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The map label for this gene is ytkP [H]

Identifier: 138895035

GI number: 138895035

Start: 1457861

End: 1458784

Strand: Direct

Name: ytkP [H]

Synonym: GTNG_1373

Alternate gene names: 138895035

Gene position: 1457861-1458784 (Clockwise)

Preceding gene: 138895029

Following gene: 138895036

Centisome position: 41.06

GC content: 54.22

Gene sequence:

>924_bases
ATGAAACTGTATGACTCCATTTTAGACTTAATTGGCGGCACGCCGATCGTGAAGTTGCGGCGTCTTCCAGACCCAGACGG
GGCGGATGTATATATGAAGCTTGAATCGTTCAATCCGGGCGGCAGTGTCAAAGACCGGCCCGCTTGGGAAATGATTCGTC
GGGCTGAAGCGGAAGGGAAAATTACACCGGGAAAAAGCACGATCATCGAACCAACGTCCGGCAACACCGGCATCGGTTTA
GCGATGGTATGCGCCGCTCGAGGTTATCGTTGCATCATTACGATGCCAGATAACGCGACGACCGAGCGGGTGAAAATTTT
AAAGGCCTACGGAGCAGAAGTGCATTTGACACCGGCGGAGAAACGGATGCAAGGGGCGATCGATGAGGCGAATCGGCTCG
CCAGCGAAATCCCTGGCAGCTTTATTCCGATGCAATTTGAAAATCCGGCCAACCCGGATGCGCACCGGCATACGACGGCA
GTCGAAATTTATGAAGCGTTTTCCGGCCGGCTCGATGCGTTCGTGTTGACGGCCGGCACCGGTGGGACGGTGACCGGGAC
AGGAGAAGAGCTGAAAAAACGCATTCCGAATTTGCGCATTTACGTTGTCGAGCCATACGGCTCGCCCGTGTTGTCGGGCG
GTAAACCAGGACCGCATAAAATTCCCGGCACGGGCCCAGGGTTTATCCCGAGCATCTTAAACCGTTCGATTTATGATGAC
ATTTTTTTGATCAAAGATGAAGATGCCCAACAGATGGCACGTGAACTGGCGGCGAAGGAAGGGATTTTGGTCGGTGCCTC
GGCCGCTGCGAGCGCCTATTACGCCGTCAAAGTGGCCAAGCAGTTTCCAAAAGGAGCGCGCGTTCTTTGCATGGCGCCTG
ATTCGGGCGAACGGTATTTGTCGTCCGATTTATTCGCGGATTAA

Upstream 100 bases:

>100_bases
TGCCTGTCCACATAGGAAAGACAGACTGTTTGAACAAAAAAAGAAAAATCATGTATAATGAAGCAGACAGAAATATCTTC
CAAAAAGGTTGGGGAACGTC

Downstream 100 bases:

>100_bases
GCAGAGGATGCAAACGTTGGTTTCACGGCTTGTTGCCTTGCAAAGGAAGGGACATTCCTCTCCGTCAAACAGGAGAGGAA
TGCTTTTGTTTATAGAAAGC

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MKLYDSILDLIGGTPIVKLRRLPDPDGADVYMKLESFNPGGSVKDRPAWEMIRRAEAEGKITPGKSTIIEPTSGNTGIGL
AMVCAARGYRCIITMPDNATTERVKILKAYGAEVHLTPAEKRMQGAIDEANRLASEIPGSFIPMQFENPANPDAHRHTTA
VEIYEAFSGRLDAFVLTAGTGGTVTGTGEELKKRIPNLRIYVVEPYGSPVLSGGKPGPHKIPGTGPGFIPSILNRSIYDD
IFLIKDEDAQQMARELAAKEGILVGASAAASAYYAVKVAKQFPKGARVLCMAPDSGERYLSSDLFAD

Sequences:

>Translated_307_residues
MKLYDSILDLIGGTPIVKLRRLPDPDGADVYMKLESFNPGGSVKDRPAWEMIRRAEAEGKITPGKSTIIEPTSGNTGIGL
AMVCAARGYRCIITMPDNATTERVKILKAYGAEVHLTPAEKRMQGAIDEANRLASEIPGSFIPMQFENPANPDAHRHTTA
VEIYEAFSGRLDAFVLTAGTGGTVTGTGEELKKRIPNLRIYVVEPYGSPVLSGGKPGPHKIPGTGPGFIPSILNRSIYDD
IFLIKDEDAQQMARELAAKEGILVGASAAASAYYAVKVAKQFPKGARVLCMAPDSGERYLSSDLFAD
>Mature_307_residues
MKLYDSILDLIGGTPIVKLRRLPDPDGADVYMKLESFNPGGSVKDRPAWEMIRRAEAEGKITPGKSTIIEPTSGNTGIGL
AMVCAARGYRCIITMPDNATTERVKILKAYGAEVHLTPAEKRMQGAIDEANRLASEIPGSFIPMQFENPANPDAHRHTTA
VEIYEAFSGRLDAFVLTAGTGGTVTGTGEELKKRIPNLRIYVVEPYGSPVLSGGKPGPHKIPGTGPGFIPSILNRSIYDD
IFLIKDEDAQQMARELAAKEGILVGASAAASAYYAVKVAKQFPKGARVLCMAPDSGERYLSSDLFAD

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=313, Percent_Identity=43.1309904153355, Blast_Score=241, Evalue=5e-64,
Organism=Homo sapiens, GI295821200, Length=313, Percent_Identity=43.1309904153355, Blast_Score=241, Evalue=5e-64,
Organism=Homo sapiens, GI4557415, Length=313, Percent_Identity=43.1309904153355, Blast_Score=241, Evalue=5e-64,
Organism=Escherichia coli, GI2367138, Length=298, Percent_Identity=42.2818791946309, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=42.7215189873418, Blast_Score=209, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=44.6666666666667, Blast_Score=251, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI115535073, Length=300, Percent_Identity=47.6666666666667, Blast_Score=251, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17562970, Length=300, Percent_Identity=43.3333333333333, Blast_Score=240, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=44.0273037542662, Blast_Score=234, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=41.8060200668896, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=41.5625, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI25147552, Length=320, Percent_Identity=40.9375, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=42.0560747663551, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17561716, Length=117, Percent_Identity=39.3162393162393, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17539800, Length=194, Percent_Identity=27.319587628866, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71996324, Length=333, Percent_Identity=27.3273273273273, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539640, Length=199, Percent_Identity=27.1356783919598, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=39.171974522293, Blast_Score=216, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6321449, Length=327, Percent_Identity=34.8623853211009, Blast_Score=158, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24643623, Length=306, Percent_Identity=40.1960784313725, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI20129101, Length=306, Percent_Identity=40.1960784313725, Blast_Score=217, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32983; Mature: 32983

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYDSILDLIGGTPIVKLRRLPDPDGADVYMKLESFNPGGSVKDRPAWEMIRRAEAEGK
CCHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCC
ITPGKSTIIEPTSGNTGIGLAMVCAARGYRCIITMPDNATTERVKILKAYGAEVHLTPAE
CCCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCEEEECHHH
KRMQGAIDEANRLASEIPGSFIPMQFENPANPDAHRHTTAVEIYEAFSGRLDAFVLTAGT
HHHHHHHHHHHHHHHHCCCCEECEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECC
GGTVTGTGEELKKRIPNLRIYVVEPYGSPVLSGGKPGPHKIPGTGPGFIPSILNRSIYDD
CCCEECCHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHCC
IFLIKDEDAQQMARELAAKEGILVGASAAASAYYAVKVAKQFPKGARVLCMAPDSGERYL
EEEEECCCHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHH
SSDLFAD
HHHCCCC
>Mature Secondary Structure
MKLYDSILDLIGGTPIVKLRRLPDPDGADVYMKLESFNPGGSVKDRPAWEMIRRAEAEGK
CCHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCC
ITPGKSTIIEPTSGNTGIGLAMVCAARGYRCIITMPDNATTERVKILKAYGAEVHLTPAE
CCCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCEEEECHHH
KRMQGAIDEANRLASEIPGSFIPMQFENPANPDAHRHTTAVEIYEAFSGRLDAFVLTAGT
HHHHHHHHHHHHHHHHCCCCEECEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECC
GGTVTGTGEELKKRIPNLRIYVVEPYGSPVLSGGKPGPHKIPGTGPGFIPSILNRSIYDD
CCCEECCHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHCC
IFLIKDEDAQQMARELAAKEGILVGASAAASAYYAVKVAKQFPKGARVLCMAPDSGERYL
EEEEECCCHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHH
SSDLFAD
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]