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The map label for this gene is norM [H]

Identifier: 138895098

GI number: 138895098

Start: 1521988

End: 1523355

Strand: Reverse

Name: norM [H]

Synonym: GTNG_1436

Alternate gene names: 138895098

Gene position: 1523355-1521988 (Counterclockwise)

Preceding gene: 138895099

Following gene: 138895091

Centisome position: 42.91

GC content: 55.34

Gene sequence:

>1368_bases
ATGATGGCAATGACCGCTTCAGCCAGCGGAAAGTGGAAGCGTTTGTTCACTTTGTTTTTACCGATTTTTGTTTCGCAAGC
CGGCCAATATATGATGAACTTTACCGATGTCGCTATGTCCGGCCACGCGAGCGCCGAAGATCTGGCCGGCGTGGCGATCG
GCTCAAGCCTATGGGTGCCGGTGTTTACCGGGGTTGGTGGCATTTTGCTCGCTCTGTCCCCCATCGTCTCCCAGCATTTC
GGCGCCGGACGGCATGAAGATATCGCTCGCACCGTCGTCCAAGCGCTTTATTTGTCCGTCGCGATTGCACTCGCCATCGT
CCTGGCCGGCTCGGTTGCCGTGCCGTTTATTTTGGAACAGATGCAACTTGAAGAGGATGTCCGGTACATTGCCTCTCACT
ATTTGCTCGCATTGTCGTTTGGAATTATCCCGCTGTTCCTTTATTCAGTGCTTCGCTACTCGATCGATGCGCTCGGGCAG
ACGAAAGTGACAATGTGGATTACGCTCACCGCTTTGCCTATTAACATGCTGTTCAACTGGCTGTTCATTTACGGACACGG
CGGATTCCCACGTCTTGGCGGCATCGGCACCGGCTATGCGACAGCAATCACGTATACGTACTGTTTTGTCGCTGCCTTGG
CTGCCATTAAACTCCGCCGTTTTGCTATGTATCGTGCGCTCGTACGTGTTTACTGCCCTTCATGGGCCTCATGGAAAGAG
CTGCTTAAAACAGGGGTGCCGATCGGGTCGGCTATCTTTTTTGAGACGAGTATTTTTGCTGCTGTAACGCTGCTTGTCGG
GCGATTTGGCGCCGAAACGGTTGCCGCCCATCAGAGCGCCCTTAATTTCGCTTCACTGTTGTATATGATCCCGCTCAGTT
TGTCAATGGCGCTGACGATCGCAGTCGGTTTCGAAGCGGGGGCTAAACGGTATGAAGATGCGAAAAAGTTTTGCTTGATT
GGCATTGCCATCGCCTTGGCTGTCGCCGCGGCTGCCGCTCTGTTTCTTTACGCCTTCCGCGGCCATGTCGCCCGACTGTA
CACGAGCGATCCCGCTGTGGCAGCGTTGACCGGAAAATTTTTGTTATATGCAATCTTCTTCCAATTTTCCGATGCTATCG
CTGCCCCCATTCAAGGAGCGCTGCGCGGCTATAAAGATGTCAACGCCGTATTTTGGGCTGCCCTTCTTGCCTATTGGGGC
ATCGGGCTTCCCGTCGGCTGTGCGCTCGCCCTGCTGACCCCTGCCGGAGCGTTCGGCTATTGGATCGGCCTCATCGCCGG
GTTGGCTGCCGGGGCGCTCTTCCTCAGTTTTCGCCTGCGGGCCATCTGGCGCCGCCACGGAAATCAACGCACGCCGCACA
TCTCGTGA

Upstream 100 bases:

>100_bases
CATAAGCGGCTTCTACAGGGGGATCGCTCCCCCTGGCTCGGGGGAGACGGAAAGATTGATGATTTAGCACAATGTGTTGT
TTTTAGACAAAGGAGGAGCC

Downstream 100 bases:

>100_bases
GGGACGTCCGGGCAGCATCTATATCAGCAAAAAGAGGATGCCCATAGACGGGCGTCCTCTTTACGACGACGTCAAAACGA
TTCACCGGTGAACCGTTCCG

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MMAMTASASGKWKRLFTLFLPIFVSQAGQYMMNFTDVAMSGHASAEDLAGVAIGSSLWVPVFTGVGGILLALSPIVSQHF
GAGRHEDIARTVVQALYLSVAIALAIVLAGSVAVPFILEQMQLEEDVRYIASHYLLALSFGIIPLFLYSVLRYSIDALGQ
TKVTMWITLTALPINMLFNWLFIYGHGGFPRLGGIGTGYATAITYTYCFVAALAAIKLRRFAMYRALVRVYCPSWASWKE
LLKTGVPIGSAIFFETSIFAAVTLLVGRFGAETVAAHQSALNFASLLYMIPLSLSMALTIAVGFEAGAKRYEDAKKFCLI
GIAIALAVAAAAALFLYAFRGHVARLYTSDPAVAALTGKFLLYAIFFQFSDAIAAPIQGALRGYKDVNAVFWAALLAYWG
IGLPVGCALALLTPAGAFGYWIGLIAGLAAGALFLSFRLRAIWRRHGNQRTPHIS

Sequences:

>Translated_455_residues
MMAMTASASGKWKRLFTLFLPIFVSQAGQYMMNFTDVAMSGHASAEDLAGVAIGSSLWVPVFTGVGGILLALSPIVSQHF
GAGRHEDIARTVVQALYLSVAIALAIVLAGSVAVPFILEQMQLEEDVRYIASHYLLALSFGIIPLFLYSVLRYSIDALGQ
TKVTMWITLTALPINMLFNWLFIYGHGGFPRLGGIGTGYATAITYTYCFVAALAAIKLRRFAMYRALVRVYCPSWASWKE
LLKTGVPIGSAIFFETSIFAAVTLLVGRFGAETVAAHQSALNFASLLYMIPLSLSMALTIAVGFEAGAKRYEDAKKFCLI
GIAIALAVAAAAALFLYAFRGHVARLYTSDPAVAALTGKFLLYAIFFQFSDAIAAPIQGALRGYKDVNAVFWAALLAYWG
IGLPVGCALALLTPAGAFGYWIGLIAGLAAGALFLSFRLRAIWRRHGNQRTPHIS
>Mature_455_residues
MMAMTASASGKWKRLFTLFLPIFVSQAGQYMMNFTDVAMSGHASAEDLAGVAIGSSLWVPVFTGVGGILLALSPIVSQHF
GAGRHEDIARTVVQALYLSVAIALAIVLAGSVAVPFILEQMQLEEDVRYIASHYLLALSFGIIPLFLYSVLRYSIDALGQ
TKVTMWITLTALPINMLFNWLFIYGHGGFPRLGGIGTGYATAITYTYCFVAALAAIKLRRFAMYRALVRVYCPSWASWKE
LLKTGVPIGSAIFFETSIFAAVTLLVGRFGAETVAAHQSALNFASLLYMIPLSLSMALTIAVGFEAGAKRYEDAKKFCLI
GIAIALAVAAAAALFLYAFRGHVARLYTSDPAVAALTGKFLLYAIFFQFSDAIAAPIQGALRGYKDVNAVFWAALLAYWG
IGLPVGCALALLTPAGAFGYWIGLIAGLAAGALFLSFRLRAIWRRHGNQRTPHIS

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=453, Percent_Identity=24.2825607064018, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI22907060, Length=450, Percent_Identity=23.5555555555556, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38261960, Length=485, Percent_Identity=22.8865979381443, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI48994890, Length=442, Percent_Identity=38.2352941176471, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI226510954, Length=447, Percent_Identity=22.5950782997763, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6321821, Length=375, Percent_Identity=20, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320545, Length=390, Percent_Identity=22.3076923076923, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49025; Mature: 49025

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAMTASASGKWKRLFTLFLPIFVSQAGQYMMNFTDVAMSGHASAEDLAGVAIGSSLWVP
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHH
VFTGVGGILLALSPIVSQHFGAGRHEDIARTVVQALYLSVAIALAIVLAGSVAVPFILEQ
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQLEEDVRYIASHYLLALSFGIIPLFLYSVLRYSIDALGQTKVTMWITLTALPINMLFNW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHH
LFIYGHGGFPRLGGIGTGYATAITYTYCFVAALAAIKLRRFAMYRALVRVYCPSWASWKE
HHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LLKTGVPIGSAIFFETSIFAAVTLLVGRFGAETVAAHQSALNFASLLYMIPLSLSMALTI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGFEAGAKRYEDAKKFCLIGIAIALAVAAAAALFLYAFRGHVARLYTSDPAVAALTGKF
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHH
LLYAIFFQFSDAIAAPIQGALRGYKDVNAVFWAALLAYWGIGLPVGCALALLTPAGAFGY
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHH
WIGLIAGLAAGALFLSFRLRAIWRRHGNQRTPHIS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MMAMTASASGKWKRLFTLFLPIFVSQAGQYMMNFTDVAMSGHASAEDLAGVAIGSSLWVP
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHH
VFTGVGGILLALSPIVSQHFGAGRHEDIARTVVQALYLSVAIALAIVLAGSVAVPFILEQ
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQLEEDVRYIASHYLLALSFGIIPLFLYSVLRYSIDALGQTKVTMWITLTALPINMLFNW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHH
LFIYGHGGFPRLGGIGTGYATAITYTYCFVAALAAIKLRRFAMYRALVRVYCPSWASWKE
HHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LLKTGVPIGSAIFFETSIFAAVTLLVGRFGAETVAAHQSALNFASLLYMIPLSLSMALTI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGFEAGAKRYEDAKKFCLIGIAIALAVAAAAALFLYAFRGHVARLYTSDPAVAALTGKF
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHH
LLYAIFFQFSDAIAAPIQGALRGYKDVNAVFWAALLAYWGIGLPVGCALALLTPAGAFGY
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHH
WIGLIAGLAAGALFLSFRLRAIWRRHGNQRTPHIS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA