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The map label for this gene is parC [H]

Identifier: 138895302

GI number: 138895302

Start: 1735082

End: 1737532

Strand: Reverse

Name: parC [H]

Synonym: GTNG_1646

Alternate gene names: 138895302

Gene position: 1737532-1735082 (Counterclockwise)

Preceding gene: 138895303

Following gene: 138895300

Centisome position: 48.94

GC content: 52.67

Gene sequence:

>2451_bases
ATGATGATGGCAGAACGATTGTTGGAATTGCCTTTAGAGGATGTGCTTGGCGACCGCTTTGGCCGCTACAGTAAATATAT
CATCCAAGACCGGGCGCTGCCTGATGCGCGTGACGGGTTAAAGCCGGTGCAGCGCCGTATTTTATATGCCATGTACGTCG
ATGGCAATACGGCCGATAAGCCGTTTCGCAAAGCGGCAAAAACAGTCGGGAACGTGATCGGCAACTTCCATCCGCATGGC
GATTCGTCAGTGTATGAGGCGATGGTGCGGATGAGCCAAGACTGGAAGCTACGTAACGTGCTTATCGAAATGCACGGCAA
CAACGGGAGCTTGGACGGCGATCCGCCGGCGGCGATGCGTTACACGGAGGCGCGCCTGTCAGCCATCGCCGCCGAGCTGC
TTCGCGACATTGACAAAGAAACGGTCGCCTTTGTGCCGAACTTTGATGATACGACGAACGAGCCGACTGTCTTGCCGGCA
ATGTTTCCGAACCTGCTCGTAAACGGTTCGACCGGTATTTCGGCTGGCTATGCGACGGACATTCCGCCGCATGCGCTCGG
TGAAGTCATCGATGCCGTCTTATTGCGAATCGACCGGCCGAATTGCACCGTCGATAACTTGATGACGGTTCTTCCCGGTC
CCGATTTTCCGACCGGCGGCATTATCCAAGGGAAGGACGGCATTCGCAAGGCGTACGAGACCGGTCGCGGAAAAATCATC
ATCCGCGCCAAAGCGACGATCGAGCAGGCAAAAGGCGGAAAACGGCATATCATGATTACCGAGTTGCCTTATGAAGTGAA
CAAAGCCAACTTAGTAAAAAAAATCGATGAGCTTCGCTTGGACAAAAAGCTGGATGGCATCGCTGACGTCCGTGACGAAA
CGGACCGGAACGGGCTGTCGATCGTGATTGAACTGAAAAAAGATGCGGATGCGGAAGCGATTCTCAACTATTTATACAAG
AATACTGACTTGCAAGTGCCGTACAGCTTCAATATGGTGGCGATTCACGAGCGCCGGCCGAAATTGATGAGCTTGCCAGA
GCTGCTTGACGCCTATATCGCTCATCGGAAAGACGTCGTCACGAACCGTTCTCATTTTGAACTGAAAAAAGCGAATGAGC
GGAAACATATTGTTGATGGTTTAATTAAGGCGCTTTCCATTTTGGACGAGGTGATCGCGACGATTCGCGCCTCAAGCGAC
AAGCGGGACGCCAAAGACCGGCTGATTGCTAACTACGGATTTACCGAGGCGCAGGCGGAGGCGATCGTGACGCTTCAGCT
GTATCGGTTGACGAATACGGACATTACAGCACTCCGTCAAGAGGCGGAAGGGCTCGACAAAACGATCGCCGAGCTGACCG
CGATTCTAGCTGATGAGAAAAAGCTTCTTGCGGTCATTAAAAAAGAGTTGAAGTCGATGAAAAAGCAATACGCTGATGAA
CGGCGAACGGTCATTGAAGAGGAGATCGAGGAGCTGAAAGTCAACGTCGAAGCACTCATTCCAGCGGAAGATGTCATCGT
GACGGTGACAAAAGAAGGATATGTGAAACGAACGAGCTACCGTTCTTACAGTGCGTCCAACGGCCAGGACATCGGGATGA
AAGAGACAGACCGATTGCTCGCCCAGTTAGAGATGAACACGACGGATGTACTCTTGTTGTTCACCCGCCGGGGATATTAT
TTGTATTGCCCGGTGCACACGTTGCCGGACATTCGCTGGAAAGACGTTGGCCAGCATATTTCAAGTCTCATTCCGATCGA
GCGCGATGATGAACTTGTTGCGGTTGTTCCGGTTTCCTCTTTTGAAACGAATGAGCAGCTTGTCTTTGTGACAAAGCATG
GGATGGTAAAGCGGACGGAGCTTTCGCAGTACCAAGTGCAGCGCTATACACGCCCGCTTGTGGCAGTCAATCTAAAAGGC
GATGATCAGGTGATCGCCGTCTACGCGACCGACGGCCGCGGCCTTATTTGGATGGCGACGCATGATGGCTATGCGCTCTT
GTTTGCTGAAGAGGAAATCAGTTTGGTCGGCGTGCGTGCCGCCGGGGTGAAAGGCATTCAACTTAAAGAGGGCGATTTTG
TTGCCGCGGTCTGCCCGATTTGTCCTGAAGAGAGCGGTTCTCTCATTGTCGTGACACAGCGCGGAGCGGTGAAAAAAATG
GCTCTTAGCGAATTCGAACCGACATCGCGCGCGAGACGTGGAGTGATGATTGTGCGCGAGGTGAAATCCAACCCGCACCG
AATCGTCGGAGCCGTCATGACTAATGATGGTGAAGAAATGATCGGAATGCGGACGGAAAAAGGGGTCACCGAAACGGTCG
ATGTTGCTTCACTCCGCTTGACCGATCGCTACGGCACTGGTTCATTCCTCATCGATACCGACGAAGCCGGGATGGTGATC
GACGTTTGGAAAGAGCCAGAGAAGTTGTTAGGAAAAGGGGAAGAGGAATGA

Upstream 100 bases:

>100_bases
GCACGTCGCCTTTGGACTCGAAGAAGAGCCAGGTTGGATCGGCTGATGGCGGCTTGAGGCAAGCCGCCTTTTTGCCGCTG
AAGTTCGTTGTGAAAGGAGA

Downstream 100 bases:

>100_bases
GGGGGAAACGCCAAGAATCCGCTATCCATAAGGTGAGCCGCTGTCGGTTGAACTGAGGGCCGACGATTGGTCAAACTTGT
ACTAGGCGGGGATTCATTGA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 816; Mature: 816

Protein sequence:

>816_residues
MMMAERLLELPLEDVLGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMYVDGNTADKPFRKAAKTVGNVIGNFHPHG
DSSVYEAMVRMSQDWKLRNVLIEMHGNNGSLDGDPPAAMRYTEARLSAIAAELLRDIDKETVAFVPNFDDTTNEPTVLPA
MFPNLLVNGSTGISAGYATDIPPHALGEVIDAVLLRIDRPNCTVDNLMTVLPGPDFPTGGIIQGKDGIRKAYETGRGKII
IRAKATIEQAKGGKRHIMITELPYEVNKANLVKKIDELRLDKKLDGIADVRDETDRNGLSIVIELKKDADAEAILNYLYK
NTDLQVPYSFNMVAIHERRPKLMSLPELLDAYIAHRKDVVTNRSHFELKKANERKHIVDGLIKALSILDEVIATIRASSD
KRDAKDRLIANYGFTEAQAEAIVTLQLYRLTNTDITALRQEAEGLDKTIAELTAILADEKKLLAVIKKELKSMKKQYADE
RRTVIEEEIEELKVNVEALIPAEDVIVTVTKEGYVKRTSYRSYSASNGQDIGMKETDRLLAQLEMNTTDVLLLFTRRGYY
LYCPVHTLPDIRWKDVGQHISSLIPIERDDELVAVVPVSSFETNEQLVFVTKHGMVKRTELSQYQVQRYTRPLVAVNLKG
DDQVIAVYATDGRGLIWMATHDGYALLFAEEEISLVGVRAAGVKGIQLKEGDFVAAVCPICPEESGSLIVVTQRGAVKKM
ALSEFEPTSRARRGVMIVREVKSNPHRIVGAVMTNDGEEMIGMRTEKGVTETVDVASLRLTDRYGTGSFLIDTDEAGMVI
DVWKEPEKLLGKGEEE

Sequences:

>Translated_816_residues
MMMAERLLELPLEDVLGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMYVDGNTADKPFRKAAKTVGNVIGNFHPHG
DSSVYEAMVRMSQDWKLRNVLIEMHGNNGSLDGDPPAAMRYTEARLSAIAAELLRDIDKETVAFVPNFDDTTNEPTVLPA
MFPNLLVNGSTGISAGYATDIPPHALGEVIDAVLLRIDRPNCTVDNLMTVLPGPDFPTGGIIQGKDGIRKAYETGRGKII
IRAKATIEQAKGGKRHIMITELPYEVNKANLVKKIDELRLDKKLDGIADVRDETDRNGLSIVIELKKDADAEAILNYLYK
NTDLQVPYSFNMVAIHERRPKLMSLPELLDAYIAHRKDVVTNRSHFELKKANERKHIVDGLIKALSILDEVIATIRASSD
KRDAKDRLIANYGFTEAQAEAIVTLQLYRLTNTDITALRQEAEGLDKTIAELTAILADEKKLLAVIKKELKSMKKQYADE
RRTVIEEEIEELKVNVEALIPAEDVIVTVTKEGYVKRTSYRSYSASNGQDIGMKETDRLLAQLEMNTTDVLLLFTRRGYY
LYCPVHTLPDIRWKDVGQHISSLIPIERDDELVAVVPVSSFETNEQLVFVTKHGMVKRTELSQYQVQRYTRPLVAVNLKG
DDQVIAVYATDGRGLIWMATHDGYALLFAEEEISLVGVRAAGVKGIQLKEGDFVAAVCPICPEESGSLIVVTQRGAVKKM
ALSEFEPTSRARRGVMIVREVKSNPHRIVGAVMTNDGEEMIGMRTEKGVTETVDVASLRLTDRYGTGSFLIDTDEAGMVI
DVWKEPEKLLGKGEEE
>Mature_816_residues
MMMAERLLELPLEDVLGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMYVDGNTADKPFRKAAKTVGNVIGNFHPHG
DSSVYEAMVRMSQDWKLRNVLIEMHGNNGSLDGDPPAAMRYTEARLSAIAAELLRDIDKETVAFVPNFDDTTNEPTVLPA
MFPNLLVNGSTGISAGYATDIPPHALGEVIDAVLLRIDRPNCTVDNLMTVLPGPDFPTGGIIQGKDGIRKAYETGRGKII
IRAKATIEQAKGGKRHIMITELPYEVNKANLVKKIDELRLDKKLDGIADVRDETDRNGLSIVIELKKDADAEAILNYLYK
NTDLQVPYSFNMVAIHERRPKLMSLPELLDAYIAHRKDVVTNRSHFELKKANERKHIVDGLIKALSILDEVIATIRASSD
KRDAKDRLIANYGFTEAQAEAIVTLQLYRLTNTDITALRQEAEGLDKTIAELTAILADEKKLLAVIKKELKSMKKQYADE
RRTVIEEEIEELKVNVEALIPAEDVIVTVTKEGYVKRTSYRSYSASNGQDIGMKETDRLLAQLEMNTTDVLLLFTRRGYY
LYCPVHTLPDIRWKDVGQHISSLIPIERDDELVAVVPVSSFETNEQLVFVTKHGMVKRTELSQYQVQRYTRPLVAVNLKG
DDQVIAVYATDGRGLIWMATHDGYALLFAEEEISLVGVRAAGVKGIQLKEGDFVAAVCPICPEESGSLIVVTQRGAVKKM
ALSEFEPTSRARRGVMIVREVKSNPHRIVGAVMTNDGEEMIGMRTEKGVTETVDVASLRLTDRYGTGSFLIDTDEAGMVI
DVWKEPEKLLGKGEEE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm. Note=Bipolarly localized [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=176, Percent_Identity=28.9772727272727, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI19913408, Length=321, Percent_Identity=24.2990654205607, Blast_Score=67, Evalue=9e-11,
Organism=Escherichia coli, GI1788562, Length=845, Percent_Identity=40.3550295857988, Blast_Score=601, Evalue=1e-173,
Organism=Escherichia coli, GI1789396, Length=535, Percent_Identity=40, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17535065, Length=290, Percent_Identity=27.2413793103448, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=383, Percent_Identity=25.8485639686684, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 91100; Mature: 91100

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMAERLLELPLEDVLGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMYVDGNTADK
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHEEEEEEECCCCCCH
PFRKAAKTVGNVIGNFHPHGDSSVYEAMVRMSQDWKLRNVLIEMHGNNGSLDGDPPAAMR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHHHH
YTEARLSAIAAELLRDIDKETVAFVPNFDDTTNEPTVLPAMFPNLLVNGSTGISAGYATD
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEHHHHCCHHEECCCCCCCCCCCCC
IPPHALGEVIDAVLLRIDRPNCTVDNLMTVLPGPDFPTGGIIQGKDGIRKAYETGRGKII
CCHHHHHHHHHHHHHEECCCCCCHHHHHEECCCCCCCCCCEEECCHHHHHHHHCCCCEEE
IRAKATIEQAKGGKRHIMITELPYEVNKANLVKKIDELRLDKKLDGIADVRDETDRNGLS
EEEECHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEE
IVIELKKDADAEAILNYLYKNTDLQVPYSFNMVAIHERRPKLMSLPELLDAYIAHRKDVV
EEEEECCCCCHHHHHHHHHCCCCEECCEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
TNRSHFELKKANERKHIVDGLIKALSILDEVIATIRASSDKRDAKDRLIANYGFTEAQAE
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCCHHCCC
AIVTLQLYRLTNTDITALRQEAEGLDKTIAELTAILADEKKLLAVIKKELKSMKKQYADE
EEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RRTVIEEEIEELKVNVEALIPAEDVIVTVTKEGYVKRTSYRSYSASNGQDIGMKETDRLL
HHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCHHHHHHH
AQLEMNTTDVLLLFTRRGYYLYCPVHTLPDIRWKDVGQHISSLIPIERDDELVAVVPVSS
HHHCCCCCEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECC
FETNEQLVFVTKHGMVKRTELSQYQVQRYTRPLVAVNLKGDDQVIAVYATDGRGLIWMAT
CCCCCEEEEEECCCCEEEHHHHHHHHHHHCCCEEEEEECCCCEEEEEEEECCCEEEEEEE
HDGYALLFAEEEISLVGVRAAGVKGIQLKEGDFVAAVCPICPEESGSLIVVTQRGAVKKM
CCCEEEEEEECCEEEEEEEECCCCCEEEECCCEEEEECCCCCCCCCCEEEEECCCCHHHH
ALSEFEPTSRARRGVMIVREVKSNPHRIVGAVMTNDGEEMIGMRTEKGVTETVDVASLRL
HHHCCCCHHHHHCCEEEEEECCCCCCEEEEEEEECCCHHHHCCCCCCCCCCEEEEEEEEE
TDRYGTGSFLIDTDEAGMVIDVWKEPEKLLGKGEEE
EECCCCCEEEEECCCCCEEEEECCCCHHHCCCCCCC
>Mature Secondary Structure
MMMAERLLELPLEDVLGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMYVDGNTADK
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHEEEEEEECCCCCCH
PFRKAAKTVGNVIGNFHPHGDSSVYEAMVRMSQDWKLRNVLIEMHGNNGSLDGDPPAAMR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHHHH
YTEARLSAIAAELLRDIDKETVAFVPNFDDTTNEPTVLPAMFPNLLVNGSTGISAGYATD
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEHHHHCCHHEECCCCCCCCCCCCC
IPPHALGEVIDAVLLRIDRPNCTVDNLMTVLPGPDFPTGGIIQGKDGIRKAYETGRGKII
CCHHHHHHHHHHHHHEECCCCCCHHHHHEECCCCCCCCCCEEECCHHHHHHHHCCCCEEE
IRAKATIEQAKGGKRHIMITELPYEVNKANLVKKIDELRLDKKLDGIADVRDETDRNGLS
EEEECHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEE
IVIELKKDADAEAILNYLYKNTDLQVPYSFNMVAIHERRPKLMSLPELLDAYIAHRKDVV
EEEEECCCCCHHHHHHHHHCCCCEECCEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
TNRSHFELKKANERKHIVDGLIKALSILDEVIATIRASSDKRDAKDRLIANYGFTEAQAE
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCCHHCCC
AIVTLQLYRLTNTDITALRQEAEGLDKTIAELTAILADEKKLLAVIKKELKSMKKQYADE
EEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RRTVIEEEIEELKVNVEALIPAEDVIVTVTKEGYVKRTSYRSYSASNGQDIGMKETDRLL
HHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCHHHHHHH
AQLEMNTTDVLLLFTRRGYYLYCPVHTLPDIRWKDVGQHISSLIPIERDDELVAVVPVSS
HHHCCCCCEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECC
FETNEQLVFVTKHGMVKRTELSQYQVQRYTRPLVAVNLKGDDQVIAVYATDGRGLIWMAT
CCCCCEEEEEECCCCEEEHHHHHHHHHHHCCCEEEEEECCCCEEEEEEEECCCEEEEEEE
HDGYALLFAEEEISLVGVRAAGVKGIQLKEGDFVAAVCPICPEESGSLIVVTQRGAVKKM
CCCEEEEEEECCEEEEEEEECCCCCEEEECCCEEEEECCCCCCCCCCEEEEECCCCHHHH
ALSEFEPTSRARRGVMIVREVKSNPHRIVGAVMTNDGEEMIGMRTEKGVTETVDVASLRL
HHHCCCCHHHHHCCEEEEEECCCCCCEEEEEEEECCCHHHHCCCCCCCCCCEEEEEEEEE
TDRYGTGSFLIDTDEAGMVIDVWKEPEKLLGKGEEE
EECCCCCEEEEECCCCCEEEEECCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]