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The map label for this gene is pyrG [H]

Identifier: 138896965

GI number: 138896965

Start: 3438933

End: 3440528

Strand: Reverse

Name: pyrG [H]

Synonym: GTNG_3334

Alternate gene names: 138896965

Gene position: 3440528-3438933 (Counterclockwise)

Preceding gene: 138896966

Following gene: 138896963

Centisome position: 96.91

GC content: 51.63

Gene sequence:

>1596_bases
ATGACAAAGTACATTTTTGTGACGGGCGGTGTCGTTTCTTCGCTAGGAAAAGGAATTACGGCTGCGTCGCTCGGACGGCT
ATTGAAAAACCGTGGATTGAACGTGACGATCCAAAAGTTTGACCCGTACATTAACGTTGACCCAGGAACCATGAGCCCGT
ACCAGCACGGTGAAGTGTTTGTCACCGATGACGGCGCGGAAACGGATTTAGACTTAGGGCATTATGAGCGGTTTATCGAT
ATTAATTTGAACAAATACAGCAACGTCACCACCGGAAAAATTTATTCCGCCGTTATCCGTAAAGAGCGGCGCGGCGACTA
CTTAGGTGGTACGGTGCAAGTCATCCCGCACATTACGAATGAAATCAAAGAGCGCGTCTTCCGCGCCGGGAAGGAAACGA
ACGCCGATGTCGTAATTACGGAGATTGGCGGTACAGTCGGTGACATCGAGTCGCTTCCGTTTTTGGAGGCCATTCGTCAA
ATCAAGAGCGATGTTGGCCGCGAAAATGTCATGTACATTCATTGTACGCTCGTGCCGTACATTAAAGCGGCTGGAGAAAT
GAAAACGAAGCCGACGCAGCATAGCGTGAAAGAACTGCGCAGCCTCGGCATTCAACCGAACATCATTGTCGTGCGCACGG
AAATGCCGATGCCACAAGAAATGAAAGACAAAATTGCACTGTTTTGCGATATCGACCCGAAAGCGGTCATTGAATCGTAC
GACGCGGATACGCTATATGCTGTTCCGCTCATGCTGCAAGAACAAAAGCTTGACCAAATCGTCTGCGAACATTTGCGCCT
CAACTGCCGCGAAGCGGATATGACGGAATGGAAAGCGCTCGTGGAGAAAGTGCGCAACTTATCGAAAACGACGAAAATCG
CCCTCGTCGGCAAATACGTCGAACTGCCGGACGCTTACATCTCGGTCGTTGAAGCGCTCCGTCATGCCGGCTATGCGTTT
GATACGGACATTGACATCCAATGGGTCAATGCGGAACATGTGACGCGCGACAATGTGGCCGAGCTGTTAAAAGATGCTGA
TGGCATTCTCGTTCCGGGCGGGTTCGGCGACCGCGGTGTTGAAGGGAAAATTGAAGCGATTCGCTATGCCCGTGAACAGC
GTGTGCCGTTCTTAGGCATTTGCTTAGGGATGCAGCTCGCTTCGATCGAATTTGCTCGTCATGTCGTCGGCCTCACCGGC
GCCCATTCGGCTGAATTTGACCCGAATACGCCGCATCCAATCATCGACTTGCTTCCGGAACAAAAAGATGTCGAAGATTT
AGGCGGTACGCTCCGTCTCGGCTTGTACCCGTGCAAGCTGCAAGAAGGGACGCTTGCCCATGCTGCGTACGGCGATGAAG
TCATTTATGAACGCCATCGTCATCGGTACGAATTTAACAACCAATACAGAAACTTAATGGAAGAGCATGGCTTCGTCTTC
TCTGGCACAAGCCCGGACGGACGGCTTGTTGAAGTCATTGAGCTGAAAGACCATCCATGGTTTGTCGCTGCTCAGTTCCA
TCCGGAGTTCACTTCGCGTCCGACGCGGCCGCAGCCGCTGTTCCGCGAGTTTGTCAAAGCGTCGCTAAAACAGTGA

Upstream 100 bases:

>100_bases
AATAATCGCTCCCTTACATATCGTAAGTGGAGCGTTTTTTATTTGCGCCTTTCGCAAACACTGAAACTGTTACTGTAATT
TCGGCAAGGGGGAAGACAAG

Downstream 100 bases:

>100_bases
CGAAAAAACGGTGTCCGTTTGTCGGACACCGTTTTTTGATGGTTTCATTCGATGGACGCACCTGTTTTCATAGCGGTGGT
TACTTATACTCCTCCAAAAT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MTKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
INLNKYSNVTTGKIYSAVIRKERRGDYLGGTVQVIPHITNEIKERVFRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ
IKSDVGRENVMYIHCTLVPYIKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPMPQEMKDKIALFCDIDPKAVIESY
DADTLYAVPLMLQEQKLDQIVCEHLRLNCREADMTEWKALVEKVRNLSKTTKIALVGKYVELPDAYISVVEALRHAGYAF
DTDIDIQWVNAEHVTRDNVAELLKDADGILVPGGFGDRGVEGKIEAIRYAREQRVPFLGICLGMQLASIEFARHVVGLTG
AHSAEFDPNTPHPIIDLLPEQKDVEDLGGTLRLGLYPCKLQEGTLAHAAYGDEVIYERHRHRYEFNNQYRNLMEEHGFVF
SGTSPDGRLVEVIELKDHPWFVAAQFHPEFTSRPTRPQPLFREFVKASLKQ

Sequences:

>Translated_531_residues
MTKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
INLNKYSNVTTGKIYSAVIRKERRGDYLGGTVQVIPHITNEIKERVFRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ
IKSDVGRENVMYIHCTLVPYIKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPMPQEMKDKIALFCDIDPKAVIESY
DADTLYAVPLMLQEQKLDQIVCEHLRLNCREADMTEWKALVEKVRNLSKTTKIALVGKYVELPDAYISVVEALRHAGYAF
DTDIDIQWVNAEHVTRDNVAELLKDADGILVPGGFGDRGVEGKIEAIRYAREQRVPFLGICLGMQLASIEFARHVVGLTG
AHSAEFDPNTPHPIIDLLPEQKDVEDLGGTLRLGLYPCKLQEGTLAHAAYGDEVIYERHRHRYEFNNQYRNLMEEHGFVF
SGTSPDGRLVEVIELKDHPWFVAAQFHPEFTSRPTRPQPLFREFVKASLKQ
>Mature_530_residues
TKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDI
NLNKYSNVTTGKIYSAVIRKERRGDYLGGTVQVIPHITNEIKERVFRAGKETNADVVITEIGGTVGDIESLPFLEAIRQI
KSDVGRENVMYIHCTLVPYIKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPMPQEMKDKIALFCDIDPKAVIESYD
ADTLYAVPLMLQEQKLDQIVCEHLRLNCREADMTEWKALVEKVRNLSKTTKIALVGKYVELPDAYISVVEALRHAGYAFD
TDIDIQWVNAEHVTRDNVAELLKDADGILVPGGFGDRGVEGKIEAIRYAREQRVPFLGICLGMQLASIEFARHVVGLTGA
HSAEFDPNTPHPIIDLLPEQKDVEDLGGTLRLGLYPCKLQEGTLAHAAYGDEVIYERHRHRYEFNNQYRNLMEEHGFVFS
GTSPDGRLVEVIELKDHPWFVAAQFHPEFTSRPTRPQPLFREFVKASLKQ

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=548, Percent_Identity=47.992700729927, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI28559085, Length=547, Percent_Identity=47.3491773308958, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI28559083, Length=547, Percent_Identity=47.3491773308958, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI221316689, Length=547, Percent_Identity=47.3491773308958, Blast_Score=511, Evalue=1e-145,
Organism=Escherichia coli, GI1789142, Length=537, Percent_Identity=57.1694599627561, Blast_Score=612, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI25148299, Length=604, Percent_Identity=40.7284768211921, Blast_Score=436, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319432, Length=560, Percent_Identity=46.4285714285714, Blast_Score=497, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6322563, Length=561, Percent_Identity=45.9893048128342, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24664469, Length=548, Percent_Identity=47.4452554744526, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI21357815, Length=493, Percent_Identity=45.4361054766734, Blast_Score=433, Evalue=1e-121,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59681; Mature: 59550

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVF
CCEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSAVIRKERRGDYLGGTVQVIPHITN
EECCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHEEHHHHHH
EIKERVFRAGKETNADVVITEIGGTVGDIESLPFLEAIRQIKSDVGRENVMYIHCTLVPY
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHH
IKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPMPQEMKDKIALFCDIDPKAVIESY
HHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHCCEEEEECCCHHHHHHCC
DADTLYAVPLMLQEQKLDQIVCEHLRLNCREADMTEWKALVEKVRNLSKTTKIALVGKYV
CCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECHH
ELPDAYISVVEALRHAGYAFDTDIDIQWVNAEHVTRDNVAELLKDADGILVPGGFGDRGV
HCCHHHHHHHHHHHHCCCEECCCCEEEEECCCCCCHHHHHHHHHCCCCEEECCCCCCCCC
EGKIEAIRYAREQRVPFLGICLGMQLASIEFARHVVGLTGAHSAEFDPNTPHPIIDLLPE
CCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCC
QKDVEDLGGTLRLGLYPCKLQEGTLAHAAYGDEVIYERHRHRYEFNNQYRNLMEEHGFVF
CCCHHHCCCEEEEEEEEEECCCCCEEEHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCEEE
SGTSPDGRLVEVIELKDHPWFVAAQFHPEFTSRPTRPQPLFREFVKASLKQ
ECCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVF
CEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSAVIRKERRGDYLGGTVQVIPHITN
EECCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHEEHHHHHH
EIKERVFRAGKETNADVVITEIGGTVGDIESLPFLEAIRQIKSDVGRENVMYIHCTLVPY
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHH
IKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPMPQEMKDKIALFCDIDPKAVIESY
HHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHCCEEEEECCCHHHHHHCC
DADTLYAVPLMLQEQKLDQIVCEHLRLNCREADMTEWKALVEKVRNLSKTTKIALVGKYV
CCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECHH
ELPDAYISVVEALRHAGYAFDTDIDIQWVNAEHVTRDNVAELLKDADGILVPGGFGDRGV
HCCHHHHHHHHHHHHCCCEECCCCEEEEECCCCCCHHHHHHHHHCCCCEEECCCCCCCCC
EGKIEAIRYAREQRVPFLGICLGMQLASIEFARHVVGLTGAHSAEFDPNTPHPIIDLLPE
CCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCC
QKDVEDLGGTLRLGLYPCKLQEGTLAHAAYGDEVIYERHRHRYEFNNQYRNLMEEHGFVF
CCCHHHCCCEEEEEEEEEECCCCCEEEHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCEEE
SGTSPDGRLVEVIELKDHPWFVAAQFHPEFTSRPTRPQPLFREFVKASLKQ
ECCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA