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The map label for this gene is guaB [H]

Identifier: 145294774

GI number: 145294774

Start: 781239

End: 782759

Strand: Direct

Name: guaB [H]

Synonym: cgR_0722

Alternate gene names: 145294774

Gene position: 781239-782759 (Clockwise)

Preceding gene: 145294772

Following gene: 145294775

Centisome position: 23.57

GC content: 55.42

Gene sequence:

>1521_bases
ATGACAACCCAGAGCCGAGTTTCTACCGGAGGAGACAACCCAAACAAGGTTGCCCTCGTTGGATTAACCTTTGATGACGT
ACTTTTGCTTCCAGATGCGTCGGACGTTGTTCCTTCAGAGGTAGATACCTCGACGCAGTTAACACGTAATATTCGCCTTA
ACACCCCTATTCTTTCTGCCGCAATGGATACCGTCACCGAGGCTCGCATGGCTATCGGCATGGCACGCCATGGCGGCATT
GGTGTTTTGCACCGCAACCTGTCTATTCAAGAGCAGGCAGAAAACGTTGAGCTGGTGAAGCGTTCCGAGTCTGGAATGGT
CACTGATCCTGTTACCTGTACTCCTGACATGAGTATCCAAGAAGTGGATGATCTGTGTGCACGTTTCCGCATTTCCGGTC
TGCCTGTTGTTGATGAGGCCGGAAAGTTGGTTGGTATTTGCACCAACCGCGATATGCGTTTTGAAAGCGACATGAACCGT
CGTGTCGCTGAAGTTATGACCCCAATGCCTTTGGTTGTTGCTGAAGAGGGCGTCACCAAGGAGCAGGCTCTTGCTTTGCT
GTCTGCAAACAAGGTGGAGAAGCTTCCTATCATCGCAAAGGACGGCAAGCTTGTCGGTCTGATCACGGTGAAGGACTTCG
TTAAGACTGAGCAGCACCCGAACGCATCCAAGGATGCATCAGGTCGTCTGCTGGTTGCGGCTGGCATCGGCACGGGCGAG
GAGTCATTCCAGCGAGCTGGTGCGCTTGCCGACGCCGGCGTCGACATTTTGGTCGTAGACTCTGCACACGCCCATAGCCG
TGGAGTTTTGGACATGGTGTCCCGCGTGAAGAAGGCGTTCCCCAAGGTCGATATCGTTGGCGGCAACTTGGCGACCCGCG
AGGCTGCGCAGGCCATGATTGAAGCTGGCGCAGACGCTATCAAGGTGGGTATTGGCCCAGGTTCTATTTGCACCACTCGC
GTTGTCGCAGGTGTCGGTGCACCTCAGATCACTGCGATCATGGAGGCAGCTGTTCCAGCTCACAAGGCTGGCGTTCCTAT
CATCGCCGATGGCGGCATGCAGTTCTCTGGTGATATCGCTAAGGCTTTGGCTGCTGGCGCTAACTCCGTGATGCTGGGCT
CCATGCTGGCTGGTACCGCTGAGGCTCCTGGTGAGACCATCACCATCAACGGCAAGCAGTACAAGCGTTACCGTGGCATG
GGCTCCATGGGCGCTATGCAGGGCCGTGGACTTAGTGGTGAGAAGCGTTCCTACTCCAAGGACCGTTACTTCCAGTCTGA
CGTTAAGAGCGAAGACAAGCTCGTTCCAGAAGGCATCGAAGGTCGCGTGCCTTTCCGCGGTGCCATCGGAGACATCATTC
ACCAGCAGGTCGGTGGACTTCGTGCAGCAATGGGCTACACCGGTTCCTCCACCATTGAAGAGCTGCACAACGCTCGTTTC
GTGCAGATCACCAGCGCGGGTCTGAAGGAATCCCACCCGCACCACATCCAGCAGACTGTAGAAGCTCCTAACTACCATTA
G

Upstream 100 bases:

>100_bases
GTTGTGGAATAGCGTGTGAGCTGCAGCGGTTATCCGATTTAAGGACAAGCTACTAAAGTTTAGATAATTGTGGACACACT
ATGAGGAGGAACTGTCGCAC

Downstream 100 bases:

>100_bases
ATTTTGCTCACTTAAACAGCCCGATTTCTTCATTGAAATCGGGCTGTTTCTGGTTGTGTCGCGTATCTCGGGTAAAGTCT
TCGTCGTATACGACCATTTA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MTTQSRVSTGGDNPNKVALVGLTFDDVLLLPDASDVVPSEVDTSTQLTRNIRLNTPILSAAMDTVTEARMAIGMARHGGI
GVLHRNLSIQEQAENVELVKRSESGMVTDPVTCTPDMSIQEVDDLCARFRISGLPVVDEAGKLVGICTNRDMRFESDMNR
RVAEVMTPMPLVVAEEGVTKEQALALLSANKVEKLPIIAKDGKLVGLITVKDFVKTEQHPNASKDASGRLLVAAGIGTGE
ESFQRAGALADAGVDILVVDSAHAHSRGVLDMVSRVKKAFPKVDIVGGNLATREAAQAMIEAGADAIKVGIGPGSICTTR
VVAGVGAPQITAIMEAAVPAHKAGVPIIADGGMQFSGDIAKALAAGANSVMLGSMLAGTAEAPGETITINGKQYKRYRGM
GSMGAMQGRGLSGEKRSYSKDRYFQSDVKSEDKLVPEGIEGRVPFRGAIGDIIHQQVGGLRAAMGYTGSSTIEELHNARF
VQITSAGLKESHPHHIQQTVEAPNYH

Sequences:

>Translated_506_residues
MTTQSRVSTGGDNPNKVALVGLTFDDVLLLPDASDVVPSEVDTSTQLTRNIRLNTPILSAAMDTVTEARMAIGMARHGGI
GVLHRNLSIQEQAENVELVKRSESGMVTDPVTCTPDMSIQEVDDLCARFRISGLPVVDEAGKLVGICTNRDMRFESDMNR
RVAEVMTPMPLVVAEEGVTKEQALALLSANKVEKLPIIAKDGKLVGLITVKDFVKTEQHPNASKDASGRLLVAAGIGTGE
ESFQRAGALADAGVDILVVDSAHAHSRGVLDMVSRVKKAFPKVDIVGGNLATREAAQAMIEAGADAIKVGIGPGSICTTR
VVAGVGAPQITAIMEAAVPAHKAGVPIIADGGMQFSGDIAKALAAGANSVMLGSMLAGTAEAPGETITINGKQYKRYRGM
GSMGAMQGRGLSGEKRSYSKDRYFQSDVKSEDKLVPEGIEGRVPFRGAIGDIIHQQVGGLRAAMGYTGSSTIEELHNARF
VQITSAGLKESHPHHIQQTVEAPNYH
>Mature_505_residues
TTQSRVSTGGDNPNKVALVGLTFDDVLLLPDASDVVPSEVDTSTQLTRNIRLNTPILSAAMDTVTEARMAIGMARHGGIG
VLHRNLSIQEQAENVELVKRSESGMVTDPVTCTPDMSIQEVDDLCARFRISGLPVVDEAGKLVGICTNRDMRFESDMNRR
VAEVMTPMPLVVAEEGVTKEQALALLSANKVEKLPIIAKDGKLVGLITVKDFVKTEQHPNASKDASGRLLVAAGIGTGEE
SFQRAGALADAGVDILVVDSAHAHSRGVLDMVSRVKKAFPKVDIVGGNLATREAAQAMIEAGADAIKVGIGPGSICTTRV
VAGVGAPQITAIMEAAVPAHKAGVPIIADGGMQFSGDIAKALAAGANSVMLGSMLAGTAEAPGETITINGKQYKRYRGMG
SMGAMQGRGLSGEKRSYSKDRYFQSDVKSEDKLVPEGIEGRVPFRGAIGDIIHQQVGGLRAAMGYTGSSTIEELHNARFV
QITSAGLKESHPHHIQQTVEAPNYH

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=466, Percent_Identity=41.4163090128755, Blast_Score=341, Evalue=1e-93,
Organism=Homo sapiens, GI34328930, Length=466, Percent_Identity=41.4163090128755, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI156616279, Length=466, Percent_Identity=41.4163090128755, Blast_Score=340, Evalue=3e-93,
Organism=Homo sapiens, GI34328928, Length=466, Percent_Identity=41.4163090128755, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI66933016, Length=462, Percent_Identity=41.1255411255411, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI217035152, Length=461, Percent_Identity=41.2147505422993, Blast_Score=331, Evalue=8e-91,
Organism=Homo sapiens, GI217035148, Length=466, Percent_Identity=40.7725321888412, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI217035150, Length=466, Percent_Identity=39.0557939914163, Blast_Score=308, Evalue=8e-84,
Organism=Homo sapiens, GI50541956, Length=373, Percent_Identity=34.3163538873995, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI50541954, Length=257, Percent_Identity=40.4669260700389, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI50541952, Length=257, Percent_Identity=40.4669260700389, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI50541948, Length=257, Percent_Identity=40.4669260700389, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI156104880, Length=271, Percent_Identity=36.1623616236162, Blast_Score=159, Evalue=5e-39,
Organism=Escherichia coli, GI1788855, Length=492, Percent_Identity=54.4715447154472, Blast_Score=484, Evalue=1e-138,
Organism=Escherichia coli, GI1786293, Length=259, Percent_Identity=36.2934362934363, Blast_Score=159, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=478, Percent_Identity=33.4728033472803, Blast_Score=258, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI71994389, Length=431, Percent_Identity=35.2668213457077, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17560440, Length=286, Percent_Identity=34.965034965035, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323585, Length=459, Percent_Identity=41.8300653594771, Blast_Score=340, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6323464, Length=461, Percent_Identity=41.648590021692, Blast_Score=335, Evalue=8e-93,
Organism=Saccharomyces cerevisiae, GI6322012, Length=487, Percent_Identity=38.8090349075975, Blast_Score=332, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=38.4615384615385, Blast_Score=247, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6319353, Length=103, Percent_Identity=45.6310679611651, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=38.1443298969072, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=38.1443298969072, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI28571163, Length=444, Percent_Identity=37.8378378378378, Blast_Score=290, Evalue=1e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53320; Mature: 53188

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQSRVSTGGDNPNKVALVGLTFDDVLLLPDASDVVPSEVDTSTQLTRNIRLNTPILSA
CCCCCCCCCCCCCCCEEEEEEEECCCEEECCCCCCCCCCCCCCCHHHHHEEEECCCHHHH
AMDTVTEARMAIGMARHGGIGVLHRNLSIQEQAENVELVKRSESGMVTDPVTCTPDMSIQ
HHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHCCHHHHEECCCCCEECCEECCCCCCHH
EVDDLCARFRISGLPVVDEAGKLVGICTNRDMRFESDMNRRVAEVMTPMPLVVAEEGVTK
HHHHHHHHHCCCCCCEECCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCH
EQALALLSANKVEKLPIIAKDGKLVGLITVKDFVKTEQHPNASKDASGRLLVAAGIGTGE
HHHHHHHHCCCHHHCCEEECCCCEEEEEEEHHHHHHCCCCCCCCCCCCCEEEEECCCCCH
ESFQRAGALADAGVDILVVDSAHAHSRGVLDMVSRVKKAFPKVDIVGGNLATREAAQAMI
HHHHHHCCHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHH
EAGADAIKVGIGPGSICTTRVVAGVGAPQITAIMEAAVPAHKAGVPIIADGGMQFSGDIA
HCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCEEECCCCEECCHHH
KALAAGANSVMLGSMLAGTAEAPGETITINGKQYKRYRGMGSMGAMQGRGLSGEKRSYSK
HHHHCCCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCCCH
DRYFQSDVKSEDKLVPEGIEGRVPFRGAIGDIIHQQVGGLRAAMGYTGSSTIEELHNARF
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHCCEE
VQITSAGLKESHPHHIQQTVEAPNYH
EEEECCCCCCCCCHHHHHHHCCCCCC
>Mature Secondary Structure 
TTQSRVSTGGDNPNKVALVGLTFDDVLLLPDASDVVPSEVDTSTQLTRNIRLNTPILSA
CCCCCCCCCCCCCCEEEEEEEECCCEEECCCCCCCCCCCCCCCHHHHHEEEECCCHHHH
AMDTVTEARMAIGMARHGGIGVLHRNLSIQEQAENVELVKRSESGMVTDPVTCTPDMSIQ
HHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHCCHHHHEECCCCCEECCEECCCCCCHH
EVDDLCARFRISGLPVVDEAGKLVGICTNRDMRFESDMNRRVAEVMTPMPLVVAEEGVTK
HHHHHHHHHCCCCCCEECCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCH
EQALALLSANKVEKLPIIAKDGKLVGLITVKDFVKTEQHPNASKDASGRLLVAAGIGTGE
HHHHHHHHCCCHHHCCEEECCCCEEEEEEEHHHHHHCCCCCCCCCCCCCEEEEECCCCCH
ESFQRAGALADAGVDILVVDSAHAHSRGVLDMVSRVKKAFPKVDIVGGNLATREAAQAMI
HHHHHHCCHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHH
EAGADAIKVGIGPGSICTTRVVAGVGAPQITAIMEAAVPAHKAGVPIIADGGMQFSGDIA
HCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCEEECCCCEECCHHH
KALAAGANSVMLGSMLAGTAEAPGETITINGKQYKRYRGMGSMGAMQGRGLSGEKRSYSK
HHHHCCCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCCCH
DRYFQSDVKSEDKLVPEGIEGRVPFRGAIGDIIHQQVGGLRAAMGYTGSSTIEELHNARF
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHCCEE
VQITSAGLKESHPHHIQQTVEAPNYH
EEEECCCCCCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]