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The map label for this gene is cobB1 [H]

Identifier: 138894960

GI number: 138894960

Start: 1385477

End: 1386205

Strand: Reverse

Name: cobB1 [H]

Synonym: GTNG_1298

Alternate gene names: 138894960

Gene position: 1386205-1385477 (Counterclockwise)

Preceding gene: 138894962

Following gene: 138894959

Centisome position: 39.04

GC content: 55.83

Gene sequence:

>729_bases
GTGACCATTGCCTCCTGGCTTACCAACTTGCGAAAGACGGTTGTGCTTACTGGCGCCGGCATGTCAACCGAAAGCGGGCT
GCCTGATTTCCGCTCGCCGCGCACGGGGCTGTGGGCGCGCTTCAATCCGAGCGAATTGGCCACCGTCGATGCCTTACACC
ACCGCCACGAGTCATTTGTTGAGTTTTACCAATATCGCATCCGCACCTTGCAACAGTGTCAGCCACATAACGGGCATCGC
CTGTTGGCTGATTGGGAGCAACGCGGAATCGTACGGACGATCGTGACCCAAAACGTCGATGGTTTTCACCAACAAGCCGG
CAGTCAATGCGTCATCGAACTGCATGGCTCGCTGCGCACCGTCCATTGCCAGCAGTGCGGGCAGAAACAGCCGAGCCATG
TTTATTTACACGGCGTATTGACGTGCGAATGCGGCGGTGTTTTACGCCCATCGGTCGTGTTGTTTGGCGAACCTCTGCCA
GAGAGAGCCATCACCCAAGCGTGGGAGGAGGCCCGCCAAGCGGACTTATTCCTTGTGCTCGGCTCATCCTTGCAAGTATC
GCCGGCGAATCAGCTGCCGTTTGTCGCCAAACAAAATGGAGCCAAATTGGTCATCATCAACTGGGAACCGACGGAACTTG
ATCATCTGGCTGATGCCGTCATTCATCAACGGAAAATTGGCGAAGTGCTCAAAGAAATTGACCAACAGCTGACGGAGGGA
GCACCATGA

Upstream 100 bases:

>100_bases
CGAAATAGACGGACAGGGAAAGCAAAATGATTGTCGAACATATATGAATGACCCATTGAACTGTAAAATGGGGAGAGAAA
AAGGTAAAGGAGGAAAAACA

Downstream 100 bases:

>100_bases
ACCGGGAAACGATTTTGCAAGAGGCGCTTCGCTCAATCGGCGACGATTCGCGAATCCGTCATTGGCGCCGAGTATCAGGC
GGCGACATCAATGACGCCTA

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 1 [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTIASWLTNLRKTVVLTGAGMSTESGLPDFRSPRTGLWARFNPSELATVDALHHRHESFVEFYQYRIRTLQQCQPHNGHR
LLADWEQRGIVRTIVTQNVDGFHQQAGSQCVIELHGSLRTVHCQQCGQKQPSHVYLHGVLTCECGGVLRPSVVLFGEPLP
ERAITQAWEEARQADLFLVLGSSLQVSPANQLPFVAKQNGAKLVIINWEPTELDHLADAVIHQRKIGEVLKEIDQQLTEG
AP

Sequences:

>Translated_242_residues
MTIASWLTNLRKTVVLTGAGMSTESGLPDFRSPRTGLWARFNPSELATVDALHHRHESFVEFYQYRIRTLQQCQPHNGHR
LLADWEQRGIVRTIVTQNVDGFHQQAGSQCVIELHGSLRTVHCQQCGQKQPSHVYLHGVLTCECGGVLRPSVVLFGEPLP
ERAITQAWEEARQADLFLVLGSSLQVSPANQLPFVAKQNGAKLVIINWEPTELDHLADAVIHQRKIGEVLKEIDQQLTEG
AP
>Mature_241_residues
TIASWLTNLRKTVVLTGAGMSTESGLPDFRSPRTGLWARFNPSELATVDALHHRHESFVEFYQYRIRTLQQCQPHNGHRL
LADWEQRGIVRTIVTQNVDGFHQQAGSQCVIELHGSLRTVHCQQCGQKQPSHVYLHGVLTCECGGVLRPSVVLFGEPLPE
RAITQAWEEARQADLFLVLGSSLQVSPANQLPFVAKQNGAKLVIINWEPTELDHLADAVIHQRKIGEVLKEIDQQLTEGA
P

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=269, Percent_Identity=33.0855018587361, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI300795542, Length=218, Percent_Identity=35.7798165137615, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI13787215, Length=235, Percent_Identity=33.1914893617021, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI6912664, Length=235, Percent_Identity=33.1914893617021, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI300797577, Length=242, Percent_Identity=31.8181818181818, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI6912660, Length=242, Percent_Identity=30.5785123966942, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI63054862, Length=238, Percent_Identity=30.2521008403361, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI300797597, Length=226, Percent_Identity=31.858407079646, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI13775602, Length=211, Percent_Identity=30.3317535545024, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI13775600, Length=211, Percent_Identity=30.3317535545024, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI7657575, Length=227, Percent_Identity=32.5991189427313, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI300797705, Length=191, Percent_Identity=30.3664921465969, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI7706712, Length=266, Percent_Identity=27.8195488721804, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI215982798, Length=156, Percent_Identity=32.0512820512821, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI308199517, Length=209, Percent_Identity=36.8421052631579, Blast_Score=107, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17541892, Length=205, Percent_Identity=34.1463414634146, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71990482, Length=272, Percent_Identity=28.6764705882353, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71990487, Length=274, Percent_Identity=28.4671532846715, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17567771, Length=274, Percent_Identity=27.007299270073, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17505510, Length=224, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325242, Length=216, Percent_Identity=30.5555555555556, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24648389, Length=195, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28571445, Length=272, Percent_Identity=31.25, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17137536, Length=228, Percent_Identity=29.3859649122807, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24645650, Length=226, Percent_Identity=29.2035398230088, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27063; Mature: 26932

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIASWLTNLRKTVVLTGAGMSTESGLPDFRSPRTGLWARFNPSELATVDALHHRHESFV
CCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHH
EFYQYRIRTLQQCQPHNGHRLLADWEQRGIVRTIVTQNVDGFHQQAGSQCVIELHGSLRT
HHHHHHHHHHHHCCCCCCCEEEECHHHCCCEEHHHHCCCCHHHHHCCCEEEEEECCCHHE
VHCQQCGQKQPSHVYLHGVLTCECGGVLRPSVVLFGEPLPERAITQAWEEARQADLFLVL
EEHHHCCCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCEEEEE
GSSLQVSPANQLPFVAKQNGAKLVIINWEPTELDHLADAVIHQRKIGEVLKEIDQQLTEG
CCCEEECCCCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AP
CC
>Mature Secondary Structure 
TIASWLTNLRKTVVLTGAGMSTESGLPDFRSPRTGLWARFNPSELATVDALHHRHESFV
CHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHH
EFYQYRIRTLQQCQPHNGHRLLADWEQRGIVRTIVTQNVDGFHQQAGSQCVIELHGSLRT
HHHHHHHHHHHHCCCCCCCEEEECHHHCCCEEHHHHCCCCHHHHHCCCEEEEEECCCHHE
VHCQQCGQKQPSHVYLHGVLTCECGGVLRPSVVLFGEPLPERAITQAWEEARQADLFLVL
EEHHHCCCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCEEEEE
GSSLQVSPANQLPFVAKQNGAKLVIINWEPTELDHLADAVIHQRKIGEVLKEIDQQLTEG
CCCEEECCCCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA