

>100_bases
TAGAACAGCTGCGGTAGCTGAAGCCAGACAGCGCGGAATTATCTAGACGCACACGTGTTGGTAACCGATCACACCAGCGC
ACGCTGCTAATCTTCACTCC

Downstream 100 bases:

>100_bases
AAAATAGCCTCCATCCAACCCGCTTTACCTGTCATCGCTTCAGGCGACTAGCATGGTGTCCATGTCTAAAATGCGCGCAC
CACTTGTACCCGGAATTCCT

Product: hypothetical protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MNKVQRRSLMALCMTVAFAGGSLTACTPRPDTADPIAEEFLQAWASQDFDTIADITDQADLATEMLSTSFDGLQADSVEL
TLDSVDSRDTIATANFSVVWKLPRDREVSYDSSMTLTKMRNEWTVRWEPSLVHPKLGANQHLELRAIEAQRANVISSDGA
PVLAPGSIYRVLADPSAGDADVVVKRVADYLNEAHATDENVNTLDVEDIMSNLGDSTYSLTTVDANLGARMEQDLAGIPG
LTFNEEASMVATDPGFAPDIVSRVARIVEDELEGSNGWRASIVTSNGAVIDDIAYDAPELAPSVRISLDHNVQRAAEEAV
DLRAEMKAMMVVMRPSTGEILAVAQTDEADKDGDVALMGQYPPGSTFKIITAAAGLAHEGLTPDSIVPCPGTMNIYGRIV
TNYNSFSLGNTSLDDAFANSCNTTFADISTNLEPGQLKNVAKQFGLGIDYQIPGLDTMTGSVPAGDIVLDRTESGYGQGL
DLASPFGMALVASTAATGSVPTPTLISGHETVASEEVPALDPEVLANVQRMMKSVVNDGTARGMRQTGGQIYAKTGEAEI
NEGSHAWFTGYREDDIAFATLVVLGGGSEAAAAVTDQFFVKLDELRAGGEVAVSEAEEQPVG

Sequences:

>Translated_622_residues
MNKVQRRSLMALCMTVAFAGGSLTACTPRPDTADPIAEEFLQAWASQDFDTIADITDQADLATEMLSTSFDGLQADSVEL
TLDSVDSRDTIATANFSVVWKLPRDREVSYDSSMTLTKMRNEWTVRWEPSLVHPKLGANQHLELRAIEAQRANVISSDGA
PVLAPGSIYRVLADPSAGDADVVVKRVADYLNEAHATDENVNTLDVEDIMSNLGDSTYSLTTVDANLGARMEQDLAGIPG
LTFNEEASMVATDPGFAPDIVSRVARIVEDELEGSNGWRASIVTSNGAVIDDIAYDAPELAPSVRISLDHNVQRAAEEAV
DLRAEMKAMMVVMRPSTGEILAVAQTDEADKDGDVALMGQYPPGSTFKIITAAAGLAHEGLTPDSIVPCPGTMNIYGRIV
TNYNSFSLGNTSLDDAFANSCNTTFADISTNLEPGQLKNVAKQFGLGIDYQIPGLDTMTGSVPAGDIVLDRTESGYGQGL
DLASPFGMALVASTAATGSVPTPTLISGHETVASEEVPALDPEVLANVQRMMKSVVNDGTARGMRQTGGQIYAKTGEAEI
NEGSHAWFTGYREDDIAFATLVVLGGGSEAAAAVTDQFFVKLDELRAGGEVAVSEAEEQPVG
>Mature_622_residues
MNKVQRRSLMALCMTVAFAGGSLTACTPRPDTADPIAEEFLQAWASQDFDTIADITDQADLATEMLSTSFDGLQADSVEL
TLDSVDSRDTIATANFSVVWKLPRDREVSYDSSMTLTKMRNEWTVRWEPSLVHPKLGANQHLELRAIEAQRANVISSDGA
PVLAPGSIYRVLADPSAGDADVVVKRVADYLNEAHATDENVNTLDVEDIMSNLGDSTYSLTTVDANLGARMEQDLAGIPG
LTFNEEASMVATDPGFAPDIVSRVARIVEDELEGSNGWRASIVTSNGAVIDDIAYDAPELAPSVRISLDHNVQRAAEEAV
DLRAEMKAMMVVMRPSTGEILAVAQTDEADKDGDVALMGQYPPGSTFKIITAAAGLAHEGLTPDSIVPCPGTMNIYGRIV
TNYNSFSLGNTSLDDAFANSCNTTFADISTNLEPGQLKNVAKQFGLGIDYQIPGLDTMTGSVPAGDIVLDRTESGYGQGL
DLASPFGMALVASTAATGSVPTPTLISGHETVASEEVPALDPEVLANVQRMMKSVVNDGTARGMRQTGGQIYAKTGEAEI
NEGSHAWFTGYREDDIAFATLVVLGGGSEAAAAVTDQFFVKLDELRAGGEVAVSEAEEQPVG

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 65993; Mature: 65993

Theoretical pI: Translated: 4.00; Mature: 4.00

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVQRRSLMALCMTVAFAGGSLTACTPRPDTADPIAEEFLQAWASQDFDTIADITDQAD
CCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCHHH
LATEMLSTSFDGLQADSVELTLDSVDSRDTIATANFSVVWKLPRDREVSYDSSMTLTKMR
HHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEECCEEEEEECCCCCCCCCCCCEEEEECC
NEWTVRWEPSLVHPKLGANQHLELRAIEAQRANVISSDGAPVLAPGSIYRVLADPSAGDA
CCEEEEECCCCCCCCCCCCCCEEEEEECHHHCCEECCCCCCEEECCCEEEEEECCCCCCH
DVVVKRVADYLNEAHATDENVNTLDVEDIMSNLGDSTYSLTTVDANLGARMEQDLAGIPG
HHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHCCCCCEEEEEEECCCCCHHHHHHCCCCC
LTFNEEASMVATDPGFAPDIVSRVARIVEDELEGSNGWRASIVTSNGAVIDDIAYDAPEL
CEECCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEHHCCCCCCC
APSVRISLDHNVQRAAEEAVDLRAEMKAMMVVMRPSTGEILAVAQTDEADKDGDVALMGQ
CCCEEEEECCCHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEEEECCCCCCCCCEEEEEC
YPPGSTFKIITAAAGLAHEGLTPDSIVPCPGTMNIYGRIVTNYNSFSLGNTSLDDAFANS
CCCCCCEEEEEEHHHHHHCCCCCCCEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHCC
CNTTFADISTNLEPGQLKNVAKQFGLGIDYQIPGLDTMTGSVPAGDIVLDRTESGYGQGL
CCCEEEEEECCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCCCC
DLASPFGMALVASTAATGSVPTPTLISGHETVASEEVPALDPEVLANVQRMMKSVVNDGT
CCCCCCCHHHHHHHCCCCCCCCCCEECCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHH
ARGMRQTGGQIYAKTGEAEINEGSHAWFTGYREDDIAFATLVVLGGGSEAAAAVTDQFFV
HHHHHHCCCEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHH
KLDELRAGGEVAVSEAEEQPVG
HHHHHCCCCCEEECCCCCCCCC
>Mature Secondary Structure
MNKVQRRSLMALCMTVAFAGGSLTACTPRPDTADPIAEEFLQAWASQDFDTIADITDQAD
CCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCHHH
LATEMLSTSFDGLQADSVELTLDSVDSRDTIATANFSVVWKLPRDREVSYDSSMTLTKMR
HHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEECCEEEEEECCCCCCCCCCCCEEEEECC
NEWTVRWEPSLVHPKLGANQHLELRAIEAQRANVISSDGAPVLAPGSIYRVLADPSAGDA
CCEEEEECCCCCCCCCCCCCCEEEEEECHHHCCEECCCCCCEEECCCEEEEEECCCCCCH
DVVVKRVADYLNEAHATDENVNTLDVEDIMSNLGDSTYSLTTVDANLGARMEQDLAGIPG
HHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHCCCCCEEEEEEECCCCCHHHHHHCCCCC
LTFNEEASMVATDPGFAPDIVSRVARIVEDELEGSNGWRASIVTSNGAVIDDIAYDAPEL
CEECCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEHHCCCCCCC
APSVRISLDHNVQRAAEEAVDLRAEMKAMMVVMRPSTGEILAVAQTDEADKDGDVALMGQ
CCCEEEEECCCHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEEEECCCCCCCCCEEEEEC
YPPGSTFKIITAAAGLAHEGLTPDSIVPCPGTMNIYGRIVTNYNSFSLGNTSLDDAFANS
CCCCCCEEEEEEHHHHHHCCCCCCCEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHCC
CNTTFADISTNLEPGQLKNVAKQFGLGIDYQIPGLDTMTGSVPAGDIVLDRTESGYGQGL
CCCEEEEEECCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCCCC
DLASPFGMALVASTAATGSVPTPTLISGHETVASEEVPALDPEVLANVQRMMKSVVNDGT
CCCCCCCHHHHHHHCCCCCCCCCCEECCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHH
ARGMRQTGGQIYAKTGEAEINEGSHAWFTGYREDDIAFATLVVLGGGSEAAAAVTDQFFV
HHHHHHCCCEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHH
KLDELRAGGEVAVSEAEEQPVG
HHHHHCCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]