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The map label for this gene is xpt

Identifier: 138895059

GI number: 138895059

Start: 1488429

End: 1489013

Strand: Direct

Name: xpt

Synonym: GTNG_1397

Alternate gene names: 138895059

Gene position: 1488429-1489013 (Clockwise)

Preceding gene: 138895055

Following gene: 138895060

Centisome position: 41.92

GC content: 55.9

Gene sequence:

>585_bases
ATGCGCGAATTGCTCGAGAAAATTGCCGCCGAGGGGGAGGTCGTCGCGGACGGAGTGCTCAAAGTCGACCGCTTCTTAAA
CCATCAAGTCGACCCGCACCTTATGAAACGGATCGGTGAGGAGTTTGCTGCTCAGTTTCACCGTGAGCGGCCGACGAAAG
TGCTAACGCTTGAGTCATCCGGTATTAGCCCGGCGCTTATGGCTGCCTATGAGCTCGGTGTGCCTCTTGTCGTTGCCCGC
AAGCGGCGACCGCTGACGATGACTAGTGAAGTGTATTGCGCGGAAGTATATTCTTTTACGAAGAAGGAGACGAACGAAAT
CATTGTTTCCCGGCCGCTACTGGATAGCAGTGACCGGGTGCTGATTATCGATGACTTTTTAGCCAACGGCCAAGCGGCGC
TCGGGATGGTGGAGGTCGTCCGTCAAGCTGGAGCGGATGTTGTCGGCATCGGTATTGTCATTGAAAAAGCGTTTCAAGAC
GGCGGCCGGCTCCTTCGTTCGCAAGGATTCCGCGTCGTTTCGCTCGCCCGCATCGCCTCGCTCAGCGATGGCGTCATTCG
ATTTCACGAAGAGGTGATGAGCTGA

Upstream 100 bases:

>100_bases
CTTGTGCCTTCCGTTTTGCTTCGGCTTAAAAGACATTGCCTGACTCATGGAATGGGTGAGGCCGGTGTTTTTTAAGCTTT
TTTTATTGGAGGGAATCAGT

Downstream 100 bases:

>100_bases
TGAAAATGAAATGGTGGCAAATCGGGTCATTAGGCATTCAGCACGTATTGGCAATGTATGCCGGGGCGATCGTCGTTCCG
CTTGTCGTCGGCGGTGCGCT

Product: xanthine phosphoribosyltransferase

Products: NA

Alternate protein names: XPRTase

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MRELLEKIAAEGEVVADGVLKVDRFLNHQVDPHLMKRIGEEFAAQFHRERPTKVLTLESSGISPALMAAYELGVPLVVAR
KRRPLTMTSEVYCAEVYSFTKKETNEIIVSRPLLDSSDRVLIIDDFLANGQAALGMVEVVRQAGADVVGIGIVIEKAFQD
GGRLLRSQGFRVVSLARIASLSDGVIRFHEEVMS

Sequences:

>Translated_194_residues
MRELLEKIAAEGEVVADGVLKVDRFLNHQVDPHLMKRIGEEFAAQFHRERPTKVLTLESSGISPALMAAYELGVPLVVAR
KRRPLTMTSEVYCAEVYSFTKKETNEIIVSRPLLDSSDRVLIIDDFLANGQAALGMVEVVRQAGADVVGIGIVIEKAFQD
GGRLLRSQGFRVVSLARIASLSDGVIRFHEEVMS
>Mature_194_residues
MRELLEKIAAEGEVVADGVLKVDRFLNHQVDPHLMKRIGEEFAAQFHRERPTKVLTLESSGISPALMAAYELGVPLVVAR
KRRPLTMTSEVYCAEVYSFTKKETNEIIVSRPLLDSSDRVLIIDDFLANGQAALGMVEVVRQAGADVVGIGIVIEKAFQD
GGRLLRSQGFRVVSLARIASLSDGVIRFHEEVMS

Specific function: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XPT subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XPT_GEOTN (A4IN63)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001125512.1
- ProteinModelPortal:   A4IN63
- SMR:   A4IN63
- STRING:   A4IN63
- GeneID:   4966336
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_1397
- NMPDR:   fig|420246.5.peg.1356
- eggNOG:   COG0503
- HOGENOM:   HBG288993
- OMA:   ATVYSFT
- ProtClustDB:   CLSK2537171
- BioCyc:   GTHE420246:GTNG_1397-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01184
- InterPro:   IPR000836
- InterPro:   IPR010079
- TIGRFAMs:   TIGR01744

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.22

Molecular weight: Translated: 21406; Mature: 21406

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER; PS00228 TUBULIN_B_AUTOREG

Important sites: BINDING 20-20 BINDING 27-27 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRELLEKIAAEGEVVADGVLKVDRFLNHQVDPHLMKRIGEEFAAQFHRERPTKVLTLESS
CHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECC
GISPALMAAYELGVPLVVARKRRPLTMTSEVYCAEVYSFTKKETNEIIVSRPLLDSSDRV
CCCHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCE
LIIDDFLANGQAALGMVEVVRQAGADVVGIGIVIEKAFQDGGRLLRSQGFRVVSLARIAS
EEEECCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LSDGVIRFHEEVMS
CCHHHHHHHHHHCC
>Mature Secondary Structure
MRELLEKIAAEGEVVADGVLKVDRFLNHQVDPHLMKRIGEEFAAQFHRERPTKVLTLESS
CHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECC
GISPALMAAYELGVPLVVARKRRPLTMTSEVYCAEVYSFTKKETNEIIVSRPLLDSSDRV
CCCHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCE
LIIDDFLANGQAALGMVEVVRQAGADVVGIGIVIEKAFQDGGRLLRSQGFRVVSLARIAS
EEEECCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LSDGVIRFHEEVMS
CCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA