Click here to switch to the map view.

The map label for this gene is gabT [H]

Identifier: 145294631

GI number: 145294631

Start: 642021

End: 643367

Strand: Direct

Name: gabT [H]

Synonym: cgR_0582

Alternate gene names: 145294631

Gene position: 642021-643367 (Clockwise)

Preceding gene: 145294629

Following gene: 145294632

Centisome position: 19.37

GC content: 62.66

Gene sequence:

>1347_bases
GTGGAAGATCTCTCATACCGCATCCCGCAGTCGCGCACCGTGGCCGAGCAGGTGCCAGGGCCGAAGTCGAAAGCGCTGGA
TGAGCGTCGACAAGCAGCAGTAGCACGAGCACTTGCACCGGGTCTGCCTGGATACGTGGTGGACGCAGACGGTGGCATCT
TGGCTGACGCGGACGGCAACCGTTTCATCGACCTGGCCTCCGGCATCGCCGTGACCACAGTCGGCGGATCCAACGCGGCC
GTCGCGAAAGCCGTCGGCGCCGCAGCTGCCCGCTTCACCCACACCTGCTTCATGGTCTCACCTTATGAAACTTACGTGGC
AATGGCGGAGAGACTCAACGCCTTGACTCCAGGCGATCACGACAAGAAGAGCGCGCTGTTTAACTCTGGCGCCGAAGCCG
TGGAAAACGCCGTCAAGGTGGCACGCGCCTACACCGGCAAGGGCGCGGTCGTGGTGTTCGACAACGCGTACCACGGACGG
ACCAACCTCACCATGGCGATGACCGCGAAGAACCGCCCATACAAGTCCGGATTCGGACCACTAGCCGCAGACGTCTACCG
TGCACCAATGTCTTACCCACTGCGCGACGGACTGTCCGGCCCGGAAGCCGCAGAGCGCGCGATCTCCGTGATCGAATCCC
AGGTCGGAGCCGAAAACCTCGCCTGCGTGGTCATTGAACCGATCCAGGGCGAAGGCGGATTCATCGTCCCCGCACCAGGA
TTCCTCGCAGCCATTTCCACCTGGTGCCGCGAGAACGACGTGGTGTTCATCGCCGATGAAATCCAATCTGGCTTCCTGCG
CACCGGCGACTGGTTCGCCAGCGACGCAGAAGGTGTGATCCCCGACGTCATCACCACCGCAAAAGGCATCGCCGGCGGCA
TGCCACTATCCGCAGTGACCGGCCGCGCAGAAATCATGGACGCACCCGGCCCCGGCGCGCTCGGCGGAACCTACGGCGGA
AACCCCGTTGCTTGCGCCGCAGCACTTGCAGCCATTGAAGTGATGGAACAAGCCGACCTTAAGACCCGCGCTCAAGAAAT
CGAGGCCATCATCCGCGATGAATTCGCGCAGCTGAGTGCCTTCCCGGAAGTCGCCGAAATCCGCGGCCGCGGAGCAATGA
TGGCTATTGAGCTTATCGACGCTACCGGCCGCCCGAACGCAGCTTTAACCGCCGCAGTGGCTGCGCGCGCAAAAGCTGAA
GGTGTGCTGCTGCTGACTTGCGGCACCGATGGCAACGTCATCCGCCTGCTGCCACCACTGGTCATTGCAGAGGACACTCT
CCGTGATGGTCTTCAGGTGTTAGTCGCAGCCCTAGAGCGCGAAACCGCGCACCAGAAGGTGGGCTAA

Upstream 100 bases:

>100_bases
TGTCTACAACTTCGCCCTCATGGACATATTAACTTCGTTGCCTCGGAGAGAATACTCATCACCTAGACAACAGTTTGTAT
CTCACCTCACAGGAGGAACC

Downstream 100 bases:

>100_bases
AATGTCTTTGACCTTCCCAGTAATCAACCCCAGCGATGGCTCCACCATCACCGAGCTAGAAAACCACGATTCCACCCAGT
GGATGTCCGCGCTCTCTGAT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MEDLSYRIPQSRTVAEQVPGPKSKALDERRQAAVARALAPGLPGYVVDADGGILADADGNRFIDLASGIAVTTVGGSNAA
VAKAVGAAAARFTHTCFMVSPYETYVAMAERLNALTPGDHDKKSALFNSGAEAVENAVKVARAYTGKGAVVVFDNAYHGR
TNLTMAMTAKNRPYKSGFGPLAADVYRAPMSYPLRDGLSGPEAAERAISVIESQVGAENLACVVIEPIQGEGGFIVPAPG
FLAAISTWCRENDVVFIADEIQSGFLRTGDWFASDAEGVIPDVITTAKGIAGGMPLSAVTGRAEIMDAPGPGALGGTYGG
NPVACAAALAAIEVMEQADLKTRAQEIEAIIRDEFAQLSAFPEVAEIRGRGAMMAIELIDATGRPNAALTAAVAARAKAE
GVLLLTCGTDGNVIRLLPPLVIAEDTLRDGLQVLVAALERETAHQKVG

Sequences:

>Translated_448_residues
MEDLSYRIPQSRTVAEQVPGPKSKALDERRQAAVARALAPGLPGYVVDADGGILADADGNRFIDLASGIAVTTVGGSNAA
VAKAVGAAAARFTHTCFMVSPYETYVAMAERLNALTPGDHDKKSALFNSGAEAVENAVKVARAYTGKGAVVVFDNAYHGR
TNLTMAMTAKNRPYKSGFGPLAADVYRAPMSYPLRDGLSGPEAAERAISVIESQVGAENLACVVIEPIQGEGGFIVPAPG
FLAAISTWCRENDVVFIADEIQSGFLRTGDWFASDAEGVIPDVITTAKGIAGGMPLSAVTGRAEIMDAPGPGALGGTYGG
NPVACAAALAAIEVMEQADLKTRAQEIEAIIRDEFAQLSAFPEVAEIRGRGAMMAIELIDATGRPNAALTAAVAARAKAE
GVLLLTCGTDGNVIRLLPPLVIAEDTLRDGLQVLVAALERETAHQKVG
>Mature_448_residues
MEDLSYRIPQSRTVAEQVPGPKSKALDERRQAAVARALAPGLPGYVVDADGGILADADGNRFIDLASGIAVTTVGGSNAA
VAKAVGAAAARFTHTCFMVSPYETYVAMAERLNALTPGDHDKKSALFNSGAEAVENAVKVARAYTGKGAVVVFDNAYHGR
TNLTMAMTAKNRPYKSGFGPLAADVYRAPMSYPLRDGLSGPEAAERAISVIESQVGAENLACVVIEPIQGEGGFIVPAPG
FLAAISTWCRENDVVFIADEIQSGFLRTGDWFASDAEGVIPDVITTAKGIAGGMPLSAVTGRAEIMDAPGPGALGGTYGG
NPVACAAALAAIEVMEQADLKTRAQEIEAIIRDEFAQLSAFPEVAEIRGRGAMMAIELIDATGRPNAALTAAVAARAKAE
GVLLLTCGTDGNVIRLLPPLVIAEDTLRDGLQVLVAALERETAHQKVG

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=428, Percent_Identity=33.411214953271, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI284507298, Length=317, Percent_Identity=38.1703470031546, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI24119277, Length=454, Percent_Identity=30.3964757709251, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI13994255, Length=417, Percent_Identity=30.6954436450839, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI37574042, Length=423, Percent_Identity=28.8416075650118, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI226442705, Length=417, Percent_Identity=28.2973621103118, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI226442709, Length=358, Percent_Identity=29.8882681564246, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1789016, Length=415, Percent_Identity=43.1325301204819, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1787560, Length=418, Percent_Identity=43.5406698564593, Blast_Score=338, Evalue=5e-94,
Organism=Escherichia coli, GI145693181, Length=378, Percent_Identity=35.4497354497354, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789759, Length=405, Percent_Identity=32.8395061728395, Blast_Score=188, Evalue=7e-49,
Organism=Escherichia coli, GI1788044, Length=410, Percent_Identity=31.7073170731707, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1786349, Length=352, Percent_Identity=29.5454545454545, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1786991, Length=431, Percent_Identity=29.9303944315545, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32564660, Length=448, Percent_Identity=31.0267857142857, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI25144271, Length=435, Percent_Identity=29.6551724137931, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71992977, Length=431, Percent_Identity=29.9303944315545, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI25144274, Length=297, Percent_Identity=31.986531986532, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17541228, Length=482, Percent_Identity=22.6141078838174, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323470, Length=434, Percent_Identity=29.9539170506912, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6324432, Length=401, Percent_Identity=29.6758104738155, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324386, Length=433, Percent_Identity=25.4041570438799, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21357415, Length=434, Percent_Identity=30.8755760368664, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI161085790, Length=449, Percent_Identity=30.0668151447661, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28574759, Length=448, Percent_Identity=30.3571428571429, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI21356575, Length=433, Percent_Identity=29.3302540415704, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI281366494, Length=468, Percent_Identity=21.3675213675214, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24667139, Length=468, Percent_Identity=21.3675213675214, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24667143, Length=468, Percent_Identity=21.3675213675214, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 46478; Mature: 46478

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDLSYRIPQSRTVAEQVPGPKSKALDERRQAAVARALAPGLPGYVVDADGGILADADGN
CCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEECCCCC
RFIDLASGIAVTTVGGSNAAVAKAVGAAAARFTHTCFMVSPYETYVAMAERLNALTPGDH
EEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHCCCCCCCC
DKKSALFNSGAEAVENAVKVARAYTGKGAVVVFDNAYHGRTNLTMAMTAKNRPYKSGFGP
CHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCH
LAADVYRAPMSYPLRDGLSGPEAAERAISVIESQVGAENLACVVIEPIQGEGGFIVPAPG
HHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEECCCH
FLAAISTWCRENDVVFIADEIQSGFLRTGDWFASDAEGVIPDVITTAKGIAGGMPLSAVT
HHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHC
GRAEIMDAPGPGALGGTYGGNPVACAAALAAIEVMEQADLKTRAQEIEAIIRDEFAQLSA
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FPEVAEIRGRGAMMAIELIDATGRPNAALTAAVAARAKAEGVLLLTCGTDGNVIRLLPPL
CCHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCH
VIAEDTLRDGLQVLVAALERETAHQKVG
HHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEDLSYRIPQSRTVAEQVPGPKSKALDERRQAAVARALAPGLPGYVVDADGGILADADGN
CCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEECCCCC
RFIDLASGIAVTTVGGSNAAVAKAVGAAAARFTHTCFMVSPYETYVAMAERLNALTPGDH
EEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHCCCCCCCC
DKKSALFNSGAEAVENAVKVARAYTGKGAVVVFDNAYHGRTNLTMAMTAKNRPYKSGFGP
CHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCH
LAADVYRAPMSYPLRDGLSGPEAAERAISVIESQVGAENLACVVIEPIQGEGGFIVPAPG
HHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEECCCH
FLAAISTWCRENDVVFIADEIQSGFLRTGDWFASDAEGVIPDVITTAKGIAGGMPLSAVT
HHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHC
GRAEIMDAPGPGALGGTYGGNPVACAAALAAIEVMEQADLKTRAQEIEAIIRDEFAQLSA
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FPEVAEIRGRGAMMAIELIDATGRPNAALTAAVAARAKAEGVLLLTCGTDGNVIRLLPPL
CCHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCH
VIAEDTLRDGLQVLVAALERETAHQKVG
HHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]