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The map label for this gene is wecB [H]

Identifier: 145294479

GI number: 145294479

Start: 472085

End: 473281

Strand: Direct

Name: wecB [H]

Synonym: cgR_0434

Alternate gene names: 145294479

Gene position: 472085-473281 (Clockwise)

Preceding gene: 145294470

Following gene: 145294480

Centisome position: 14.24

GC content: 48.37

Gene sequence:

>1197_bases
ATGCGCAAGCCAAAAATTATGACGGTTTATGGCACTCGGCCTGAAGCTATCAAAGTTGCACCCGTGATTAAAGCCCTTGA
ACAAGACGAACGTTTTGAATCGGTTGCGGTTTCCACTGGCCAGCATAAAGAGATGCTGGATCAGGTGAATGAGATGTTCA
GTATCAAACCTGCATACGATTTAGGGTTGATGAACAAAGTCTCCACTTTGAGCGGAGTTGTATCAAAAGCGCTCGAAGGC
CTTGACGAAATTATTGAAGCAGAGAATCCTGACGTAATTATCTCTCAAGGAGATACCTCCACAGCGATGTCAGCAGCGCT
GGCAGGCTTCCATCGCGAGGTTAAGATTGTTCACCTTGAAGCGGGGCTGCGTACAGGTAACATCCATTCGCCTTTTCCGG
AGGAGGCGAATCGTCGGATTATCGGGCAAGTCTCTGAACTGCATTTAGCACCTACTGAAATATCAAGAGAAAACTTGCGG
CGAGAAAATTTCCGCAGTGCAGATACTGTCGTTGTGGGAAACACCGTCATCGATGCATTGCTTGAAGCTGCCACATGGGA
AACCACATTCGAGGATCAGCGACTTAATGACTTAGTGGAGTCGGATCAACGAATTGTGCTTGTAACCACCCACCGACGTG
AGAATTTGACTGCAATGTCGGAAATTGGTGGAGCTGTACAGCAATTGGCTGAAGCGTATCCTGATGTGATTTTTGCACTC
CCACTTCACCTCAATCCCAAGGTGCGAGATATGGTTCTACCAAAAGTAGATGCTCTTCCAAACGTGATTATCACTGATCC
TCTCCCATACGACCAGTTCACCAAATTGATGGCGTCATCGACATTGGTTTTAACTGACTCTGGTGGAGTCCAGGAGGAAG
CGCCGGCGTTTGGAAAGCCAGTCTTGTGTATGCGCGAAAATACTGAGCGACCGGAAGCGGTTTTGGCTGGAACGGTTAAG
CTCGTGGGCACTAATCAAGCGCGGATCATCACTGAAACCAGGCTGTTGCTAGATGACCCAACCGCATTTAGTGCTATGGC
TCAAGCTATTAATCCCTATGGTGACGGTAAAGCTGCAAAGCGCTCAGTTGCCGCGATTGCAGCATTACTTGGTGTTGGAG
AGCGTCTCCCTGATTTTCAGCCAGAGAAACCTATCGAACCCGGTTTGGATGAGCCCCGTTTGAGTGATCAATTGTGA

Upstream 100 bases:

>100_bases
TGGTTGCGTGAGATGAGCTTCCGGGTCATTTTATTTTGCTCTAAAAGCTCTTAAGAGAAGGTAAAGCTTCTTTGTGGGTT
AAATCTGGATTGGATAATTA

Downstream 100 bases:

>100_bases
AATGAAACCGACTTTTGTGAAACTCATTCGGGAAAGCTGATCAAACCAAAATTCCAAATTGAAGAAGCAATATGAGTACA
ATTGCGCAGTAAGATTGTCT

Product: hypothetical protein

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MRKPKIMTVYGTRPEAIKVAPVIKALEQDERFESVAVSTGQHKEMLDQVNEMFSIKPAYDLGLMNKVSTLSGVVSKALEG
LDEIIEAENPDVIISQGDTSTAMSAALAGFHREVKIVHLEAGLRTGNIHSPFPEEANRRIIGQVSELHLAPTEISRENLR
RENFRSADTVVVGNTVIDALLEAATWETTFEDQRLNDLVESDQRIVLVTTHRRENLTAMSEIGGAVQQLAEAYPDVIFAL
PLHLNPKVRDMVLPKVDALPNVIITDPLPYDQFTKLMASSTLVLTDSGGVQEEAPAFGKPVLCMRENTERPEAVLAGTVK
LVGTNQARIITETRLLLDDPTAFSAMAQAINPYGDGKAAKRSVAAIAALLGVGERLPDFQPEKPIEPGLDEPRLSDQL

Sequences:

>Translated_398_residues
MRKPKIMTVYGTRPEAIKVAPVIKALEQDERFESVAVSTGQHKEMLDQVNEMFSIKPAYDLGLMNKVSTLSGVVSKALEG
LDEIIEAENPDVIISQGDTSTAMSAALAGFHREVKIVHLEAGLRTGNIHSPFPEEANRRIIGQVSELHLAPTEISRENLR
RENFRSADTVVVGNTVIDALLEAATWETTFEDQRLNDLVESDQRIVLVTTHRRENLTAMSEIGGAVQQLAEAYPDVIFAL
PLHLNPKVRDMVLPKVDALPNVIITDPLPYDQFTKLMASSTLVLTDSGGVQEEAPAFGKPVLCMRENTERPEAVLAGTVK
LVGTNQARIITETRLLLDDPTAFSAMAQAINPYGDGKAAKRSVAAIAALLGVGERLPDFQPEKPIEPGLDEPRLSDQL
>Mature_398_residues
MRKPKIMTVYGTRPEAIKVAPVIKALEQDERFESVAVSTGQHKEMLDQVNEMFSIKPAYDLGLMNKVSTLSGVVSKALEG
LDEIIEAENPDVIISQGDTSTAMSAALAGFHREVKIVHLEAGLRTGNIHSPFPEEANRRIIGQVSELHLAPTEISRENLR
RENFRSADTVVVGNTVIDALLEAATWETTFEDQRLNDLVESDQRIVLVTTHRRENLTAMSEIGGAVQQLAEAYPDVIFAL
PLHLNPKVRDMVLPKVDALPNVIITDPLPYDQFTKLMASSTLVLTDSGGVQEEAPAFGKPVLCMRENTERPEAVLAGTVK
LVGTNQARIITETRLLLDDPTAFSAMAQAINPYGDGKAAKRSVAAIAALLGVGERLPDFQPEKPIEPGLDEPRLSDQL

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=369, Percent_Identity=46.6124661246612, Blast_Score=329, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 43483; Mature: 43483

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKPKIMTVYGTRPEAIKVAPVIKALEQDERFESVAVSTGQHKEMLDQVNEMFSIKPAYD
CCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCHH
LGLMNKVSTLSGVVSKALEGLDEIIEAENPDVIISQGDTSTAMSAALAGFHREVKIVHLE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCEEEEEEEE
AGLRTGNIHSPFPEEANRRIIGQVSELHLAPTEISRENLRRENFRSADTVVVGNTVIDAL
CCCCCCCCCCCCCHHHCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECHHHHHHH
LEAATWETTFEDQRLNDLVESDQRIVLVTTHRRENLTAMSEIGGAVQQLAEAYPDVIFAL
HHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEE
PLHLNPKVRDMVLPKVDALPNVIITDPLPYDQFTKLMASSTLVLTDSGGVQEEAPAFGKP
CCCCCCCHHHHHCCCHHCCCCEEEECCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCC
VLCMRENTERPEAVLAGTVKLVGTNQARIITETRLLLDDPTAFSAMAQAINPYGDGKAAK
EEEECCCCCCCHHHHEEEEEEEECCCEEEEEEEEEEECCCHHHHHHHHHHCCCCCCHHHH
RSVAAIAALLGVGERLPDFQPEKPIEPGLDEPRLSDQL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRKPKIMTVYGTRPEAIKVAPVIKALEQDERFESVAVSTGQHKEMLDQVNEMFSIKPAYD
CCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCHH
LGLMNKVSTLSGVVSKALEGLDEIIEAENPDVIISQGDTSTAMSAALAGFHREVKIVHLE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCEEEEEEEE
AGLRTGNIHSPFPEEANRRIIGQVSELHLAPTEISRENLRRENFRSADTVVVGNTVIDAL
CCCCCCCCCCCCCHHHCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECHHHHHHH
LEAATWETTFEDQRLNDLVESDQRIVLVTTHRRENLTAMSEIGGAVQQLAEAYPDVIFAL
HHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEE
PLHLNPKVRDMVLPKVDALPNVIITDPLPYDQFTKLMASSTLVLTDSGGVQEEAPAFGKP
CCCCCCCHHHHHCCCHHCCCCEEEECCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCC
VLCMRENTERPEAVLAGTVKLVGTNQARIITETRLLLDDPTAFSAMAQAINPYGDGKAAK
EEEECCCCCCCHHHHEEEEEEEECCCEEEEEEEEEEECCCHHHHHHHHHHCCCCCCHHHH
RSVAAIAALLGVGERLPDFQPEKPIEPGLDEPRLSDQL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]