Click here to switch to the map view.

The map label for this gene is hsrA [H]

Identifier: 145294289

GI number: 145294289

Start: 265319

End: 266680

Strand: Direct

Name: hsrA [H]

Synonym: cgR_0245

Alternate gene names: 145294289

Gene position: 265319-266680 (Clockwise)

Preceding gene: 145294288

Following gene: 145294290

Centisome position: 8.01

GC content: 55.36

Gene sequence:

>1362_bases
ATGCGCAATGATCGGTCCTTTAGCGTTCCCATTGCGCTGCTTGCCGCGGGAGCACTGTTTCTAGAAATCCTCGACGGCAC
CATCCTGACAACCGCAGTCCCAGCTATTGCTCGTGACTTCGGTATTGACGCCGTGGATGTCAGCATCGCCCTGGTTGCGT
ACTTGGCAGCCGCAGCAGCTGGTATTCCGGCTGCAGGGTGGCTGGCGGATCGATTTGGTGTGCGTAAAGTGCTATTACTG
GCTTTAGCGGTGTTCACTGCTGCCTCCTTGGTGTGCGCGGTCGCGCCGGGGCTGACTGTGCTTACCGGTGCTCGCGTTAT
CCAAGGTCTTGGTGGTGCACTACTCGTCCCAGTCGGGCGATTAGCAGTAATCCGGGGAACTGACCCCAAGGATCTCCTCG
ATGCCATCGCGTTTTTAACCTGGCCGGCTCTGGTTGCCCCAGTGATTGCCCCACTTCTGGGAGGCCTGATTGCCGACACC
ATTGGTTGGCGATGGATCTTCCTACTCAACGTGCCTTTAGGAATCGTCGCGATCATTGCTGGACTATTCATCCTGCCCAA
GCACACCGCAGTGGAAGTCAAACGTTTTGATCTCCCAGGTTTCCTCGGCGCAATGCTAGTGATGGTGGGGCTGACCGTGG
CTGCTGAATTAATTTCCAGGGGAAGCCCGGCCGAACTCGTTGTTGCCGGGTGCTTGATTTTCAGTGCAGCAATCGTGTGC
GGTTTTGTAGTGCGCTGGCTACGAGTTCCAGGCAGGCTTTTTGATCTCAGCATCATGCGCATCCCAGGCTTCCGGGTAGG
TAATTCCTCCGGCAGTGTCTACCGCTTGGTAATCACCGCAGCACCATTCATGTTCACCCTGCTCTTCCAGGTGGCGTTTG
GGTGGTCTGCAACATTAGCGGGTGCCATGGTGGTCGCACTATTCGCAGGAAATGTGGCCATCAAACCTTTCACCACGCCG
ATCATTAAGCGTTGGAATTTCAAACCAGTACTGGTCTTTTCTAACGCTGCTGGCGCCTTGGTATTGGCATCATTCTTGTT
CGTTCGCGTAGATACTCCACTGGTGCTCATTGCGCTGCTGCTCTTTGTTTCGGGCGCATTAAGATCCCTCGGTTTCAGCG
CCTACAACACCTTGCAGTTTGTCGATATCTCACCAGAACAAACCAGCAACGCCAACGTGTTATCAGCAACCCTGCACCAA
CTAGGCATGTCTTTGGGTATTGCGGTAGCAGTCATCGCCATGTCCCTTGCACCCACCGCCAACTGGGCATTCCCACTGGC
AGCAGCGTTGTTCCTCATTCCTTTAATCGGCGCACTATCTTTGCCTCGCGACGGCGGTGCCCGAGCCTTTTCCTCCTCTT
AG

Upstream 100 bases:

>100_bases
CGCATAGAGTTATCTCGAAACTACCAAGACGGTTTCTTTTCTTTAGATCTAAGGAGGAGAGACCGTCTTTCACCCTTTCA
TCTGATTGGACATCGACGCC

Downstream 100 bases:

>100_bases
AAACCCACTTCTGAAAGGTATAAAAACATGACTATTCGAATCGGACTCGTTGGCTACGGTGTCGGCGGCAGGCTCTTTCA
CACCCCTTACATCCAAGCTT

Product: hypothetical protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MRNDRSFSVPIALLAAGALFLEILDGTILTTAVPAIARDFGIDAVDVSIALVAYLAAAAAGIPAAGWLADRFGVRKVLLL
ALAVFTAASLVCAVAPGLTVLTGARVIQGLGGALLVPVGRLAVIRGTDPKDLLDAIAFLTWPALVAPVIAPLLGGLIADT
IGWRWIFLLNVPLGIVAIIAGLFILPKHTAVEVKRFDLPGFLGAMLVMVGLTVAAELISRGSPAELVVAGCLIFSAAIVC
GFVVRWLRVPGRLFDLSIMRIPGFRVGNSSGSVYRLVITAAPFMFTLLFQVAFGWSATLAGAMVVALFAGNVAIKPFTTP
IIKRWNFKPVLVFSNAAGALVLASFLFVRVDTPLVLIALLLFVSGALRSLGFSAYNTLQFVDISPEQTSNANVLSATLHQ
LGMSLGIAVAVIAMSLAPTANWAFPLAAALFLIPLIGALSLPRDGGARAFSSS

Sequences:

>Translated_453_residues
MRNDRSFSVPIALLAAGALFLEILDGTILTTAVPAIARDFGIDAVDVSIALVAYLAAAAAGIPAAGWLADRFGVRKVLLL
ALAVFTAASLVCAVAPGLTVLTGARVIQGLGGALLVPVGRLAVIRGTDPKDLLDAIAFLTWPALVAPVIAPLLGGLIADT
IGWRWIFLLNVPLGIVAIIAGLFILPKHTAVEVKRFDLPGFLGAMLVMVGLTVAAELISRGSPAELVVAGCLIFSAAIVC
GFVVRWLRVPGRLFDLSIMRIPGFRVGNSSGSVYRLVITAAPFMFTLLFQVAFGWSATLAGAMVVALFAGNVAIKPFTTP
IIKRWNFKPVLVFSNAAGALVLASFLFVRVDTPLVLIALLLFVSGALRSLGFSAYNTLQFVDISPEQTSNANVLSATLHQ
LGMSLGIAVAVIAMSLAPTANWAFPLAAALFLIPLIGALSLPRDGGARAFSSS
>Mature_453_residues
MRNDRSFSVPIALLAAGALFLEILDGTILTTAVPAIARDFGIDAVDVSIALVAYLAAAAAGIPAAGWLADRFGVRKVLLL
ALAVFTAASLVCAVAPGLTVLTGARVIQGLGGALLVPVGRLAVIRGTDPKDLLDAIAFLTWPALVAPVIAPLLGGLIADT
IGWRWIFLLNVPLGIVAIIAGLFILPKHTAVEVKRFDLPGFLGAMLVMVGLTVAAELISRGSPAELVVAGCLIFSAAIVC
GFVVRWLRVPGRLFDLSIMRIPGFRVGNSSGSVYRLVITAAPFMFTLLFQVAFGWSATLAGAMVVALFAGNVAIKPFTTP
IIKRWNFKPVLVFSNAAGALVLASFLFVRVDTPLVLIALLLFVSGALRSLGFSAYNTLQFVDISPEQTSNANVLSATLHQ
LGMSLGIAVAVIAMSLAPTANWAFPLAAALFLIPLIGALSLPRDGGARAFSSS

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=397, Percent_Identity=34.0050377833753, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI1788392, Length=397, Percent_Identity=32.7455919395466, Blast_Score=198, Evalue=7e-52,
Organism=Escherichia coli, GI1789042, Length=316, Percent_Identity=29.1139240506329, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788710, Length=317, Percent_Identity=28.7066246056782, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI87081983, Length=312, Percent_Identity=29.4871794871795, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790146, Length=156, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321663, Length=159, Percent_Identity=28.9308176100629, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322958, Length=171, Percent_Identity=29.8245614035088, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47176; Mature: 47176

Theoretical pI: Translated: 10.56; Mature: 10.56

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNDRSFSVPIALLAAGALFLEILDGTILTTAVPAIARDFGIDAVDVSIALVAYLAAAAA
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GIPAAGWLADRFGVRKVLLLALAVFTAASLVCAVAPGLTVLTGARVIQGLGGALLVPVGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHEECCCC
LAVIRGTDPKDLLDAIAFLTWPALVAPVIAPLLGGLIADTIGWRWIFLLNVPLGIVAIIA
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
GLFILPKHTAVEVKRFDLPGFLGAMLVMVGLTVAAELISRGSPAELVVAGCLIFSAAIVC
HHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GFVVRWLRVPGRLFDLSIMRIPGFRVGNSSGSVYRLVITAAPFMFTLLFQVAFGWSATLA
HHHHHHHHCCCHHEEEEEEECCCEEECCCCCCEEEEHHHHHHHHHHHHHHHHHCHHHHHH
GAMVVALFAGNVAIKPFTTPIIKRWNFKPVLVFSNAAGALVLASFLFVRVDTPLVLIALL
HHHHHHHHHCCEEECCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHH
LFVSGALRSLGFSAYNTLQFVDISPEQTSNANVLSATLHQLGMSLGIAVAVIAMSLAPTA
HHHHHHHHHCCHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NWAFPLAAALFLIPLIGALSLPRDGGARAFSSS
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MRNDRSFSVPIALLAAGALFLEILDGTILTTAVPAIARDFGIDAVDVSIALVAYLAAAAA
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GIPAAGWLADRFGVRKVLLLALAVFTAASLVCAVAPGLTVLTGARVIQGLGGALLVPVGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHEECCCC
LAVIRGTDPKDLLDAIAFLTWPALVAPVIAPLLGGLIADTIGWRWIFLLNVPLGIVAIIA
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
GLFILPKHTAVEVKRFDLPGFLGAMLVMVGLTVAAELISRGSPAELVVAGCLIFSAAIVC
HHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GFVVRWLRVPGRLFDLSIMRIPGFRVGNSSGSVYRLVITAAPFMFTLLFQVAFGWSATLA
HHHHHHHHCCCHHEEEEEEECCCEEECCCCCCEEEEHHHHHHHHHHHHHHHHHCHHHHHH
GAMVVALFAGNVAIKPFTTPIIKRWNFKPVLVFSNAAGALVLASFLFVRVDTPLVLIALL
HHHHHHHHHCCEEECCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHH
LFVSGALRSLGFSAYNTLQFVDISPEQTSNANVLSATLHQLGMSLGIAVAVIAMSLAPTA
HHHHHHHHHCCHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NWAFPLAAALFLIPLIGALSLPRDGGARAFSSS
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]