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The map label for this gene is merR1 [H]

Identifier: 145294207

GI number: 145294207

Start: 179933

End: 180322

Strand: Direct

Name: merR1 [H]

Synonym: cgR_0164

Alternate gene names: 145294207

Gene position: 179933-180322 (Clockwise)

Preceding gene: 145294205

Following gene: 145294208

Centisome position: 5.43

GC content: 67.44

Gene sequence:

>390_bases
ATGCGGATCGGAGAACTCGCCGAGAGGGCGGGCACTACCGCGAAGACCCTTCGCTTCTACGAGGAACAGGGCCTTCTGCC
CCCGACCGAGCGCACGCCGTCCGGATACCGCGACTACGCGCCCGAGACGGTCGCTCGGATCGACTTCGTCCACCGCGGCC
AGGCCGCGGGCCTCACCCTCGCCCAGATCCGCCAGATCCTCGACATCCGCGACGGCGGCCATGCGCCCTGCGAGCACGTG
CGCGACCTGCTTGACGTGCGCCTCGCTGAGATCGAGCAGCAGATCGCGCAGCTCTCCGTGCTGCGCGACACTATCGCGGA
CCTCAGACAGGACGCCGCGCACCCGGACCCTGAAACGTGCAGCACCGATCAAGTGTGTAGGTACTTGTAA

Upstream 100 bases:

>100_bases
ATCGCTGCTCCTGTTAACTCTTGGCTTTCTGCTCTGTCTCAGCCATACTGGACCTTCCAGTACAGGGGAAGGTCAAGCGC
GGCCACGGAGGGAGACAGCA

Downstream 100 bases:

>100_bases
TCCAATTGGGCACACCTCCTTAGCAACCACGCTATGCGAGAGTTGCAGCTCGACGAGAGCAAAGATGGCAGGATTGATCA
CCAGGATCGATCTTTAAATA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 129; Mature: 129

Protein sequence:

>129_residues
MRIGELAERAGTTAKTLRFYEEQGLLPPTERTPSGYRDYAPETVARIDFVHRGQAAGLTLAQIRQILDIRDGGHAPCEHV
RDLLDVRLAEIEQQIAQLSVLRDTIADLRQDAAHPDPETCSTDQVCRYL

Sequences:

>Translated_129_residues
MRIGELAERAGTTAKTLRFYEEQGLLPPTERTPSGYRDYAPETVARIDFVHRGQAAGLTLAQIRQILDIRDGGHAPCEHV
RDLLDVRLAEIEQQIAQLSVLRDTIADLRQDAAHPDPETCSTDQVCRYL
>Mature_129_residues
MRIGELAERAGTTAKTLRFYEEQGLLPPTERTPSGYRDYAPETVARIDFVHRGQAAGLTLAQIRQILDIRDGGHAPCEHV
RDLLDVRLAEIEQQIAQLSVLRDTIADLRQDAAHPDPETCSTDQVCRYL

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=108, Percent_Identity=35.1851851851852, Blast_Score=74, Evalue=4e-15,
Organism=Escherichia coli, GI1786695, Length=120, Percent_Identity=27.5, Blast_Score=62, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14467; Mature: 14467

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGELAERAGTTAKTLRFYEEQGLLPPTERTPSGYRDYAPETVARIDFVHRGQAAGLTL
CCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCH
AQIRQILDIRDGGHAPCEHVRDLLDVRLAEIEQQIAQLSVLRDTIADLRQDAAHPDPETC
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
STDQVCRYL
CHHHHHHCC
>Mature Secondary Structure
MRIGELAERAGTTAKTLRFYEEQGLLPPTERTPSGYRDYAPETVARIDFVHRGQAAGLTL
CCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCH
AQIRQILDIRDGGHAPCEHVRDLLDVRLAEIEQQIAQLSVLRDTIADLRQDAAHPDPETC
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
STDQVCRYL
CHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2492496; 2305262 [H]