Click here to switch to the map view.

The map label for this gene is cueR [H]

Identifier: 138894998

GI number: 138894998

Start: 1422074

End: 1422463

Strand: Direct

Name: cueR [H]

Synonym: GTNG_1336

Alternate gene names: 138894998

Gene position: 1422074-1422463 (Clockwise)

Preceding gene: 138894997

Following gene: 138894999

Centisome position: 40.05

GC content: 48.97

Gene sequence:

>390_bases
ATGGGCTATTTTACCATTTCTGATTTGGCGCAGGAGTTTCATGTAAGCACACGGACGATCCGCTATTATGAAGAGCGCGG
GCTGCTTGCCCCGATTCGGACGGAGTCAGGGCAACGGCTGTATACGAAAAAGGAGCGGGCAAAGCTCAAGCTCATTTTGC
GCGGCAAACGGTTCGGCTTTTCGCTTGAGGAAATTCATGAGATGATTGCGCTGTTTGATGAGGATCGCACCGGAAAGAAA
CAACTCGAAAAAACGGTCGAATATGGACGTAAAAAAATTAAGGAGGTGAGCGAGCGGATTGACGATTTGCTGAAGCTGAA
GGCGGAGATGGAGGCGTTGCTTTCCGATTTTGAAAAGCGATTGCGAGAATGGGAGGATAGAGCTGAATGA

Upstream 100 bases:

>100_bases
CACCTTTTTTCTTTGATGAGAAAGCAGGAGGTTGATTGACTTTTACGTCAACGTCAATTAAAATAAAATCCAGAATATTA
AATCTACAGAAAGGATTACG

Downstream 100 bases:

>100_bases
ACATTTCTGAACTTCTCGCCCGTCATGCGAGGAAGTTTCCTGAAAAAACGGCGGTCATTGATGGGGAAACGGAGCTTTCG
TATGCTGAAGTGAACCGAAC

Product: mercuric resistance operon regulatory protein MerR

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 129; Mature: 128

Protein sequence:

>129_residues
MGYFTISDLAQEFHVSTRTIRYYEERGLLAPIRTESGQRLYTKKERAKLKLILRGKRFGFSLEEIHEMIALFDEDRTGKK
QLEKTVEYGRKKIKEVSERIDDLLKLKAEMEALLSDFEKRLREWEDRAE

Sequences:

>Translated_129_residues
MGYFTISDLAQEFHVSTRTIRYYEERGLLAPIRTESGQRLYTKKERAKLKLILRGKRFGFSLEEIHEMIALFDEDRTGKK
QLEKTVEYGRKKIKEVSERIDDLLKLKAEMEALLSDFEKRLREWEDRAE
>Mature_128_residues
GYFTISDLAQEFHVSTRTIRYYEERGLLAPIRTESGQRLYTKKERAKLKLILRGKRFGFSLEEIHEMIALFDEDRTGKKQ
LEKTVEYGRKKIKEVSERIDDLLKLKAEMEALLSDFEKRLREWEDRAE

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=112, Percent_Identity=33.9285714285714, Blast_Score=66, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15433; Mature: 15302

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYFTISDLAQEFHVSTRTIRYYEERGLLAPIRTESGQRLYTKKERAKLKLILRGKRFGF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
SLEEIHEMIALFDEDRTGKKQLEKTVEYGRKKIKEVSERIDDLLKLKAEMEALLSDFEKR
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LREWEDRAE
HHHHHHCCC
>Mature Secondary Structure 
GYFTISDLAQEFHVSTRTIRYYEERGLLAPIRTESGQRLYTKKERAKLKLILRGKRFGF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
SLEEIHEMIALFDEDRTGKKQLEKTVEYGRKKIKEVSERIDDLLKLKAEMEALLSDFEKR
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LREWEDRAE
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]