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The map label for this gene is thrB [H]

Identifier: 138896549

GI number: 138896549

Start: 3017002

End: 3017916

Strand: Reverse

Name: thrB [H]

Synonym: GTNG_2912

Alternate gene names: 138896549

Gene position: 3017916-3017002 (Counterclockwise)

Preceding gene: 138896550

Following gene: 138896547

Centisome position: 85.0

GC content: 55.96

Gene sequence:

>915_bases
ATGAAAGAAGATGAGATGTTAAAAATCGTCGTTCCGGGAAGTACGGCGAACTTAGGGCCCGGCTTCGATTCGGTTGGGCT
CGCCGTCTCCCGTTACTTAACGCTTGACGTCCGCCTGGCGAGAACGTGGTCGTTTACGCCAAAAACAGCGGAAGTAAGCG
ACATTCCGCGCGGGACGGACAATTTAGTATACAAAGTGGCCAATGAGACGGCGAAAGCGCATGGCCGTCAGCTGCCGAGC
TGTGAGGTGGATGTATACAGCGATATTCCGTTTACGCGGGGGCTCGGAAGCAGTGCGGCAGCGGTCGTCGCTGGTATTGA
GCTTGCTGATGCGCTGCTTGAATTAGGATTGACGCGCGAACAAAAAATGGAACTAGCCACTCGTTATGAAGGCCATCCCG
ACAATGTCGGTGCCTCGCTATACGGCGGATTGGTCATCGGTTGCTACCGCGAAGCGGGTGTGGACGTCGTTCATGTTCCG
GAATTGGCTATTGAACTTGTCGCCATTATCCCGGCGTATGAATTGGAAACAAAAAAAGCGCGCGGGCAGTTGCCTGAACA
ATGGATGAGGCAGCAAGCGGTCGAGGCGAGCGCCATCAGCAATGTTCTTGTCGCCGCGTTGTTGACGAAAAACTGGAAAC
TAGCGGGTCGCATGATGGCAGCCGATTTGTTTCACCAGCCATACCGAAAATCACTTGTCCCGGAATTGGAGCGGGCCCAA
GCGCTGGCTGAGGAATACGAGGCGATTGGCGCCGCGTTAAGCGGGGCGGGACCGACGGTGCTTGTGTTCGCTGAACCGGG
AAAAGGCGAACAGCTTGAACGGCAGCTGCGCCCGCATTTCCCTGCCTGCGAAGTCACATGGCTCGCTATTGAACCGCACG
GTAGCCGCGTGTACAAACTGGCGCTTGAGGCGTAA

Upstream 100 bases:

>100_bases
AAGACCCGGCCGTCGCCCTCGATACCGCAGCGATTGAACCGATCGTGCTGCCGAACGATGAACAAGTCGTGCTGGAGCAT
TTGCAAGGGGTTGTTCATAC

Downstream 100 bases:

>100_bases
AAAAATCCGAACAGCGGTGGGCTGTTCGGATTTTTTTGAGATTAAAACACTTGCTCGACCTCAACGACGCCTGGCACTTC
TTCAAACAAGGCGCGCTCGA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKEDEMLKIVVPGSTANLGPGFDSVGLAVSRYLTLDVRLARTWSFTPKTAEVSDIPRGTDNLVYKVANETAKAHGRQLPS
CEVDVYSDIPFTRGLGSSAAAVVAGIELADALLELGLTREQKMELATRYEGHPDNVGASLYGGLVIGCYREAGVDVVHVP
ELAIELVAIIPAYELETKKARGQLPEQWMRQQAVEASAISNVLVAALLTKNWKLAGRMMAADLFHQPYRKSLVPELERAQ
ALAEEYEAIGAALSGAGPTVLVFAEPGKGEQLERQLRPHFPACEVTWLAIEPHGSRVYKLALEA

Sequences:

>Translated_304_residues
MKEDEMLKIVVPGSTANLGPGFDSVGLAVSRYLTLDVRLARTWSFTPKTAEVSDIPRGTDNLVYKVANETAKAHGRQLPS
CEVDVYSDIPFTRGLGSSAAAVVAGIELADALLELGLTREQKMELATRYEGHPDNVGASLYGGLVIGCYREAGVDVVHVP
ELAIELVAIIPAYELETKKARGQLPEQWMRQQAVEASAISNVLVAALLTKNWKLAGRMMAADLFHQPYRKSLVPELERAQ
ALAEEYEAIGAALSGAGPTVLVFAEPGKGEQLERQLRPHFPACEVTWLAIEPHGSRVYKLALEA
>Mature_304_residues
MKEDEMLKIVVPGSTANLGPGFDSVGLAVSRYLTLDVRLARTWSFTPKTAEVSDIPRGTDNLVYKVANETAKAHGRQLPS
CEVDVYSDIPFTRGLGSSAAAVVAGIELADALLELGLTREQKMELATRYEGHPDNVGASLYGGLVIGCYREAGVDVVHVP
ELAIELVAIIPAYELETKKARGQLPEQWMRQQAVEASAISNVLVAALLTKNWKLAGRMMAADLFHQPYRKSLVPELERAQ
ALAEEYEAIGAALSGAGPTVLVFAEPGKGEQLERQLRPHFPACEVTWLAIEPHGSRVYKLALEA

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=274, Percent_Identity=27.3722627737226, Blast_Score=92, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321814, Length=345, Percent_Identity=31.5942028985507, Blast_Score=135, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 32946; Mature: 32946

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEDEMLKIVVPGSTANLGPGFDSVGLAVSRYLTLDVRLARTWSFTPKTAEVSDIPRGTD
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHEEEEEEEEEEECCCCCCCCCCCCCCCCC
NLVYKVANETAKAHGRQLPSCEVDVYSDIPFTRGLGSSAAAVVAGIELADALLELGLTRE
HHEEEHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHH
QKMELATRYEGHPDNVGASLYGGLVIGCYREAGVDVVHVPELAIELVAIIPAYELETKKA
HHHHHHHHCCCCCCCCCHHHHCCEEEEEEHHCCCCEEEHHHHHHHHHHHHCCHHHHHHHH
RGQLPEQWMRQQAVEASAISNVLVAALLTKNWKLAGRMMAADLFHQPYRKSLVPELERAQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ALAEEYEAIGAALSGAGPTVLVFAEPGKGEQLERQLRPHFPACEVTWLAIEPHGSRVYKL
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCCCCEEEEEEEECCCCEEEEE
ALEA
EECC
>Mature Secondary Structure
MKEDEMLKIVVPGSTANLGPGFDSVGLAVSRYLTLDVRLARTWSFTPKTAEVSDIPRGTD
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHEEEEEEEEEEECCCCCCCCCCCCCCCCC
NLVYKVANETAKAHGRQLPSCEVDVYSDIPFTRGLGSSAAAVVAGIELADALLELGLTRE
HHEEEHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHH
QKMELATRYEGHPDNVGASLYGGLVIGCYREAGVDVVHVPELAIELVAIIPAYELETKKA
HHHHHHHHCCCCCCCCCHHHHCCEEEEEEHHCCCCEEEHHHHHHHHHHHHCCHHHHHHHH
RGQLPEQWMRQQAVEASAISNVLVAALLTKNWKLAGRMMAADLFHQPYRKSLVPELERAQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ALAEEYEAIGAALSGAGPTVLVFAEPGKGEQLERQLRPHFPACEVTWLAIEPHGSRVYKL
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCCCCEEEEEEEECCCCEEEEE
ALEA
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA