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The map label for this gene is maeB [C]

Identifier: 138894963

GI number: 138894963

Start: 1388615

End: 1389898

Strand: Direct

Name: maeB [C]

Synonym: GTNG_1301

Alternate gene names: 138894963

Gene position: 1388615-1389898 (Clockwise)

Preceding gene: 138894961

Following gene: 138894964

Centisome position: 39.11

GC content: 50.78

Gene sequence:

>1284_bases
GTGCGTGACATTACCGTCAGCGCGCTCGATACGAAGCAATGCGATTTGATCATCGAGGCGCTGAAAAAAATTCGAGGCGT
CAAAATTGTGAACGTTTCCGACCGCACGTTTTTAATGCACATCGGGGGGAAAATTGAAACGAATTCGAAAATTCCGGTGA
AAACACGTGATGATTTGTCGCGAGTGTATACGCCGGGCGTGGCACGCGTTTGCACGGCTATCGCTGAAGATCCGCGCAAA
GCGTATTCGTTAACGATTAAACGCAACACCGTCGCGGTCGTGTCCGACGGTACGGCAGTGCTCGGGCTTGGGGACATCGG
CCCGTATGCAGCGATGCCGGTCATGGAAGGGAAAGCGATGCTGTTTAAACAGTTTGCGGGAGTCGATGCGTTCCCAGTTT
GCTTGGACACGAAAGATACGGAAGAAATCATTCAAATTGTGAAAGCGATTGCCCCGGCGTTTGGCGGCATTAATTTGGAA
GACATTTCGGCGCCGCGTTGCTTTGAAATTGAGGCGCGTTTGAAAGAAGAACTTGACATCCCGGTGTTCCACGACGACCA
ACATGGCACAGCGGTCGTGTTGCTTGCTGGATTGCTGAATGCGTTGAAAATTGTCGATAAAAAGCTTGAGGATATCAAAG
TCGTCTTAACTGGTATTGGCGCGGCCGGCATCGCTTGCACGAAAATTTTGCTTGCTGCCGGTGTGCGCAACATTATCGGG
GTCGACCGTTATGGCGCCATCCACCGCGATGAAACGTACGAAAATCCGTATTGGCAAGAATATGCACAAATCACCAATCC
TTATAATCTCAAAGGAAGCTTGTCGGATGTGATCGTTGGTGCGGACGTATTTATCGGCGTTTCCGCCCCAGGCATTTTGA
AAGTCGAAGACGTGAAAAAAATGGCCCGCGATCCGATCGTGTTTGCGATGGCCAACCCGGTGCCGGAAATCGATCCGGAG
CTGGCCGAACCGTACGTGCGCGTGATGGCGACCGGACGTTCTGACTATCCGAACCAAATTAACAACGTTCTTTGCTTCCC
GGGCATTTTCCGCGGTGCATTGGACTGCCGAGCGAAAGAAATTAATGAAGAAATGAAGCTTGCTGCCGCAAAAGCGATTG
CTTCGGTTGTCACCGAAGATGAATTGAACGAAACGTATATCATCCCAAGTGTATTTAACAGTAAAGTAGTAGAACGCGTT
CGCCAGGCAGTCATTGAAGCAGCTTACCGCACCGGGGTCGCTCGGAAGGACAACATTCCGGTTGGTGGGTATACAGGACA
GTAA

Upstream 100 bases:

>100_bases
AAAAGATATCGTCTCATTTAGCGATATCGCCGCAGCCATTGGCAAAGCAGGTGGAGACATCGTCGGGATTGACGTCATCT
CATCGAGTAAAGTTCATACA

Downstream 100 bases:

>100_bases
ACAAGCAACCCAATCGAACCGATGGACGGCTTCCTTTGTAAGGGGAAGCCGTTTTTTCGTTGCAGGAGCGTCTTATTGCG
GGCGAATCACGTTTAGAAAT

Product: malic enzyme

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRDITVSALDTKQCDLIIEALKKIRGVKIVNVSDRTFLMHIGGKIETNSKIPVKTRDDLSRVYTPGVARVCTAIAEDPRK
AYSLTIKRNTVAVVSDGTAVLGLGDIGPYAAMPVMEGKAMLFKQFAGVDAFPVCLDTKDTEEIIQIVKAIAPAFGGINLE
DISAPRCFEIEARLKEELDIPVFHDDQHGTAVVLLAGLLNALKIVDKKLEDIKVVLTGIGAAGIACTKILLAAGVRNIIG
VDRYGAIHRDETYENPYWQEYAQITNPYNLKGSLSDVIVGADVFIGVSAPGILKVEDVKKMARDPIVFAMANPVPEIDPE
LAEPYVRVMATGRSDYPNQINNVLCFPGIFRGALDCRAKEINEEMKLAAAKAIASVVTEDELNETYIIPSVFNSKVVERV
RQAVIEAAYRTGVARKDNIPVGGYTGQ

Sequences:

>Translated_427_residues
MRDITVSALDTKQCDLIIEALKKIRGVKIVNVSDRTFLMHIGGKIETNSKIPVKTRDDLSRVYTPGVARVCTAIAEDPRK
AYSLTIKRNTVAVVSDGTAVLGLGDIGPYAAMPVMEGKAMLFKQFAGVDAFPVCLDTKDTEEIIQIVKAIAPAFGGINLE
DISAPRCFEIEARLKEELDIPVFHDDQHGTAVVLLAGLLNALKIVDKKLEDIKVVLTGIGAAGIACTKILLAAGVRNIIG
VDRYGAIHRDETYENPYWQEYAQITNPYNLKGSLSDVIVGADVFIGVSAPGILKVEDVKKMARDPIVFAMANPVPEIDPE
LAEPYVRVMATGRSDYPNQINNVLCFPGIFRGALDCRAKEINEEMKLAAAKAIASVVTEDELNETYIIPSVFNSKVVERV
RQAVIEAAYRTGVARKDNIPVGGYTGQ
>Mature_427_residues
MRDITVSALDTKQCDLIIEALKKIRGVKIVNVSDRTFLMHIGGKIETNSKIPVKTRDDLSRVYTPGVARVCTAIAEDPRK
AYSLTIKRNTVAVVSDGTAVLGLGDIGPYAAMPVMEGKAMLFKQFAGVDAFPVCLDTKDTEEIIQIVKAIAPAFGGINLE
DISAPRCFEIEARLKEELDIPVFHDDQHGTAVVLLAGLLNALKIVDKKLEDIKVVLTGIGAAGIACTKILLAAGVRNIIG
VDRYGAIHRDETYENPYWQEYAQITNPYNLKGSLSDVIVGADVFIGVSAPGILKVEDVKKMARDPIVFAMANPVPEIDPE
LAEPYVRVMATGRSDYPNQINNVLCFPGIFRGALDCRAKEINEEMKLAAAKAIASVVTEDELNETYIIPSVFNSKVVERV
RQAVIEAAYRTGVARKDNIPVGGYTGQ

Specific function: In addition to the NAD-dependent oxidative decarboxylation of L-malate, the enzyme catalyzes the decarboxylation of oxaloacetate [H]

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505145, Length=460, Percent_Identity=26.9565217391304, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI62420882, Length=434, Percent_Identity=26.7281105990783, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI62420880, Length=434, Percent_Identity=26.7281105990783, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI239049447, Length=434, Percent_Identity=26.7281105990783, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI4505143, Length=435, Percent_Identity=24.367816091954, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI270265879, Length=415, Percent_Identity=26.7469879518072, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788806, Length=399, Percent_Identity=48.3709273182957, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI87081919, Length=486, Percent_Identity=23.8683127572016, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17537199, Length=404, Percent_Identity=29.2079207920792, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322823, Length=401, Percent_Identity=27.1820448877805, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646386, Length=388, Percent_Identity=26.8041237113402, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646388, Length=388, Percent_Identity=26.8041237113402, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281362674, Length=467, Percent_Identity=23.7687366167024, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI21356279, Length=467, Percent_Identity=23.7687366167024, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI281362672, Length=467, Percent_Identity=23.7687366167024, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI78707242, Length=439, Percent_Identity=25.0569476082005, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI78707238, Length=439, Percent_Identity=25.0569476082005, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI78707240, Length=428, Percent_Identity=25.2336448598131, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 46402; Mature: 46402

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00331 MALIC_ENZYMES ; PS00217 SUGAR_TRANSPORT_2 ; PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDITVSALDTKQCDLIIEALKKIRGVKIVNVSDRTFLMHIGGKIETNSKIPVKTRDDLS
CCCEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCEEECCCCCCCCCHHHHH
RVYTPGVARVCTAIAEDPRKAYSLTIKRNTVAVVSDGTAVLGLGDIGPYAAMPVMEGKAM
HHCCCCHHHHHHHHHHCCCHHEEEEEECCEEEEEECCCEEEEECCCCCHHHCCHHCCHHH
LFKQFAGVDAFPVCLDTKDTEEIIQIVKAIAPAFGGINLEDISAPRCFEIEARLKEELDI
HHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEHHHHHHHHCCC
PVFHDDQHGTAVVLLAGLLNALKIVDKKLEDIKVVLTGIGAAGIACTKILLAAGVRNIIG
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
VDRYGAIHRDETYENPYWQEYAQITNPYNLKGSLSDVIVGADVFIGVSAPGILKVEDVKK
CCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHEEECCEEEEECCCCCEEEHHHHHH
MARDPIVFAMANPVPEIDPELAEPYVRVMATGRSDYPNQINNVLCFPGIFRGALDCRAKE
HHHCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCEEECCHHHHHHHHHHHHH
INEEMKLAAAKAIASVVTEDELNETYIIPSVFNSKVVERVRQAVIEAAYRTGVARKDNIP
HHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
VGGYTGQ
CCCCCCC
>Mature Secondary Structure
MRDITVSALDTKQCDLIIEALKKIRGVKIVNVSDRTFLMHIGGKIETNSKIPVKTRDDLS
CCCEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCEEECCCCCCCCCHHHHH
RVYTPGVARVCTAIAEDPRKAYSLTIKRNTVAVVSDGTAVLGLGDIGPYAAMPVMEGKAM
HHCCCCHHHHHHHHHHCCCHHEEEEEECCEEEEEECCCEEEEECCCCCHHHCCHHCCHHH
LFKQFAGVDAFPVCLDTKDTEEIIQIVKAIAPAFGGINLEDISAPRCFEIEARLKEELDI
HHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEHHHHHHHHCCC
PVFHDDQHGTAVVLLAGLLNALKIVDKKLEDIKVVLTGIGAAGIACTKILLAAGVRNIIG
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
VDRYGAIHRDETYENPYWQEYAQITNPYNLKGSLSDVIVGADVFIGVSAPGILKVEDVKK
CCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHEEECCEEEEECCCCCEEEHHHHHH
MARDPIVFAMANPVPEIDPELAEPYVRVMATGRSDYPNQINNVLCFPGIFRGALDCRAKE
HHHCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCEEECCHHHHHHHHHHHHH
INEEMKLAAAKAIASVVTEDELNETYIIPSVFNSKVVERVRQAVIEAAYRTGVARKDNIP
HHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
VGGYTGQ
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2644282 [H]