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The map label for this gene is pbuX [H]

Identifier: 138895060

GI number: 138895060

Start: 1489013

End: 1490320

Strand: Direct

Name: pbuX [H]

Synonym: GTNG_1398

Alternate gene names: 138895060

Gene position: 1489013-1490320 (Clockwise)

Preceding gene: 138895059

Following gene: 138895064

Centisome position: 41.94

GC content: 54.36

Gene sequence:

>1308_bases
ATGAAAATGAAATGGTGGCAAATCGGGTCATTAGGCATTCAGCACGTATTGGCAATGTATGCCGGGGCGATCGTCGTTCC
GCTTGTCGTCGGCGGTGCGCTTCAGCTATCGGGAGAGCAGCTCACCTATTTAGTAGCCGTTGATTTATTGACGTGCGGCA
TCGCGACGTTTTTGCAAGTATGGAAGAATAAGTTGTTTGGCATCGGCTTGCCGGTCATGCTTGGCTGTACGTTTACGGCG
GTCGGGCCGATGATCGCCATCGGCGGTCAATACGGAATGACAGCCGTATATGGTTCGATCCTTTGCGCTGGGCTTGTCGT
CGTGCTCATCAGCCCGTATTTCGGCAAGTTGCGGGCGTTGTTCCCTCCGGTTGTCACCGGTTCGGTCGTAACAATTATTG
GCTTGACGCTCATTCCGGCGGCTGTGAACAATATGGCTGGAGGACAAGGAGCAGAAGATTTTGGCGATCCAACTAACTTG
GCGCTGTCGTTTGGCGTGCTCGCGCTCATTGTTGTATTGTACCGCTGTTTCAAAGGCTTCATTCGCTCGATTGCCATTTT
GCTTGGAATGGCCGCCGGCACTGTTGTCGCGGCCGTGATGGGAAAAGTAGACTGGACGGCCGTCACCGAAGCATCGTGGG
TTCATCTGCCGCAGCCGTTTTATTTCGGTGTTCCATCATTCCATGGCTCGGCCATCTTGACGATGGTGTTGGTCGCTATC
GTCAGCCTCGTCGAATCGACCGGCGTCTACTTCGCGTTGTCTGATATTTGCCGTCGCCGGTTGACGGATGAGGATTTGGC
GGGCGGTTACCGCGCCGAAGGGTTGGCGATCATCGTCGGCGGGCTGCTAAATGCGTTTCCGTATACGACATACTCGCAAA
ACGTTGGCCTCGTTCAATTATCGGGGGTGAAAACGCGAAACGTCATTTATGCCGCCGCTCTGTTTCTCATCTTGCTTGGA
TTTGTGCCGAAAATCGCCGCTGTGGCGACGATCATTCCAGCCCCGGTGCTCGGCGGGGCGATGCTCGCCATGTTTGGCAT
GGTCATCGCTTATGGCGTGAAAATGTTGAGCCAAGTCGACTTGACTGTGCAAGAAAACTTGCTGATTATCGCTTGCTCGA
TCGGCGTGGGGCTCGGGGTGACGGCGGTACCGAACTTATTCGCCGAGCTCCCGGCCGGCCTCCGCATTTTGACGGATAGC
GGCATCGTCGCCGGCAGCATGACGGCCATCATCTTAAATGCAGTCTTCCATTTCGGTAAGGTAAGAAGATCGGCTACATT
GCCGTTGCAGGAACAAAAAATTTCCTAA

Upstream 100 bases:

>100_bases
GCCGGCTCCTTCGTTCGCAAGGATTCCGCGTCGTTTCGCTCGCCCGCATCGCCTCGCTCAGCGATGGCGTCATTCGATTT
CACGAAGAGGTGATGAGCTG

Downstream 100 bases:

>100_bases
TCGTGTTGTCCTTTCTAAATATCCAACATATTTAGACTCAAAATATGTTAGAGTGTCGTCTACATGTCATCAACGTTTTC
TGATCAGATTGATTAAGAAA

Product: xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKMKWWQIGSLGIQHVLAMYAGAIVVPLVVGGALQLSGEQLTYLVAVDLLTCGIATFLQVWKNKLFGIGLPVMLGCTFTA
VGPMIAIGGQYGMTAVYGSILCAGLVVVLISPYFGKLRALFPPVVTGSVVTIIGLTLIPAAVNNMAGGQGAEDFGDPTNL
ALSFGVLALIVVLYRCFKGFIRSIAILLGMAAGTVVAAVMGKVDWTAVTEASWVHLPQPFYFGVPSFHGSAILTMVLVAI
VSLVESTGVYFALSDICRRRLTDEDLAGGYRAEGLAIIVGGLLNAFPYTTYSQNVGLVQLSGVKTRNVIYAAALFLILLG
FVPKIAAVATIIPAPVLGGAMLAMFGMVIAYGVKMLSQVDLTVQENLLIIACSIGVGLGVTAVPNLFAELPAGLRILTDS
GIVAGSMTAIILNAVFHFGKVRRSATLPLQEQKIS

Sequences:

