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The map label for this gene is fadE [H]

Identifier: 138896595

GI number: 138896595

Start: 3054631

End: 3056415

Strand: Reverse

Name: fadE [H]

Synonym: GTNG_2958

Alternate gene names: 138896595

Gene position: 3056415-3054631 (Counterclockwise)

Preceding gene: 138896596

Following gene: 138896594

Centisome position: 86.09

GC content: 51.65

Gene sequence:

>1785_bases
ATGGCAAAAACGGTCGAAAATGCGATTCAAGGCGGCAGCTTTTTAATTGAGGACATTCCGGCGGAGCGTGTGTTTACGCC
GGAAGATTTCACCGATGAGCATCAAATGATCGCCAAGACAACGGAAGAGTACGTCAACAACGAAGTGCTTCCACAGCTCG
AGCATCTCGAAAACCATGAGTTTGATCGCTCGGTGAAACTGCTTCGCAAGGCGGGCGAACTTGGGCTGTTGAGCGCCGAC
ATCCCGGAGGAGTACGGTGGGTTAGGACTGGACAAAGTGAGCTCTGCCATCATTGCCGAACATATGGCGCCGGCCGGCGG
TTTCGCCATTTCGCACGGGGCGCACGTCGGCATCGGATCGCTGCCGATTGTCTTGTTCGGTACGGAAGAACAAAAACAAA
AATATTTGCCGTATTTAGCGACTGGAGAAAAGATTGCCGCTTACGCTTTAACCGAACCGGGCTCCGGTTCCGACGCGCTT
GGGGCAAAAACGACGGCGAAATTGAACGCCGAAGGGACGCATTACATTTTAAACGGTGAAAAACAATGGATCACCAACTC
CGGCTTCGCTGATGTATTTGTCGTTTACGCGAAAGTGGACGGCCAGCATTTCACCGCGTTCATCGTCGAGCGCGACTTCC
CGGGCGTCTCAACCGGTCCGGAAGAAAAGAAAATGGGGATTAAAAGCTCGTCAACAAGGACGCTCATTTTGCAAGATGTG
CCGGTGCCGAAAGAAAACGTGCTCGGTGAAATCGGCAAAGGCCATGTCATCGCCTTCAACATTTTGAACATCGGCCGCTA
CAAACTCGGTCTCGGGGCGGTCGGCGGGGCGAAACGGGCGCTTGAAATCACGCTGAAATACGCCAACCAACGCCAGCAAT
TCAAGCGACCGATTTCGAAGTTTACGCTGACGCAAGAAAAATTCGCGACGATGGCAGCGCGGCTGTACGCGGCGGAAAGC
TCCGTCTACCGCACGGTCGGTTTGTTCGATGAACGGATGGGCTTGCTTGATGCGGAAAAAGCGAAGGACGGCAAAGAAAT
TGCCAAGTCCATCGCTGAATATGCGATCGAATGCTCATTGAACAAGTTTTTCTCCACTGAAGTGCTCGATTACATTGTTG
ATGAAGGGGTACAAATTCACGGCGGCTACGGCTTTATGCAAGAGTATGAAATCGAGCGCGCTTATCGCGATTCGCGCATT
AACCGCATTTTTGAAGGGACGAATGAAATCAACCGCCTGCTCGTGCCGGGCATGTATTTGAAAAAAGCCATGAAAGGCGA
GCTGCCGCTCTTCCAAAAAGCGCAACAGCTGCAAGAAGAGCTCATGATGATGACGGCCGAGGAACCGGGTTCAGGGGTGC
TTGAGCAAGAGAAATATTTGGTGCGCAACGCGAAAAAGATCGCTTTGATGGTCGCTGGCTTAGCGGTGCAAAAATACGGT
CAACGGATCGAGGAAGAACAAGAAGTGCTTGTCAATATCGCTGATATCGTTTCCAACATTTATGCGATGGAATCGGCGCT
TTTGCGCACAGAAAAAGCAATTCAAGCGAGCGGGGAAGAGAAAAACAAGCAAAAAGTGTTGTATACGCAAATTTTCTGCC
AAGAGGCGTTCAATGAAATCGAAGCCCATGCGAAAGAAACGCTCGTTGCCGTGGAGCAAGGCGACACGCTTCGGATGATG
CTCGCCGCTCTCCGTCGGTTGACGCGTCATACCCCGATCAACGTGATCGCGAAAAAACGCGAAGCGGCTGCAGCCCTCAT
TGAAGCAGAACAGTATATTGTGTGA

Upstream 100 bases:

>100_bases
AGGCGTCTTTGAACTGCTGTGATGTGAAGTCAATAGAAAATCCAGCGGGCGGCGCTGCCGCCCGGGTAATCACACGATAG
TTGGAGGAGGAAAATAAACA

Downstream 100 bases:

>100_bases
TAATAGGAAGTACCAGGTTTGTCCTGGTACTTCTTTCTGTCAGAAGCAGGTAGCAATGGTTCGGAAAAATGGGGACAGCC
GATCAATTGTTTCCGTTAAC

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MAKTVENAIQGGSFLIEDIPAERVFTPEDFTDEHQMIAKTTEEYVNNEVLPQLEHLENHEFDRSVKLLRKAGELGLLSAD
IPEEYGGLGLDKVSSAIIAEHMAPAGGFAISHGAHVGIGSLPIVLFGTEEQKQKYLPYLATGEKIAAYALTEPGSGSDAL
GAKTTAKLNAEGTHYILNGEKQWITNSGFADVFVVYAKVDGQHFTAFIVERDFPGVSTGPEEKKMGIKSSSTRTLILQDV
PVPKENVLGEIGKGHVIAFNILNIGRYKLGLGAVGGAKRALEITLKYANQRQQFKRPISKFTLTQEKFATMAARLYAAES
SVYRTVGLFDERMGLLDAEKAKDGKEIAKSIAEYAIECSLNKFFSTEVLDYIVDEGVQIHGGYGFMQEYEIERAYRDSRI
NRIFEGTNEINRLLVPGMYLKKAMKGELPLFQKAQQLQEELMMMTAEEPGSGVLEQEKYLVRNAKKIALMVAGLAVQKYG
QRIEEEQEVLVNIADIVSNIYAMESALLRTEKAIQASGEEKNKQKVLYTQIFCQEAFNEIEAHAKETLVAVEQGDTLRMM
LAALRRLTRHTPINVIAKKREAAAALIEAEQYIV

Sequences:

>Translated_594_residues
MAKTVENAIQGGSFLIEDIPAERVFTPEDFTDEHQMIAKTTEEYVNNEVLPQLEHLENHEFDRSVKLLRKAGELGLLSAD
IPEEYGGLGLDKVSSAIIAEHMAPAGGFAISHGAHVGIGSLPIVLFGTEEQKQKYLPYLATGEKIAAYALTEPGSGSDAL
GAKTTAKLNAEGTHYILNGEKQWITNSGFADVFVVYAKVDGQHFTAFIVERDFPGVSTGPEEKKMGIKSSSTRTLILQDV
PVPKENVLGEIGKGHVIAFNILNIGRYKLGLGAVGGAKRALEITLKYANQRQQFKRPISKFTLTQEKFATMAARLYAAES
SVYRTVGLFDERMGLLDAEKAKDGKEIAKSIAEYAIECSLNKFFSTEVLDYIVDEGVQIHGGYGFMQEYEIERAYRDSRI
NRIFEGTNEINRLLVPGMYLKKAMKGELPLFQKAQQLQEELMMMTAEEPGSGVLEQEKYLVRNAKKIALMVAGLAVQKYG
QRIEEEQEVLVNIADIVSNIYAMESALLRTEKAIQASGEEKNKQKVLYTQIFCQEAFNEIEAHAKETLVAVEQGDTLRMM
LAALRRLTRHTPINVIAKKREAAAALIEAEQYIV
>Mature_593_residues
AKTVENAIQGGSFLIEDIPAERVFTPEDFTDEHQMIAKTTEEYVNNEVLPQLEHLENHEFDRSVKLLRKAGELGLLSADI
PEEYGGLGLDKVSSAIIAEHMAPAGGFAISHGAHVGIGSLPIVLFGTEEQKQKYLPYLATGEKIAAYALTEPGSGSDALG
AKTTAKLNAEGTHYILNGEKQWITNSGFADVFVVYAKVDGQHFTAFIVERDFPGVSTGPEEKKMGIKSSSTRTLILQDVP
VPKENVLGEIGKGHVIAFNILNIGRYKLGLGAVGGAKRALEITLKYANQRQQFKRPISKFTLTQEKFATMAARLYAAESS
VYRTVGLFDERMGLLDAEKAKDGKEIAKSIAEYAIECSLNKFFSTEVLDYIVDEGVQIHGGYGFMQEYEIERAYRDSRIN
RIFEGTNEINRLLVPGMYLKKAMKGELPLFQKAQQLQEELMMMTAEEPGSGVLEQEKYLVRNAKKIALMVAGLAVQKYGQ
RIEEEQEVLVNIADIVSNIYAMESALLRTEKAIQASGEEKNKQKVLYTQIFCQEAFNEIEAHAKETLVAVEQGDTLRMML
AALRRLTRHTPINVIAKKREAAAALIEAEQYIV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=579, Percent_Identity=34.7150259067358, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI4557235, Length=497, Percent_Identity=36.0160965794769, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI76496475, Length=497, Percent_Identity=36.0160965794769, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI4557233, Length=421, Percent_Identity=35.3919239904988, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI7656849, Length=393, Percent_Identity=34.6055979643766, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI187960098, Length=402, Percent_Identity=34.3283582089552, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI4557231, Length=402, Percent_Identity=34.3283582089552, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI226958412, Length=394, Percent_Identity=33.248730964467, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI226958414, Length=376, Percent_Identity=34.0425531914894, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI4501859, Length=393, Percent_Identity=32.0610687022901, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI4501857, Length=407, Percent_Identity=31.4496314496315, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI4503943, Length=391, Percent_Identity=30.9462915601023, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI7669494, Length=369, Percent_Identity=31.4363143631436, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI48976061, Length=431, Percent_Identity=24.8259860788863, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI211971008, Length=431, Percent_Identity=24.8259860788863, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI38505218, Length=354, Percent_Identity=25.9887005649718, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786223, Length=363, Percent_Identity=29.7520661157025, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI87081958, Length=391, Percent_Identity=27.6214833759591, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI87081702, Length=359, Percent_Identity=26.7409470752089, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082384, Length=324, Percent_Identity=25.3086419753086, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71985184, Length=523, Percent_Identity=36.5200764818356, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71985192, Length=317, Percent_Identity=42.2712933753943, Blast_Score=224, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI17534899, Length=375, Percent_Identity=36.2666666666667, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17569725, Length=408, Percent_Identity=34.8039215686275, Blast_Score=221, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI17570075, Length=387, Percent_Identity=34.8837209302326, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17538396, Length=392, Percent_Identity=32.9081632653061, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17506239, Length=393, Percent_Identity=34.3511450381679, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17508101, Length=389, Percent_Identity=32.9048843187661, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17533517, Length=387, Percent_Identity=28.6821705426357, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17534353, Length=392, Percent_Identity=30.3571428571429, Blast_Score=168, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI32563615, Length=238, Percent_Identity=40.7563025210084, Blast_Score=161, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71990804, Length=259, Percent_Identity=38.2239382239382, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71982178, Length=283, Percent_Identity=33.5689045936396, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17505929, Length=390, Percent_Identity=25.6410256410256, Blast_Score=122, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17551932, Length=386, Percent_Identity=29.0155440414508, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17531909, Length=252, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17540912, Length=356, Percent_Identity=23.314606741573, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI86563383, Length=336, Percent_Identity=23.8095238095238, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI86563381, Length=336, Percent_Identity=23.8095238095238, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281363737, Length=475, Percent_Identity=36.6315789473684, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI21356377, Length=416, Percent_Identity=35.5769230769231, Blast_Score=249, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24646207, Length=400, Percent_Identity=36.5, Blast_Score=238, Evalue=8e-63,
Organism=Drosophila melanogaster, GI24660351, Length=411, Percent_Identity=35.036496350365, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24666513, Length=390, Percent_Identity=33.8461538461538, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI21355753, Length=394, Percent_Identity=32.741116751269, Blast_Score=200, Evalue=3e-51,
Organism=Drosophila melanogaster, GI19920834, Length=286, Percent_Identity=35.6643356643357, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24652780, Length=505, Percent_Identity=22.7722772277228, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45550141, Length=312, Percent_Identity=24.3589743589744, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221473076, Length=312, Percent_Identity=24.3589743589744, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 65816; Mature: 65685

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTVENAIQGGSFLIEDIPAERVFTPEDFTDEHQMIAKTTEEYVNNEVLPQLEHLENHE
CCCCHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCC
FDRSVKLLRKAGELGLLSADIPEEYGGLGLDKVSSAIIAEHMAPAGGFAISHGAHVGIGS
HHHHHHHHHHCCCCCEEECCCCHHHCCCCHHHHHHHHHHHHCCCCCCCEECCCCEECCCC
LPIVLFGTEEQKQKYLPYLATGEKIAAYALTEPGSGSDALGAKTTAKLNAEGTHYILNGE
CCEEEECCCHHHHHCCCEEECCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCEEEECCC
KQWITNSGFADVFVVYAKVDGQHFTAFIVERDFPGVSTGPEEKKMGIKSSSTRTLILQDV
HHEECCCCCCEEEEEEEEECCCEEEEEEEEECCCCCCCCCHHHHCCCCCCCCCEEEEECC
PVPKENVLGEIGKGHVIAFNILNIGRYKLGLGAVGGAKRALEITLKYANQRQQFKRPISK
CCCHHHHHHCCCCCCEEEEEEEECCCEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHH
FTLTQEKFATMAARLYAAESSVYRTVGLFDERMGLLDAEKAKDGKEIAKSIAEYAIECSL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHH
NKFFSTEVLDYIVDEGVQIHGGYGFMQEYEIERAYRDSRINRIFEGTNEINRLLVPGMYL
HHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHH
KKAMKGELPLFQKAQQLQEELMMMTAEEPGSGVLEQEKYLVRNAKKIALMVAGLAVQKYG
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRIEEEQEVLVNIADIVSNIYAMESALLRTEKAIQASGEEKNKQKVLYTQIFCQEAFNEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
EAHAKETLVAVEQGDTLRMMLAALRRLTRHTPINVIAKKREAAAALIEAEQYIV
HHHHHHHEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKTVENAIQGGSFLIEDIPAERVFTPEDFTDEHQMIAKTTEEYVNNEVLPQLEHLENHE
CCCHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCC
FDRSVKLLRKAGELGLLSADIPEEYGGLGLDKVSSAIIAEHMAPAGGFAISHGAHVGIGS
HHHHHHHHHHCCCCCEEECCCCHHHCCCCHHHHHHHHHHHHCCCCCCCEECCCCEECCCC
LPIVLFGTEEQKQKYLPYLATGEKIAAYALTEPGSGSDALGAKTTAKLNAEGTHYILNGE
CCEEEECCCHHHHHCCCEEECCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCEEEECCC
KQWITNSGFADVFVVYAKVDGQHFTAFIVERDFPGVSTGPEEKKMGIKSSSTRTLILQDV
HHEECCCCCCEEEEEEEEECCCEEEEEEEEECCCCCCCCCHHHHCCCCCCCCCEEEEECC
PVPKENVLGEIGKGHVIAFNILNIGRYKLGLGAVGGAKRALEITLKYANQRQQFKRPISK
CCCHHHHHHCCCCCCEEEEEEEECCCEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHH
FTLTQEKFATMAARLYAAESSVYRTVGLFDERMGLLDAEKAKDGKEIAKSIAEYAIECSL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHH
NKFFSTEVLDYIVDEGVQIHGGYGFMQEYEIERAYRDSRINRIFEGTNEINRLLVPGMYL
HHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHH
KKAMKGELPLFQKAQQLQEELMMMTAEEPGSGVLEQEKYLVRNAKKIALMVAGLAVQKYG
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRIEEEQEVLVNIADIVSNIYAMESALLRTEKAIQASGEEKNKQKVLYTQIFCQEAFNEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
EAHAKETLVAVEQGDTLRMMLAALRRLTRHTPINVIAKKREAAAALIEAEQYIV
HHHHHHHEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]