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The map label for this gene is thrS [H]

Identifier: 145295791

GI number: 145295791

Start: 1908721

End: 1910781

Strand: Reverse

Name: thrS [H]

Synonym: cgR_1716

Alternate gene names: 145295791

Gene position: 1910781-1908721 (Counterclockwise)

Preceding gene: 145295792

Following gene: 145295790

Centisome position: 57.65

GC content: 55.22

Gene sequence:

>2061_bases
GTGAACACCACAGATACCGCAGTAGCAAACCTTGTTGTTTTTGAGGTCCCTGCAGGCACCGCAATTGGTGCAGCAATGCG
CGAACTAGATCTGCCCAACAAGGGTCCAGAGGCTATCGTTTGTGCAAAAGACGCTGAAGGCCAACTAAAGGATCTTTCAC
ACGTCCCAGAAGCCACTGCTACGTTCACCGCTGTACCTGCAAATACTGATGACGGCCGCGCAGTAATCCGCCACTCGTGC
GCTCACGTGCTGGCACAGGCTGTCCAGGCAGAATTCCCAGGAACCAAGTTGGGCATCGGCCCAGCCATTGAAAATGGTTT
CTACTACGACTTTGATGTGGCTGAGCCTTTCACTCCGGAAGATCTCAAGACCATTGAAAAGCGGATGAAGAAGATCATCA
AGACCGGCCAGAAGTTTGAGCGCCGCGTCTATGAATCCGCTGAAGCTGCAGCGGAAGAGTTGAAGAACGAGCCTTACAAG
CTGGAACTTATCCAGGACAAGGGCAACGTTGATCCTAACTCTGATGAAGCCACCGAAGTGGGCGCAGGCGAACTGACCGC
GTATGACAACGTCAACCCTCGCACCAGTGAGGTGGAGTGGTCGGATCTTTGCCGTGGACCACACATTCCAACCACCCGCT
ACATTCCAGCATTCGCGTTGACTCGTTCGTCTGCTGCGTACTGGCGTGGCGATCAAGACAACGCTGGCCTGCAGCGCATC
TATGGTACCGCGTGGGAGGATAAGGAATCCCTCGATGCCTACCAGACCATGCTCGCTGAGGCAGAAAAGCGCGATCACCG
CCGTCTAGGCACCGAACTTGATTTGTTCTCCTTCCCAGATGATCTGGGCTCTGGTTTGCCAGTATTCCATCCCAACGGTG
GCATCGTGCGCAATGAGATGGAAGATCACTCCCGTCGCCGCCACATCGCAGCCGGCTACTCCTTTGTGAACACCCCGCAC
ATCACCAAGCAGGATCTCTTTGAGCGTTCCGGTCACCTTGGTTTCTACAAGGATGGTATGTTCCCTCCAATGCAGGTGGA
TGCGGAATTCGACGAAGACGGCAATGTGACCAAGCCGGGCCAAGAGTACTACCTCAAGCCCATGAACTGCCCAATGCACA
ACCTCATCTTCGATTCTCGTGGACGTTCTTACCGTGAGCTTCCACTGCGTCTTTTTGAGTTCGGCAACGTCTACCGCTAC
GAAAAGTCCGGTGTGATCCACGGCCTGACCCGTGCCCGTGGCTTCACCCAGGACGATGCTCATATCTACTGCACCGAGGA
TCAGCTGGAAGCAGAGCTCACCTCTGTACTGGACTTCATCCTGTCGCTGCTGCGTGACTACGGTTTGGATGATTTCTACC
TGGAGCTCTCCACCCGCGATCCTAAGAAGTCAGTCGGTTCTGATGAGATCTGGGAGCGTTCCACTGAAATCTTGAACCGT
GTGGCCACCAATTCTGGCCTGGAACTTGTTCCAGACCCAGAAGGTGCCGCATTCTACGGCCCTAAGATTTCTGTTCAGGC
ACGCGACGCGATTGGCCGTACCTGGCAGATGTCCACCGTGCAGCTCGACTTCAACATGCCTGAGCGCTTCAACTTGGAAT
ACACCTCATCTGATGGTTCCAAGCAGCAGCCCATCATGATCCACCGCGCACTGTTTGGTTCCATCGAGCGCTTCTTCGGC
GTGTTGTTGGAGCACTACGCTGGTGCTTTCCCAGCATGGCTGGCACCTCACCAGGTCATGGGTATTCCAGTTGCTGATGA
TTGCATTCCACACCTGGAGACAATCACCGCTCAGCTGCGTGAAAAGGGTATCCGCGCAGACGTGGACACCTCCGATGATC
GCATGCAGAAGAAGATCCGCAACCACACCACCGGCAAGGTTCCATTCATGCTGCTTGCCGGTGCCCGCGATGTGGAAGCA
AACGCAGTGAGCTTCCGTTTCTTGGACGGCACCCAGGTCAACGGCGTGCCCGTCGATGAGGCAATCGCTGTGATTTCTTC
CTGGATTGGTGACCGCATCAACGATCAGCCGAGCGAGGACTCCATTGCAGCTCGCAGGTAG

Upstream 100 bases:

>100_bases
GGACGTATCGGGAGCGCCAGGTCAGCTGCGCACCTTGAACTAGTGGGGGCGGCCAGGTATGCCGTTTGCCCACGTGAGCG
CACGAAGGAGCGCAATTTTC

Downstream 100 bases:

>100_bases
CCCTGAGATGGACTCATCTGACAGCCACGTTGGTCAGGATGTATATGTTGATCAAGGTCTAGGGGAGCCCGACAGACTGG
AACGTCTGTGGGCGCCCTAC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MNTTDTAVANLVVFEVPAGTAIGAAMRELDLPNKGPEAIVCAKDAEGQLKDLSHVPEATATFTAVPANTDDGRAVIRHSC
AHVLAQAVQAEFPGTKLGIGPAIENGFYYDFDVAEPFTPEDLKTIEKRMKKIIKTGQKFERRVYESAEAAAEELKNEPYK
LELIQDKGNVDPNSDEATEVGAGELTAYDNVNPRTSEVEWSDLCRGPHIPTTRYIPAFALTRSSAAYWRGDQDNAGLQRI
YGTAWEDKESLDAYQTMLAEAEKRDHRRLGTELDLFSFPDDLGSGLPVFHPNGGIVRNEMEDHSRRRHIAAGYSFVNTPH
ITKQDLFERSGHLGFYKDGMFPPMQVDAEFDEDGNVTKPGQEYYLKPMNCPMHNLIFDSRGRSYRELPLRLFEFGNVYRY
EKSGVIHGLTRARGFTQDDAHIYCTEDQLEAELTSVLDFILSLLRDYGLDDFYLELSTRDPKKSVGSDEIWERSTEILNR
VATNSGLELVPDPEGAAFYGPKISVQARDAIGRTWQMSTVQLDFNMPERFNLEYTSSDGSKQQPIMIHRALFGSIERFFG
VLLEHYAGAFPAWLAPHQVMGIPVADDCIPHLETITAQLREKGIRADVDTSDDRMQKKIRNHTTGKVPFMLLAGARDVEA
NAVSFRFLDGTQVNGVPVDEAIAVISSWIGDRINDQPSEDSIAARR

Sequences:

>Translated_686_residues
MNTTDTAVANLVVFEVPAGTAIGAAMRELDLPNKGPEAIVCAKDAEGQLKDLSHVPEATATFTAVPANTDDGRAVIRHSC
AHVLAQAVQAEFPGTKLGIGPAIENGFYYDFDVAEPFTPEDLKTIEKRMKKIIKTGQKFERRVYESAEAAAEELKNEPYK
LELIQDKGNVDPNSDEATEVGAGELTAYDNVNPRTSEVEWSDLCRGPHIPTTRYIPAFALTRSSAAYWRGDQDNAGLQRI
YGTAWEDKESLDAYQTMLAEAEKRDHRRLGTELDLFSFPDDLGSGLPVFHPNGGIVRNEMEDHSRRRHIAAGYSFVNTPH
ITKQDLFERSGHLGFYKDGMFPPMQVDAEFDEDGNVTKPGQEYYLKPMNCPMHNLIFDSRGRSYRELPLRLFEFGNVYRY
EKSGVIHGLTRARGFTQDDAHIYCTEDQLEAELTSVLDFILSLLRDYGLDDFYLELSTRDPKKSVGSDEIWERSTEILNR
VATNSGLELVPDPEGAAFYGPKISVQARDAIGRTWQMSTVQLDFNMPERFNLEYTSSDGSKQQPIMIHRALFGSIERFFG
VLLEHYAGAFPAWLAPHQVMGIPVADDCIPHLETITAQLREKGIRADVDTSDDRMQKKIRNHTTGKVPFMLLAGARDVEA
NAVSFRFLDGTQVNGVPVDEAIAVISSWIGDRINDQPSEDSIAARR
>Mature_686_residues
MNTTDTAVANLVVFEVPAGTAIGAAMRELDLPNKGPEAIVCAKDAEGQLKDLSHVPEATATFTAVPANTDDGRAVIRHSC
AHVLAQAVQAEFPGTKLGIGPAIENGFYYDFDVAEPFTPEDLKTIEKRMKKIIKTGQKFERRVYESAEAAAEELKNEPYK
LELIQDKGNVDPNSDEATEVGAGELTAYDNVNPRTSEVEWSDLCRGPHIPTTRYIPAFALTRSSAAYWRGDQDNAGLQRI
YGTAWEDKESLDAYQTMLAEAEKRDHRRLGTELDLFSFPDDLGSGLPVFHPNGGIVRNEMEDHSRRRHIAAGYSFVNTPH
ITKQDLFERSGHLGFYKDGMFPPMQVDAEFDEDGNVTKPGQEYYLKPMNCPMHNLIFDSRGRSYRELPLRLFEFGNVYRY
EKSGVIHGLTRARGFTQDDAHIYCTEDQLEAELTSVLDFILSLLRDYGLDDFYLELSTRDPKKSVGSDEIWERSTEILNR
VATNSGLELVPDPEGAAFYGPKISVQARDAIGRTWQMSTVQLDFNMPERFNLEYTSSDGSKQQPIMIHRALFGSIERFFG
VLLEHYAGAFPAWLAPHQVMGIPVADDCIPHLETITAQLREKGIRADVDTSDDRMQKKIRNHTTGKVPFMLLAGARDVEA
NAVSFRFLDGTQVNGVPVDEAIAVISSWIGDRINDQPSEDSIAARR

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=629, Percent_Identity=36.724960254372, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI38202255, Length=608, Percent_Identity=36.8421052631579, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI20070344, Length=628, Percent_Identity=35.6687898089172, Blast_Score=344, Evalue=2e-94,
Organism=Escherichia coli, GI1788013, Length=641, Percent_Identity=37.9095163806552, Blast_Score=466, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI71984192, Length=650, Percent_Identity=35.0769230769231, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71984184, Length=650, Percent_Identity=35.0769230769231, Blast_Score=385, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6322112, Length=667, Percent_Identity=36.2818590704648, Blast_Score=400, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6322654, Length=400, Percent_Identity=33.75, Blast_Score=239, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24583842, Length=623, Percent_Identity=35.7945425361156, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI28574141, Length=623, Percent_Identity=35.7945425361156, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24583839, Length=621, Percent_Identity=35.9098228663446, Blast_Score=392, Evalue=1e-109,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 76632; Mature: 76632

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTDTAVANLVVFEVPAGTAIGAAMRELDLPNKGPEAIVCAKDAEGQLKDLSHVPEATA
CCCCHHHHEEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCE
TFTAVPANTDDGRAVIRHSCAHVLAQAVQAEFPGTKLGIGPAIENGFYYDFDVAEPFTPE
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEEECCCCCCCHH
DLKTIEKRMKKIIKTGQKFERRVYESAEAAAEELKNEPYKLELIQDKGNVDPNSDEATEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHC
GAGELTAYDNVNPRTSEVEWSDLCRGPHIPTTRYIPAFALTRSSAAYWRGDQDNAGLQRI
CCCCEEEECCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHEECCCCCEECCCCCCCCHHHH
YGTAWEDKESLDAYQTMLAEAEKRDHRRLGTELDLFSFPDDLGSGLPVFHPNGGIVRNEM
HCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHCCCCCEECCCCCEECCHH
EDHSRRRHIAAGYSFVNTPHITKQDLFERSGHLGFYKDGMFPPMQVDAEFDEDGNVTKPG
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCEECCCCCCCCEECCCCCCCCCCCCCC
QEYYLKPMNCPMHNLIFDSRGRSYRELPLRLFEFGNVYRYEKSGVIHGLTRARGFTQDDA
HHHEECCCCCCHHHHEECCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCCCC
HIYCTEDQLEAELTSVLDFILSLLRDYGLDDFYLELSTRDPKKSVGSDEIWERSTEILNR
EEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHCCCCHHHHHHHHHHHHH
VATNSGLELVPDPEGAAFYGPKISVQARDAIGRTWQMSTVQLDFNMPERFNLEYTSSDGS
HHCCCCCEEEECCCCCEEECCEEEEEEHHHCCCEEEEEEEEEECCCCCCCCEEEECCCCC
KQQPIMIHRALFGSIERFFGVLLEHYAGAFPAWLAPHQVMGIPVADDCIPHLETITAQLR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCEECCCCHHHHHHHHHHHHHHHH
EKGIRADVDTSDDRMQKKIRNHTTGKVPFMLLAGARDVEANAVSFRFLDGTQVNGVPVDE
HCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCHHH
AIAVISSWIGDRINDQPSEDSIAARR
HHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNTTDTAVANLVVFEVPAGTAIGAAMRELDLPNKGPEAIVCAKDAEGQLKDLSHVPEATA
CCCCHHHHEEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCE
TFTAVPANTDDGRAVIRHSCAHVLAQAVQAEFPGTKLGIGPAIENGFYYDFDVAEPFTPE
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEEECCCCCCCHH
DLKTIEKRMKKIIKTGQKFERRVYESAEAAAEELKNEPYKLELIQDKGNVDPNSDEATEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHC
GAGELTAYDNVNPRTSEVEWSDLCRGPHIPTTRYIPAFALTRSSAAYWRGDQDNAGLQRI
CCCCEEEECCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHEECCCCCEECCCCCCCCHHHH
YGTAWEDKESLDAYQTMLAEAEKRDHRRLGTELDLFSFPDDLGSGLPVFHPNGGIVRNEM
HCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHCCCCCEECCCCCEECCHH
EDHSRRRHIAAGYSFVNTPHITKQDLFERSGHLGFYKDGMFPPMQVDAEFDEDGNVTKPG
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCEECCCCCCCCEECCCCCCCCCCCCCC
QEYYLKPMNCPMHNLIFDSRGRSYRELPLRLFEFGNVYRYEKSGVIHGLTRARGFTQDDA
HHHEECCCCCCHHHHEECCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCCCC
HIYCTEDQLEAELTSVLDFILSLLRDYGLDDFYLELSTRDPKKSVGSDEIWERSTEILNR
EEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHCCCCHHHHHHHHHHHHH
VATNSGLELVPDPEGAAFYGPKISVQARDAIGRTWQMSTVQLDFNMPERFNLEYTSSDGS
HHCCCCCEEEECCCCCEEECCEEEEEEHHHCCCEEEEEEEEEECCCCCCCCEEEECCCCC
KQQPIMIHRALFGSIERFFGVLLEHYAGAFPAWLAPHQVMGIPVADDCIPHLETITAQLR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCEECCCCHHHHHHHHHHHHHHHH
EKGIRADVDTSDDRMQKKIRNHTTGKVPFMLLAGARDVEANAVSFRFLDGTQVNGVPVDE
HCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCHHH
AIAVISSWIGDRINDQPSEDSIAARR
HHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]