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The map label for this gene is thyA [H]

Identifier: 138895327

GI number: 138895327

Start: 1762167

End: 1762961

Strand: Reverse

Name: thyA [H]

Synonym: GTNG_1671

Alternate gene names: 138895327

Gene position: 1762961-1762167 (Counterclockwise)

Preceding gene: 138895328

Following gene: 138895326

Centisome position: 49.66

GC content: 50.57

Gene sequence:

>795_bases
TTGCGGCAATATTTACAGTTATTAGAAGACATTTTGGAAAACGGTGTCGAAAAGGAGGATCGAACCGGTGTCGGCACGTT
GTCGGTGTTCGGTCGCCAGCTCCGTTTTAACTTGCAGGACGGGTTTCCGCTCGTGACGACGAAAAAATTACATATTCGTT
CGATTATTTATGAATTGCTCTGGTTTTTAAAAGGTGACACCAATGTCCGCTATTTGCAGGAGAATGGCGTGACGATTTGG
GACGAATGGGCCGACGAAAACGGCGATCTAGGGCCTGTCTATGGAGCACAATGGCGGTCATGGAAAGGGGCGGACGGGAA
AACGGTCGACCAAATCGCTTCGGTCGTTGAGGAGATCAAGAGAAATCCGAACTCGCGTCGACTGCTCGTGAACGCCTGGA
ATGTGGCGGAGTTAGACAAGATGAAGTTGCCGCCGTGCCATTATGCGTTTCAGTTTTACGTCGCTAACGGCCGGTTGTCA
TGCATGTGGCAGCAGCGCTCCGTCGATACATTTTTAGGGCTGCCGTTTAACATCGCCAGCTACGCGCTCTTGACGCATAT
GATTGCCGAGCAGTGCGGGCTGGATGTTGGTGAATTGATTTTCACCGGTGGGGATGTTCACTTGTATAAAAACCATATTG
AGCAAGCTAAACTGCAGCTGACGCGCGAGCCGCGACCGCTGCCGAAGCTTGTGCTGAAACGGAAGCCGTCGTCCATTTTT
GACTATGAATATGACGATTTTGAAATCGTCGGTTATGACCCTCATCCGACGATTAAAGCGCCAGTGGCGGTGTAA

Upstream 100 bases:

>100_bases
CAACTGGCGGAACGAGCCTCATAAGAAGGCTCTTTTTTTTGTGATGAGGGCGGTGCTTTATGAGGTGCTTTATGATATGA
TAAAGCGTGAGGTGAGGACA

Downstream 100 bases:

>100_bases
AGGAGAGAAGACGATGATTTCGCACATTGTGGCGATGGATGAAAACCGGGTGATCGGCAAAGATAATCAGTTGCCGTGGC
ATTTGCCGGCCGATTTAGCG

Product: thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MRQYLQLLEDILENGVEKEDRTGVGTLSVFGRQLRFNLQDGFPLVTTKKLHIRSIIYELLWFLKGDTNVRYLQENGVTIW
DEWADENGDLGPVYGAQWRSWKGADGKTVDQIASVVEEIKRNPNSRRLLVNAWNVAELDKMKLPPCHYAFQFYVANGRLS
CMWQQRSVDTFLGLPFNIASYALLTHMIAEQCGLDVGELIFTGGDVHLYKNHIEQAKLQLTREPRPLPKLVLKRKPSSIF
DYEYDDFEIVGYDPHPTIKAPVAV

Sequences:

>Translated_264_residues
MRQYLQLLEDILENGVEKEDRTGVGTLSVFGRQLRFNLQDGFPLVTTKKLHIRSIIYELLWFLKGDTNVRYLQENGVTIW
DEWADENGDLGPVYGAQWRSWKGADGKTVDQIASVVEEIKRNPNSRRLLVNAWNVAELDKMKLPPCHYAFQFYVANGRLS
CMWQQRSVDTFLGLPFNIASYALLTHMIAEQCGLDVGELIFTGGDVHLYKNHIEQAKLQLTREPRPLPKLVLKRKPSSIF
DYEYDDFEIVGYDPHPTIKAPVAV
>Mature_264_residues
MRQYLQLLEDILENGVEKEDRTGVGTLSVFGRQLRFNLQDGFPLVTTKKLHIRSIIYELLWFLKGDTNVRYLQENGVTIW
DEWADENGDLGPVYGAQWRSWKGADGKTVDQIASVVEEIKRNPNSRRLLVNAWNVAELDKMKLPPCHYAFQFYVANGRLS
CMWQQRSVDTFLGLPFNIASYALLTHMIAEQCGLDVGELIFTGGDVHLYKNHIEQAKLQLTREPRPLPKLVLKRKPSSIF
DYEYDDFEIVGYDPHPTIKAPVAV

Specific function: Provides the sole de novo source of dTMP for DNA biosynthesis [H]

COG id: COG0207

COG function: function code F; Thymidylate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate synthase family. Bacterial- type thyA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507751, Length=283, Percent_Identity=52.2968197879859, Blast_Score=285, Evalue=4e-77,
Organism=Escherichia coli, GI1789191, Length=264, Percent_Identity=69.3181818181818, Blast_Score=416, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71993377, Length=283, Percent_Identity=45.583038869258, Blast_Score=258, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6324648, Length=227, Percent_Identity=47.136563876652, Blast_Score=199, Evalue=3e-52,
Organism=Drosophila melanogaster, GI17137556, Length=284, Percent_Identity=48.943661971831, Blast_Score=280, Evalue=9e-76,

Paralogues:

None

Copy number: 391 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000398
- InterPro:   IPR020940 [H]

Pfam domain/function: PF00303 Thymidylat_synt [H]

EC number: =2.1.1.45 [H]

Molecular weight: Translated: 30345; Mature: 30345

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00091 THYMIDYLATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQYLQLLEDILENGVEKEDRTGVGTLSVFGRQLRFNLQDGFPLVTTKKLHIRSIIYELL
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEEECCCCCCEEEECHHHHHHHHHHHH
WFLKGDTNVRYLQENGVTIWDEWADENGDLGPVYGAQWRSWKGADGKTVDQIASVVEEIK
HHHCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RNPNSRRLLVNAWNVAELDKMKLPPCHYAFQFYVANGRLSCMWQQRSVDTFLGLPFNIAS
CCCCCCEEEEEECCCHHHHHCCCCCCCEEEEEEEECCEEEEEEECCCCHHHHCCCHHHHH
YALLTHMIAEQCGLDVGELIFTGGDVHLYKNHIEQAKLQLTREPRPLPKLVLKRKPSSIF
HHHHHHHHHHHHCCCHHHHEEECCCEEEHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCC
DYEYDDFEIVGYDPHPTIKAPVAV
CCCCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MRQYLQLLEDILENGVEKEDRTGVGTLSVFGRQLRFNLQDGFPLVTTKKLHIRSIIYELL
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEEECCCCCCEEEECHHHHHHHHHHHH
WFLKGDTNVRYLQENGVTIWDEWADENGDLGPVYGAQWRSWKGADGKTVDQIASVVEEIK
HHHCCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RNPNSRRLLVNAWNVAELDKMKLPPCHYAFQFYVANGRLSCMWQQRSVDTFLGLPFNIAS
CCCCCCEEEEEECCCHHHHHCCCCCCCEEEEEEEECCEEEEEEECCCCHHHHCCCHHHHH
YALLTHMIAEQCGLDVGELIFTGGDVHLYKNHIEQAKLQLTREPRPLPKLVLKRKPSSIF
HHHHHHHHHHHHCCCHHHHEEECCCEEEHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCC
DYEYDDFEIVGYDPHPTIKAPVAV
CCCCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA