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The map label for this gene is tyrP [H]

Identifier: 145294633

GI number: 145294633

Start: 644769

End: 646016

Strand: Direct

Name: tyrP [H]

Synonym: cgR_0584

Alternate gene names: 145294633

Gene position: 644769-646016 (Clockwise)

Preceding gene: 145294632

Following gene: 145294634

Centisome position: 19.45

GC content: 56.09

Gene sequence:

>1248_bases
ATGACTACCGAATCAATAGTTGGGCACAATGCTGCAGGTACAGCACCTCAGAATGTGTCCTCTGCTAAGAAGAAGTACCT
CAGCGTTGCCCAAGGCGTTGCCCTTATCTACGGAACCAACATCGGCGCCGGTGTGCTCAGCCTCCCATACGCTGCCCGCA
ACGGTGGTTTCCTCGCCCTGGTTGTTGCCCTGCTCATTGCGGGAACACTGACCACCATCTCCATGCTCTACATCGCCGAA
GTATCCCTGCGCACCAAGAAGCCACTGCAGCTTTCCGGCCTGGCAGAAAAATACCTGGGGCAGTGGGGCCGCTGGCTGGT
GTTCATTGCCATTGTGGTCAACAGCGTGGGTGCACTGATTGCCTACGCATCAGGATCCGGCATTTTGATAGGCAACCTCA
CCGGCCTGCCACCAATCGTGGGCACCCTTGGATTCTTTGTTTTAGGCACCTTGATCATGTGGAAAGGCCTGCACACGGCA
AGCTTCGTGGAGGCATTGATCACCACTGGCATGGCAACGATCATCATCGTGCTGTGTGGATGGACAGTGCTTGGCCCTGG
AATTTCCGCAGACAACCTGATCGTGTTCCACCCATTCTTCATCGTTCCGATCATGAACCTCGCGGTCTTTACCTTCCTTG
CCCAATATGTGGTTCCAGAAATCGCACGAGGAGTTAACCCTGCCACCCCGAAGGCAGTGCCACGCGCGATCATCATCGGC
ATGGTCGCAACTGGTGTCACCCTGGCAGCTGTACCATTCGCGGCACTAGGGCTTCTGGGCACAGGCGTCAGTGAAGTTGT
CACCATCTCCTGGGGTGAGGCACTCGCCCCAGTGGCCTATTACATGGCCAATGCCTTCGCACTATTGGCCATGTTCACTT
CATTCATCGCCATTGGATTCACCGCGATGCGCAACGTACTAGATATTGGCCACTGGCCAGAACACGGATGGCAGCGATCC
GTTGCTGTCGGACTAACTGTTCTTCCACCACTGGCAATTTCACTTGCGGGATTAGGCGGATTCGTGGCAGCACTGAGCTA
CGCCGGAGGATTTGCCGGAGCAATCATGTCCATCATCCCCGTGCTGTTGCTGCGCAACTCCCGCAAGCGTGGCGACCAAG
AACCAGTGTGGAAAGCCACCTGGCAAGCGCACCCCATCTTCCAGATCCTGTTGATTGTGGTGTACTCCCTGGCGTTTGTG
TACTCGGTTCTCGCGATCGTCGGATTAATGCCTGCGGGTTGGGCATAG

Upstream 100 bases:

>100_bases
GAGAAGGCGGAACCGAAGGAATCGAAGAATATCTCTCCGTGCGTTACCTCGCTTTGCCGTGACACATGAGCTGTCCGGTA
AATAACCCGAAGGAAAAAAC

Downstream 100 bases:

>100_bases
TCACTTCCTGTTGTGGCTGCCTGTTGCAGCCAAATACGGCCAACGGCTCCTTGGAAATTTAAGGGGTCGTTGGCCTTATT
ATTTTAGGGAAAGCCCATCC

Product: hypothetical protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MTTESIVGHNAAGTAPQNVSSAKKKYLSVAQGVALIYGTNIGAGVLSLPYAARNGGFLALVVALLIAGTLTTISMLYIAE
VSLRTKKPLQLSGLAEKYLGQWGRWLVFIAIVVNSVGALIAYASGSGILIGNLTGLPPIVGTLGFFVLGTLIMWKGLHTA
SFVEALITTGMATIIIVLCGWTVLGPGISADNLIVFHPFFIVPIMNLAVFTFLAQYVVPEIARGVNPATPKAVPRAIIIG
MVATGVTLAAVPFAALGLLGTGVSEVVTISWGEALAPVAYYMANAFALLAMFTSFIAIGFTAMRNVLDIGHWPEHGWQRS
VAVGLTVLPPLAISLAGLGGFVAALSYAGGFAGAIMSIIPVLLLRNSRKRGDQEPVWKATWQAHPIFQILLIVVYSLAFV
YSVLAIVGLMPAGWA

Sequences:

>Translated_415_residues
MTTESIVGHNAAGTAPQNVSSAKKKYLSVAQGVALIYGTNIGAGVLSLPYAARNGGFLALVVALLIAGTLTTISMLYIAE
VSLRTKKPLQLSGLAEKYLGQWGRWLVFIAIVVNSVGALIAYASGSGILIGNLTGLPPIVGTLGFFVLGTLIMWKGLHTA
SFVEALITTGMATIIIVLCGWTVLGPGISADNLIVFHPFFIVPIMNLAVFTFLAQYVVPEIARGVNPATPKAVPRAIIIG
MVATGVTLAAVPFAALGLLGTGVSEVVTISWGEALAPVAYYMANAFALLAMFTSFIAIGFTAMRNVLDIGHWPEHGWQRS
VAVGLTVLPPLAISLAGLGGFVAALSYAGGFAGAIMSIIPVLLLRNSRKRGDQEPVWKATWQAHPIFQILLIVVYSLAFV
YSVLAIVGLMPAGWA
>Mature_414_residues
TTESIVGHNAAGTAPQNVSSAKKKYLSVAQGVALIYGTNIGAGVLSLPYAARNGGFLALVVALLIAGTLTTISMLYIAEV
SLRTKKPLQLSGLAEKYLGQWGRWLVFIAIVVNSVGALIAYASGSGILIGNLTGLPPIVGTLGFFVLGTLIMWKGLHTAS
FVEALITTGMATIIIVLCGWTVLGPGISADNLIVFHPFFIVPIMNLAVFTFLAQYVVPEIARGVNPATPKAVPRAIIIGM
VATGVTLAAVPFAALGLLGTGVSEVVTISWGEALAPVAYYMANAFALLAMFTSFIAIGFTAMRNVLDIGHWPEHGWQRSV
AVGLTVLPPLAISLAGLGGFVAALSYAGGFAGAIMSIIPVLLLRNSRKRGDQEPVWKATWQAHPIFQILLIVVYSLAFVY
SVLAIVGLMPAGWA

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=371, Percent_Identity=29.1105121293801, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43430; Mature: 43299

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTESIVGHNAAGTAPQNVSSAKKKYLSVAQGVALIYGTNIGAGVLSLPYAARNGGFLAL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHEEEECCCCCHHHHCCCCCCCCCHHHH
VVALLIAGTLTTISMLYIAEVSLRTKKPLQLSGLAEKYLGQWGRWLVFIAIVVNSVGALI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYASGSGILIGNLTGLPPIVGTLGFFVLGTLIMWKGLHTASFVEALITTGMATIIIVLCG
EEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
WTVLGPGISADNLIVFHPFFIVPIMNLAVFTFLAQYVVPEIARGVNPATPKAVPRAIIIG
HHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
MVATGVTLAAVPFAALGLLGTGVSEVVTISWGEALAPVAYYMANAFALLAMFTSFIAIGF
HHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAMRNVLDIGHWPEHGWQRSVAVGLTVLPPLAISLAGLGGFVAALSYAGGFAGAIMSIIP
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VLLLRNSRKRGDQEPVWKATWQAHPIFQILLIVVYSLAFVYSVLAIVGLMPAGWA
HHHHHCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTESIVGHNAAGTAPQNVSSAKKKYLSVAQGVALIYGTNIGAGVLSLPYAARNGGFLAL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHEEEECCCCCHHHHCCCCCCCCCHHHH
VVALLIAGTLTTISMLYIAEVSLRTKKPLQLSGLAEKYLGQWGRWLVFIAIVVNSVGALI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYASGSGILIGNLTGLPPIVGTLGFFVLGTLIMWKGLHTASFVEALITTGMATIIIVLCG
EEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
WTVLGPGISADNLIVFHPFFIVPIMNLAVFTFLAQYVVPEIARGVNPATPKAVPRAIIIG
HHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
MVATGVTLAAVPFAALGLLGTGVSEVVTISWGEALAPVAYYMANAFALLAMFTSFIAIGF
HHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAMRNVLDIGHWPEHGWQRSVAVGLTVLPPLAISLAGLGGFVAALSYAGGFAGAIMSIIP
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VLLLRNSRKRGDQEPVWKATWQAHPIFQILLIVVYSLAFVYSVLAIVGLMPAGWA
HHHHHCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]