>Translated_435_residues
MKMKWWQIGSLGIQHVLAMYAGAIVVPLVVGGALQLSGEQLTYLVAVDLLTCGIATFLQVWKNKLFGIGLPVMLGCTFTA
VGPMIAIGGQYGMTAVYGSILCAGLVVVLISPYFGKLRALFPPVVTGSVVTIIGLTLIPAAVNNMAGGQGAEDFGDPTNL
ALSFGVLALIVVLYRCFKGFIRSIAILLGMAAGTVVAAVMGKVDWTAVTEASWVHLPQPFYFGVPSFHGSAILTMVLVAI
VSLVESTGVYFALSDICRRRLTDEDLAGGYRAEGLAIIVGGLLNAFPYTTYSQNVGLVQLSGVKTRNVIYAAALFLILLG
FVPKIAAVATIIPAPVLGGAMLAMFGMVIAYGVKMLSQVDLTVQENLLIIACSIGVGLGVTAVPNLFAELPAGLRILTDS
GIVAGSMTAIILNAVFHFGKVRRSATLPLQEQKIS
>Mature_435_residues
MKMKWWQIGSLGIQHVLAMYAGAIVVPLVVGGALQLSGEQLTYLVAVDLLTCGIATFLQVWKNKLFGIGLPVMLGCTFTA
VGPMIAIGGQYGMTAVYGSILCAGLVVVLISPYFGKLRALFPPVVTGSVVTIIGLTLIPAAVNNMAGGQGAEDFGDPTNL
ALSFGVLALIVVLYRCFKGFIRSIAILLGMAAGTVVAAVMGKVDWTAVTEASWVHLPQPFYFGVPSFHGSAILTMVLVAI
VSLVESTGVYFALSDICRRRLTDEDLAGGYRAEGLAIIVGGLLNAFPYTTYSQNVGLVQLSGVKTRNVIYAAALFLILLG
FVPKIAAVATIIPAPVLGGAMLAMFGMVIAYGVKMLSQVDLTVQENLLIIACSIGVGLGVTAVPNLFAELPAGLRILTDS
GIVAGSMTAIILNAVFHFGKVRRSATLPLQEQKIS

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=489, Percent_Identity=23.721881390593, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI44680148, Length=170, Percent_Identity=30.5882352941176, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI40316845, Length=170, Percent_Identity=30.5882352941176, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI44680143, Length=219, Percent_Identity=27.8538812785388, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI87082181, Length=411, Percent_Identity=43.0656934306569, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1790087, Length=424, Percent_Identity=34.6698113207547, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI87082178, Length=436, Percent_Identity=33.9449541284404, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1788843, Length=438, Percent_Identity=30.5936073059361, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87081818, Length=450, Percent_Identity=30, Blast_Score=139, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17558856, Length=228, Percent_Identity=31.140350877193, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17542262, Length=426, Percent_Identity=25.5868544600939, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17541904, Length=427, Percent_Identity=22.7166276346604, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17542260, Length=208, Percent_Identity=26.9230769230769, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71993493, Length=191, Percent_Identity=27.2251308900524, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356175, Length=418, Percent_Identity=26.0765550239234, Blast_Score=98, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45544; Mature: 45544

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKWWQIGSLGIQHVLAMYAGAIVVPLVVGGALQLSGEQLTYLVAVDLLTCGIATFLQV
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHH
WKNKLFGIGLPVMLGCTFTAVGPMIAIGGQYGMTAVYGSILCAGLVVVLISPYFGKLRAL
HHHHHHCCCCHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPPVVTGSVVTIIGLTLIPAAVNNMAGGQGAEDFGDPTNLALSFGVLALIVVLYRCFKGF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
IRSIAILLGMAAGTVVAAVMGKVDWTAVTEASWVHLPQPFYFGVPSFHGSAILTMVLVAI
HHHHHHHHHHHHHHHHHHHHCCCCHHEECCCCEEECCCCCEECCCCCCHHHHHHHHHHHH
VSLVESTGVYFALSDICRRRLTDEDLAGGYRAEGLAIIVGGLLNAFPYTTYSQNVGLVQL
HHHHHHCCHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEE
SGVKTRNVIYAAALFLILLGFVPKIAAVATIIPAPVLGGAMLAMFGMVIAYGVKMLSQVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LTVQENLLIIACSIGVGLGVTAVPNLFAELPAGLRILTDSGIVAGSMTAIILNAVFHFGK
CEEECCEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
VRRSATLPLQEQKIS
HHHCCCCCCHHCCCC
>Mature Secondary Structure
MKMKWWQIGSLGIQHVLAMYAGAIVVPLVVGGALQLSGEQLTYLVAVDLLTCGIATFLQV
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHH
WKNKLFGIGLPVMLGCTFTAVGPMIAIGGQYGMTAVYGSILCAGLVVVLISPYFGKLRAL
HHHHHHCCCCHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPPVVTGSVVTIIGLTLIPAAVNNMAGGQGAEDFGDPTNLALSFGVLALIVVLYRCFKGF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
IRSIAILLGMAAGTVVAAVMGKVDWTAVTEASWVHLPQPFYFGVPSFHGSAILTMVLVAI
HHHHHHHHHHHHHHHHHHHHCCCCHHEECCCCEEECCCCCEECCCCCCHHHHHHHHHHHH
VSLVESTGVYFALSDICRRRLTDEDLAGGYRAEGLAIIVGGLLNAFPYTTYSQNVGLVQL
HHHHHHCCHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEE
SGVKTRNVIYAAALFLILLGFVPKIAAVATIIPAPVLGGAMLAMFGMVIAYGVKMLSQVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LTVQENLLIIACSIGVGLGVTAVPNLFAELPAGLRILTDSGIVAGSMTAIILNAVFHFGK
CEEECCEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
VRRSATLPLQEQKIS
HHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]