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The map label for this gene is rnc [H]

Identifier: 138894713

GI number: 138894713

Start: 1112922

End: 1113662

Strand: Direct

Name: rnc [H]

Synonym: GTNG_1045

Alternate gene names: 138894713

Gene position: 1112922-1113662 (Clockwise)

Preceding gene: 138894712

Following gene: 138894714

Centisome position: 31.35

GC content: 50.88

Gene sequence:

>741_bases
ATGTCAAAACAAAGAGATAAAGGGCGCATTTACGAAAAAAGGCGGGCGAAGTTTCAAGAACTGCAGAAGAAAATCGGCAT
CACCTTCCAAAATGAAAAGCTATTGATACAAGCGTTCACCCATTCATCGTATGTGAATGAGCATCGGCGGCGGTTCCATG
AGGACAACGAGCGGCTTGAGTTTTTAGGCGACGCCGTGTTGGAGCTGACCGTTTCCCAATATTTATTTCAAAAGTTTCCG
CATATGAGTGAAGGGCAATTGACGAAACTGCGGGCGGCCATTGTCTGTGAGCCGTCGCTTGTGAAATTTGCCAACGCCTT
GTCGTTCGGCGAGCTTGTTTTGCTCGGCAAAGGCGAAGAGCTGACTGGGGGGCGGACGCGCCCGGCGTTGCTCGCCGACG
TGTTCGAGGCGTTTATTGGCGCCCTTTATTTGGATCAAGGAATGGACGTGGTCCTTCGTTTTTTAGGACAAACGATGTTC
CCGAAGATTGACGAAGGTGCTTTTTCTCATGTGATGGATTTTAAAAGCCAGTTGCAAGAATTGGTGCAACGCGATGGCAG
CGGAACGCTTGAATACGCCATTTTGGAAGAAAAAGGACCGGCTCACAATAAAGAATTTGTCGCCCGTGTGGCATTGAACG
GGCAAGAGCTCGGCGTCGGTGTCGGCCGCTCGAAAAAAGAGGCTGAGCAACATGCGGCGCAAATGGCGCTCGAAACGTTG
CGGGCCGCCGACAAGCAATAA

Upstream 100 bases:

>100_bases
AAAAGTGAACCGTTCTCGTTGGTGTAGCGGGTCAGTGAACGGATATAATAAAAGATAGTATACGGCCAGTTTGTCTGGAA
TGAAGTCGGAGGGCATTTTT

Downstream 100 bases:

>100_bases
AAGGCTGGCGCTTGACGTCAGTCTTTTTCTATCGGCGTTTTTCTGCCTTTGTATGGTATATTGATAAAAGATAGAACATC
CTTGTCCGCCGTTCAGTCCG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MSKQRDKGRIYEKRRAKFQELQKKIGITFQNEKLLIQAFTHSSYVNEHRRRFHEDNERLEFLGDAVLELTVSQYLFQKFP
HMSEGQLTKLRAAIVCEPSLVKFANALSFGELVLLGKGEELTGGRTRPALLADVFEAFIGALYLDQGMDVVLRFLGQTMF
PKIDEGAFSHVMDFKSQLQELVQRDGSGTLEYAILEEKGPAHNKEFVARVALNGQELGVGVGRSKKEAEQHAAQMALETL
RAADKQ

Sequences:

>Translated_246_residues
MSKQRDKGRIYEKRRAKFQELQKKIGITFQNEKLLIQAFTHSSYVNEHRRRFHEDNERLEFLGDAVLELTVSQYLFQKFP
HMSEGQLTKLRAAIVCEPSLVKFANALSFGELVLLGKGEELTGGRTRPALLADVFEAFIGALYLDQGMDVVLRFLGQTMF
PKIDEGAFSHVMDFKSQLQELVQRDGSGTLEYAILEEKGPAHNKEFVARVALNGQELGVGVGRSKKEAEQHAAQMALETL
RAADKQ
>Mature_245_residues
SKQRDKGRIYEKRRAKFQELQKKIGITFQNEKLLIQAFTHSSYVNEHRRRFHEDNERLEFLGDAVLELTVSQYLFQKFPH
MSEGQLTKLRAAIVCEPSLVKFANALSFGELVLLGKGEELTGGRTRPALLADVFEAFIGALYLDQGMDVVLRFLGQTMFP
KIDEGAFSHVMDFKSQLQELVQRDGSGTLEYAILEEKGPAHNKEFVARVALNGQELGVGVGRSKKEAEQHAAQMALETLR
AADKQ

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=229, Percent_Identity=34.9344978165939, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI155030236, Length=229, Percent_Identity=34.9344978165939, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI29294649, Length=265, Percent_Identity=28.6792452830189, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI29294651, Length=265, Percent_Identity=28.6792452830189, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1788920, Length=225, Percent_Identity=36, Blast_Score=127, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17506883, Length=236, Percent_Identity=33.8983050847458, Blast_Score=116, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI193202651, Length=236, Percent_Identity=33.8983050847458, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17552834, Length=271, Percent_Identity=28.0442804428044, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323895, Length=223, Percent_Identity=31.390134529148, Blast_Score=82, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17137682, Length=229, Percent_Identity=31.8777292576419, Blast_Score=104, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27803; Mature: 27672

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQRDKGRIYEKRRAKFQELQKKIGITFQNEKLLIQAFTHSSYVNEHRRRFHEDNERLE
CCCCCCHHHHHHHHHHHHHHHHHHHCCEECCCEEEEEHHHHHHHHHHHHHHHCCCHHHHH
FLGDAVLELTVSQYLFQKFPHMSEGQLTKLRAAIVCEPSLVKFANALSFGELVLLGKGEE
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCC
LTGGRTRPALLADVFEAFIGALYLDQGMDVVLRFLGQTMFPKIDEGAFSHVMDFKSQLQE
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LVQRDGSGTLEYAILEEKGPAHNKEFVARVALNGQELGVGVGRSKKEAEQHAAQMALETL
HHHCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHH
RAADKQ
HHCCCC
>Mature Secondary Structure 
SKQRDKGRIYEKRRAKFQELQKKIGITFQNEKLLIQAFTHSSYVNEHRRRFHEDNERLE
CCCCCHHHHHHHHHHHHHHHHHHHCCEECCCEEEEEHHHHHHHHHHHHHHHCCCHHHHH
FLGDAVLELTVSQYLFQKFPHMSEGQLTKLRAAIVCEPSLVKFANALSFGELVLLGKGEE
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCC
LTGGRTRPALLADVFEAFIGALYLDQGMDVVLRFLGQTMFPKIDEGAFSHVMDFKSQLQE
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LVQRDGSGTLEYAILEEKGPAHNKEFVARVALNGQELGVGVGRSKKEAEQHAAQMALETL
HHHCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHH
RAADKQ
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA