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The map label for this gene is hisA [H]

Identifier: 138896659

GI number: 138896659

Start: 3118293

End: 3119030

Strand: Reverse

Name: hisA [H]

Synonym: GTNG_3022

Alternate gene names: 138896659

Gene position: 3119030-3118293 (Counterclockwise)

Preceding gene: 138896660

Following gene: 138896658

Centisome position: 87.85

GC content: 57.32

Gene sequence:

>738_bases
ATGGCATCGTTTACGATTTACCCGGCCATCGATATGCGCGGCGGCAAATGTGTTCGCCTGCTGCAAGGTGATTACAACAA
AGAAACGGTGTACGGTGATTCACCAGTCGCGATGGCTGAGCAATTCGCCGCCCAAGGGGCAGAGTGGATTCATATGGTGG
ATTTGGATGGGGCCAAAGAAGGACGCCGGGTGAACGATCGGTTTGTGATTGAAGCGGCCAATCGGCTTTCGGTGAATGTC
CAAGTCGGCGGCGGCATTCGTACGGAGGAAGATGTCGCTTACTATTTGGAACGCGGCGTCGCCCGTGTCATCTTAGGGAG
TGCCGCCATTTCCAATCCGACGTTTGTGAAAAAGATGTTGCAAACGTACGGCCGCCGCATCGTCATCGGCATCGACGCTC
GCGACGGCTTCGTGGCGACAGAAGGCTGGCTTGAGACGTCGAACGTGAAAGCGGAAGAGCTCGGCCAAATGCTTGCTGAA
GCGGGGGCGGAGACGTTTATTTTCACCGATATTGCCACTGATGGCACGCTGTCGGGGCCGAACATCACCGCTGCGGTCCG
GTTGGCGGAGGCGACTGGAAAAGAAGTCATCGCCTCCGGTGGCGTCCGTTCTCTGGATGATTTGCGCGCGCTCCGCGAAT
ACGCCGAACAAGGCATCGGTGGGGCGATCGTTGGCAAGGCGCTGTACACAAACCAATTTACGCTCGCGGAAGCGTTAAAG
GCGGTGAACGAGCGGTGA

Upstream 100 bases:

>100_bases
ATGTGTTTGGCACACAGTTTCATCCGGAAAAAAGCGGCGCGGTCGGCATGAGCATTTTGAACCGTTATGTCGGCATCGTC
ACAGGAAGGGAGAATGGCTG

Downstream 100 bases:

>100_bases
TCACGAAGCGCATCATTCCGTGCTTGGATGTGAAAGACGGCCGCGTTGTCAAAGGGGTGCAGTTCGTTCAGTTGCGCGAT
GCTGGTGATCCAGTCGAACT

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MASFTIYPAIDMRGGKCVRLLQGDYNKETVYGDSPVAMAEQFAAQGAEWIHMVDLDGAKEGRRVNDRFVIEAANRLSVNV
QVGGGIRTEEDVAYYLERGVARVILGSAAISNPTFVKKMLQTYGRRIVIGIDARDGFVATEGWLETSNVKAEELGQMLAE
AGAETFIFTDIATDGTLSGPNITAAVRLAEATGKEVIASGGVRSLDDLRALREYAEQGIGGAIVGKALYTNQFTLAEALK
AVNER

Sequences:

>Translated_245_residues
MASFTIYPAIDMRGGKCVRLLQGDYNKETVYGDSPVAMAEQFAAQGAEWIHMVDLDGAKEGRRVNDRFVIEAANRLSVNV
QVGGGIRTEEDVAYYLERGVARVILGSAAISNPTFVKKMLQTYGRRIVIGIDARDGFVATEGWLETSNVKAEELGQMLAE
AGAETFIFTDIATDGTLSGPNITAAVRLAEATGKEVIASGGVRSLDDLRALREYAEQGIGGAIVGKALYTNQFTLAEALK
AVNER
>Mature_244_residues
ASFTIYPAIDMRGGKCVRLLQGDYNKETVYGDSPVAMAEQFAAQGAEWIHMVDLDGAKEGRRVNDRFVIEAANRLSVNVQ
VGGGIRTEEDVAYYLERGVARVILGSAAISNPTFVKKMLQTYGRRIVIGIDARDGFVATEGWLETSNVKAEELGQMLAEA
GAETFIFTDIATDGTLSGPNITAAVRLAEATGKEVIASGGVRSLDDLRALREYAEQGIGGAIVGKALYTNQFTLAEALKA
VNER

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=244, Percent_Identity=39.7540983606557, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1788336, Length=252, Percent_Identity=23.8095238095238, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26344; Mature: 26213

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASFTIYPAIDMRGGKCVRLLQGDYNKETVYGDSPVAMAEQFAAQGAEWIHMVDLDGAKE
CCCEEEEEEEECCCCCEEEEECCCCCCCEEECCCCHHHHHHHHHCCCCEEEEEECCCCCC
GRRVNDRFVIEAANRLSVNVQVGGGIRTEEDVAYYLERGVARVILGSAAISNPTFVKKML
CCCCCCEEEEEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QTYGRRIVIGIDARDGFVATEGWLETSNVKAEELGQMLAEAGAETFIFTDIATDGTLSGP
HHCCCEEEEEEECCCCEEEECCEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
NITAAVRLAEATGKEVIASGGVRSLDDLRALREYAEQGIGGAIVGKALYTNQFTLAEALK
CEEEEEEEHHHCCHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHH
AVNER
HHCCC
>Mature Secondary Structure 
ASFTIYPAIDMRGGKCVRLLQGDYNKETVYGDSPVAMAEQFAAQGAEWIHMVDLDGAKE
CCEEEEEEEECCCCCEEEEECCCCCCCEEECCCCHHHHHHHHHCCCCEEEEEECCCCCC
GRRVNDRFVIEAANRLSVNVQVGGGIRTEEDVAYYLERGVARVILGSAAISNPTFVKKML
CCCCCCEEEEEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QTYGRRIVIGIDARDGFVATEGWLETSNVKAEELGQMLAEAGAETFIFTDIATDGTLSGP
HHCCCEEEEEEECCCCEEEECCEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
NITAAVRLAEATGKEVIASGGVRSLDDLRALREYAEQGIGGAIVGKALYTNQFTLAEALK
CEEEEEEEHHHCCHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHH
AVNER
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA