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The map label for this gene is glyQS

Identifier: 138897004

GI number: 138897004

Start: 3480975

End: 3482375

Strand: Reverse

Name: glyQS

Synonym: GTNG_3375

Alternate gene names: 138897004

Gene position: 3482375-3480975 (Counterclockwise)

Preceding gene: 138897005

Following gene: 138897003

Centisome position: 98.09

GC content: 49.61

Gene sequence:

>1401_bases
ATGGAGGAGGATGATGACATGGCTGCAACAATGGAAGAAATCGTTGCCCACGCCAAGCATCGCGGCTTCGTGTTTCCGGG
GTCGGAAATTTACGGTGGGCTGGCGAACACATGGGATTACGGTCCGCTCGGTGTCGAGCTGAAAAATAACATTAAACGGG
CGTGGTGGAAAAAGTTCGTCCAAGAATCGCCACACAATGTCGGTTTGGACGCTGCCATTTTAATGAACCCAAAAACGTGG
GAAGCATCCGGCCATTTAGGCAACTTCAACGATCCGATGGTCGACTGCAAACAGTGTAAAGCGCGTCATCGCGCCGACAA
GCTGATTGAGCAGGCACTTGAAGAAAAAGGAATTGAGATGGTCGTTGACGGTTTGCCGCTTGCCAAGATGGAAGAGCTTA
TCCGTGAATACGACATCGCTTGTCCAGAATGCGGCAGTCGTGACTTTACGAACGTGCGTCAGTTTAATTTAATGTTCAAA
ACATACCAAGGTGTCACCGAATCAAGCGCTAACGAAATTTATTTGCGCCCGGAGACGGCCCAAGGTATTTTTGTCAACTT
TAAAAACGTCCAGCGCACGATGCGCAAAAAATTACCGTTTGGCATCGCGCAAATCGGAAAAAGTTTCCGCAACGAAATTA
CGCCAGGGAACTTTACGTTCCGCACACGTGAATTTGAACAAATGGAGCTTGAGTTTTTCTGCAAACCGGGCGAAGAGCTG
AAATGGTTCGACTACTGGAAACAATTTTGCAAGGAATGGCTGTTGTCGCTCGGCATGAACGAAGAACATATCCGCCTGCG
CGACCATACGAAAGAAGAATTATCCCACTATAGTAATGCGACGACTGATATCGAGTATCAGTTCCCGTTCGGCTGGGGCG
AGCTCTGGGGTATTGCGTCGCGCACCGATTACGACTTAAAACAGCATATGGAACACTCCGGTGAGGATTTCCATTATCTT
GACCAAGAAACGAATGAGCGCTACATCCCGTACTGCATTGAGCCGTCGCTCGGTGCCGACCGTGTCACGCTCGCGTTTAT
GATTGACGCCTATGACGAGGAAGAGCTCGAAGACGGCACGACCCGGACAGTTATGCATTTGCATCCAGCGCTTGCGCCGT
ACAAAGCAGCTGTCTTGCCGTTATCGAAAAAGCTGGGTGACGGAGCGCGCCGAATTTATGAAGAGCTCGCGAAGCATTTC
ATGGTCGACTACGATGAAACAGGTTCGATTGGCAAGCGGTATCGTCGTCAAGATGAAATCGGCACGCCGTTTTGTATCAC
GTACGACTTTGAGTCCGAGCAAGATGGCCAAGTAACCGTTCGTGACCGTGACACGATGGAACAAGTGCGGTTGCCGATTG
GGGAGCTCAAAGCCTTTTTGGATAAAAAAATTGCCTTTTAA

Upstream 100 bases:

>100_bases
CCATTGGCGCATCAACTAGGGTGGAACCGCGGGAGCTACGCTCTCGTCCCTAGGCAGTAAGCCTAGGGGCGAGGGCGTTT
TTGATTGTTGGAAATCGAAT

Downstream 100 bases:

>100_bases
TGAAATGGGCGGGGTTGACTCAAAAGATATAGAATGGTGAATCTGTCAATGCGCATATACAGTCATGGAGAAAGGGTATC
TCATTGTTTTTGAGATGCCC

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MEEDDDMAATMEEIVAHAKHRGFVFPGSEIYGGLANTWDYGPLGVELKNNIKRAWWKKFVQESPHNVGLDAAILMNPKTW
EASGHLGNFNDPMVDCKQCKARHRADKLIEQALEEKGIEMVVDGLPLAKMEELIREYDIACPECGSRDFTNVRQFNLMFK
TYQGVTESSANEIYLRPETAQGIFVNFKNVQRTMRKKLPFGIAQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGEEL
KWFDYWKQFCKEWLLSLGMNEEHIRLRDHTKEELSHYSNATTDIEYQFPFGWGELWGIASRTDYDLKQHMEHSGEDFHYL
DQETNERYIPYCIEPSLGADRVTLAFMIDAYDEEELEDGTTRTVMHLHPALAPYKAAVLPLSKKLGDGARRIYEELAKHF
MVDYDETGSIGKRYRRQDEIGTPFCITYDFESEQDGQVTVRDRDTMEQVRLPIGELKAFLDKKIAF

Sequences:

>Translated_466_residues
MEEDDDMAATMEEIVAHAKHRGFVFPGSEIYGGLANTWDYGPLGVELKNNIKRAWWKKFVQESPHNVGLDAAILMNPKTW
EASGHLGNFNDPMVDCKQCKARHRADKLIEQALEEKGIEMVVDGLPLAKMEELIREYDIACPECGSRDFTNVRQFNLMFK
TYQGVTESSANEIYLRPETAQGIFVNFKNVQRTMRKKLPFGIAQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGEEL
KWFDYWKQFCKEWLLSLGMNEEHIRLRDHTKEELSHYSNATTDIEYQFPFGWGELWGIASRTDYDLKQHMEHSGEDFHYL
DQETNERYIPYCIEPSLGADRVTLAFMIDAYDEEELEDGTTRTVMHLHPALAPYKAAVLPLSKKLGDGARRIYEELAKHF
MVDYDETGSIGKRYRRQDEIGTPFCITYDFESEQDGQVTVRDRDTMEQVRLPIGELKAFLDKKIAF
>Mature_466_residues
MEEDDDMAATMEEIVAHAKHRGFVFPGSEIYGGLANTWDYGPLGVELKNNIKRAWWKKFVQESPHNVGLDAAILMNPKTW
EASGHLGNFNDPMVDCKQCKARHRADKLIEQALEEKGIEMVVDGLPLAKMEELIREYDIACPECGSRDFTNVRQFNLMFK
TYQGVTESSANEIYLRPETAQGIFVNFKNVQRTMRKKLPFGIAQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGEEL
KWFDYWKQFCKEWLLSLGMNEEHIRLRDHTKEELSHYSNATTDIEYQFPFGWGELWGIASRTDYDLKQHMEHSGEDFHYL
DQETNERYIPYCIEPSLGADRVTLAFMIDAYDEEELEDGTTRTVMHLHPALAPYKAAVLPLSKKLGDGARRIYEELAKHF
MVDYDETGSIGKRYRRQDEIGTPFCITYDFESEQDGQVTVRDRDTMEQVRLPIGELKAFLDKKIAF

Specific function: Catalyzes the attachment of glycine to tRNA(Gly)

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI116805340, Length=368, Percent_Identity=31.7934782608696, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI70887790, Length=316, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI32564541, Length=348, Percent_Identity=31.8965517241379, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17554996, Length=348, Percent_Identity=31.8965517241379, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6325338, Length=358, Percent_Identity=30.4469273743017, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6319597, Length=397, Percent_Identity=29.4710327455919, Blast_Score=149, Evalue=7e-37,
Organism=Drosophila melanogaster, GI21357965, Length=363, Percent_Identity=33.6088154269972, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24664462, Length=363, Percent_Identity=33.6088154269972, Blast_Score=183, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYG_GEOTN (A4ITQ8)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001127457.1
- ProteinModelPortal:   A4ITQ8
- SMR:   A4ITQ8
- STRING:   A4ITQ8
- GeneID:   4968297
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_3375
- NMPDR:   fig|420246.5.peg.3227
- eggNOG:   COG0423
- HOGENOM:   HBG319978
- OMA:   GSEWGEL
- PhylomeDB:   A4ITQ8
- ProtClustDB:   PRK04173
- BioCyc:   GTHE420246:GTNG_3375-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00253_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR10745
- PRINTS:   PR01043
- TIGRFAMs:   TIGR00389

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.14

Molecular weight: Translated: 54164; Mature: 54164

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 104-104 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEDDDMAATMEEIVAHAKHRGFVFPGSEIYGGLANTWDYGPLGVELKNNIKRAWWKKFV
CCCCHHHHHHHHHHHHHHHHCCEECCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QESPHNVGLDAAILMNPKTWEASGHLGNFNDPMVDCKQCKARHRADKLIEQALEEKGIEM
HCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEE
VVDGLPLAKMEELIREYDIACPECGSRDFTNVRQFNLMFKTYQGVTESSANEIYLRPETA
EECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCC
QGIFVNFKNVQRTMRKKLPFGIAQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGEEL
CEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCHHHHHCCCEEECCCCCC
KWFDYWKQFCKEWLLSLGMNEEHIRLRDHTKEELSHYSNATTDIEYQFPFGWGELWGIAS
HHHHHHHHHHHHHHHHCCCCCCCEEHHHCCHHHHHHHCCCCCEEEEECCCCHHHHHCCCC
RTDYDLKQHMEHSGEDFHYLDQETNERYIPYCIEPSLGADRVTLAFMIDAYDEEELEDGT
CCCHHHHHHHHCCCCCCEECCCCCCCCCCCEEECCCCCCCCEEEEEEEECCCHHHHCCCC
TRTVMHLHPALAPYKAAVLPLSKKLGDGARRIYEELAKHFMVDYDETGSIGKRYRRQDEI
CEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHCC
GTPFCITYDFESEQDGQVTVRDRDTMEQVRLPIGELKAFLDKKIAF
CCCEEEEEECCCCCCCEEEECCHHHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MEEDDDMAATMEEIVAHAKHRGFVFPGSEIYGGLANTWDYGPLGVELKNNIKRAWWKKFV
CCCCHHHHHHHHHHHHHHHHCCEECCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QESPHNVGLDAAILMNPKTWEASGHLGNFNDPMVDCKQCKARHRADKLIEQALEEKGIEM
HCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEE
VVDGLPLAKMEELIREYDIACPECGSRDFTNVRQFNLMFKTYQGVTESSANEIYLRPETA
EECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCC
QGIFVNFKNVQRTMRKKLPFGIAQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGEEL
CEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCHHHHHCCCEEECCCCCC
KWFDYWKQFCKEWLLSLGMNEEHIRLRDHTKEELSHYSNATTDIEYQFPFGWGELWGIAS
HHHHHHHHHHHHHHHHCCCCCCCEEHHHCCHHHHHHHCCCCCEEEEECCCCHHHHHCCCC
RTDYDLKQHMEHSGEDFHYLDQETNERYIPYCIEPSLGADRVTLAFMIDAYDEEELEDGT
CCCHHHHHHHHCCCCCCEECCCCCCCCCCCEEECCCCCCCCEEEEEEEECCCHHHHCCCC
TRTVMHLHPALAPYKAAVLPLSKKLGDGARRIYEELAKHFMVDYDETGSIGKRYRRQDEI
CEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHCC
GTPFCITYDFESEQDGQVTVRDRDTMEQVRLPIGELKAFLDKKIAF
CCCEEEEEECCCCCCCEEEECCHHHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA