Click here to switch to the map view.

The map label for this gene is parE [H]

Identifier: 138895303

GI number: 138895303

Start: 1737587

End: 1739440

Strand: Reverse

Name: parE [H]

Synonym: GTNG_1647

Alternate gene names: 138895303

Gene position: 1739440-1737587 (Counterclockwise)

Preceding gene: 138895304

Following gene: 138895302

Centisome position: 48.99

GC content: 51.94

Gene sequence:

>1854_bases
ATGTACATCGGCAGCACTGACAGCCGCGGCCTGCATCATCTTGTCTATGAAATTGTCGACAACTCCGTTGACGAGGCATT
GGCTGGATACGGAAATTACATTCTTGTTCAAATACATAAAGATAACAGTGTCACCGTTTTGGACGAAGGGCGCGGCATGC
CGGTCGGAATGCATAAGCTCGGCAAACCGACGCCGGAAGTGATTTTGACTGTGCTGCATGCCGGCGGTAAGTTCGGTCAA
GGCGGGTATAAAACGAGCGGTGGTTTGCACGGGGTCGGGGCATCAGTCGTCAACGCCCTATCCGAATGGCTTGTTGTCAC
GATTCATCGCGACGGCTTTATCTATCGGCAACGGTTTGAGAACGGCGGCAAGCCGGTGACGACGCTTGAAAACATCGGAA
CGACAAACAAAACGGGGACAATCATTCAATTTAAGCCTGACCCGACGATTTTCAGCACAACGGTGTTCGATTATGAAACG
TTAAGCGAACGGCTGCGCGAATCGGCGTTTTTATTAAAAGGGCTGAAAATCGAACTTGTCGATGAACGGACCGGCATGCG
CGAGGTGTTTCATTACGAAAACGGGATTGAAGCGTTTGTTGCCTATTTGAATGAAGAAAAAGACGTGCTCCATCCGGTCG
CCTATTTTGCCGGCGAGCAAAACGGCATTGAAGTCGAGTTTGCGTTTCAATTTCATGACGGCTACTCGGAAAACGTCTTG
TCGTTTGTCAACAATGTGCGCACAAAAGACGGAGGCACGCACGAAGCCGGGGCGAAAACGGCGATGACACGCGTCTTTAA
CGAATATGCGCGCCGTGTCGGCTTATTAAAAGAAAAGGATAAAAACCTTGAAGGAACTGATATTCGTGAAGGGATGTCAG
CGATTGTCTCGGTGCGCATTCCGGAGCATTTGTTGCAGTTTGAAGGACAGACAAAAGGCAAGCTTGGGACGAGCGAGGCG
CGTTCGGCTGTTGATGCGGTCGTGTCTGAACAGTTGACCTACTTTTTGCAAGAAAACCCAGATGTGAGTGCGATGCTCAT
TAAAAAGGCGATCCGGGCGTATCAAGCGCGTGAAGCGGCCCGCAAAGCGCGCGAGGAAGCGCGAAGCGGCAAAAAGCGGA
AAGGAAAAGAGGCGCTTTTAAGCGGCAAGTTGACGCCGGCACAAGGGCGCAATCCGCAAAAAAACGAGCTGTATTTGGTC
GAAGGCGACTCAGCGGGCGGCTCGGCGAAGCAAGGGCGTGACCGCCGTTTTCAGGCGGTGCTGCCGCTGCGCGGGAAAGT
CATTAACACTGAAAAAGCGAAGCTTGGCGATATTTTAAAAAATGAGGAAATCAATACGATCATTCATGCCATTGGCGGCG
GTGTCGGCGCTGATTTTTCGATTGAGGACATTAACTACGACAAAGTGATCATCATGACAGACGCCGACACGGACGGCGCC
CATATTCAAGTGCTCCTGCTCACGTTTTTTTATCGCTATATGCGTCCGCTTATTGAAGCAGGGAAAGTATACATTGCCTT
GCCACCGCTTTACAAAATCAGTAAAGGAAGCGGCAAAAAGGAAACAGTGGAGTATGCGTGGACGGATGAGCAGCTTAGGG
AGATCACGAAAAAAATGGGGCGCGGCTATACGATTCAGCGCTACAAAGGGCTTGGTGAAATGAACGCCGATCAGCTGTGG
GAAACGACGATGAACCCAGAGACGCGCACGTTAATTCGCGTACGCATCGAAGACGCCGCCCGCGCCGAGCGGCGGGTGAC
GACGCTCATGGGTGACAAAGTCGAGCCGCGCCGCAAATGGATCGAAACGCACGTCGCCTTTGGACTCGAAGAAGAGCCAG
GTTGGATCGGCTGA

Upstream 100 bases:

>100_bases
AGGAAGGGGTGGCCTTGTGGCAAAACGAACGGTATACGAATATAACGAAGATGCGATTCAAGTATTAGAAGGGCTTGAGG
CGGTGAGAAAGCGGCCGGGC

Downstream 100 bases:

>100_bases
TGGCGGCTTGAGGCAAGCCGCCTTTTTGCCGCTGAAGTTCGTTGTGAAAGGAGAATGATGATGGCAGAACGATTGTTGGA
ATTGCCTTTAGAGGATGTGC

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MYIGSTDSRGLHHLVYEIVDNSVDEALAGYGNYILVQIHKDNSVTVLDEGRGMPVGMHKLGKPTPEVILTVLHAGGKFGQ
GGYKTSGGLHGVGASVVNALSEWLVVTIHRDGFIYRQRFENGGKPVTTLENIGTTNKTGTIIQFKPDPTIFSTTVFDYET
LSERLRESAFLLKGLKIELVDERTGMREVFHYENGIEAFVAYLNEEKDVLHPVAYFAGEQNGIEVEFAFQFHDGYSENVL
SFVNNVRTKDGGTHEAGAKTAMTRVFNEYARRVGLLKEKDKNLEGTDIREGMSAIVSVRIPEHLLQFEGQTKGKLGTSEA
RSAVDAVVSEQLTYFLQENPDVSAMLIKKAIRAYQAREAARKAREEARSGKKRKGKEALLSGKLTPAQGRNPQKNELYLV
EGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLGDILKNEEINTIIHAIGGGVGADFSIEDINYDKVIIMTDADTDGA
HIQVLLLTFFYRYMRPLIEAGKVYIALPPLYKISKGSGKKETVEYAWTDEQLREITKKMGRGYTIQRYKGLGEMNADQLW
ETTMNPETRTLIRVRIEDAARAERRVTTLMGDKVEPRRKWIETHVAFGLEEEPGWIG

Sequences:

>Translated_617_residues
MYIGSTDSRGLHHLVYEIVDNSVDEALAGYGNYILVQIHKDNSVTVLDEGRGMPVGMHKLGKPTPEVILTVLHAGGKFGQ
GGYKTSGGLHGVGASVVNALSEWLVVTIHRDGFIYRQRFENGGKPVTTLENIGTTNKTGTIIQFKPDPTIFSTTVFDYET
LSERLRESAFLLKGLKIELVDERTGMREVFHYENGIEAFVAYLNEEKDVLHPVAYFAGEQNGIEVEFAFQFHDGYSENVL
SFVNNVRTKDGGTHEAGAKTAMTRVFNEYARRVGLLKEKDKNLEGTDIREGMSAIVSVRIPEHLLQFEGQTKGKLGTSEA
RSAVDAVVSEQLTYFLQENPDVSAMLIKKAIRAYQAREAARKAREEARSGKKRKGKEALLSGKLTPAQGRNPQKNELYLV
EGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLGDILKNEEINTIIHAIGGGVGADFSIEDINYDKVIIMTDADTDGA
HIQVLLLTFFYRYMRPLIEAGKVYIALPPLYKISKGSGKKETVEYAWTDEQLREITKKMGRGYTIQRYKGLGEMNADQLW
ETTMNPETRTLIRVRIEDAARAERRVTTLMGDKVEPRRKWIETHVAFGLEEEPGWIG
>Mature_617_residues
MYIGSTDSRGLHHLVYEIVDNSVDEALAGYGNYILVQIHKDNSVTVLDEGRGMPVGMHKLGKPTPEVILTVLHAGGKFGQ
GGYKTSGGLHGVGASVVNALSEWLVVTIHRDGFIYRQRFENGGKPVTTLENIGTTNKTGTIIQFKPDPTIFSTTVFDYET
LSERLRESAFLLKGLKIELVDERTGMREVFHYENGIEAFVAYLNEEKDVLHPVAYFAGEQNGIEVEFAFQFHDGYSENVL
SFVNNVRTKDGGTHEAGAKTAMTRVFNEYARRVGLLKEKDKNLEGTDIREGMSAIVSVRIPEHLLQFEGQTKGKLGTSEA
RSAVDAVVSEQLTYFLQENPDVSAMLIKKAIRAYQAREAARKAREEARSGKKRKGKEALLSGKLTPAQGRNPQKNELYLV
EGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLGDILKNEEINTIIHAIGGGVGADFSIEDINYDKVIIMTDADTDGA
HIQVLLLTFFYRYMRPLIEAGKVYIALPPLYKISKGSGKKETVEYAWTDEQLREITKKMGRGYTIQRYKGLGEMNADQLW
ETTMNPETRTLIRVRIEDAARAERRVTTLMGDKVEPRRKWIETHVAFGLEEEPGWIG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=577, Percent_Identity=25.3032928942808, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI19913408, Length=629, Percent_Identity=24.1653418124006, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI48994957, Length=523, Percent_Identity=52.3900573613767, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1789408, Length=610, Percent_Identity=37.8688524590164, Blast_Score=380, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17535065, Length=618, Percent_Identity=26.6990291262136, Blast_Score=146, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI212645845, Length=563, Percent_Identity=25.7548845470693, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI212645657, Length=178, Percent_Identity=30.3370786516854, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=186, Percent_Identity=31.7204301075269, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17136538, Length=628, Percent_Identity=25.9554140127389, Blast_Score=135, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 68813; Mature: 68813

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS50096 IQ ; PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIGSTDSRGLHHLVYEIVDNSVDEALAGYGNYILVQIHKDNSVTVLDEGRGMPVGMHKL
CCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCCHHHC
GKPTPEVILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVTIHRDGFIYRQRFE
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCEEEEEEECCCCEEHHHHH
NGGKPVTTLENIGTTNKTGTIIQFKPDPTIFSTTVFDYETLSERLRESAFLLKGLKIELV
CCCCCEEHHHHCCCCCCCCEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEE
DERTGMREVFHYENGIEAFVAYLNEEKDVLHPVAYFAGEQNGIEVEFAFQFHDGYSENVL
CCCCCHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHH
SFVNNVRTKDGGTHEAGAKTAMTRVFNEYARRVGLLKEKDKNLEGTDIREGMSAIVSVRI
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHEEECC
PEHLLQFEGQTKGKLGTSEARSAVDAVVSEQLTYFLQENPDVSAMLIKKAIRAYQAREAA
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RKAREEARSGKKRKGKEALLSGKLTPAQGRNPQKNELYLVEGDSAGGSAKQGRDRRFQAV
HHHHHHHHCCHHHCCHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEE
LPLRGKVINTEKAKLGDILKNEEINTIIHAIGGGVGADFSIEDINYDKVIIMTDADTDGA
CCCCCEEECCCHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCCCEEEEEECCCCCCC
HIQVLLLTFFYRYMRPLIEAGKVYIALPPLYKISKGSGKKETVEYAWTDEQLREITKKMG
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCCCCCEEEEEECHHHHHHHHHHHC
RGYTIQRYKGLGEMNADQLWETTMNPETRTLIRVRIEDAARAERRVTTLMGDKVEPRRKW
CCEEEHHHCCCCCCCHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHCCCCCHHHHH
IETHVAFGLEEEPGWIG
HHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MYIGSTDSRGLHHLVYEIVDNSVDEALAGYGNYILVQIHKDNSVTVLDEGRGMPVGMHKL
CCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCCHHHC
GKPTPEVILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVTIHRDGFIYRQRFE
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCEEEEEEECCCCEEHHHHH
NGGKPVTTLENIGTTNKTGTIIQFKPDPTIFSTTVFDYETLSERLRESAFLLKGLKIELV
CCCCCEEHHHHCCCCCCCCEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEE
DERTGMREVFHYENGIEAFVAYLNEEKDVLHPVAYFAGEQNGIEVEFAFQFHDGYSENVL
CCCCCHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHH
SFVNNVRTKDGGTHEAGAKTAMTRVFNEYARRVGLLKEKDKNLEGTDIREGMSAIVSVRI
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHEEECC
PEHLLQFEGQTKGKLGTSEARSAVDAVVSEQLTYFLQENPDVSAMLIKKAIRAYQAREAA
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RKAREEARSGKKRKGKEALLSGKLTPAQGRNPQKNELYLVEGDSAGGSAKQGRDRRFQAV
HHHHHHHHCCHHHCCHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEE
LPLRGKVINTEKAKLGDILKNEEINTIIHAIGGGVGADFSIEDINYDKVIIMTDADTDGA
CCCCCEEECCCHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCCCEEEEEECCCCCCC
HIQVLLLTFFYRYMRPLIEAGKVYIALPPLYKISKGSGKKETVEYAWTDEQLREITKKMG
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCCCCCEEEEEECHHHHHHHHHHHC
RGYTIQRYKGLGEMNADQLWETTMNPETRTLIRVRIEDAARAERRVTTLMGDKVEPRRKW
CCEEEHHHCCCCCCCHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHCCCCCHHHHH
IETHVAFGLEEEPGWIG
HHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]