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The map label for this gene is speD

Identifier: 138894915

GI number: 138894915

Start: 1325602

End: 1326396

Strand: Reverse

Name: speD

Synonym: GTNG_1253

Alternate gene names: 138894915

Gene position: 1326396-1325602 (Counterclockwise)

Preceding gene: 138894916

Following gene: 138894914

Centisome position: 37.36

GC content: 43.77

Gene sequence:

>795_bases
ATGAACGACACACCGCACGTGAAATTGCACGGGTTTAACAATTTGACGAAGTCGCTCAGCTTCAATATGTACGATATTTG
CTATACGAAAACACCCAAGGAGCGGGAAGCGTATATTTCCTATATCGACGATGTTTACAACGCCGAGCGGCTGACAAACA
TTTTGAAACACGTCGCCGACATCATCGGCGCCCATGTGTTAAACATCGCCAAACAAGATTACGTTCCGCAAGGCGCAAGT
GTGACGATGCTCGTTTCCGAAGGGCCGGTTGTAGAAGTGCCGCAAGCCGAGGCGCCGTTGCCTGAGGCAGTCGTGCTTTC
GCTTGATAAAAGCCATATTACCGTTCATACATACCCAGAATACCATCCGAGTGATGGAATTAGTACGTTCCGTGCCGATA
TTGACGTCGTCACCTGCGGAGAAATTTCGCCGTTAAAAGCGCTCGATTATTTGATTCAGTCGTTTGAAGCCGACATTATG
ATAATCGATTACCGCGTGCGCGGGTTTACACGTGACATTCACGGATACAAATTGTTTATTGACCATGATATTACATCGAT
TCAAAATTATATTCCAGAAGATATTCGTGAGAAGTACGATATGATTGACGTGAACATTTATCAAGAGAACATTTTCCATA
CAAAATGCAAGCTGCGGCAGTTTGATTTAGACAACTATCTATTCGGACATACGAAAGATGCCTTATCTAAACAAGAAGTA
GAGGAAACGACCGCCAAACTGAAGAGAGAAATGGACGAAATTTTTTACGGAAAAAATATGCCTAGCGGCTTTTAA

Upstream 100 bases:

>100_bases
GCAGTGAGAAGTTGGCCTCCATTCCTTTCTACACAAAACAGCAACTATATTGGGTGCAAATCGGACAAATTAAGAAAAAA
CGAAAGGGATGATCTAAGCC

Downstream 100 bases:

>100_bases
GAAAAGGAAGCTTTTCGGCACTGTGCTCACCGATCAGCCATTCAAGCTTCCCCTGCAGCTTCTCCGTTTGCACTATGTAT
GGTATGCTAGTAGAAAAAAG

Product: S-adenosylmethionine decarboxylase

Products: NA

Alternate protein names: AdoMetDC; SAMDC

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MNDTPHVKLHGFNNLTKSLSFNMYDICYTKTPKEREAYISYIDDVYNAERLTNILKHVADIIGAHVLNIAKQDYVPQGAS
VTMLVSEGPVVEVPQAEAPLPEAVVLSLDKSHITVHTYPEYHPSDGISTFRADIDVVTCGEISPLKALDYLIQSFEADIM
IIDYRVRGFTRDIHGYKLFIDHDITSIQNYIPEDIREKYDMIDVNIYQENIFHTKCKLRQFDLDNYLFGHTKDALSKQEV
EETTAKLKREMDEIFYGKNMPSGF

Sequences:

>Translated_264_residues
MNDTPHVKLHGFNNLTKSLSFNMYDICYTKTPKEREAYISYIDDVYNAERLTNILKHVADIIGAHVLNIAKQDYVPQGAS
VTMLVSEGPVVEVPQAEAPLPEAVVLSLDKSHITVHTYPEYHPSDGISTFRADIDVVTCGEISPLKALDYLIQSFEADIM
IIDYRVRGFTRDIHGYKLFIDHDITSIQNYIPEDIREKYDMIDVNIYQENIFHTKCKLRQFDLDNYLFGHTKDALSKQEV
EETTAKLKREMDEIFYGKNMPSGF
>Mature_264_residues
MNDTPHVKLHGFNNLTKSLSFNMYDICYTKTPKEREAYISYIDDVYNAERLTNILKHVADIIGAHVLNIAKQDYVPQGAS
VTMLVSEGPVVEVPQAEAPLPEAVVLSLDKSHITVHTYPEYHPSDGISTFRADIDVVTCGEISPLKALDYLIQSFEADIM
IIDYRVRGFTRDIHGYKLFIDHDITSIQNYIPEDIREKYDMIDVNIYQENIFHTKCKLRQFDLDNYLFGHTKDALSKQEV
EETTAKLKREMDEIFYGKNMPSGF

Specific function: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine

COG id: COG1586

COG function: function code E; S-adenosylmethionine decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily

Homologues:

Organism=Escherichia coli, GI1786311, Length=260, Percent_Identity=63.0769230769231, Blast_Score=341, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SPED_GEOTN (A4IMR9)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001125368.1
- ProteinModelPortal:   A4IMR9
- STRING:   A4IMR9
- GeneID:   4966192
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_1253
- NMPDR:   fig|420246.5.peg.1215
- eggNOG:   COG1586
- HOGENOM:   HBG303125
- OMA:   YNAERLT
- PhylomeDB:   A4IMR9
- ProtClustDB:   PRK05462
- BioCyc:   GTHE420246:GTNG_1253-MONOMER
- HAMAP:   MF_00465
- InterPro:   IPR003826
- InterPro:   IPR009165
- InterPro:   IPR016067
- Gene3D:   G3DSA:3.60.90.10
- PIRSF:   PIRSF001356
- TIGRFAMs:   TIGR03331

Pfam domain/function: PF02675 AdoMet_dc; SSF56276 S-AdenosylMet_decarbase_core

EC number: =4.1.1.50

Molecular weight: Translated: 30323; Mature: 30323

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: ACT_SITE 111-111 ACT_SITE 116-116 ACT_SITE 139-139

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTPHVKLHGFNNLTKSLSFNMYDICYTKTPKEREAYISYIDDVYNAERLTNILKHVAD
CCCCCEEEEECCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHH
IIGAHVLNIAKQDYVPQGASVTMLVSEGPVVEVPQAEAPLPEAVVLSLDKSHITVHTYPE
HHHHHHHHHHHHCCCCCCCEEEEEECCCCEEECCCCCCCCCCEEEEEECCCEEEEEECCC
YHPSDGISTFRADIDVVTCGEISPLKALDYLIQSFEADIMIIDYRVRGFTRDIHGYKLFI
CCCCCCCHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEEEECCEEECCCCEEEEE
DHDITSIQNYIPEDIREKYDMIDVNIYQENIFHTKCKLRQFDLDNYLFGHTKDALSKQEV
ECCHHHHHHHCCHHHHHHHCEEEEEEEHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHH
EETTAKLKREMDEIFYGKNMPSGF
HHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNDTPHVKLHGFNNLTKSLSFNMYDICYTKTPKEREAYISYIDDVYNAERLTNILKHVAD
CCCCCEEEEECCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHH
IIGAHVLNIAKQDYVPQGASVTMLVSEGPVVEVPQAEAPLPEAVVLSLDKSHITVHTYPE
HHHHHHHHHHHHCCCCCCCEEEEEECCCCEEECCCCCCCCCCEEEEEECCCEEEEEECCC
YHPSDGISTFRADIDVVTCGEISPLKALDYLIQSFEADIMIIDYRVRGFTRDIHGYKLFI
CCCCCCCHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEEEECCEEECCCCEEEEE
DHDITSIQNYIPEDIREKYDMIDVNIYQENIFHTKCKLRQFDLDNYLFGHTKDALSKQEV
ECCHHHHHHHCCHHHHHHHCEEEEEEEHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHH
EETTAKLKREMDEIFYGKNMPSGF
HHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA