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The map label for this gene is gcp [H]

Identifier: 145294764

GI number: 145294764

Start: 772810

End: 773844

Strand: Direct

Name: gcp [H]

Synonym: cgR_0712

Alternate gene names: 145294764

Gene position: 772810-773844 (Clockwise)

Preceding gene: 145294763

Following gene: 145294765

Centisome position: 23.32

GC content: 56.33

Gene sequence:

>1035_bases
ATGATCGTTTTGGGAATTGAAAGCTCCTGCGATGAAACAGGCGTAGGCGTAGTCAAACTTGATGGCGAAGGAAACCTGGA
GATCCTCGCCGACTCAGTGGCCTCCTCCATGCAAGAACACGCTCGTTTTGGTGGCGTCGTGCCAGAAATCGCTTCCCGGG
CCCACTTGGAATCTATGGTCCCCGTGATGCGTGAAGCGTTGAGGCAGGCGGGCGTCGATAAGCCAGATGCTGTGGCTGCA
ACTGTGGGCCCTGGTTTGGCGGGCGCGCTGCTCGTTGGAGCCAGCGCCGCAAAGGCGTATGCCGCTGCGTGGGGAGTTCC
GTTTTACGCGGTCAACCACCTGGGCGGACACGTCGCCGTGGCCAATCTGGAAGGTGAAACTCTTCCACACGCGGTGGCTT
TGCTGGTTTCCGGCGGACACACTCAATTGTTGGAAGTCGACGCCGTGGGATTACCCATGAAGGAATTGGGATCCACCCTC
GACGATGCCGCTGGCGAAGCCTATGACAAAGTCTCAAGGCTGTTGGGATTGGGCTACCCAGGCGGCCCCATCATTGATAA
ATTGGCGCGCCGGGGTAATCCAGAGGCCATTGCTTTCCCCCGCGGATTGATGAAAAAGTCGGATTCTCGGCATGATTTCA
GCTTCTCCGGTTTGAAAACCTCCGTTGCCCGCTACGTGGAAGCTGCGGAAAGAAACGGTGAAGTTATTTCCGTGGAGGAC
GTCTGCGCATCATTCCAAGAAGCGGTGTGTGATGTGTTGACGTTTAAGGCCGTGCGTGCGTGCCGCGATGTCGGTGCGAA
GGTGCTGCTGTTGGGTGGAGGAGTGGCTGCCAACTCTCGTCTGCGGGAGCTTGCTCAAGAACGTTGCGATAAAGCCGGCA
TCGAACTCCGGGTTCCTCGTTTCAATTTGTGCACCGATAATGGTGTCATGATTGCAGCGTTGGCGGCTCAAAGAATCCAC
GAAGGTGCTCAAGAATCACCAATTTCGGTCGGAACTGATCCTTCTTTGTCCGTTGAGACCCCACAGGTGTTTTAA

Upstream 100 bases:

>100_bases
CTACCGGCCATCCGGAGCTGACGCCTACACCATGCAACGCCCACGCTTGAGCGATCGCAAAGATCAACAGACAGACACAG
AGGGGACACCCAACTAAACC

Downstream 100 bases:

>100_bases
ACATTTAGTATTAGTTCCATGAAACCAGTCTTCTCCGTTGACCAAATCCGACGCGCAGAAAACACCCTTTTTGAGCTTCA
GGCAGATCCGGATGAGCTGA

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MIVLGIESSCDETGVGVVKLDGEGNLEILADSVASSMQEHARFGGVVPEIASRAHLESMVPVMREALRQAGVDKPDAVAA
TVGPGLAGALLVGASAAKAYAAAWGVPFYAVNHLGGHVAVANLEGETLPHAVALLVSGGHTQLLEVDAVGLPMKELGSTL
DDAAGEAYDKVSRLLGLGYPGGPIIDKLARRGNPEAIAFPRGLMKKSDSRHDFSFSGLKTSVARYVEAAERNGEVISVED
VCASFQEAVCDVLTFKAVRACRDVGAKVLLLGGGVAANSRLRELAQERCDKAGIELRVPRFNLCTDNGVMIAALAAQRIH
EGAQESPISVGTDPSLSVETPQVF

Sequences:

>Translated_344_residues
MIVLGIESSCDETGVGVVKLDGEGNLEILADSVASSMQEHARFGGVVPEIASRAHLESMVPVMREALRQAGVDKPDAVAA
TVGPGLAGALLVGASAAKAYAAAWGVPFYAVNHLGGHVAVANLEGETLPHAVALLVSGGHTQLLEVDAVGLPMKELGSTL
DDAAGEAYDKVSRLLGLGYPGGPIIDKLARRGNPEAIAFPRGLMKKSDSRHDFSFSGLKTSVARYVEAAERNGEVISVED
VCASFQEAVCDVLTFKAVRACRDVGAKVLLLGGGVAANSRLRELAQERCDKAGIELRVPRFNLCTDNGVMIAALAAQRIH
EGAQESPISVGTDPSLSVETPQVF
>Mature_344_residues
MIVLGIESSCDETGVGVVKLDGEGNLEILADSVASSMQEHARFGGVVPEIASRAHLESMVPVMREALRQAGVDKPDAVAA
TVGPGLAGALLVGASAAKAYAAAWGVPFYAVNHLGGHVAVANLEGETLPHAVALLVSGGHTQLLEVDAVGLPMKELGSTL
DDAAGEAYDKVSRLLGLGYPGGPIIDKLARRGNPEAIAFPRGLMKKSDSRHDFSFSGLKTSVARYVEAAERNGEVISVED
VCASFQEAVCDVLTFKAVRACRDVGAKVLLLGGGVAANSRLRELAQERCDKAGIELRVPRFNLCTDNGVMIAALAAQRIH
EGAQESPISVGTDPSLSVETPQVF

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family [H]

Homologues:

Organism=Homo sapiens, GI116812636, Length=344, Percent_Identity=33.4302325581395, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI8923380, Length=332, Percent_Identity=31.0240963855422, Blast_Score=125, Evalue=5e-29,
Organism=Escherichia coli, GI1789445, Length=327, Percent_Identity=44.954128440367, Blast_Score=243, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71995670, Length=320, Percent_Identity=32.8125, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17557464, Length=326, Percent_Identity=30.6748466257669, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322891, Length=343, Percent_Identity=28.8629737609329, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320099, Length=339, Percent_Identity=27.1386430678466, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI20129063, Length=339, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI21357207, Length=339, Percent_Identity=29.2035398230088, Blast_Score=127, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861 [H]

Pfam domain/function: PF00814 Peptidase_M22 [H]

EC number: =3.4.24.57 [H]

Molecular weight: Translated: 35801; Mature: 35801

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVLGIESSCDETGVGVVKLDGEGNLEILADSVASSMQEHARFGGVVPEIASRAHLESMV
CEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
PVMREALRQAGVDKPDAVAATVGPGLAGALLVGASAAKAYAAAWGVPFYAVNHLGGHVAV
HHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEE
ANLEGETLPHAVALLVSGGHTQLLEVDAVGLPMKELGSTLDDAAGEAYDKVSRLLGLGYP
EECCCCHHHHHHHHEECCCCCEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCC
GGPIIDKLARRGNPEAIAFPRGLMKKSDSRHDFSFSGLKTSVARYVEAAERNGEVISVED
CCHHHHHHHHCCCCCEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHH
VCASFQEAVCDVLTFKAVRACRDVGAKVLLLGGGVAANSRLRELAQERCDKAGIELRVPR
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEECCC
FNLCTDNGVMIAALAAQRIHEGAQESPISVGTDPSLSVETPQVF
EEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIVLGIESSCDETGVGVVKLDGEGNLEILADSVASSMQEHARFGGVVPEIASRAHLESMV
CEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
PVMREALRQAGVDKPDAVAATVGPGLAGALLVGASAAKAYAAAWGVPFYAVNHLGGHVAV
HHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEE
ANLEGETLPHAVALLVSGGHTQLLEVDAVGLPMKELGSTLDDAAGEAYDKVSRLLGLGYP
EECCCCHHHHHHHHEECCCCCEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCC
GGPIIDKLARRGNPEAIAFPRGLMKKSDSRHDFSFSGLKTSVARYVEAAERNGEVISVED
CCHHHHHHHHCCCCCEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHH
VCASFQEAVCDVLTFKAVRACRDVGAKVLLLGGGVAANSRLRELAQERCDKAGIELRVPR
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEECCC
FNLCTDNGVMIAALAAQRIHEGAQESPISVGTDPSLSVETPQVF
EEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]